PT91929A - Processo para a preparacao de pro-uroquinase humana - Google Patents
Processo para a preparacao de pro-uroquinase humanaInfo
- Publication number
- PT91929A PT91929A PT91929A PT9192989A PT91929A PT 91929 A PT91929 A PT 91929A PT 91929 A PT91929 A PT 91929A PT 9192989 A PT9192989 A PT 9192989A PT 91929 A PT91929 A PT 91929A
- Authority
- PT
- Portugal
- Prior art keywords
- uroquinase
- preparation
- human pro
- pro
- human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888823833A GB8823833D0 (en) | 1988-10-11 | 1988-10-11 | Production of human prourokinase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT91929A true PT91929A (pt) | 1990-04-30 |
| PT91929B PT91929B (pt) | 1995-05-31 |
Family
ID=10645030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT91929A PT91929B (pt) | 1988-10-11 | 1989-10-09 | Processo para a preparacao de pro-uroquinase humana |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5866358A (pt) |
| EP (2) | EP0365894A1 (pt) |
| JP (1) | JPH03502526A (pt) |
| KR (1) | KR900702020A (pt) |
| CN (1) | CN1042181A (pt) |
| CA (1) | CA2000408A1 (pt) |
| DK (1) | DK141090A (pt) |
| FI (1) | FI902893A0 (pt) |
| GB (1) | GB8823833D0 (pt) |
| IL (1) | IL91919A0 (pt) |
| MY (1) | MY104233A (pt) |
| PH (1) | PH27348A (pt) |
| PT (1) | PT91929B (pt) |
| WO (1) | WO1990004023A1 (pt) |
| YU (1) | YU197489A (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09252773A (ja) * | 1996-01-19 | 1997-09-30 | Oriental Yeast Co Ltd | ヒトｂｐｇｍの免疫測定法 |
| US6380371B1 (en) * | 1998-12-10 | 2002-04-30 | The Regents Of The University Of California | Endoglycan: a novel protein having selectin ligand and chemokine presentation activity |
| CA2426115A1 (en) * | 2003-04-18 | 2004-10-18 | Victor Gurewich | Methods, devices, and compositions for lysis of occlusive blood clots while sparing wound sealing clots |
| US7070958B2 (en) * | 2003-04-18 | 2006-07-04 | Thrombolytic Science, Inc. | Methods of making pro-urokinase mutants |
| US7837992B2 (en) | 2006-06-22 | 2010-11-23 | Beth Israel Deaconess Medical Center | C-1 inhibitor prevents non-specific plasminogen activation by a prourokinase mutant without impeding fibrin-specific fibrinolysis |
| US20100143325A1 (en) * | 2008-12-09 | 2010-06-10 | Vascular Laboratory, Inc. | Composition And Methods Involving Thrombolytic Agents |
| CN103789291B (zh) * | 2014-02-24 | 2016-08-17 | 东北制药集团股份有限公司 | 一种重组大肠杆菌发酵液中分离纯化重组人尿激酶原的制备工艺 |
| JP6826040B2 (ja) | 2014-11-03 | 2021-02-03 | スロンボリティック・サイエンス・リミテッド・ライアビリティ・カンパニーＴｈｒｏｍｂｏｌｙｔｉｃ Ｓｃｉｅｎｃｅ， Ｌｌｃ | 安全かつ効果的な血栓溶解（Ｔｈｒｏｍｂｏｌｙｓｉｓ）のための方法および組成物 |
| US11154596B2 (en) | 2017-06-16 | 2021-10-26 | Thrombolytic Science, Llc | Methods for thrombolysis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5390286A (en) * | 1985-01-25 | 1986-08-13 | Sagami Chemical Research Center | Stabilized human prourokinase |
| FR2594845B1 (fr) * | 1986-02-21 | 1989-12-01 | Genetica | Preparation par voie microbiologique de l'activateur tissulaire humain du plasminogene (t-pa) et conversion de l'enzyme ainsi obtenue en sa forme active |
-
1988
- 1988-10-11 GB GB888823833A patent/GB8823833D0/en active Pending
-
1989
- 1989-10-06 KR KR1019900701227A patent/KR900702020A/ko not_active Application Discontinuation
- 1989-10-06 EP EP89118586A patent/EP0365894A1/en not_active Withdrawn
- 1989-10-06 WO PCT/EP1989/001168 patent/WO1990004023A1/en not_active Application Discontinuation
- 1989-10-06 US US07/536,556 patent/US5866358A/en not_active Expired - Fee Related
- 1989-10-06 EP EP89911367A patent/EP0407490A1/en active Pending
- 1989-10-06 IL IL91919A patent/IL91919A0/xx unknown
- 1989-10-06 JP JP1510599A patent/JPH03502526A/ja active Pending
- 1989-10-09 PT PT91929A patent/PT91929B/pt not_active IP Right Cessation
- 1989-10-10 PH PH39358A patent/PH27348A/en unknown
- 1989-10-10 MY MYPI89001389A patent/MY104233A/en unknown
- 1989-10-10 CN CN89108587A patent/CN1042181A/zh active Pending
- 1989-10-10 CA CA002000408A patent/CA2000408A1/en not_active Abandoned
- 1989-10-11 YU YU01974/89A patent/YU197489A/xx unknown
-
1990
- 1990-06-08 DK DK141090A patent/DK141090A/da not_active Application Discontinuation
- 1990-06-08 FI FI902893A patent/FI902893A0/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MY104233A (en) | 1994-02-28 |
| FI902893A0 (fi) | 1990-06-08 |
| DK141090A (da) | 1990-08-13 |
| WO1990004023A1 (en) | 1990-04-19 |
| JPH03502526A (ja) | 1991-06-13 |
| CA2000408A1 (en) | 1990-04-11 |
| EP0365894A1 (en) | 1990-05-02 |
| EP0407490A1 (en) | 1991-01-16 |
| IL91919A0 (en) | 1990-06-10 |
| CN1042181A (zh) | 1990-05-16 |
| YU197489A (en) | 1991-08-31 |
| PH27348A (en) | 1993-06-08 |
| KR900702020A (ko) | 1990-12-05 |
| US5866358A (en) | 1999-02-02 |
| GB8823833D0 (en) | 1988-11-16 |
| PT91929B (pt) | 1995-05-31 |
| DK141090D0 (da) | 1990-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19941118 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19960531 |