PT89193A - Processo para a preparacao de acidos aralifatil-aminoalcano-difosfonicos - Google Patents
Processo para a preparacao de acidos aralifatil-aminoalcano-difosfonicosInfo
- Publication number
- PT89193A PT89193A PT89193A PT8919388A PT89193A PT 89193 A PT89193 A PT 89193A PT 89193 A PT89193 A PT 89193A PT 8919388 A PT8919388 A PT 8919388A PT 89193 A PT89193 A PT 89193A
- Authority
- PT
- Portugal
- Prior art keywords
- denotes
- aliphatic radical
- aralifatil
- aminoalcan
- preparation
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000003913 calcium metabolism Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Detergent Compositions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Pyridine Compounds (AREA)
- Steroid Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH484787 | 1987-12-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT89193A true PT89193A (pt) | 1989-12-29 |
| PT89193B PT89193B (pt) | 1993-06-30 |
Family
ID=4283590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT89193A PT89193B (pt) | 1987-12-11 | 1988-12-09 | Processo para a preparacao de acidos aralifatil-aminoalcano-difosfonicos |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0320455B1 (pt) |
| JP (1) | JPH01197495A (pt) |
| KR (1) | KR890009956A (pt) |
| AT (1) | ATE90353T1 (pt) |
| AU (1) | AU609549B2 (pt) |
| CA (1) | CA1329609C (pt) |
| DD (1) | DD283631A5 (pt) |
| DE (1) | DE3881659D1 (pt) |
| DK (1) | DK688488A (pt) |
| ES (1) | ES2054868T3 (pt) |
| FI (1) | FI92704C (pt) |
| HU (1) | HU202880B (pt) |
| IE (1) | IE62738B1 (pt) |
| IL (1) | IL88620A (pt) |
| MX (1) | MX14109A (pt) |
| NO (1) | NO176663C (pt) |
| NZ (1) | NZ227273A (pt) |
| PH (1) | PH26416A (pt) |
| PT (1) | PT89193B (pt) |
| YU (1) | YU221388A (pt) |
| ZA (1) | ZA889157B (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW198039B (pt) * | 1988-11-28 | 1993-01-11 | Ciba Geigy Ag | |
| US5270365A (en) * | 1991-12-17 | 1993-12-14 | Merck & Co., Inc. | Prevention and treatment of periodontal disease with alendronate |
| US5763611A (en) * | 1992-05-29 | 1998-06-09 | The Procter & Gamble Company | Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| KR100266484B1 (ko) * | 1992-05-29 | 2000-09-15 | 제이코버스 코넬리스 레이서 | 칼슘및인산염의이상대사를치료하기위한티오-치환된질소-함유헤테로사이클릭포스포네이트화합물 |
| JPH07507315A (ja) * | 1992-05-29 | 1995-08-10 | プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド | カルシウムおよびホスフェート代謝異常治療用含硫ホスホネート化合物 |
| US5753634A (en) * | 1992-05-29 | 1998-05-19 | The Procter & Gamble Company | Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism |
| US5391743A (en) * | 1992-05-29 | 1995-02-21 | Procter & Gamble Pharmaceuticals, Inc. | Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque |
| NZ253541A (en) * | 1992-05-29 | 1997-01-29 | Procter & Gamble Pharma | Cyclic quaternary-n-containing phosphonate derivatives and medicaments |
| HUT72437A (en) * | 1992-06-30 | 1996-04-29 | Procter & Gamble Pharma | Compositions for the treatment of arthritis containing phosphonates and nsaids |
| EP3084483A1 (en) * | 2013-12-19 | 2016-10-26 | 3M Innovative Properties Company | Articles comprising self-assembled layers comprising nanoparticles with a phosphorous surface treatment |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| PH27078A (en) * | 1984-12-21 | 1993-02-01 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonates |
| DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
-
1988
- 1988-12-02 EP EP88810830A patent/EP0320455B1/de not_active Expired - Lifetime
- 1988-12-02 DE DE8888810830T patent/DE3881659D1/de not_active Expired - Fee Related
- 1988-12-02 ES ES88810830T patent/ES2054868T3/es not_active Expired - Lifetime
- 1988-12-02 AT AT88810830T patent/ATE90353T1/de not_active IP Right Cessation
- 1988-12-06 PH PH37887A patent/PH26416A/en unknown
- 1988-12-07 ZA ZA889157A patent/ZA889157B/xx unknown
- 1988-12-07 IL IL8862088A patent/IL88620A/en not_active IP Right Cessation
- 1988-12-07 YU YU02213/88A patent/YU221388A/xx unknown
- 1988-12-08 JP JP63308986A patent/JPH01197495A/ja active Pending
- 1988-12-09 NZ NZ227273A patent/NZ227273A/en unknown
- 1988-12-09 CA CA000585416A patent/CA1329609C/en not_active Expired - Fee Related
- 1988-12-09 PT PT89193A patent/PT89193B/pt not_active IP Right Cessation
- 1988-12-09 FI FI885710A patent/FI92704C/fi not_active IP Right Cessation
- 1988-12-09 DK DK688488A patent/DK688488A/da not_active Application Discontinuation
- 1988-12-09 DD DD88322931A patent/DD283631A5/de not_active IP Right Cessation
- 1988-12-09 HU HU886378A patent/HU202880B/hu not_active IP Right Cessation
- 1988-12-09 KR KR1019880016363A patent/KR890009956A/ko not_active Application Discontinuation
- 1988-12-09 MX MX1410988A patent/MX14109A/es unknown
- 1988-12-09 NO NO885489A patent/NO176663C/no unknown
- 1988-12-09 IE IE368088A patent/IE62738B1/en not_active IP Right Cessation
- 1988-12-09 AU AU26738/88A patent/AU609549B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| IL88620A (en) | 1994-11-28 |
| FI92704C (fi) | 1994-12-27 |
| MX14109A (es) | 1994-02-28 |
| FI885710A0 (fi) | 1988-12-09 |
| JPH01197495A (ja) | 1989-08-09 |
| NZ227273A (en) | 1991-06-25 |
| FI92704B (fi) | 1994-09-15 |
| HUT48899A (en) | 1989-07-28 |
| IL88620A0 (en) | 1989-07-31 |
| DK688488D0 (da) | 1988-12-09 |
| CA1329609C (en) | 1994-05-17 |
| PT89193B (pt) | 1993-06-30 |
| ES2054868T3 (es) | 1994-08-16 |
| IE62738B1 (en) | 1995-02-22 |
| HU202880B (en) | 1991-04-29 |
| NO176663B (no) | 1995-01-30 |
| AU609549B2 (en) | 1991-05-02 |
| FI885710A (fi) | 1989-06-12 |
| NO885489D0 (no) | 1988-12-09 |
| DD283631A5 (de) | 1990-10-17 |
| KR890009956A (ko) | 1989-08-05 |
| ZA889157B (en) | 1989-07-26 |
| NO885489L (no) | 1989-06-12 |
| EP0320455B1 (de) | 1993-06-09 |
| YU221388A (en) | 1990-06-30 |
| IE883680L (en) | 1989-06-11 |
| DE3881659D1 (en) | 1993-07-15 |
| ATE90353T1 (de) | 1993-06-15 |
| AU2673888A (en) | 1989-06-15 |
| EP0320455A1 (de) | 1989-06-14 |
| PH26416A (en) | 1992-07-15 |
| DK688488A (da) | 1989-06-12 |
| NO176663C (no) | 1995-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19921215 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19960630 |