DK141090A - Fremstilling af human prourokinase - Google Patents

Fremstilling af human prourokinase Download PDF

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Publication number
DK141090A
DK141090A DK141090A DK141090A DK141090A DK 141090 A DK141090 A DK 141090A DK 141090 A DK141090 A DK 141090A DK 141090 A DK141090 A DK 141090A DK 141090 A DK141090 A DK 141090A
Authority
DK
Denmark
Prior art keywords
preparation
human prourokinase
prourokinase
human
Prior art date
Application number
DK141090A
Other languages
English (en)
Other versions
DK141090D0 (da
Inventor
Anna Brandazza
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of DK141090D0 publication Critical patent/DK141090D0/da
Publication of DK141090A publication Critical patent/DK141090A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK141090A 1988-10-11 1990-06-08 Fremstilling af human prourokinase DK141090A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888823833A GB8823833D0 (en) 1988-10-11 1988-10-11 Production of human prourokinase
PCT/EP1989/001168 WO1990004023A1 (en) 1988-10-11 1989-10-06 Production of human prourokinase

Publications (2)

Publication Number Publication Date
DK141090D0 DK141090D0 (da) 1990-06-08
DK141090A true DK141090A (da) 1990-08-13

Family

ID=10645030

Family Applications (1)

Application Number Title Priority Date Filing Date
DK141090A DK141090A (da) 1988-10-11 1990-06-08 Fremstilling af human prourokinase

Country Status (15)

Country Link
US (1) US5866358A (da)
EP (2) EP0407490A1 (da)
JP (1) JPH03502526A (da)
KR (1) KR900702020A (da)
CN (1) CN1042181A (da)
CA (1) CA2000408A1 (da)
DK (1) DK141090A (da)
FI (1) FI902893A0 (da)
GB (1) GB8823833D0 (da)
IL (1) IL91919A0 (da)
MY (1) MY104233A (da)
PH (1) PH27348A (da)
PT (1) PT91929B (da)
WO (1) WO1990004023A1 (da)
YU (1) YU197489A (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09252773A (ja) * 1996-01-19 1997-09-30 Oriental Yeast Co Ltd ヒトｂｐｇｍの免疫測定法
US6380371B1 (en) * 1998-12-10 2002-04-30 The Regents Of The University Of California Endoglycan: a novel protein having selectin ligand and chemokine presentation activity
CA2426115A1 (en) * 2003-04-18 2004-10-18 Victor Gurewich Methods, devices, and compositions for lysis of occlusive blood clots while sparing wound sealing clots
US7070958B2 (en) * 2003-04-18 2006-07-04 Thrombolytic Science, Inc. Methods of making pro-urokinase mutants
US7837992B2 (en) 2006-06-22 2010-11-23 Beth Israel Deaconess Medical Center C-1 inhibitor prevents non-specific plasminogen activation by a prourokinase mutant without impeding fibrin-specific fibrinolysis
US20100143325A1 (en) * 2008-12-09 2010-06-10 Vascular Laboratory, Inc. Composition And Methods Involving Thrombolytic Agents
CN103789291B (zh) * 2014-02-24 2016-08-17 东北制药集团股份有限公司 一种重组大肠杆菌发酵液中分离纯化重组人尿激酶原的制备工艺
BR112017008749A2 (pt) 2014-11-03 2017-12-19 Thrombolytic Science Llc métodos e composições para trombólise segura e eficaz
WO2018232305A1 (en) 2017-06-16 2018-12-20 Thrombolytic Science, Llc Methods and compositions for thrombolysis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0210279B1 (en) * 1985-01-25 1991-08-14 Sagami Chemical Research Center Stabilized human prourokinase
FR2594845B1 (fr) * 1986-02-21 1989-12-01 Genetica Preparation par voie microbiologique de l'activateur tissulaire humain du plasminogene (t-pa) et conversion de l'enzyme ainsi obtenue en sa forme active

Also Published As

Publication number Publication date
YU197489A (en) 1991-08-31
IL91919A0 (en) 1990-06-10
WO1990004023A1 (en) 1990-04-19
US5866358A (en) 1999-02-02
JPH03502526A (ja) 1991-06-13
PH27348A (en) 1993-06-08
PT91929A (pt) 1990-04-30
CN1042181A (zh) 1990-05-16
DK141090D0 (da) 1990-06-08
PT91929B (pt) 1995-05-31
KR900702020A (ko) 1990-12-05
CA2000408A1 (en) 1990-04-11
MY104233A (en) 1994-02-28
EP0407490A1 (en) 1991-01-16
EP0365894A1 (en) 1990-05-02
FI902893A0 (fi) 1990-06-08
GB8823833D0 (en) 1988-11-16

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment