PT78752A - Improved process for preparing immunotoxin conjugates or relating thereto - Google Patents
Improved process for preparing immunotoxin conjugates or relating theretoInfo
- Publication number
- PT78752A PT78752A PT78752A PT7875284A PT78752A PT 78752 A PT78752 A PT 78752A PT 78752 A PT78752 A PT 78752A PT 7875284 A PT7875284 A PT 7875284A PT 78752 A PT78752 A PT 78752A
- Authority
- PT
- Portugal
- Prior art keywords
- relating
- improved process
- immunotoxin conjugates
- preparing
- preparing immunotoxin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/54—Polycondensates of aldehydes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6829—Bacterial toxins, e.g. diphteria toxins or Pseudomonas exotoxin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6819—Plant toxins
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/813—Cancer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/819—Multifunctional antigen or antibody
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/506,540 US4664911A (en) | 1983-06-21 | 1983-06-21 | Immunotoxin conjugates employing toxin B chain moieties |
Publications (1)
Publication Number | Publication Date |
---|---|
PT78752A true PT78752A (en) | 1984-07-01 |
Family
ID=24015007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT78752A PT78752A (en) | 1983-06-21 | 1984-06-15 | Improved process for preparing immunotoxin conjugates or relating thereto |
Country Status (18)
Country | Link |
---|---|
US (1) | US4664911A (pt) |
EP (1) | EP0129434B1 (pt) |
JP (1) | JPH0639387B2 (pt) |
KR (1) | KR860001803B1 (pt) |
AT (1) | ATE46084T1 (pt) |
AU (1) | AU570049B2 (pt) |
CA (1) | CA1232838A (pt) |
DE (1) | DE3479633D1 (pt) |
DK (1) | DK297184A (pt) |
ES (2) | ES8604425A1 (pt) |
FI (1) | FI842420A (pt) |
GB (1) | GB2142032B (pt) |
GR (1) | GR82368B (pt) |
HU (1) | HUT34348A (pt) |
IL (1) | IL72117A0 (pt) |
PL (1) | PL248202A1 (pt) |
PT (1) | PT78752A (pt) |
ZA (1) | ZA844512B (pt) |
Families Citing this family (84)
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US4925922A (en) * | 1983-02-22 | 1990-05-15 | Xoma Corporation | Potentiation of cytotoxic conjugates |
FR2550944B1 (fr) * | 1983-08-23 | 1985-12-06 | Sanofi Sa | Association pharmaceutique a base d'anticorps anticellules tumorales et de conjugues cytotoxiques, appropriee notamment pour le traitement des cancers |
US4590071A (en) * | 1984-09-25 | 1986-05-20 | Xoma Corporation | Human melanoma specific immunotoxins |
EP0232447A1 (en) * | 1986-02-13 | 1987-08-19 | Xoma Corporation | Lectin immunotoxins |
US6103243A (en) * | 1985-05-15 | 2000-08-15 | Biotechnology Australia Pty, Ltd | Oral vaccines |
US5283323A (en) * | 1985-08-07 | 1994-02-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method of producing immune response |
NZ218460A (en) * | 1985-11-29 | 1989-07-27 | Univ Melbourne | Ricin-antibody conjugate |
IL80972A (en) * | 1985-12-20 | 1992-08-18 | Sanofi Sa | Modified ribosome-inactivating glycoproteins,their preparation,immunotoxins containing them and pharmaceutical compositions containing such immunotoxins |
FR2602682B1 (fr) * | 1986-08-12 | 1988-12-02 | Sanofi Sa | Immunotoxines a longue duree d'action in vivo comportant une glycoproteine inhibant les ribosomes, modifiee par oxydation des motifs osidiques et formation d'une base de schiff |
US4831122A (en) * | 1986-01-09 | 1989-05-16 | Regents Of The University Of Minnesota | Radioimmunotoxins |
JP2594803B2 (ja) * | 1986-03-20 | 1997-03-26 | ダナ ファーバー キャンサー インスティテュート,インコーポレイテッド | レクチン複合体及びそれを製造する方法及びプローブ |
US5239062A (en) * | 1986-03-20 | 1993-08-24 | Dana-Farber Cancer Institute, Inc. | Blocked lectins, methods and affinity support for making same using affinity ligands, and method of killing selected cell populations having reduced nonselective cytotoxicity |
US5395924A (en) * | 1986-03-20 | 1995-03-07 | Dana-Farber Cancer Institute, Inc. | Blocked lectins; methods and affinity support for making the same using affinity ligands; and method of killing selected cell populations having reduced non-selective cytotoxicity |
US4806494A (en) * | 1986-07-24 | 1989-02-21 | The United States Of America As Represented By The Department Of Health & Human Services | Monoclonal antibody against ovarian cancer cells (OVB-3) |
FR2604092B1 (fr) * | 1986-09-19 | 1990-04-13 | Immunotech Sa | Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo |
JPH01501476A (ja) * | 1986-10-09 | 1989-05-25 | ネオルックス コーポレイション | 抗体、抗体断片、ホルモン並びに他の標的剤、およびそれらの配合体を標的とする改良方法 |
US4808705A (en) * | 1986-12-19 | 1989-02-28 | Cetus Corporation | Stable formulations of ricin toxin a chain and of RTA-immunoconjugates and stabilizer screening methods therefor |
US5320942A (en) * | 1987-02-19 | 1994-06-14 | Vito Quaranta | Method of diagnosing the presence of abnormal epithelial tissue using monoclonal antibodies to the A6 B4 cell surface protein |
US4962048A (en) * | 1987-02-19 | 1990-10-09 | Scripps Clinic & Research Foundation | Monoclonal antibodies to human pancreatic cancer |
US6657050B1 (en) | 1987-05-29 | 2003-12-02 | Tanox, Inc. | Chimeric viral-neutralizing immunoglobulins |
US5834599A (en) * | 1987-05-29 | 1998-11-10 | Tanox Biosystems, Inc. | Immunoconjugates which neutralize HIV-1 infection |
US5981278A (en) * | 1987-05-29 | 1999-11-09 | Tanox, Inc. | Chimeric monoclonal antibodies which neutralize HIV-1 infection and their applications in therapy and prevention for AIDS |
CA1335227C (en) * | 1987-06-22 | 1995-04-11 | Wylie W. Vale, Jr. | Crf analog conjugates |
IE890206L (en) * | 1988-02-02 | 1989-08-02 | Akzo Nv | Immunotoxins from barley toxin |
WO1989006967A1 (en) * | 1988-02-03 | 1989-08-10 | Xoma Corporation | Immunosupression with anti-pan t-cell immunotoxin compositions |
US5827934A (en) * | 1988-03-08 | 1998-10-27 | The University Of Wyoming | Cytotoxic diphtheria toxin fragments |
KR900700134A (ko) * | 1988-04-15 | 1990-08-11 | 원본미기재 | Il-2 수용체-특이적 키메릭 항체 |
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US5045451A (en) * | 1988-10-26 | 1991-09-03 | Board Of Regents | Methods for screening antibodies for use as immunotoxins |
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US5876438A (en) * | 1993-08-02 | 1999-03-02 | Houston Biotechnology Incorporated | Polymeric device for the delivery of immunotoxins for the prevention of secondary cataract |
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FR2437213A1 (fr) * | 1978-09-28 | 1980-04-25 | Cm Ind | Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation |
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FR2516794B1 (fr) * | 1981-11-20 | 1985-10-25 | Sanofi Sa | Nouveaux medicaments anticancereux pour le traitement des leucemies t constitues de la chaine a de la ricine et d'un anticorps monoclonal specifique |
FR2536997B1 (fr) * | 1982-03-11 | 1987-08-07 | Sanofi Sa | Medicaments cytotoxiques comportant au moins une immunotoxine et de la methylamine |
FR2523445A1 (fr) * | 1982-03-17 | 1983-09-23 | Sanofi Sa | Nouveaux conjugues associant, par liaison covalente, une enzyme et un anticorps, et associations medicamenteuses utilisant lesdits conjugues |
US4500637A (en) * | 1982-07-19 | 1985-02-19 | The United States Of America As Represented By The Department Of Health And Human Services | Prevention of graft versus host disease following bone marrow transplantation |
-
1983
- 1983-06-21 US US06/506,540 patent/US4664911A/en not_active Expired - Fee Related
-
1984
- 1984-06-14 FI FI842420A patent/FI842420A/fi not_active Application Discontinuation
- 1984-06-14 PL PL24820284A patent/PL248202A1/xx unknown
- 1984-06-14 GR GR75017A patent/GR82368B/el unknown
- 1984-06-14 ZA ZA844512A patent/ZA844512B/xx unknown
- 1984-06-15 IL IL72117A patent/IL72117A0/xx unknown
- 1984-06-15 PT PT78752A patent/PT78752A/pt not_active IP Right Cessation
- 1984-06-18 AU AU29480/84A patent/AU570049B2/en not_active Ceased
- 1984-06-18 CA CA000456816A patent/CA1232838A/en not_active Expired
- 1984-06-18 GB GB08415507A patent/GB2142032B/en not_active Expired
- 1984-06-18 DK DK297184A patent/DK297184A/da not_active Application Discontinuation
- 1984-06-18 DE DE8484304096T patent/DE3479633D1/de not_active Expired
- 1984-06-18 EP EP84304096A patent/EP0129434B1/en not_active Expired
- 1984-06-18 ES ES533510A patent/ES8604425A1/es not_active Expired
- 1984-06-18 AT AT84304096T patent/ATE46084T1/de active
- 1984-06-19 HU HU842360A patent/HUT34348A/hu unknown
- 1984-06-19 KR KR1019840003431A patent/KR860001803B1/ko not_active IP Right Cessation
- 1984-06-20 JP JP59127258A patent/JPH0639387B2/ja not_active Expired - Lifetime
-
1985
- 1985-07-03 ES ES544846A patent/ES8606884A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES8606884A1 (es) | 1986-04-16 |
PL248202A1 (en) | 1985-03-26 |
KR850000248A (ko) | 1985-02-26 |
EP0129434A2 (en) | 1984-12-27 |
EP0129434A3 (en) | 1985-09-18 |
GB2142032B (en) | 1987-05-13 |
HUT34348A (en) | 1985-03-28 |
CA1232838A (en) | 1988-02-16 |
FI842420A (fi) | 1984-12-22 |
ES533510A0 (es) | 1986-02-01 |
FI842420A0 (fi) | 1984-06-14 |
ES544846A0 (es) | 1986-04-16 |
DE3479633D1 (en) | 1989-10-12 |
IL72117A0 (en) | 1984-10-31 |
DK297184D0 (da) | 1984-06-18 |
US4664911A (en) | 1987-05-12 |
AU570049B2 (en) | 1988-03-03 |
DK297184A (da) | 1984-12-22 |
ES8604425A1 (es) | 1986-02-01 |
JPS6069033A (ja) | 1985-04-19 |
GB2142032A (en) | 1985-01-09 |
ZA844512B (en) | 1986-02-26 |
AU2948084A (en) | 1985-01-03 |
JPH0639387B2 (ja) | 1994-05-25 |
KR860001803B1 (ko) | 1986-10-23 |
ATE46084T1 (de) | 1989-09-15 |
GR82368B (pt) | 1984-12-13 |
EP0129434B1 (en) | 1989-09-06 |
GB8415507D0 (en) | 1984-07-25 |
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