PT92025A - Processo para a preparacao de spiro-isoquinolina-pirrolidina-tetronas e seus analogos, uteis como inibidores da reductase da aldose - Google Patents

Processo para a preparacao de spiro-isoquinolina-pirrolidina-tetronas e seus analogos, uteis como inibidores da reductase da aldose

Info

Publication number
PT92025A
PT92025A PT92025A PT9202589A PT92025A PT 92025 A PT92025 A PT 92025A PT 92025 A PT92025 A PT 92025A PT 9202589 A PT9202589 A PT 9202589A PT 92025 A PT92025 A PT 92025A
Authority
PT
Portugal
Prior art keywords
isokinoline
tetrones
spiro
pyrrolidine
analogs
Prior art date
Application number
PT92025A
Other languages
English (en)
Other versions
PT92025B (pt
Inventor
Michael Sotirios Malamas
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of PT92025A publication Critical patent/PT92025A/pt
Publication of PT92025B publication Critical patent/PT92025B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT92025A 1988-10-20 1989-10-18 Processo para a preparacao de spiro-isoquinolina-pirrolidina-tetronas e seus analogos, uteis como inibidores da reductase da aldose PT92025B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26043488A 1988-10-20 1988-10-20
US07/357,563 US4927831A (en) 1988-10-20 1989-05-26 Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors

Publications (2)

Publication Number Publication Date
PT92025A true PT92025A (pt) 1990-04-30
PT92025B PT92025B (pt) 1995-07-18

Family

ID=26947989

Family Applications (1)

Application Number Title Priority Date Filing Date
PT92025A PT92025B (pt) 1988-10-20 1989-10-18 Processo para a preparacao de spiro-isoquinolina-pirrolidina-tetronas e seus analogos, uteis como inibidores da reductase da aldose

Country Status (9)

Country Link
US (1) US4927831A (pt)
JP (1) JP2888559B2 (pt)
KR (1) KR0143998B1 (pt)
CA (1) CA1337351C (pt)
DK (1) DK170702B1 (pt)
HU (1) HU206211B (pt)
IL (1) IL92054A (pt)
PH (1) PH27278A (pt)
PT (1) PT92025B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428066A (en) * 1989-03-08 1995-06-27 Larner; Joseph Method of reducing elevated blood sugar in humans
US5045544A (en) * 1990-05-21 1991-09-03 American Home Products Corporation N'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US5093496A (en) * 1990-05-21 1992-03-03 American Home Products Corporation Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
US5037831A (en) * 1990-05-21 1991-08-06 American Home Products Corporation Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
US5068332A (en) * 1990-10-12 1991-11-26 American Home Products Corporation Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US5081241A (en) * 1990-10-11 1992-01-14 American Home Products Corporation Spiro-pyridazines and analogs thereof useful as aldose reductase inhibitors
US5102886A (en) * 1990-10-12 1992-04-07 American Home Products Corporation 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
US5130425A (en) * 1990-10-12 1992-07-14 American Home Products Corporation Spiro-lactams and analogs thereof useful as aldose reductase inhibitors
US5106978A (en) * 1991-05-22 1992-04-21 American Home Products Corporation Process and intermediates for the preparation of spiro(isoquinoline-4(1H), 3'-pyrrolidine)-1,2', 3,5'(2H)-tetrones which are useful as aldose reductase inhibitors
US5169948A (en) * 1991-05-22 1992-12-08 American Home Products Corporation Process and intermediates for the preparation of spiro[isoquinoline-4(1H),3-pyrrolidine]1,2,3,5 (2H)-tetrones which are useful as aldose reductase inhibitors
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US6384013B1 (en) 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US5221686A (en) * 1992-08-04 1993-06-22 American Home Products Corporation Spiro[1,2-benzisothiazole-3(2H),5'-oxazolidine]-2',4'-dione 1,1-dioxides as antihyperglycemic agents
WO2000052037A1 (en) 1999-03-03 2000-09-08 Eli Lilly And Company Echinocandin/carbohydrate complexes
CA2362481C (en) * 1999-03-03 2008-11-04 Eli Lilly And Company Echinocandin pharmaceutical formulations containing micelle-forming surfactants
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
US6777048B2 (en) 2002-12-18 2004-08-17 Eastman Chemical Company Polyester compositions containing silicon carbide
AU2004271740B2 (en) * 2003-09-12 2010-10-28 Merck Serono Sa Benzothiazole derivatives for the treatment of diabetes
ES2385219T3 (es) * 2003-09-12 2012-07-19 Merck Serono Sa Derivados de sulfonamida para el tratamiento de diabetes
CN1997638B (zh) * 2004-04-07 2011-07-06 默克雪兰诺有限公司 作为ptp1-b抑制剂的1,1'-(1,2-乙炔二基)双苯衍生物
AU2005272646A1 (en) * 2004-08-12 2006-02-23 Wyeth Combination therapy for diabetes, obesity, and cardiovascular diseases using GDF-8 inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5241586U (pt) * 1975-09-18 1977-03-24
JPS5241587U (pt) * 1975-09-18 1977-03-24
FR2525603A1 (fr) * 1982-04-27 1983-10-28 Adir Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique
FR2544317B2 (fr) * 1983-04-12 1985-07-05 Adir Benzoazacycloalkyl-spiro-imidazolidines et les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
DK519189D0 (da) 1989-10-19
DK170702B1 (da) 1995-12-11
KR900006334A (ko) 1990-05-07
IL92054A (en) 1994-07-31
US4927831A (en) 1990-05-22
CA1337351C (en) 1995-10-17
DK519189A (da) 1990-04-21
IL92054A0 (en) 1990-07-12
JPH02164880A (ja) 1990-06-25
HU895335D0 (en) 1990-01-28
KR0143998B1 (ko) 1998-07-15
JP2888559B2 (ja) 1999-05-10
PH27278A (en) 1993-05-04
PT92025B (pt) 1995-07-18
HUT52775A (en) 1990-08-28
HU206211B (en) 1992-09-28

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Legal Events

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PC3A Transfer or assignment

Free format text: WYETH US

Effective date: 20030123

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20070914