PT3443970T - Fagos antibacterianos, péptidos fágicos e métodos de utilização dos mesmos - Google Patents

Fagos antibacterianos, péptidos fágicos e métodos de utilização dos mesmos

Info

Publication number
PT3443970T
PT3443970T PT181927666T PT18192766T PT3443970T PT 3443970 T PT3443970 T PT 3443970T PT 181927666 T PT181927666 T PT 181927666T PT 18192766 T PT18192766 T PT 18192766T PT 3443970 T PT3443970 T PT 3443970T
Authority
PT
Portugal
Prior art keywords
phagic
antibacterial
peptides
pages
methods
Prior art date
Application number
PT181927666T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Technophage Investig E Desenvolvimento Em Biotecnologia Sa
Tecnifar Ind Tecnica Farmaceutica S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technophage Investig E Desenvolvimento Em Biotecnologia Sa, Tecnifar Ind Tecnica Farmaceutica S A filed Critical Technophage Investig E Desenvolvimento Em Biotecnologia Sa
Publication of PT3443970T publication Critical patent/PT3443970T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00031—Uses of virus other than therapeutic or vaccine, e.g. disinfectant
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PT181927666T 2010-09-17 2011-09-19 Fagos antibacterianos, péptidos fágicos e métodos de utilização dos mesmos PT3443970T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38401510P 2010-09-17 2010-09-17

Publications (1)

Publication Number Publication Date
PT3443970T true PT3443970T (pt) 2020-10-09

Family

ID=45755483

Family Applications (2)

Application Number Title Priority Date Filing Date
PT181927666T PT3443970T (pt) 2010-09-17 2011-09-19 Fagos antibacterianos, péptidos fágicos e métodos de utilização dos mesmos
PT11820825T PT2616087T (pt) 2010-09-17 2011-09-19 Fagos antibacterianos, péptidos fágicos e métodos de utilização dos mesmos

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT11820825T PT2616087T (pt) 2010-09-17 2011-09-19 Fagos antibacterianos, péptidos fágicos e métodos de utilização dos mesmos

Country Status (13)

Country Link
US (3) US9222077B2 (cg-RX-API-DMAC7.html)
EP (4) EP2616087B1 (cg-RX-API-DMAC7.html)
JP (3) JP6058540B2 (cg-RX-API-DMAC7.html)
CN (1) CN103732235B (cg-RX-API-DMAC7.html)
AU (3) AU2011302722B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013006400B1 (cg-RX-API-DMAC7.html)
CA (3) CA3154006C (cg-RX-API-DMAC7.html)
ES (3) ES2703629T3 (cg-RX-API-DMAC7.html)
PL (1) PL3789031T3 (cg-RX-API-DMAC7.html)
PT (2) PT3443970T (cg-RX-API-DMAC7.html)
RU (2) RU2614114C2 (cg-RX-API-DMAC7.html)
SG (1) SG188566A1 (cg-RX-API-DMAC7.html)
WO (1) WO2012036580A2 (cg-RX-API-DMAC7.html)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3443970T (pt) * 2010-09-17 2020-10-09 Technophage Investig E Desenvolvimento Em Biotecnologia Sa Fagos antibacterianos, péptidos fágicos e métodos de utilização dos mesmos
BR112014023321B1 (pt) * 2012-03-19 2022-06-14 Technophage, Investigação E Desenvolvimento Em Biotecnologia, Sa Composições compreendendo fagos antibacterianos e seus usos
JP6351119B2 (ja) * 2012-05-07 2018-07-04 マイクレオス ビー．ブイ． サルモネラの生物的防除のための及び食品の製造若しくは加工におけるバクテリオファージ
EP2799063A1 (en) * 2013-04-30 2014-11-05 Ferring B.V. Bacteriophage therapy
EP2865383A1 (en) * 2013-10-25 2015-04-29 Pherecydes Pharma Phage therapy of pseudomonas infections
EP2893933A1 (en) 2014-01-10 2015-07-15 Pherecydes Pharma Phage Therapy of E coli infections
CN103981154B (zh) * 2014-05-28 2016-07-06 大连理工大学 一种铜绿假单胞菌噬菌体及其在水貂出血性肺炎预防中的应用
GB2543453A (en) * 2014-06-26 2017-04-19 Univ Rockefeller Acinetobacter lysins
EP3018201A1 (en) * 2014-11-07 2016-05-11 Pherecydes Pharma Phage therapy
EP3234136B1 (en) 2014-12-16 2024-08-21 C3J Therapeutics, Inc. Compositions of and methods for in vitro viral genome engineering
CN108135971A (zh) * 2015-09-17 2018-06-08 抗非特公司 溶素恢复/增强在肺表面活性物质存在下由此抑制的抗生素的抗菌活性的用途
EP3436471B1 (en) * 2016-03-28 2021-11-03 Illumina, Inc. Recombinase mutants
WO2018106135A2 (en) 2016-12-05 2018-06-14 Technophage, Investigação E Desenvolvimento Em Biotecnologia, Sa Bacteriophage compositions comprising respiratory antibacterial phages and methods of use thereof
WO2018151417A1 (ko) * 2017-02-17 2018-08-23 주식회사 인트론바이오테크놀로지 신규한 녹농균 박테리오파지 Pse-AEP-4 및 이의 녹농균 증식 억제 용도
GB201712145D0 (en) * 2017-07-28 2017-09-13 Univ Leuven Kath Novel dnase
AU2019276253A1 (en) 2018-05-30 2020-11-26 Lysando Ag Novel antimicrobial proteins
WO2020130652A2 (ko) * 2018-12-18 2020-06-25 연세대학교 산학협력단 세균을 용균하는 신규한 박테리오파지
US20220073567A1 (en) * 2018-12-24 2022-03-10 Mikroliz Biyoteknoloji San. Ve Tic. Ltd. Sti. Acinetobacter baumannii bacteriophage mikab48 or lytic protein derived from the bacteriophage
CA3132657A1 (en) * 2019-06-17 2020-12-24 Phagelux Canada Inc. Bacterial control through dispersion of bacteriophage powders
RU2717420C1 (ru) * 2019-06-28 2020-03-23 Акционерное общество "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Штамм бактериофага Pseudomonas aeruginosa N 327 (500321), предназначенный для приготовления моно- и поливалентных лечебно-профилактических препаратов бактериофагов
RU2717435C1 (ru) * 2019-06-28 2020-03-23 Акционерное общество "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Штамм бактериофага Pseudomonas aeruginosa N 326 (500320), предназначенный для приготовления моно- и поливалентных лечебно-профилактических препаратов бактериофагов
RU2717451C1 (ru) * 2019-06-28 2020-03-23 Акционерное общество "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Штамм бактериофага Pseudomonas aeruginosa N 323 (500317), предназначенный для приготовления моно- и поливалентных лечебно-профилактических препаратов бактериофагов
RU2717973C1 (ru) * 2019-06-28 2020-03-27 Акционерное общество "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Штамм бактериофага Pseudomonas aeruginosa N 322 (500316), предназначенный для приготовления моно- и поливалентных лечебно-профилактических препаратов бактериофагов
RU2717022C1 (ru) * 2019-06-28 2020-03-17 Акционерное общество "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Штамм бактериофага Pseudomonas aeruginosa N 328 (500322), предназначенный для приготовления моно- и поливалентных лечебно-профилактических препаратов бактериофагов
RU2717972C1 (ru) * 2019-06-28 2020-03-27 Акционерное общество "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Штамм бактериофага Pseudomonas aeruginosa N 324 (500318), предназначенный для приготовления моно- и поливалентных лечебно-профилактических препаратов бактериофагов
RU2717026C1 (ru) * 2019-06-28 2020-03-17 Акционерное общество "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Штамм бактериофага Pseudomonas aeruginosa N 325 (500319), предназначенный для приготовления моно- и поливалентных лечебно-профилактических препаратов бактериофагов
RU2707505C1 (ru) * 2019-09-17 2019-11-27 федеральное государственное бюджетное образовательное учреждение высшего образования "Приволжский исследовательский медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО "ПИМУ" Минздрава России) Способ лечения бактериальных инфекций дыхательных путей
US20210187046A1 (en) 2019-12-19 2021-06-24 Technophage, Investigação E Desenvolvimento Em Biotecnologia, Sa Cocktail compositions comprising respiratory antibacterial phages and methods of use thereof
CN113214364B (zh) * 2020-01-21 2022-11-22 天津大学 一种多重耐药鲍曼不动杆菌识别元件的挖掘与验证
FR3110574A1 (fr) * 2020-05-20 2021-11-26 Vetophage Capture de bacteries a l’aide de bacteriophages ou de proteines de bacteriophage
WO2021235876A1 (ko) 2020-05-22 2021-11-25 주식회사 라이센텍 신규한 폴리펩타이드, 융합 폴리펩타이드, 및 이를 포함하는 그람음성균에 대한 항생제
WO2022040592A1 (en) * 2020-08-20 2022-02-24 The Board Of Regents Of The University Of Texas System Combination immunotherapy methods for the treatment of cancer
US20240415904A1 (en) * 2021-05-12 2024-12-19 Biomx Ltd. Staphylococcus bacteriophage and uses thereof
WO2023101639A1 (en) * 2021-11-30 2023-06-08 Yildiz Teknik Universitesi Antimicrobial agent for lysis of s. aureus
CN114807106B (zh) * 2022-04-25 2023-09-01 昆明市延安医院 一种裂解酶pEf51和穿孔素蛋白pEf191的应用
EP4673163A2 (en) * 2023-02-27 2026-01-07 The Regents of the University of California Proteins that inhibit cyclic-oligonucleotide-based anti-phage signaling system (cbass)
US20250160335A1 (en) * 2023-11-16 2025-05-22 The United States Of America, As Represented By The Secretary Of Agriculture Formulation of a lytic bacteriophage cocktail for biocontrol of shiga toxin-producing escherichia coli strains
CN119139561A (zh) * 2024-11-15 2024-12-17 浙江大学 一种噬菌体复合水凝胶及其制备方法和在促进牙槽骨修复中的应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
ES2145019T3 (es) * 1992-06-25 2000-07-01 Aventis Res & Tech Gmbh & Co Pseudomonas aeruginosa y su utilizacion para la preparacion de l-ramnosa.
AU699322B2 (en) 1994-04-05 1998-12-03 Exponential Biotherapies, Inc. Antibacterial therapy with genotypically modified bacteriophage
RU2112800C1 (ru) * 1996-03-29 1998-06-10 Государственный научный центр прикладной микробиологии Штамм пилеспецифического бактериофага pseudomonas aeruginosa гнцпм n 03, используемый для приготовления лечебного препарата против синегнойной палочки
CA2251724A1 (en) 1996-04-15 1997-10-23 Paul Averback Compositions containing bacteriophages and methods of using bacteriophages to treat infections
US5863560A (en) 1996-09-11 1999-01-26 Virotex Corporation Compositions and methods for topical application of therapeutic agents
US7138419B2 (en) * 2000-12-27 2006-11-21 Corus Pharma, Inc. Process for manufacturing bulk solutions and a lyophilized pure α-aztreonam lysinate
DE10115310A1 (de) * 2001-03-28 2002-10-10 Nodar A Daniela Bakteriophagen-Präparation
EP1504088B1 (en) 2002-03-25 2007-08-15 University Of Warwick Bacteriophages useful for therapy and prophylaxis of bacterial infections
GB0300597D0 (en) * 2003-01-10 2003-02-12 Microbiological Res Authority Phage biofilms
US20050095222A1 (en) 2003-10-29 2005-05-05 Taro Suzuki Allergen inhibitor, allergen-inhibiting method, allergen-inhibiting fiber and allergen-inhibiting sheet
EP1833497A4 (en) 2004-11-02 2009-11-11 Cangagen Life Sciences Inc BACTERIOPHAGE COMPOSITIONS
WO2006047870A1 (en) 2004-11-02 2006-05-11 Gangagen Life Sciences Inc. Stabilized bacteriophage formulations
CA2593992A1 (en) 2004-12-06 2006-06-15 Rodney M. Donlan Inhibition of biofilm formation using bacteriophage
US20080260697A1 (en) 2005-05-26 2008-10-23 Gangagen Life Sciences Inc. Bacterial Management in Animal Holding Systems
CN105884904B (zh) * 2006-05-05 2020-06-16 冈戈根股份有限公司 噬菌体衍生的抗微生物活性剂
IE20060488A1 (en) * 2006-06-29 2008-01-09 Teagasc Agric Food Dev Authori Recombinant staphylococcal phage lysin as an antibacterial agent
CN101003793A (zh) * 2007-01-11 2007-07-25 中国人民解放军第三军医大学 噬菌体对环境中致病菌的净化技术
WO2008121830A2 (en) 2007-03-30 2008-10-09 National Research Council Of Canada Phage receptor binding proteins for antibacterial therapy and other novel uses
EP2103308A1 (de) * 2008-03-20 2009-09-23 PhytoLine GmbH Verfahren zur Herstellung eines Gemisches von Bakteriophagen und deren Verwendung für die Therapie von Antibiotika-resistenten Staphylococcen
CA2638130A1 (en) * 2008-07-21 2010-01-21 Canadian Forest Products Ltd. Composite wood product and method of manufacture utilizing wood infected by bark beetles
EP2318531A4 (en) * 2008-07-24 2011-11-09 Us Agriculture TO RESISTANCE DEVELOPMENT REFRACTORY ANTIMICROBIAL ACTIVE SUBSTANCES
GB0815484D0 (en) * 2008-08-26 2008-10-01 Univ Leuven Kath Antibacterial agents
US8563504B2 (en) 2008-10-10 2013-10-22 Lusomedicamenta, S.A. Antibacterial phage peptides and methods of use thereof
KR101016918B1 (ko) * 2009-01-08 2011-02-25 주식회사 인트론바이오테크놀로지 박테리아 특이적 넓은 항균 활성을 갖는 신규한 리신 단백질
PT3115054T (pt) 2009-02-06 2019-12-16 Technophage Investig E Desenvolvimento Em Biotecnologia Sa Fagos antibacterianos, péptidos fágicos e métodos de utilização dos mesmos
WO2010149795A1 (en) 2009-06-26 2010-12-29 Lysando Holding Establishment Antimicrobial agents
PT3443970T (pt) * 2010-09-17 2020-10-09 Technophage Investig E Desenvolvimento Em Biotecnologia Sa Fagos antibacterianos, péptidos fágicos e métodos de utilização dos mesmos
CA2833176C (en) * 2011-04-12 2023-05-16 C.B. Appaiah Chimeric antibacterial polypeptides

Also Published As

Publication number Publication date
US9737579B2 (en) 2017-08-22
EP2616087B1 (en) 2018-10-24
EP3789031A1 (en) 2021-03-10
RU2013117275A (ru) 2014-10-27
AU2011302722B2 (en) 2016-05-26
AU2015255313C1 (en) 2017-11-02
JP6234983B2 (ja) 2017-11-22
CA2811472C (en) 2019-08-27
EP3789031C0 (en) 2023-08-02
JP6355691B2 (ja) 2018-07-11
CA3048783C (en) 2022-05-24
CN103732235B (zh) 2018-01-02
EP3789031B1 (en) 2023-08-02
EP4332217A2 (en) 2024-03-06
ES2703629T3 (es) 2019-03-11
AU2015255313A1 (en) 2015-12-03
US20140079671A1 (en) 2014-03-20
BR112013006400B1 (pt) 2023-03-21
SG188566A1 (en) 2013-04-30
JP6058540B2 (ja) 2017-01-11
AU2011302722A1 (en) 2013-04-11
US20160074446A1 (en) 2016-03-17
RU2017106290A (ru) 2019-01-21
CA2811472A1 (en) 2012-03-22
PL3789031T3 (pl) 2024-01-15
JP2013541333A (ja) 2013-11-14
CA3154006A1 (en) 2012-03-22
JP2017046695A (ja) 2017-03-09
RU2725726C2 (ru) 2020-07-03
RU2614114C2 (ru) 2017-03-22
AU2015255313B2 (en) 2017-07-20
PT2616087T (pt) 2018-12-20
US9399049B2 (en) 2016-07-26
EP3443970A3 (en) 2019-05-15
CA3048783A1 (en) 2012-03-22
EP4332217A3 (en) 2024-05-22
AU2016219667B2 (en) 2018-04-05
CN103732235A (zh) 2014-04-16
EP2616087A2 (en) 2013-07-24
WO2012036580A3 (en) 2012-11-01
EP3443970B1 (en) 2020-09-09
JP2016104011A (ja) 2016-06-09
WO2012036580A2 (en) 2012-03-22
ES2956367T3 (es) 2023-12-20
CA3154006C (en) 2025-09-09
RU2017106290A3 (cg-RX-API-DMAC7.html) 2019-12-25
US20160317590A1 (en) 2016-11-03
ES2825050T3 (es) 2021-05-14
US9222077B2 (en) 2015-12-29
BR112013006400A2 (cg-RX-API-DMAC7.html) 2021-12-07
EP3443970A2 (en) 2019-02-20
AU2016219667A1 (en) 2016-09-22

Similar Documents

Publication Publication Date Title
PT3443970T (pt) Fagos antibacterianos, péptidos fágicos e métodos de utilização dos mesmos
FR21C1038I2 (fr) 5-fluoro-1h-pyrazolopyridines substituees et leur utilisation
IL222961B (en) DNA binding proteins and their uses
BR112013013167A2 (pt) inibidores de bromodomínio e usos dos mesmos
BR112015001838A2 (pt) composições de inibidor de efluxo e métodos de tratamento utilizando o mesmo.
CR20150380A (es) Compuestos de carbamoilpiridona policíclicos y su uso farmacéutico
BR112013014075A2 (pt) grampo cirúrgico e dispositivo de manipulação do grampo dos mesmos
BR112013023681A2 (pt) compostos de álcool propargílico 6,5-heterocíclico e uso dos mesmos
BR112013021524A2 (pt) micro-organismos recombinantes e usos dos mesmos
BR112012020718A2 (pt) complexo de metal-ligante e catalisador
DE102010037468A8 (de) Chirurgischer Clip
LT2552434T (lt) Peptidai ir jų naudojimas
LT2605789T (lt) Modifikuoti relaksino polipeptidai ir jų panaudojimas
BR112012004731A2 (pt) peptídeos derivados de wnt10 e uso dos mesmos
BR112015001628A2 (pt) polipeptídeos de fator x modificados e uso dos mesmos
BR112013014235A2 (pt) anticorpos anti-ccr4 e usos dos mesmos
PT2641343T (pt) Configuração de subtrama
BR112012022879A2 (pt) composto, composição farmacêutica, uso do composto e método de tratamento
BR112012031226A2 (pt) composto, uso do composto, composição farmacêutica, e uso de composição farmacêutica
HRP20160922T1 (hr) Oligopeptidni spojevi i njihove uporabe
ME02224B (me) Antikancerski fuzioni protein
HUE053623T2 (hu) Vegyületek és azok felhasználása
BR112013013551A2 (pt) composto e uso médico do mesmo
BR112013014915A2 (pt) composição curativa e métodos de tratamento
FR2964937B1 (fr) Triporteur et direction de triporteur