PT87644A - Process for preparing cardiovascularly active n,n'-dimethyl-n-(3,4,5-trimethoxybenzyl)-n'-<3,3-di-(4-fluorophenyl)-propyl>-ethylenediamine - Google Patents

Process for preparing cardiovascularly active n,n'-dimethyl-n-(3,4,5-trimethoxybenzyl)-n'-<3,3-di-(4-fluorophenyl)-propyl>-ethylenediamine

Info

Publication number
PT87644A
PT87644A PT87644A PT8764488A PT87644A PT 87644 A PT87644 A PT 87644A PT 87644 A PT87644 A PT 87644A PT 8764488 A PT8764488 A PT 8764488A PT 87644 A PT87644 A PT 87644A
Authority
PT
Portugal
Prior art keywords
trimethoxybenzyl
fluorophenyl
ethylenediamine
dimethyl
propyl
Prior art date
Application number
PT87644A
Other languages
English (en)
Other versions
PT87644B (pt
Inventor
Cesare Casagrande
Francesco Santangelo
Maria Luisa Calabi
Original Assignee
Simes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Simes filed Critical Simes
Publication of PT87644A publication Critical patent/PT87644A/pt
Publication of PT87644B publication Critical patent/PT87644B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
PT87644A 1987-06-05 1988-06-03 Processo para a preparacao de n,n'-dimetil-n-(3,4,5-trimetoxibenzil)-n'-{3,3-di-(4-fluorfenil)-propil}-etilenodiamina cardiovascularmente activa PT87644B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20800/87A IT1205124B (it) 1987-06-05 1987-06-05 Composto attivo nella terapia carciovascolare

Publications (2)

Publication Number Publication Date
PT87644A true PT87644A (pt) 1988-07-01
PT87644B PT87644B (pt) 1992-09-30

Family

ID=11172253

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87644A PT87644B (pt) 1987-06-05 1988-06-03 Processo para a preparacao de n,n'-dimetil-n-(3,4,5-trimetoxibenzil)-n'-{3,3-di-(4-fluorfenil)-propil}-etilenodiamina cardiovascularmente activa

Country Status (12)

Country Link
US (1) US4988735A (pt)
EP (1) EP0293925B1 (pt)
JP (1) JP2560083B2 (pt)
AT (1) ATE68474T1 (pt)
AU (1) AU601283B2 (pt)
CA (1) CA1329398C (pt)
DE (1) DE3865531D1 (pt)
ES (1) ES2039506T3 (pt)
FI (1) FI89262C (pt)
GR (1) GR3002925T3 (pt)
IT (1) IT1205124B (pt)
PT (1) PT87644B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2074946B1 (es) * 1993-07-19 1996-06-16 Ferrer Int Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida.
US5407955A (en) * 1994-02-18 1995-04-18 Eli Lilly And Company Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease
US7511077B2 (en) * 2005-02-09 2009-03-31 Neuromed Pharmaceuticals Ltd. Diamine calcium channel blockers

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3400155A (en) * 1963-03-01 1968-09-03 Hoechst Ag N-(1-phenyl-propyl-(2))-n-aminoethyl-(2')-diphenylamines and the salts thereof
US3321523A (en) * 1965-03-29 1967-05-23 Donau Pharmazie G M B H N-(beta-diethylamino ethyl)-n-[beta-(p-methoxy phenyl) ethyl] anilines and salts thereof
US3876702A (en) * 1968-04-26 1975-04-08 Rudolf Theodor Petersen N,n-bis-(diphenylalkyl)-alkylendiamine and their salts
FR2279383A1 (fr) * 1974-04-25 1976-02-20 Synthelabo Nouveaux derives tetrasubstitues des alcoylene-diamines, leurs sels, leur preparation et les medicaments qui en contiennent
IT1150959B (it) * 1980-06-10 1986-12-17 Simes Sostanze datate di attivita' antispastica vasale e procedimenti per la loro preparazione
IT1164389B (it) * 1983-08-05 1987-04-08 Zambon Spa Derivati n-sostituiti dell'1-(4'-alchiltiofenil)-2-ammino-1,3-propandiolo
DE3542994A1 (de) * 1985-12-05 1987-06-11 Basf Ag Basisch substituierte phenylacetaldehyde, ihre herstellung und diese enthaltende arzneimittel
GB8603765D0 (en) * 1986-02-15 1986-03-19 Beecham Wuelfung Gmbh & Co Kg Compounds
HU200591B (en) * 1986-07-11 1990-07-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new diphenyl propylamine derivatives and pharmaceutical compositions comprising such compounds

Also Published As

Publication number Publication date
FI89262C (fi) 1993-09-10
PT87644B (pt) 1992-09-30
DE3865531D1 (de) 1991-11-21
EP0293925A3 (en) 1989-02-15
AU1691888A (en) 1988-12-08
AU601283B2 (en) 1990-09-06
FI882644A (fi) 1988-12-06
GR3002925T3 (en) 1993-01-25
EP0293925B1 (en) 1991-10-16
EP0293925A2 (en) 1988-12-07
FI89262B (fi) 1993-05-31
JP2560083B2 (ja) 1996-12-04
FI882644A0 (fi) 1988-06-03
CA1329398C (en) 1994-05-10
US4988735A (en) 1991-01-29
IT1205124B (it) 1989-03-15
ATE68474T1 (de) 1991-11-15
ES2039506T3 (es) 1993-10-01
IT8720800A0 (it) 1987-06-05
JPS6485952A (en) 1989-03-30

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920312

PC3A Transfer or assignment

Free format text: 920820 ZAMBON GROUP S.P.A. IT

PD3A Change of proprietorship
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19950930