PT946526E - Acidos carboxilicos macrociclicos complexos de metais sua utilizacao e processo para a sua preparacao - Google Patents
Acidos carboxilicos macrociclicos complexos de metais sua utilizacao e processo para a sua preparacaoInfo
- Publication number
- PT946526E PT946526E PT97952805T PT97952805T PT946526E PT 946526 E PT946526 E PT 946526E PT 97952805 T PT97952805 T PT 97952805T PT 97952805 T PT97952805 T PT 97952805T PT 946526 E PT946526 E PT 946526E
- Authority
- PT
- Portugal
- Prior art keywords
- complex
- carboxylic acids
- preparation
- metal complex
- acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Radiology & Medical Imaging (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19652387A DE19652387A1 (de) | 1996-12-04 | 1996-12-04 | Macrocyclische Metallkomplexcarbonsäuren, ihre Verwendung sowie Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT946526E true PT946526E (pt) | 2004-02-27 |
Family
ID=7814929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97952805T PT946526E (pt) | 1996-12-04 | 1997-11-26 | Acidos carboxilicos macrociclicos complexos de metais sua utilizacao e processo para a sua preparacao |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0946526B1 (pt) |
| JP (1) | JP4252112B2 (pt) |
| KR (1) | KR100495846B1 (pt) |
| CN (1) | CN1100767C (pt) |
| AT (1) | ATE253056T1 (pt) |
| AU (1) | AU734983B2 (pt) |
| CA (1) | CA2274132C (pt) |
| DE (2) | DE19652387A1 (pt) |
| DK (1) | DK0946526T3 (pt) |
| ES (1) | ES2208968T3 (pt) |
| HK (1) | HK1022153A1 (pt) |
| IL (1) | IL130271A (pt) |
| PT (1) | PT946526E (pt) |
| TW (1) | TW434232B (pt) |
| WO (1) | WO1998024774A1 (pt) |
| ZA (1) | ZA9710931B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1369134A1 (en) | 2002-06-05 | 2003-12-10 | Bracco Imaging S.p.A. | New agents for magnetic imaging method |
| DE102007058220A1 (de) | 2007-12-03 | 2009-06-04 | Bayer Schering Pharma Aktiengesellschaft | Dimere macrocyclisch substituierte Benzolderivate |
| KR101334780B1 (ko) | 2010-08-13 | 2013-12-02 | 한국생명공학연구원 | 요오드를 함유한 방사형상의 고분자 화합물, 이의 제조방법 및 이를 포함하는 ｃｔ용 조영제 조성물 |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| KR102464647B1 (ko) | 2016-11-28 | 2022-11-08 | 바이엘 파마 악티엔게젤샤프트 | 자기 공명 영상화에 사용하기 위한 높은 이완도 가돌리늄 킬레이트 화합물 |
| JP2020517584A (ja) * | 2017-04-27 | 2020-06-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 修飾ｍｒｉ造影剤およびその使用 |
| AU2019382881A1 (en) | 2018-11-23 | 2021-05-20 | Bayer Aktiengesellschaft | Formulation of contrast media and process of preparation thereof |
| CN114573521B (zh) * | 2020-12-01 | 2023-10-27 | 威智医药股份有限公司 | 一种钆布醇及其中间体的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA894792B (en) * | 1988-06-24 | 1991-04-24 | Dow Chemical Co | Macrocyclic bifunctional chelants,complexes thereof and their antibody conjugates |
| DE3938992A1 (de) * | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| DE4009119A1 (de) * | 1990-03-19 | 1991-09-26 | Schering Ag | 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| DE4344460A1 (de) * | 1993-12-22 | 1995-06-29 | Schering Ag | Metallkomplexe von dendrimeren Makromolekülen, diese enthaltende diagnostische Mittel sowie Verfahren zur Herstellung der Komplexe und Mittel |
| DE4425857A1 (de) * | 1994-07-07 | 1996-01-11 | Schering Ag | Kaskaden-Polymer-Komplexe, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| DE19525924A1 (de) * | 1995-07-04 | 1997-01-09 | Schering Ag | Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| DE19549286A1 (de) * | 1995-12-22 | 1997-06-26 | Schering Ag | Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
-
1996
- 1996-12-04 DE DE19652387A patent/DE19652387A1/de not_active Withdrawn
-
1997
- 1997-11-25 TW TW086117682A patent/TW434232B/zh not_active IP Right Cessation
- 1997-11-26 EP EP97952805A patent/EP0946526B1/de not_active Expired - Lifetime
- 1997-11-26 WO PCT/EP1997/006593 patent/WO1998024774A1/de active IP Right Grant
- 1997-11-26 DE DE59710931T patent/DE59710931D1/de not_active Expired - Lifetime
- 1997-11-26 CN CN97180330A patent/CN1100767C/zh not_active Expired - Fee Related
- 1997-11-26 PT PT97952805T patent/PT946526E/pt unknown
- 1997-11-26 JP JP52514898A patent/JP4252112B2/ja not_active Expired - Fee Related
- 1997-11-26 IL IL13027197A patent/IL130271A/xx not_active IP Right Cessation
- 1997-11-26 AU AU56554/98A patent/AU734983B2/en not_active Ceased
- 1997-11-26 CA CA002274132A patent/CA2274132C/en not_active Expired - Fee Related
- 1997-11-26 DK DK97952805T patent/DK0946526T3/da active
- 1997-11-26 AT AT97952805T patent/ATE253056T1/de not_active IP Right Cessation
- 1997-11-26 KR KR10-1999-7004964A patent/KR100495846B1/ko not_active IP Right Cessation
- 1997-11-26 ES ES97952805T patent/ES2208968T3/es not_active Expired - Lifetime
- 1997-12-04 ZA ZA9710931A patent/ZA9710931B/xx unknown
-
2000
- 2000-02-26 HK HK00101186A patent/HK1022153A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE59710931D1 (de) | 2003-12-04 |
| AU5655498A (en) | 1998-06-29 |
| EP0946526A1 (de) | 1999-10-06 |
| AU734983B2 (en) | 2001-06-28 |
| CN1239958A (zh) | 1999-12-29 |
| IL130271A0 (en) | 2000-06-01 |
| KR100495846B1 (ko) | 2005-06-17 |
| JP4252112B2 (ja) | 2009-04-08 |
| WO1998024774A1 (de) | 1998-06-11 |
| CA2274132A1 (en) | 1998-06-11 |
| JP2001504843A (ja) | 2001-04-10 |
| EP0946526B1 (de) | 2003-10-29 |
| ES2208968T3 (es) | 2004-06-16 |
| ATE253056T1 (de) | 2003-11-15 |
| IL130271A (en) | 2005-05-17 |
| ZA9710931B (en) | 1998-06-15 |
| DE19652387A1 (de) | 1998-06-10 |
| CN1100767C (zh) | 2003-02-05 |
| DK0946526T3 (da) | 2004-01-12 |
| KR20000057402A (ko) | 2000-09-15 |
| CA2274132C (en) | 2008-02-12 |
| HK1022153A1 (en) | 2000-07-28 |
| TW434232B (en) | 2001-05-16 |
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