PT74838B - Process for preparing 1,5-substituted isoquinoline derivatives - Google Patents

Process for preparing 1,5-substituted isoquinoline derivatives

Info

Publication number
PT74838B
PT74838B PT74838A PT7483882A PT74838B PT 74838 B PT74838 B PT 74838B PT 74838 A PT74838 A PT 74838A PT 7483882 A PT7483882 A PT 7483882A PT 74838 B PT74838 B PT 74838B
Authority
PT
Portugal
Prior art keywords
preparing
isoquinoline derivatives
substituted isoquinoline
substituted
derivatives
Prior art date
Application number
PT74838A
Other languages
English (en)
Other versions
PT74838A (en
Inventor
Harman Smith Lowrie
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of PT74838A publication Critical patent/PT74838A/pt
Publication of PT74838B publication Critical patent/PT74838B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT74838A 1981-05-04 1982-05-03 Process for preparing 1,5-substituted isoquinoline derivatives PT74838B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26054781A 1981-05-04 1981-05-04
US06/329,789 US4473501A (en) 1981-05-04 1981-12-11 Dihydro azino isoquinolines

Publications (2)

Publication Number Publication Date
PT74838A PT74838A (en) 1982-06-01
PT74838B true PT74838B (en) 1983-12-07

Family

ID=26948062

Family Applications (1)

Application Number Title Priority Date Filing Date
PT74838A PT74838B (en) 1981-05-04 1982-05-03 Process for preparing 1,5-substituted isoquinoline derivatives

Country Status (7)

Country Link
US (1) US4473501A (pt)
EP (1) EP0064294A1 (pt)
AU (1) AU8321782A (pt)
DK (1) DK198182A (pt)
ES (1) ES511914A0 (pt)
NO (1) NO821458L (pt)
PT (1) PT74838B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60237070A (ja) * 1984-05-08 1985-11-25 Nisshin Flour Milling Co Ltd 光学活性イソカルボスチリル誘導体の製法
SE8801518D0 (sv) * 1988-04-22 1988-04-22 Astra Pharma Prod A novel process
TW575567B (en) 1998-10-23 2004-02-11 Akzo Nobel Nv Serine protease inhibitor
CA2464109A1 (en) * 2001-10-18 2003-12-24 Michigan State University Process for the preparation of oxazolidinones and method of use thereof
US7094789B2 (en) * 2002-07-22 2006-08-22 Asahi Kasei Pharma Corporation 5-substituted isoquinoline derivatives
JPWO2008120655A1 (ja) 2007-03-30 2010-07-15 株式会社医薬分子設計研究所 Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有するオキサゾリジノン誘導体

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA536744A (en) * 1957-02-05 Druey Jean Isoquinoline compounds and process of making same
CH307873A (de) * 1952-05-30 1955-06-15 Ciba Geigy Verfahren zur Herstellung einer neuen Isochinolinverbindung.
GB1058822A (en) * 1963-07-30 1967-02-15 Ici Ltd 3-amino-2-hydroxypropoxy heterocyclic derivatives
US3753994A (en) * 1970-08-10 1973-08-21 Sterling Drug Inc 1,1'-azinobis(1,2,3,4-tetrahydroisoquinolines)
US4009170A (en) * 1970-08-10 1977-02-22 Sterling Drug Inc. 1-Ethoxy-3,4-dihydroisoquindines
US3946009A (en) * 1972-05-05 1976-03-23 Merck Sharp & Dohme (I.A.) Corporation 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines
US4115575A (en) * 1973-02-20 1978-09-19 Ciba-Geigy Corporation 2-(3-Amino-2-hydroxy-propoxy)-pyrazines
US4073909A (en) * 1973-10-08 1978-02-14 Sandoz Ltd. Isoquinoline compounds
SE431451B (sv) * 1973-10-24 1984-02-06 Otsuka Pharma Co Ltd Forfarande for framstellning av 2,3-dihydroxipropoxikinoliner eller -isokinoliner
JPS538707B2 (pt) * 1974-02-05 1978-03-31
JPS5318032B2 (pt) * 1974-03-04 1978-06-13
DE2639718A1 (de) * 1976-09-03 1978-03-16 Thomae Gmbh Dr K Neue phenylaethylamine
DE2644833A1 (de) * 1976-10-05 1978-04-20 Boehringer Sohn Ingelheim Neue 1-aryloxy-2-hydroxy-3-alkylenaminopropane und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
PT74838A (en) 1982-06-01
ES8401066A1 (es) 1983-12-01
AU8321782A (en) 1982-11-11
DK198182A (da) 1982-11-05
ES511914A0 (es) 1983-12-01
NO821458L (no) 1982-11-05
US4473501A (en) 1984-09-25
EP0064294A1 (en) 1982-11-10

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