PT90638A - Processo para melhorar a resposta imunitaria e de preparacao de analogos 7-desaza-7-oxa- e 7-desaza-7-tia- de derivados 8-substituidos de 9-(1'-beta-d-aldoglicosidil)guanina - Google Patents

Processo para melhorar a resposta imunitaria e de preparacao de analogos 7-desaza-7-oxa- e 7-desaza-7-tia- de derivados 8-substituidos de 9-(1'-beta-d-aldoglicosidil)guanina

Info

Publication number
PT90638A
PT90638A PT90638A PT9063889A PT90638A PT 90638 A PT90638 A PT 90638A PT 90638 A PT90638 A PT 90638A PT 9063889 A PT9063889 A PT 9063889A PT 90638 A PT90638 A PT 90638A
Authority
PT
Portugal
Prior art keywords
discasa
aldoglycosidyl
tia
oxa
guinea
Prior art date
Application number
PT90638A
Other languages
English (en)
Other versions
PT90638B (pt
Inventor
Michael Goodman
Edward P Gamson
Original Assignee
Scripps Clinic Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic Res filed Critical Scripps Clinic Res
Publication of PT90638A publication Critical patent/PT90638A/pt
Publication of PT90638B publication Critical patent/PT90638B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT90638A 1988-05-24 1989-05-23 Processo para melhorar a resposta imunitaria e de preparacao de analogos 7-desaza-7-oxa- e 7-desaza-7-tia- de derivados 8-substituidos de 9-(1'-beta-d-aldoglicosidil)guanina PT90638B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/198,141 US5166141A (en) 1983-11-01 1988-05-24 Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals

Publications (2)

Publication Number Publication Date
PT90638A true PT90638A (pt) 1989-11-30
PT90638B PT90638B (pt) 1994-10-31

Family

ID=22732151

Family Applications (1)

Application Number Title Priority Date Filing Date
PT90638A PT90638B (pt) 1988-05-24 1989-05-23 Processo para melhorar a resposta imunitaria e de preparacao de analogos 7-desaza-7-oxa- e 7-desaza-7-tia- de derivados 8-substituidos de 9-(1'-beta-d-aldoglicosidil)guanina

Country Status (7)

Country Link
US (1) US5166141A (pt)
EP (1) EP0343945A3 (pt)
JP (1) JPH0249789A (pt)
AU (1) AU627178B2 (pt)
DK (1) DK250089A (pt)
IE (1) IE891673L (pt)
PT (1) PT90638B (pt)

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US5476659A (en) * 1982-11-09 1995-12-19 The Scripps Research Institute Cancerous B cell treatment using substituted nucleoside derivatives
US5041426A (en) * 1987-12-21 1991-08-20 Brigham Young University Immune system enhancing 3-β-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and nucleotides
US5994321A (en) * 1993-12-20 1999-11-30 Aronex Pharmaceuticals, Inc. Antiviral guanine analogs
US5446045A (en) * 1993-12-20 1995-08-29 Revankar; Ganapathi R. Antiviral guanine analogs
US5768154A (en) * 1996-04-08 1998-06-16 Asko, Inc. Method and apparatus for measuring the width of metal strip
CN1233254A (zh) * 1996-10-16 1999-10-27 Icn药品公司 嘌呤l－核苷、其类似物及其用途
US6509320B1 (en) * 1996-10-16 2003-01-21 Icn Pharmaceuticals, Inc. Purine L-nucleosides, analogs and uses thereof
EP1103559A1 (en) * 1997-01-17 2001-05-30 ICN Pharmaceuticals, Inc. Autoimmune nucleosides
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
US7560544B2 (en) * 2004-12-17 2009-07-14 Anadys Pharmaceuticals, Inc. 3,5-Disubsitituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof
JP5117391B2 (ja) 2005-11-21 2013-01-16 アナディス ファーマシューティカルズ インク ５−アミノ−３Ｈ−チアゾロ［４，５−ｄ］ピリミジン−２−オンを調製するための新規な方法
EP2034834B1 (en) * 2006-06-22 2011-01-26 Anadys Pharmaceuticals, Inc. Prodrugs of 5-amino-3-(3'-deoxy-beta-d-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione
DE602007012881D1 (en) 2006-07-18 2011-04-14 Anadys Pharmaceuticals Inc Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen
US20110166092A1 (en) 2007-08-20 2011-07-07 Anadys Pharmaceuticals, Inc. Dosing methods for treating disease
SI3230298T1 (sl) 2014-12-08 2021-04-30 F. Hoffmann-La Roche Ag Spojine 3-substituiranega 5-amino-6H-tiazolo(4,5-d)pirimidin-2,7-diona za zdravljenje ali preprečevanje okužbe z virusom
KR102359212B1 (ko) 2015-03-16 2022-02-08 에프. 호프만-라 로슈 아게 Tlr7 작용제 및 hbv 캡시드 조립 억제제를 사용하는 병용 치료
EP3294745B1 (en) 2015-05-08 2020-01-01 H. Hoffnabb-La Roche Ag Novel oxathiolane carboxylic acids and derivatives for the treatment and prophylaxis of virus infection
CN107592864B (zh) 2015-05-12 2021-04-16 豪夫迈·罗氏有限公司 用于治疗和预防病毒感染的新的取代的氨基噻唑并嘧啶二酮
WO2017001307A1 (en) 2015-06-30 2017-01-05 F. Hoffmann-La Roche Ag Novel substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection
AU2018205994B2 (en) 2017-01-06 2021-09-09 F. Hoffmann-La Roche Ag Process for the preparation of 3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds

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GB971700A (en) * 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents
AT290523B (de) * 1962-01-05 1971-06-11 Merck & Co Inc Verfahren zur Herstellung neuer α-(3-Indolyl)-carbonsäuren
FR4841M (pt) * 1964-05-07 1967-02-20
US3313848A (en) * 1964-06-18 1967-04-11 Parke Davis & Co Anthranilic acids and derivatives
FR1546478A (fr) * 1967-01-27 1968-11-22 Rhone Poulenc Sa Nouveaux dérivés de l'acide benzoyl-3 phénylacétique et leur préparation
CH510660A (de) * 1967-09-11 1971-07-31 Ciba Geigy Ag Verfahren zur Herstellung neuer Glucofuranoside
DE1793336C3 (de) * 1967-09-11 1974-10-03 Ciba-Geigy Ag, Basel (Schweiz) D-Glucofuranoside, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
US3538077A (en) * 1967-09-26 1970-11-03 Ciba Geigy Corp D-glucofuranoside ether-esters
US3767805A (en) * 1968-03-27 1973-10-23 Ciba Geigy Corp Tertiary aminoacids in antiinflammatory compositions
US3600437A (en) * 1969-05-28 1971-08-17 Lilly Co Eli Substituted phenylalkanoic acids and derivatives thereof
US3654349A (en) * 1970-05-01 1972-04-04 Merck & Co Inc Substituted indenyl acetic acids
US3849572A (en) * 1970-09-15 1974-11-19 Merck & Co Inc Biphenyleneacetic acid anti-inflammatory agents
US3993755A (en) * 1973-04-09 1976-11-23 Valter Osvaldovich Kulbakh Pharmaceutical composition containing the N-methyl-d-glucosamine complex of 4-methyluracil and use thereof
US4486436A (en) * 1982-07-22 1984-12-04 Analgesic Associates Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
US4643992A (en) * 1982-11-09 1987-02-17 Scripps Clinic And Research Foundation Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
US4746651A (en) * 1983-11-01 1988-05-24 Scripps Clinic And Research Foundation Antimicrobial chemotherapeutic potentiation using substituted nucleoside derivatives
US4880784A (en) * 1987-12-21 1989-11-14 Brigham Young University Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives
US5041426A (en) * 1987-12-21 1991-08-20 Brigham Young University Immune system enhancing 3-β-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and nucleotides

Also Published As

Publication number Publication date
AU627178B2 (en) 1992-08-20
JPH0249789A (ja) 1990-02-20
IE891673L (en) 1989-11-24
PT90638B (pt) 1994-10-31
DK250089A (da) 1989-11-25
EP0343945A2 (en) 1989-11-29
EP0343945A3 (en) 1991-05-15
US5166141A (en) 1992-11-24
DK250089D0 (da) 1989-05-23
AU3481289A (en) 1989-11-30

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19940406

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19961031