PT3872085T - Sequências de aav ancestrais e utilizações destas - Google Patents
Sequências de aav ancestrais e utilizações destasInfo
- Publication number
- PT3872085T PT3872085T PT211613724T PT21161372T PT3872085T PT 3872085 T PT3872085 T PT 3872085T PT 211613724 T PT211613724 T PT 211613724T PT 21161372 T PT21161372 T PT 21161372T PT 3872085 T PT3872085 T PT 3872085T
- Authority
- PT
- Portugal
- Prior art keywords
- aav sequences
- ancestral aav
- ancestral
- sequences
- aav
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Materials For Medical Uses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562199059P | 2015-07-30 | 2015-07-30 | |
| US201562203002P | 2015-08-10 | 2015-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3872085T true PT3872085T (pt) | 2023-04-13 |
Family
ID=57885044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT211613724T PT3872085T (pt) | 2015-07-30 | 2016-07-29 | Sequências de aav ancestrais e utilizações destas |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10738087B2 (pt) |
| EP (3) | EP4134375A1 (pt) |
| JP (2) | JP7166168B2 (pt) |
| CN (1) | CN108603235A (pt) |
| AU (1) | AU2016298394C1 (pt) |
| CA (2) | CA2994160C (pt) |
| DK (1) | DK3872085T3 (pt) |
| ES (1) | ES2945427T3 (pt) |
| FI (1) | FI3872085T3 (pt) |
| HK (1) | HK1254848A1 (pt) |
| HU (1) | HUE061388T2 (pt) |
| LT (1) | LT3872085T (pt) |
| PL (1) | PL3872085T3 (pt) |
| PT (1) | PT3872085T (pt) |
| WO (1) | WO2017019994A2 (pt) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112029737A (zh) * | 2005-04-07 | 2020-12-04 | 宾夕法尼亚大学托管会 | 增强腺相关病毒载体功能的方法 |
| WO2015191508A1 (en) | 2014-06-09 | 2015-12-17 | Voyager Therapeutics, Inc. | Chimeric capsids |
| WO2016073693A2 (en) | 2014-11-05 | 2016-05-12 | Voyager Therapeutics, Inc. | Aadc polynucleotides for the treatment of parkinson's disease |
| US10597660B2 (en) | 2014-11-14 | 2020-03-24 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
| SG11201703419UA (en) | 2014-11-14 | 2017-05-30 | Voyager Therapeutics Inc | Modulatory polynucleotides |
| WO2016094783A1 (en) | 2014-12-12 | 2016-06-16 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scaav |
| ES2945427T3 (es) * | 2015-07-30 | 2023-07-03 | Massachusetts Eye & Ear Infirmary | Secuencias de AAV ancestrales y usos de las mismas |
| EP3831842A1 (en) | 2015-09-28 | 2021-06-09 | The University of North Carolina at Chapel Hill | Methods and compositions for antibody-evading virus vectors |
| CA3006569A1 (en) | 2015-12-02 | 2017-06-08 | Voyager Therapeutics, Inc. | Assays for the detection of aav neutralizing antibodies |
| US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| EP3458589A4 (en) | 2016-05-18 | 2020-01-01 | Voyager Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATING HUNTINGTON'S DISEASE |
| KR20240056729A (ko) | 2016-05-18 | 2024-04-30 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| US11584780B2 (en) | 2016-07-26 | 2023-02-21 | Biomarin Pharmaceutical Inc. | Adeno-associated virus capsid proteins |
| US20190185864A1 (en) | 2016-08-23 | 2019-06-20 | Akouos, Inc. | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
| CN110650673B (zh) | 2016-08-30 | 2024-04-09 | 加利福尼亚大学董事会 | 用于生物医学靶向和递送的方法以及用于实践该方法的装置和系统 |
| US11603542B2 (en) | 2017-05-05 | 2023-03-14 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
| JP2020518259A (ja) | 2017-05-05 | 2020-06-25 | ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ハンチントン病治療組成物および方法 |
| WO2018209154A1 (en) * | 2017-05-10 | 2018-11-15 | Massachusetts Eye And Ear Infirmary | Methods and compositions for modifying assembly-activating protein (app)-dependence of viruses |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| EP3654860A1 (en) | 2017-07-17 | 2020-05-27 | Voyager Therapeutics, Inc. | Trajectory array guide system |
| US11512327B2 (en) | 2017-08-03 | 2022-11-29 | Voyager Therapeutics, Inc. | Compositions and methods for delivery of AAV |
| WO2019067982A2 (en) * | 2017-09-29 | 2019-04-04 | Massachusetts Eye And Ear Infirmary | PRODUCTION OF ADENO-ASSOCIATED VIRUSES IN INSECT CELLS |
| AU2018352236A1 (en) | 2017-10-16 | 2020-04-23 | The Curators Of The University Of Missouri | Treatment of amyotrophic lateral sclerosis (ALS) |
| US20200237799A1 (en) | 2017-10-16 | 2020-07-30 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
| EP3774854A1 (en) | 2018-04-03 | 2021-02-17 | Stridebio, Inc. | Antibody-evading virus vectors |
| KR20210008501A (ko) | 2018-05-09 | 2021-01-22 | 바이오마린 파머수티컬 인크. | 페닐케톤뇨증을 치료하는 방법 |
| JP7438981B2 (ja) | 2018-05-11 | 2024-02-27 | マサチューセッツ アイ アンド イヤー インファーマリー | アデノ随伴ウイルスの肝臓特異的向性 |
| TW202005978A (zh) | 2018-05-14 | 2020-02-01 | 美商拜奧馬林製藥公司 | 新穎肝靶向腺相關病毒載體 |
| UY38407A (es) | 2018-10-15 | 2020-05-29 | Novartis Ag | Anticuerpos estabilizadores de trem2 |
| TW202102525A (zh) | 2019-03-21 | 2021-01-16 | 美商史崔德生物公司 | 重組腺相關病毒載體 |
| CA3134507A1 (en) * | 2019-04-29 | 2020-11-05 | Kalyani NAMBIAR | Novel aav capsids and compositions containing same |
| CN110423778B (zh) * | 2019-07-26 | 2023-04-21 | 上海科技大学 | 一种逆行性重组2型腺相关病毒在感染螺旋神经元中的应用 |
| WO2021073568A1 (en) * | 2019-10-16 | 2021-04-22 | Wuxi Apptec (Shanghai) Co., Ltd. | A novel aav variant |
| US20220251542A1 (en) * | 2019-10-16 | 2022-08-11 | Wuxi Apptec (Shanghai) Co., Ltd. | Novel aav library |
| MX2022004352A (es) | 2019-10-17 | 2022-07-19 | Stridebio Inc | Vectores virales adenoasociados para el tratamiento de la enfermedad de niemann-pick tipo c. |
| EP4114958A1 (en) | 2020-02-21 | 2023-01-11 | Akouos, Inc. | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
| CA3201533A1 (en) | 2020-11-11 | 2022-05-19 | European Molecular Biology Laboratory | Modified viral particles for gene therapy |
| IL308356A (en) | 2021-05-12 | 2024-01-01 | Fond Telethon | Vector system |
| WO2023214346A1 (en) | 2022-05-06 | 2023-11-09 | Novartis Ag | Novel recombinant aav vp2 fusion polypeptides |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US368925A (en) * | 1887-08-30 | Feed mechanism for sewing-machines | ||
| US242997A (en) * | 1881-06-14 | Reversible seat | ||
| US5037384B2 (en) | 1988-01-12 | 1995-12-26 | Cornell Res Foundation Inc | Method and apparatus for the treatment of complicated retinal detachments |
| US20040115621A1 (en) | 2000-02-18 | 2004-06-17 | Allen Rodrigo | Ancestral viruses and vaccines |
| US6692526B1 (en) | 2000-03-15 | 2004-02-17 | Michael E. Snyder | Ophthalmological surgery colorant and delivery system |
| AU2004278684B2 (en) | 2003-09-30 | 2011-05-12 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses therefor |
| CN112029737A (zh) | 2005-04-07 | 2020-12-04 | 宾夕法尼亚大学托管会 | 增强腺相关病毒载体功能的方法 |
| US8388668B2 (en) | 2005-08-05 | 2013-03-05 | Gholam A. Peyman | Methods to regulate polarization of excitable cells |
| AU2014244167A1 (en) * | 2013-03-13 | 2015-10-08 | The Children's Hospital Of Philadelphia | Adeno-associated virus vectors and methods of use thereof |
| CN115093464A (zh) | 2013-10-11 | 2022-09-23 | 马萨诸塞眼科耳科诊所 | 预测祖先病毒序列的方法及其用途 |
| ES2945427T3 (es) * | 2015-07-30 | 2023-07-03 | Massachusetts Eye & Ear Infirmary | Secuencias de AAV ancestrales y usos de las mismas |
| WO2018209154A1 (en) * | 2017-05-10 | 2018-11-15 | Massachusetts Eye And Ear Infirmary | Methods and compositions for modifying assembly-activating protein (app)-dependence of viruses |
-
2016
- 2016-07-29 ES ES21161372T patent/ES2945427T3/es active Active
- 2016-07-29 US US15/748,738 patent/US10738087B2/en active Active
- 2016-07-29 EP EP22182170.5A patent/EP4134375A1/en not_active Withdrawn
- 2016-07-29 WO PCT/US2016/044819 patent/WO2017019994A2/en unknown
- 2016-07-29 AU AU2016298394A patent/AU2016298394C1/en active Active
- 2016-07-29 DK DK21161372.4T patent/DK3872085T3/da active
- 2016-07-29 PT PT211613724T patent/PT3872085T/pt unknown
- 2016-07-29 CN CN201680057177.2A patent/CN108603235A/zh active Pending
- 2016-07-29 FI FIEP21161372.4T patent/FI3872085T3/fi active
- 2016-07-29 CA CA2994160A patent/CA2994160C/en active Active
- 2016-07-29 CA CA3126951A patent/CA3126951A1/en not_active Abandoned
- 2016-07-29 JP JP2018504699A patent/JP7166168B2/ja active Active
- 2016-07-29 EP EP21161372.4A patent/EP3872085B1/en active Active
- 2016-07-29 EP EP16831443.3A patent/EP3329017B1/en not_active Withdrawn - After Issue
- 2016-07-29 LT LTEP21161372.4T patent/LT3872085T/lt unknown
- 2016-07-29 PL PL21161372.4T patent/PL3872085T3/pl unknown
- 2016-07-29 HU HUE21161372A patent/HUE061388T2/hu unknown
-
2018
- 2018-10-31 HK HK18113943.1A patent/HK1254848A1/zh unknown
-
2020
- 2020-08-10 US US16/989,454 patent/US20210017235A1/en active Pending
-
2021
- 2021-06-16 JP JP2021099934A patent/JP7222028B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HUE061388T2 (hu) | 2023-06-28 |
| US20210017235A1 (en) | 2021-01-21 |
| US20190100560A1 (en) | 2019-04-04 |
| CA2994160A1 (en) | 2017-02-02 |
| WO2017019994A2 (en) | 2017-02-02 |
| JP2018521670A (ja) | 2018-08-09 |
| EP3872085B1 (en) | 2023-03-01 |
| CA3126951A1 (en) | 2017-02-02 |
| ES2945427T3 (es) | 2023-07-03 |
| AU2016298394A1 (en) | 2018-02-22 |
| EP3329017B1 (en) | 2021-03-10 |
| FI3872085T3 (fi) | 2023-04-19 |
| JP7166168B2 (ja) | 2022-11-07 |
| LT3872085T (lt) | 2023-05-10 |
| PL3872085T3 (pl) | 2023-06-05 |
| JP7222028B2 (ja) | 2023-02-14 |
| EP3872085A1 (en) | 2021-09-01 |
| EP4134375A1 (en) | 2023-02-15 |
| CA2994160C (en) | 2021-08-10 |
| JP2021175397A (ja) | 2021-11-04 |
| US10738087B2 (en) | 2020-08-11 |
| HK1254848A1 (zh) | 2019-07-26 |
| EP3329017A2 (en) | 2018-06-06 |
| AU2016298394C1 (en) | 2024-02-15 |
| EP3329017A4 (en) | 2018-12-26 |
| AU2016298394B2 (en) | 2022-07-28 |
| DK3872085T3 (da) | 2023-04-03 |
| CN108603235A (zh) | 2018-09-28 |
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