PT76632B - Process for the preparation of 1-alkyl-1,2,3,4,5,6-hexahydro-azepine <4,5-b> indoles - Google Patents

Process for the preparation of 1-alkyl-1,2,3,4,5,6-hexahydro-azepine <4,5-b> indoles

Info

Publication number
PT76632B
PT76632B PT76632A PT7663283A PT76632B PT 76632 B PT76632 B PT 76632B PT 76632 A PT76632 A PT 76632A PT 7663283 A PT7663283 A PT 7663283A PT 76632 B PT76632 B PT 76632B
Authority
PT
Portugal
Prior art keywords
azepine
indoles
hexahydro
alkyl
preparation
Prior art date
Application number
PT76632A
Other languages
English (en)
Portuguese (pt)
Other versions
PT76632A (en
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of PT76632A publication Critical patent/PT76632A/pt
Publication of PT76632B publication Critical patent/PT76632B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT76632A 1982-05-06 1983-05-04 Process for the preparation of 1-alkyl-1,2,3,4,5,6-hexahydro-azepine <4,5-b> indoles PT76632B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH2806/82A CH649553A5 (de) 1982-05-06 1982-05-06 Azepinoindole und verfahren zu deren herstellung.

Publications (2)

Publication Number Publication Date
PT76632A PT76632A (en) 1983-06-01
PT76632B true PT76632B (en) 1986-01-27

Family

ID=4242007

Family Applications (1)

Application Number Title Priority Date Filing Date
PT76632A PT76632B (en) 1982-05-06 1983-05-04 Process for the preparation of 1-alkyl-1,2,3,4,5,6-hexahydro-azepine <4,5-b> indoles

Country Status (17)

Country Link
JP (1) JPS58203993A (de)
AU (1) AU1425683A (de)
BE (1) BE896590A (de)
CH (1) CH649553A5 (de)
DE (1) DE3315467A1 (de)
DK (1) DK199883A (de)
ES (1) ES8502440A1 (de)
FI (1) FI831475L (de)
FR (1) FR2526434A1 (de)
GB (1) GB2120662B (de)
HU (1) HU189275B (de)
IL (1) IL68576A0 (de)
IT (1) IT1197644B (de)
NL (1) NL8301552A (de)
PT (1) PT76632B (de)
SE (1) SE8302554L (de)
ZA (1) ZA833266B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU193083B (en) * 1984-02-22 1987-08-28 Sandoz Ag Process for preparing diazepinoindole derivatives further pharmaceutical compositions containing such compounds
AU582564B2 (en) * 1985-02-20 1989-04-06 Sandoz Ltd. 2,3,4,5-tetrahydro-11-phenyl-1H-``1,4``diazepino``1,7-a`` indoles, their production and pharmaceutical compositions containing them
AR034264A1 (es) * 2000-09-20 2004-02-18 Upjohn Co Derivados azepino(4,5-b)indol sustituidos y composiciones farmaceuticas
DE60206636T2 (de) 2001-08-08 2006-06-22 Pharmacia & Upjohn Co. Llc, Kalamazoo THERAPEUTISCHE 1H-PYRIDO[4,3-b]INDOLE
CA2636992C (en) * 2006-01-19 2015-10-06 Athersys, Inc. Thiophenyl and pyrrolyl azepines as serotonin 5-ht2c receptor ligands and uses thereof
CN101945872B (zh) 2008-01-11 2014-07-23 阿尔巴尼分子研究公司 作为mch拮抗剂的(1-吖嗪酮)-取代的吡啶并吲哚
EP2448585B1 (de) 2009-07-01 2014-01-01 Albany Molecular Research, Inc. Azinon-substituiertes azepin[b]indol und pyrido-pyrrolo-azepin mch-1 antagonisten, verfahren zur herstellung und verwendung davon
WO2011003021A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
US8629158B2 (en) 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8618299B2 (en) 2009-07-01 2013-12-31 Albany Molecular Research, Inc. Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
WO2012088124A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
US8697700B2 (en) 2010-12-21 2014-04-15 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3070467D1 (en) * 1979-11-02 1985-05-15 Sandoz Ag Azepinoindoles, process for their production and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IL68576A0 (en) 1983-09-30
GB2120662A (en) 1983-12-07
IT1197644B (it) 1988-12-06
SE8302554L (sv) 1983-11-07
CH649553A5 (de) 1985-05-31
JPS58203993A (ja) 1983-11-28
FI831475A0 (fi) 1983-04-29
GB8312159D0 (en) 1983-06-08
GB2120662B (en) 1985-09-11
HU189275B (en) 1986-06-30
FI831475L (fi) 1983-11-07
IT8348232A0 (it) 1983-05-06
DK199883D0 (da) 1983-05-04
ES522008A0 (es) 1985-01-01
SE8302554D0 (sv) 1983-05-04
BE896590A (fr) 1983-10-28
PT76632A (en) 1983-06-01
DK199883A (da) 1983-11-07
AU1425683A (en) 1983-11-10
DE3315467A1 (de) 1983-11-17
FR2526434A1 (fr) 1983-11-10
ZA833266B (en) 1984-12-24
ES8502440A1 (es) 1985-01-01
NL8301552A (nl) 1983-12-01

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