PT3423076T - Formulações tópicas contendo ciclosporina e respetivas utilizações - Google Patents
Formulações tópicas contendo ciclosporina e respetivas utilizaçõesInfo
- Publication number
- PT3423076T PT3423076T PT177606431T PT17760643T PT3423076T PT 3423076 T PT3423076 T PT 3423076T PT 177606431 T PT177606431 T PT 177606431T PT 17760643 T PT17760643 T PT 17760643T PT 3423076 T PT3423076 T PT 3423076T
- Authority
- PT
- Portugal
- Prior art keywords
- containing formulations
- topical cyclosporine
- cyclosporine
- topical
- formulations
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
- 108010036949 Cyclosporine Proteins 0.000 title 1
- 229960001265 ciclosporin Drugs 0.000 title 1
- 229930182912 cyclosporin Natural products 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000000699 topical effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662301576P | 2016-02-29 | 2016-02-29 | |
| US201662302058P | 2016-03-01 | 2016-03-01 | |
| US201662302730P | 2016-03-02 | 2016-03-02 | |
| US201662311177P | 2016-03-21 | 2016-03-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3423076T true PT3423076T (pt) | 2024-07-01 |
Family
ID=59744365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT177606431T PT3423076T (pt) | 2016-02-29 | 2017-02-28 | Formulações tópicas contendo ciclosporina e respetivas utilizações |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US10918694B2 (pt) |
| EP (2) | EP4410312A2 (pt) |
| JP (2) | JP7072517B2 (pt) |
| KR (1) | KR20180117661A (pt) |
| CN (1) | CN109843316A (pt) |
| AU (2) | AU2017227585C1 (pt) |
| BR (1) | BR112018067946A8 (pt) |
| CA (1) | CA3015626A1 (pt) |
| DK (1) | DK3423076T3 (pt) |
| ES (1) | ES2981702T3 (pt) |
| FI (1) | FI3423076T3 (pt) |
| IL (1) | IL268056A (pt) |
| MX (1) | MX2018010395A (pt) |
| NZ (1) | NZ755442A (pt) |
| PL (1) | PL3423076T3 (pt) |
| PT (1) | PT3423076T (pt) |
| RU (1) | RU2747455C2 (pt) |
| SA (1) | SA519410114B1 (pt) |
| SG (1) | SG11201906729RA (pt) |
| WO (1) | WO2017151657A1 (pt) |
| ZA (1) | ZA201904704B (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3050298A1 (en) | 2012-08-24 | 2014-02-27 | Sun Pharma Global Fze | Ophthalmic formulation of polyoxyl lipid or polyoxyl fatty acid and polyalkoxylated alcohol for use in the treatment of ocular conditions |
| US20200237859A1 (en) | 2019-01-25 | 2020-07-30 | Newport Research, Inc. | Aqueous suspensions of cyclosporin |
| US11324800B2 (en) | 2015-01-15 | 2022-05-10 | Wellspring Ophthalmics, Inc. | Aqueous suspensions of cyclosporin |
| US20190231885A1 (en) | 2015-11-10 | 2019-08-01 | Sun Pharma Global Fze | Topical formulations and uses thereof |
| CN109843316A (zh) | 2016-02-29 | 2019-06-04 | 太阳制药全球公司 | 含有环孢菌素的局部制剂及其用途 |
| CN112957450A (zh) * | 2019-12-20 | 2021-06-15 | 艾棣维欣(苏州)生物制药有限公司 | 一种难溶性药物的水溶液及其制备方法 |
| JP2024521968A (ja) | 2021-06-14 | 2024-06-04 | サン ファーマシューティカル インダストリーズ リミテッド | 白内障手術を受ける患者において使用するための、シクロスポリン製剤 |
| JP2024530244A (ja) | 2021-08-20 | 2024-08-16 | サン ファーマシューティカル インダストリーズ リミテッド | 安定なシクロスポリン眼科用製剤及びその製造プロセス |
| WO2024042550A1 (en) * | 2022-08-25 | 2024-02-29 | Sentiss Pharma Private Limited | Ophthalmic combination composition |
| WO2024098043A2 (en) * | 2022-11-04 | 2024-05-10 | Qlaris Bio, Inc. | Topical ocular delivery of cromakalim |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993023010A1 (en) * | 1992-05-13 | 1993-11-25 | Sandoz Ltd. | Ophthalmic compositions containing a cyclosporin |
| NZ247516A (en) | 1993-04-28 | 1995-02-24 | Bernard Charles Sherman | Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant |
| US5484597A (en) | 1993-07-30 | 1996-01-16 | Chesebrough-Pond's Usa Co. | Clear hydroalcholic cosmetic microemulsions |
| NZ280689A (en) | 1995-12-15 | 1997-08-22 | Bernard Charles Sherma Sherman | Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol |
| MX9701946A (es) | 1997-03-14 | 1998-04-30 | Arturo Jimenez Bayardo | Solucion oftalmica transportadora. |
| US7678836B2 (en) | 1999-11-04 | 2010-03-16 | Fxs Ventures, Llc | Method for rendering a contact lens wettable |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| US20030176356A1 (en) | 2001-04-24 | 2003-09-18 | University Of North Texas Health Science Center | Endothelin antagonists and endothelin-converting enzyme inhibitors for the treatment of glaucoma |
| JP2005506990A (ja) | 2001-10-19 | 2005-03-10 | アイソテクニカ インコーポレーテッド | 新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート |
| WO2004069181A2 (en) | 2003-02-03 | 2004-08-19 | Pharmacia Corporation | Composition for the treatment of intraocular pressure |
| JP2004238346A (ja) | 2003-02-07 | 2004-08-26 | Shiono Chemical Co Ltd | トラニラストの安定な水溶液製剤 |
| AU2003228126A1 (en) | 2003-05-02 | 2004-11-23 | Arturo Jimenez Bayardo | Method of preparing an aqueous solution of cyclosporin-a and resulting aqueous solution |
| US7087237B2 (en) | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
| ES2314354T3 (es) | 2004-11-09 | 2009-03-16 | Novagali Pharma S.A. | Emulsion de tipo aceite en agua con baja concentracion de agente cationico y potencial zeta positivo. |
| US20090209599A1 (en) | 2005-06-09 | 2009-08-20 | Yoko Endo | Eye drop containing roflumilast |
| CN102772358A (zh) | 2005-06-16 | 2012-11-14 | 美瑞德生物工程公司 | 药物组合物及其用途 |
| US20070015691A1 (en) * | 2005-07-13 | 2007-01-18 | Allergan, Inc. | Cyclosporin compositions |
| PL1904056T3 (pl) | 2005-07-18 | 2009-09-30 | Minu Llc | Zastosowanie makrolidu do przywracania czucia rogówkowego |
| US10137083B2 (en) | 2006-03-07 | 2018-11-27 | SGN Nanopharma Inc | Ophthalmic preparations |
| JPWO2007126110A1 (ja) | 2006-04-24 | 2009-09-17 | ナノキャリア株式会社 | 低分子薬物内包ポリマーミセルの製造方法 |
| JPWO2007136134A1 (ja) | 2006-05-23 | 2009-10-01 | ナノキャリア株式会社 | 疎水性薬物内包ポリマーミセルの製造方法 |
| WO2008010341A1 (fr) | 2006-07-18 | 2008-01-24 | Nanocarrier Co., Ltd. | Polypeptide physiologiquement actif, micelle de polymère ayant une protéine enfermée dans celle-ci, et procédé d'obtention de la micelle de polymère |
| US20100310462A1 (en) | 2007-04-18 | 2010-12-09 | Biochromix Ab | Binding of pathological forms of proteins using conjugated polyelectrolytes |
| US8512687B2 (en) | 2007-07-09 | 2013-08-20 | Novagali Pharma Sa | Oil in water emulsion comprising NSAIDs and quaternary ammonium halides |
| WO2009028674A1 (ja) | 2007-08-29 | 2009-03-05 | Wakamoto Pharmaceutical Co., Ltd. | ラタノプロスト含有水性医薬組成物 |
| MX2007011165A (es) | 2007-09-12 | 2009-03-11 | Arturo Jimenez Bayardo | Composición farmacéutica estable de timolol, dorzolamida y brimonidina. |
| JP5668476B2 (ja) | 2007-10-08 | 2015-02-12 | オーリニア・ファーマシューティカルズ・インコーポレイテッドＡｕｒｉｎｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | カルシニューリン阻害剤またはｍＴＯＲ阻害剤を含む眼科用組成物 |
| US20090286718A1 (en) * | 2008-01-04 | 2009-11-19 | Sirion Therapeutics, Inc. | Stable Aqueous Cyclosporin Compositions |
| TWI544927B (zh) | 2008-03-17 | 2016-08-11 | 愛爾康研究有限公司 | 具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物 |
| AU2009260572B2 (en) | 2008-05-28 | 2015-07-23 | Alcon Research, Ltd. | Self-preserved emulsions |
| EP2127638A1 (en) | 2008-05-30 | 2009-12-02 | Santen Pharmaceutical Co., Ltd | Method and composition for treating ocular hypertension and glaucoma |
| US20110040113A1 (en) | 2009-06-02 | 2011-02-17 | Nian Wu | Pure PEG-lipid conjugates |
| CN102458370A (zh) | 2009-06-09 | 2012-05-16 | 卢克斯生物科技公司 | 用于眼科用途的表面药物递送系统 |
| EP2478906A4 (en) | 2009-09-17 | 2013-02-20 | Senju Pharma Co | AQUEOUS OPHTHALMIC DROPS THAT CONTAIN LATANOPROST, AND A METHOD OF INHIBITING ADSORPTION OF LATANOPROST ON A RESIN |
| US8637569B2 (en) | 2009-10-22 | 2014-01-28 | Api Genesis, Llc | Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds |
| EP2538965B1 (en) | 2010-02-25 | 2017-04-12 | Schepens Eye Research Institute | Therapeutic compositions for the treatment of dry eye disease |
| WO2011138801A1 (en) | 2010-05-07 | 2011-11-10 | Sun Pharma Advanced Research Company Ltd. | Novel ophthalmic compositions |
| US20130065888A1 (en) | 2011-08-15 | 2013-03-14 | Biserka Cetina-Cizmek | Ophthalmic formulations and processes for their preparation |
| US9278132B2 (en) | 2012-02-13 | 2016-03-08 | Bausch & Lomb Incorporated | Ophthalmic pharmaceutical compositions and methods of making and using same |
| KR101211902B1 (ko) * | 2012-04-30 | 2012-12-13 | 주식회사 휴온스 | 사이클로스포린 함유 무자극성 나노에멀젼 안약 조성물 |
| RU2014149993A (ru) | 2012-05-11 | 2016-07-10 | Сипла Лимитед | Фармацевтическая композиция |
| CA3050298A1 (en) * | 2012-08-24 | 2014-02-27 | Sun Pharma Global Fze | Ophthalmic formulation of polyoxyl lipid or polyoxyl fatty acid and polyalkoxylated alcohol for use in the treatment of ocular conditions |
| US10946076B2 (en) | 2013-02-13 | 2021-03-16 | The Research Foundation For The State University Of New York | Glaucoma treatment |
| JP2017519813A (ja) | 2014-05-23 | 2017-07-20 | オキュラー テクノロジーズ エスアーエールエル | 局所製剤およびその使用 |
| US20150352176A1 (en) * | 2014-06-06 | 2015-12-10 | Newport Research, Inc. | Oil-free and fat-free aqueous suspensions of cyclosporin |
| US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| US20180133217A1 (en) | 2015-05-04 | 2018-05-17 | Ocular Technologies Sarl | Topical formulations and uses thereof |
| US20190231885A1 (en) | 2015-11-10 | 2019-08-01 | Sun Pharma Global Fze | Topical formulations and uses thereof |
| EP3373924A4 (en) | 2015-11-12 | 2019-06-19 | Sun Pharma Global FZE | TOPICAL FORMULATIONS AND USES THEREOF |
| CN109843316A (zh) | 2016-02-29 | 2019-06-04 | 太阳制药全球公司 | 含有环孢菌素的局部制剂及其用途 |
| WO2017152129A2 (en) | 2016-03-03 | 2017-09-08 | Ocular Technologies Sarl | Treatment of glaucoma and/or retinal diseases and formulations useful therefore |
-
2017
- 2017-02-28 CN CN201780026587.5A patent/CN109843316A/zh active Pending
- 2017-02-28 WO PCT/US2017/020008 patent/WO2017151657A1/en active Application Filing
- 2017-02-28 JP JP2018545269A patent/JP7072517B2/ja active Active
- 2017-02-28 NZ NZ755442A patent/NZ755442A/en active IP Right Revival
- 2017-02-28 KR KR1020187027785A patent/KR20180117661A/ko not_active Application Discontinuation
- 2017-02-28 PT PT177606431T patent/PT3423076T/pt unknown
- 2017-02-28 DK DK17760643.1T patent/DK3423076T3/da active
- 2017-02-28 AU AU2017227585A patent/AU2017227585C1/en active Active
- 2017-02-28 ES ES17760643T patent/ES2981702T3/es active Active
- 2017-02-28 EP EP24169238.3A patent/EP4410312A2/en active Pending
- 2017-02-28 MX MX2018010395A patent/MX2018010395A/es unknown
- 2017-02-28 BR BR112018067946A patent/BR112018067946A8/pt unknown
- 2017-02-28 CA CA3015626A patent/CA3015626A1/en active Pending
- 2017-02-28 US US16/079,928 patent/US10918694B2/en active Active
- 2017-02-28 EP EP17760643.1A patent/EP3423076B1/en active Active
- 2017-02-28 FI FIEP17760643.1T patent/FI3423076T3/fi active
- 2017-02-28 SG SG11201906729RA patent/SG11201906729RA/en unknown
- 2017-02-28 PL PL17760643.1T patent/PL3423076T3/pl unknown
- 2017-02-28 RU RU2019130403A patent/RU2747455C2/ru active
-
2019
- 2019-07-14 IL IL268056A patent/IL268056A/en unknown
- 2019-07-17 ZA ZA2019/04704A patent/ZA201904704B/en unknown
- 2019-09-12 SA SA519410114A patent/SA519410114B1/ar unknown
-
2021
- 2021-01-07 US US17/143,863 patent/US20210145924A1/en not_active Abandoned
-
2022
- 2022-05-10 JP JP2022077492A patent/JP7547411B2/ja active Active
- 2022-05-11 AU AU2022203135A patent/AU2022203135A1/en active Pending
- 2022-09-26 US US17/935,177 patent/US11951153B2/en active Active
-
2024
- 2024-02-28 US US18/590,539 patent/US20240197818A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1248526A1 (zh) | 包含大麻萜酚的化妝品和局部施用組合物 | |
| ZA201805805B (en) | Formulations and methods | |
| ZA201904704B (en) | Topical cyclosporine-containing formulations and uses thereof | |
| EP3303379A4 (en) | TIGIT-BINDING ACTIVE SUBSTANCES AND USES THEREOF | |
| EP3253890A4 (en) | Tnfrsf-binding agents and uses thereof | |
| EP3324967A4 (en) | PRIDOPIDINE-BASED FORMULATIONS AND USE OF THE SAME | |
| HK1231376A1 (zh) | 局部製劑及其應用 | |
| EP3191114A4 (en) | Occidiofungin formulations and uses thereof | |
| HUE056401T2 (hu) | Topikális készítmények és kezelések | |
| IL268583A (en) | Preparations and methods for use on the skin | |
| SG11201706938XA (en) | Topical formulation | |
| GB201608762D0 (en) | Compositions and uses thereof | |
| EP3373924A4 (en) | TOPICAL FORMULATIONS AND USES THEREOF | |
| IL265531A (en) | N 3 -cyclically substituted thienouraciles and use thereof | |
| PL3373976T3 (pl) | Preparaty do stosowania miejscowego i ich zastosowanie | |
| EP3525767A4 (en) | TOPICAL FORMULATIONS AND TREATMENTS | |
| GB201614897D0 (en) | Compositions and uses thereof | |
| GB201602409D0 (en) | Compositions and uses thereof | |
| GB201520755D0 (en) | Nanoparticle formulations and their uses | |
| IL265251A (en) | Compositions of sealing material and their uses | |
| GB201716745D0 (en) | New formulations and uses thereof | |
| IL248576A0 (en) | Anti-lice preparation and its uses | |
| GB201619949D0 (en) | nOMV-antigen conjugated compounds and use thereof | |
| AU2016902150A0 (en) | Formulations and therapeutic uses thereof | |
| GB201602398D0 (en) | Compositions and uses thereof |