PT3409659T - Derivado de adamantano e sua utilização - Google Patents
Derivado de adamantano e sua utilizaçãoInfo
- Publication number
- PT3409659T PT3409659T PT177443272T PT17744327T PT3409659T PT 3409659 T PT3409659 T PT 3409659T PT 177443272 T PT177443272 T PT 177443272T PT 17744327 T PT17744327 T PT 17744327T PT 3409659 T PT3409659 T PT 3409659T
- Authority
- PT
- Portugal
- Prior art keywords
- adamantane derivative
- adamantane
- derivative
- Prior art date
Links
- ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical class C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/14—Compounds containing azido groups with azido groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016012392 | 2016-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3409659T true PT3409659T (pt) | 2021-02-22 |
Family
ID=59398520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT177443272T PT3409659T (pt) | 2016-01-26 | 2017-01-26 | Derivado de adamantano e sua utilização |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10487045B2 (pt) |
| EP (1) | EP3409659B1 (pt) |
| JP (1) | JP6808154B2 (pt) |
| KR (1) | KR20180104100A (pt) |
| CN (1) | CN108495841B (pt) |
| AU (1) | AU2017213377B2 (pt) |
| CA (1) | CA3012312C (pt) |
| DK (1) | DK3409659T3 (pt) |
| EA (1) | EA201891688A1 (pt) |
| ES (1) | ES2852275T3 (pt) |
| PL (1) | PL3409659T3 (pt) |
| PT (1) | PT3409659T (pt) |
| WO (1) | WO2017131097A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180104100A (ko) | 2016-01-26 | 2018-09-19 | 고쿠리츠다이가쿠호진 도호쿠다이가쿠 | 아다만탄 유도체 및 그 사용 |
| WO2018181986A1 (ja) * | 2017-03-31 | 2018-10-04 | 国立大学法人東北大学 | アダマンチルメチルアミン誘導体およびその医薬としての使用 |
| KR102663372B1 (ko) * | 2017-08-02 | 2024-05-03 | 뉴시그널 테라퓨틱스 가부시키가이샤 | 아다만틸메틸아민 유도체 및 그 의약으로서의 사용 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1836161B1 (en) | 2004-12-22 | 2016-07-20 | BHI Limited Partnership | Methods and compositions for treating amyloid-related diseases |
| CN101309922A (zh) * | 2005-09-23 | 2008-11-19 | 艾博特公司 | 氨基-氮杂-金刚烷衍生物和使用方法 |
| US7897766B2 (en) | 2005-09-23 | 2011-03-01 | Abbott Laboratories | Amino-aza-adamantane derivatives and methods of use |
| EP2125750B1 (en) | 2007-02-26 | 2014-05-21 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2497771A1 (en) | 2007-03-23 | 2012-09-12 | Abbott Laboratories | 4 -substituted azaadamantane derivatives and methods of use thereof |
| WO2009020140A1 (ja) * | 2007-08-06 | 2009-02-12 | Dainippon Sumitomo Pharma Co., Ltd. | アダマンチルウレア誘導体 |
| MX2010014337A (es) | 2008-07-25 | 2011-02-15 | Lundbeck & Co As H | Derivados de adamantil diamida y usos de los mismos. |
| US20110212943A1 (en) | 2008-10-15 | 2011-09-01 | Orchid Research Laboratories Limited | Novel bridged cyclic compounds as histone deacetylase inhibitors |
| JP5562716B2 (ja) | 2010-05-12 | 2014-07-30 | 花王株式会社 | 電位依存性カチオンチャネル抑制剤 |
| WO2012175520A1 (en) * | 2011-06-20 | 2012-12-27 | Novartis Ag | Hydroxy substituted isoquinolinone derivatives |
| CN104001150A (zh) * | 2013-02-27 | 2014-08-27 | 中国药科大学 | 光学纯的二肽类衍生物及其制备方法和在医药上的用途 |
| WO2015087262A1 (en) * | 2013-12-11 | 2015-06-18 | Ranbaxy Laboratories Limited | Process for the preparation of saxagliptin and its intermediates |
| KR20180104100A (ko) | 2016-01-26 | 2018-09-19 | 고쿠리츠다이가쿠호진 도호쿠다이가쿠 | 아다만탄 유도체 및 그 사용 |
| CN107556244B (zh) | 2016-07-01 | 2021-09-03 | 上海迪诺医药科技有限公司 | 并环化合物、其药物组合物及应用 |
-
2017
- 2017-01-26 KR KR1020187024304A patent/KR20180104100A/ko active Search and Examination
- 2017-01-26 DK DK17744327.2T patent/DK3409659T3/da active
- 2017-01-26 WO PCT/JP2017/002760 patent/WO2017131097A1/ja active Application Filing
- 2017-01-26 CN CN201780008087.9A patent/CN108495841B/zh active Active
- 2017-01-26 JP JP2017563819A patent/JP6808154B2/ja active Active
- 2017-01-26 ES ES17744327T patent/ES2852275T3/es active Active
- 2017-01-26 CA CA3012312A patent/CA3012312C/en active Active
- 2017-01-26 AU AU2017213377A patent/AU2017213377B2/en active Active
- 2017-01-26 US US16/072,586 patent/US10487045B2/en active Active
- 2017-01-26 PL PL17744327T patent/PL3409659T3/pl unknown
- 2017-01-26 EP EP17744327.2A patent/EP3409659B1/en active Active
- 2017-01-26 PT PT177443272T patent/PT3409659T/pt unknown
- 2017-01-26 EA EA201891688A patent/EA201891688A1/ru unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US10487045B2 (en) | 2019-11-26 |
| EP3409659A4 (en) | 2019-09-18 |
| PL3409659T3 (pl) | 2021-08-02 |
| EP3409659A1 (en) | 2018-12-05 |
| CA3012312C (en) | 2024-01-02 |
| JP6808154B2 (ja) | 2021-01-06 |
| ES2852275T3 (es) | 2021-09-13 |
| WO2017131097A1 (ja) | 2017-08-03 |
| KR20180104100A (ko) | 2018-09-19 |
| CA3012312A1 (en) | 2017-08-03 |
| EA201891688A1 (ru) | 2018-12-28 |
| US20190055191A1 (en) | 2019-02-21 |
| EP3409659B1 (en) | 2020-12-30 |
| CN108495841B (zh) | 2021-06-15 |
| AU2017213377B2 (en) | 2021-05-20 |
| CN108495841A (zh) | 2018-09-04 |
| DK3409659T3 (da) | 2021-03-22 |
| JPWO2017131097A1 (ja) | 2018-12-13 |
| AU2017213377A1 (en) | 2018-08-23 |
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