ES2054868T3 - Acidos aralifatilaminoalcanodifosfonicos. - Google Patents
Acidos aralifatilaminoalcanodifosfonicos.Info
- Publication number
- ES2054868T3 ES2054868T3 ES88810830T ES88810830T ES2054868T3 ES 2054868 T3 ES2054868 T3 ES 2054868T3 ES 88810830 T ES88810830 T ES 88810830T ES 88810830 T ES88810830 T ES 88810830T ES 2054868 T3 ES2054868 T3 ES 2054868T3
- Authority
- ES
- Spain
- Prior art keywords
- denotes
- aliphatic radical
- acids
- formula
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000003913 calcium metabolism Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Detergent Compositions (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Steroid Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
LOS ACIDOS ARALIFATILAMINOALCANDIFOSFONICOS DE FORMULA DONDE R1 ES UN RESTO AROMATICO SUSTITUIDO ALIFATIOCO, R2 ES H O UN RESTO MONOVALENTE ALIFATICO Y ALK ES UN RESTO BIVALENTE ALIFATICO, Y SUS SALES POSEEN UN CLARO EFECTO REGULADOR SOBRE EL METABOLISMO DEL CALCIO Y PUEDEN SER UTILIZADOS COMO MEDICAMENTOS PARA EL TRATAMIENTO DE ENFERMEDADES ORIGINADAS POR TRASTORNOS DEL MISMO. SE PUEDEN OBTENER, POR EJEMPLO, HACIENDO REACCIONAR UN COMPUESTO DE LA FORMULA DONDE X3 ES CARBOXI Y R0 ES UN RESTO R2, CON ACIDO FOSFOROSO Y TRICLORURO DE FOSFORO, E HIDROLIZANDO EL PRODUCTO PRIMARIO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH484787 | 1987-12-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2054868T3 true ES2054868T3 (es) | 1994-08-16 |
Family
ID=4283590
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88810830T Expired - Lifetime ES2054868T3 (es) | 1987-12-11 | 1988-12-02 | Acidos aralifatilaminoalcanodifosfonicos. |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0320455B1 (es) |
JP (1) | JPH01197495A (es) |
KR (1) | KR890009956A (es) |
AT (1) | ATE90353T1 (es) |
AU (1) | AU609549B2 (es) |
CA (1) | CA1329609C (es) |
DD (1) | DD283631A5 (es) |
DE (1) | DE3881659D1 (es) |
DK (1) | DK688488A (es) |
ES (1) | ES2054868T3 (es) |
FI (1) | FI92704C (es) |
HU (1) | HU202880B (es) |
IE (1) | IE62738B1 (es) |
IL (1) | IL88620A (es) |
MX (1) | MX14109A (es) |
NO (1) | NO176663C (es) |
NZ (1) | NZ227273A (es) |
PH (1) | PH26416A (es) |
PT (1) | PT89193B (es) |
YU (1) | YU221388A (es) |
ZA (1) | ZA889157B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW198039B (es) * | 1988-11-28 | 1993-01-11 | Ciba Geigy Ag | |
US5270365A (en) * | 1991-12-17 | 1993-12-14 | Merck & Co., Inc. | Prevention and treatment of periodontal disease with alendronate |
US5391743A (en) * | 1992-05-29 | 1995-02-21 | Procter & Gamble Pharmaceuticals, Inc. | Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque |
CA2136818C (en) * | 1992-05-29 | 2000-01-18 | Susan M. Kaas | Sulfur-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism |
US5763611A (en) * | 1992-05-29 | 1998-06-09 | The Procter & Gamble Company | Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
EP0642521A1 (en) * | 1992-05-29 | 1995-03-15 | Procter & Gamble Pharmaceuticals | Thio-substituted nitrogen-containing heterocyclic phosphonate compounds for treating abnormal calcium and phosphate metabolism |
US5753634A (en) * | 1992-05-29 | 1998-05-19 | The Procter & Gamble Company | Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism |
NZ253541A (en) * | 1992-05-29 | 1997-01-29 | Procter & Gamble Pharma | Cyclic quaternary-n-containing phosphonate derivatives and medicaments |
RU2119794C1 (ru) * | 1992-06-30 | 1998-10-10 | Проктер энд Гэмбл Фармасьютикалз, Инк. | Использование фосфонатов и нестероидных противовоспалительных лекарственных средств для лечения артрита, способ лечения |
EP3084483A1 (en) * | 2013-12-19 | 2016-10-26 | 3M Innovative Properties Company | Articles comprising self-assembled layers comprising nanoparticles with a phosphorous surface treatment |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
PH27078A (en) * | 1984-12-21 | 1993-02-01 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonates |
DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
-
1988
- 1988-12-02 AT AT88810830T patent/ATE90353T1/de not_active IP Right Cessation
- 1988-12-02 EP EP88810830A patent/EP0320455B1/de not_active Expired - Lifetime
- 1988-12-02 DE DE8888810830T patent/DE3881659D1/de not_active Expired - Fee Related
- 1988-12-02 ES ES88810830T patent/ES2054868T3/es not_active Expired - Lifetime
- 1988-12-06 PH PH37887A patent/PH26416A/en unknown
- 1988-12-07 IL IL8862088A patent/IL88620A/en not_active IP Right Cessation
- 1988-12-07 YU YU02213/88A patent/YU221388A/xx unknown
- 1988-12-07 ZA ZA889157A patent/ZA889157B/xx unknown
- 1988-12-08 JP JP63308986A patent/JPH01197495A/ja active Pending
- 1988-12-09 CA CA000585416A patent/CA1329609C/en not_active Expired - Fee Related
- 1988-12-09 MX MX1410988A patent/MX14109A/es unknown
- 1988-12-09 IE IE368088A patent/IE62738B1/en not_active IP Right Cessation
- 1988-12-09 NO NO885489A patent/NO176663C/no unknown
- 1988-12-09 NZ NZ227273A patent/NZ227273A/en unknown
- 1988-12-09 HU HU886378A patent/HU202880B/hu not_active IP Right Cessation
- 1988-12-09 DK DK688488A patent/DK688488A/da not_active Application Discontinuation
- 1988-12-09 AU AU26738/88A patent/AU609549B2/en not_active Ceased
- 1988-12-09 KR KR1019880016363A patent/KR890009956A/ko not_active Application Discontinuation
- 1988-12-09 FI FI885710A patent/FI92704C/fi not_active IP Right Cessation
- 1988-12-09 PT PT89193A patent/PT89193B/pt not_active IP Right Cessation
- 1988-12-09 DD DD88322931A patent/DD283631A5/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK688488D0 (da) | 1988-12-09 |
IE62738B1 (en) | 1995-02-22 |
FI92704B (fi) | 1994-09-15 |
KR890009956A (ko) | 1989-08-05 |
FI885710A0 (fi) | 1988-12-09 |
FI92704C (fi) | 1994-12-27 |
FI885710A (fi) | 1989-06-12 |
YU221388A (en) | 1990-06-30 |
CA1329609C (en) | 1994-05-17 |
MX14109A (es) | 1994-02-28 |
JPH01197495A (ja) | 1989-08-09 |
PT89193A (pt) | 1989-12-29 |
NO176663C (no) | 1995-05-10 |
PT89193B (pt) | 1993-06-30 |
ATE90353T1 (de) | 1993-06-15 |
EP0320455A1 (de) | 1989-06-14 |
PH26416A (en) | 1992-07-15 |
DK688488A (da) | 1989-06-12 |
IL88620A0 (en) | 1989-07-31 |
AU609549B2 (en) | 1991-05-02 |
DE3881659D1 (en) | 1993-07-15 |
DD283631A5 (de) | 1990-10-17 |
EP0320455B1 (de) | 1993-06-09 |
AU2673888A (en) | 1989-06-15 |
IE883680L (en) | 1989-06-11 |
NO885489L (no) | 1989-06-12 |
NO176663B (no) | 1995-01-30 |
ZA889157B (en) | 1989-07-26 |
NZ227273A (en) | 1991-06-25 |
HU202880B (en) | 1991-04-29 |
NO885489D0 (no) | 1988-12-09 |
HUT48899A (en) | 1989-07-28 |
IL88620A (en) | 1994-11-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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