PT2912030T - Processo melhorado de fabrico de 5-(2,6-di-4-morfolinil-4- pirimidinil)-4-trifluorometilpiridin-2-amina - Google Patents
Processo melhorado de fabrico de 5-(2,6-di-4-morfolinil-4- pirimidinil)-4-trifluorometilpiridin-2-aminaInfo
- Publication number
- PT2912030T PT2912030T PT137798419T PT13779841T PT2912030T PT 2912030 T PT2912030 T PT 2912030T PT 137798419 T PT137798419 T PT 137798419T PT 13779841 T PT13779841 T PT 13779841T PT 2912030 T PT2912030 T PT 2912030T
- Authority
- PT
- Portugal
- Prior art keywords
- trifluoromethylpyridin
- morpholinyl
- pyrimidinyl
- amine
- manufacturing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261717237P | 2012-10-23 | 2012-10-23 | |
| US201361842101P | 2013-07-02 | 2013-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2912030T true PT2912030T (pt) | 2016-11-30 |
Family
ID=49448162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT137798419T PT2912030T (pt) | 2012-10-23 | 2013-10-21 | Processo melhorado de fabrico de 5-(2,6-di-4-morfolinil-4- pirimidinil)-4-trifluorometilpiridin-2-amina |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9637468B2 (OSRAM) |
| EP (1) | EP2912030B1 (OSRAM) |
| JP (1) | JP6267213B2 (OSRAM) |
| KR (1) | KR102128127B1 (OSRAM) |
| CN (1) | CN104736532B (OSRAM) |
| AU (2) | AU2013336807B2 (OSRAM) |
| BR (1) | BR112015007243B1 (OSRAM) |
| CA (1) | CA2885471C (OSRAM) |
| ES (1) | ES2605638T3 (OSRAM) |
| IN (1) | IN2015DN01331A (OSRAM) |
| MX (1) | MX360703B (OSRAM) |
| PL (1) | PL2912030T3 (OSRAM) |
| PT (1) | PT2912030T (OSRAM) |
| RU (1) | RU2646760C2 (OSRAM) |
| WO (1) | WO2014064058A1 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140069235A (ko) | 2011-09-27 | 2014-06-09 | 노파르티스 아게 | 돌연변이체 idh의 억제제로서의 3-피리미딘-4-일-옥사졸리딘-2-온 |
| UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
| US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
| CN105050602B (zh) * | 2013-01-12 | 2018-05-25 | 张大为 | 作为pi3激酶抑制剂的吡啶化合物 |
| KR20150131224A (ko) | 2013-03-14 | 2015-11-24 | 노파르티스 아게 | 돌연변이 idh의 억제제로서의 3-피리미딘-4-일-옥사졸리딘-2-온 |
| CA2944697C (en) | 2014-04-22 | 2022-07-19 | Universitaet Basel | Manufacturing process for triazine, pyrimidine and pyridine derivatives |
| WO2016050201A1 (zh) * | 2014-09-29 | 2016-04-07 | 山东轩竹医药科技有限公司 | 高选择性取代嘧啶类pi3k抑制剂 |
| CN105085476B (zh) * | 2014-11-24 | 2018-03-09 | 苏州晶云药物科技有限公司 | 5‑[2,6‑二(4‑吗啉基)‑4‑嘧啶基]‑4‑(三氟甲基)‑2‑吡啶胺二盐酸盐的晶型及其制备方法 |
| CN105001151B (zh) * | 2015-08-28 | 2017-07-14 | 苏州明锐医药科技有限公司 | 布帕尼西中间体及其制备方法 |
| CN106543140A (zh) * | 2015-09-21 | 2017-03-29 | 苏州晶云药物科技有限公司 | 5-[2,6-二(4-吗啉基)-4-嘧啶基]-4-(三氟甲基)-2-吡啶胺盐酸盐的晶型及其制备方法 |
| CN107793394A (zh) * | 2017-08-03 | 2018-03-13 | 上海厚璞生物科技有限公司 | 一种生产选择性pi3k抑制剂的系列关键中间体 |
| IL283901B2 (en) * | 2018-12-18 | 2025-03-01 | Astrazeneca Ab | Process and intermediates for the preparation of 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((R)-S-methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl}-1H-pyrrolo[2,3-b]pyridine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002062805A1 (en) * | 2001-02-08 | 2002-08-15 | Toyama Chemical Co., Ltd. | 6-substituted alkylamino-3-pyridylboric acid derivative or salt thereof and processes for producing these |
| JP4673218B2 (ja) * | 2002-11-21 | 2011-04-20 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | ホスホチジルイノシトール（ｐｉ）３−キナーゼインヒビターとしての２，４，６−三置換ピリミジン、および癌の処置におけるその使用 |
| JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| EP2621908A2 (en) * | 2010-10-01 | 2013-08-07 | Novartis AG | Manufacturing process for pyrimidine derivatives |
-
2013
- 2013-10-21 CA CA2885471A patent/CA2885471C/en active Active
- 2013-10-21 JP JP2015538398A patent/JP6267213B2/ja active Active
- 2013-10-21 EP EP13779841.9A patent/EP2912030B1/en active Active
- 2013-10-21 ES ES13779841.9T patent/ES2605638T3/es active Active
- 2013-10-21 PT PT137798419T patent/PT2912030T/pt unknown
- 2013-10-21 BR BR112015007243-7A patent/BR112015007243B1/pt active IP Right Grant
- 2013-10-21 RU RU2015119259A patent/RU2646760C2/ru active
- 2013-10-21 IN IN1331DEN2015 patent/IN2015DN01331A/en unknown
- 2013-10-21 WO PCT/EP2013/071996 patent/WO2014064058A1/en not_active Ceased
- 2013-10-21 AU AU2013336807A patent/AU2013336807B2/en active Active
- 2013-10-21 PL PL13779841T patent/PL2912030T3/pl unknown
- 2013-10-21 MX MX2015005188A patent/MX360703B/es active IP Right Grant
- 2013-10-21 KR KR1020157010087A patent/KR102128127B1/ko active Active
- 2013-10-21 CN CN201380055482.4A patent/CN104736532B/zh active Active
- 2013-10-21 US US14/437,177 patent/US9637468B2/en active Active
-
2016
- 2016-10-07 AU AU2016238941A patent/AU2016238941A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2885471A1 (en) | 2014-05-01 |
| RU2015119259A (ru) | 2016-12-20 |
| CA2885471C (en) | 2021-02-23 |
| CN104736532A (zh) | 2015-06-24 |
| MX360703B (es) | 2018-11-14 |
| US20150246897A1 (en) | 2015-09-03 |
| BR112015007243B1 (pt) | 2022-02-08 |
| CN104736532B (zh) | 2017-04-05 |
| EP2912030B1 (en) | 2016-08-31 |
| KR102128127B1 (ko) | 2020-06-30 |
| IN2015DN01331A (OSRAM) | 2015-07-03 |
| JP2016502510A (ja) | 2016-01-28 |
| AU2016238941A1 (en) | 2016-11-03 |
| ES2605638T3 (es) | 2017-03-15 |
| EP2912030A1 (en) | 2015-09-02 |
| MX2015005188A (es) | 2015-09-07 |
| WO2014064058A1 (en) | 2014-05-01 |
| BR112015007243A2 (pt) | 2017-07-04 |
| AU2013336807A1 (en) | 2015-03-05 |
| AU2013336807B2 (en) | 2016-10-27 |
| PL2912030T3 (pl) | 2017-02-28 |
| KR20150072408A (ko) | 2015-06-29 |
| US9637468B2 (en) | 2017-05-02 |
| JP6267213B2 (ja) | 2018-01-24 |
| RU2646760C2 (ru) | 2018-03-07 |
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