PT2869841T - Novos regimes de reforço principal envolvendo polipétidos imunogénicos codificados por polinucleótidos - Google Patents
Novos regimes de reforço principal envolvendo polipétidos imunogénicos codificados por polinucleótidosInfo
- Publication number
- PT2869841T PT2869841T PT137341111T PT13734111T PT2869841T PT 2869841 T PT2869841 T PT 2869841T PT 137341111 T PT137341111 T PT 137341111T PT 13734111 T PT13734111 T PT 13734111T PT 2869841 T PT2869841 T PT 2869841T
- Authority
- PT
- Portugal
- Prior art keywords
- polynucleotides
- polypeptides encoded
- immunogenic polypeptides
- regimens involving
- boosting regimens
- Prior art date
Links
- 230000002163 immunogen Effects 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 title 1
- 108091033319 polynucleotide Proteins 0.000 title 1
- 239000002157 polynucleotide Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/235—Adenoviridae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/275—Poxviridae, e.g. avipoxvirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2012/063196 WO2014005643A1 (en) | 2012-07-05 | 2012-07-05 | Novel prime-boosting regimens involving immunogenic polypeptides encoded by polynucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2869841T true PT2869841T (pt) | 2021-10-28 |
Family
ID=48746554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT137341111T PT2869841T (pt) | 2012-07-05 | 2013-07-05 | Novos regimes de reforço principal envolvendo polipétidos imunogénicos codificados por polinucleótidos |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20150209420A1 (forum.php) |
| JP (1) | JP6244358B2 (forum.php) |
| KR (1) | KR20150038010A (forum.php) |
| CN (1) | CN104780937A (forum.php) |
| AU (1) | AU2013285398A1 (forum.php) |
| BR (1) | BR112014033077A2 (forum.php) |
| CA (1) | CA2878367A1 (forum.php) |
| DK (1) | DK2869841T3 (forum.php) |
| EA (1) | EA201492230A1 (forum.php) |
| ES (1) | ES2895070T3 (forum.php) |
| HU (1) | HUE056675T2 (forum.php) |
| IL (1) | IL236414A0 (forum.php) |
| IN (1) | IN2014KN03063A (forum.php) |
| LT (1) | LT2869841T (forum.php) |
| MX (1) | MX365391B (forum.php) |
| PT (1) | PT2869841T (forum.php) |
| SG (1) | SG11201408746XA (forum.php) |
| WO (2) | WO2014005643A1 (forum.php) |
| ZA (1) | ZA201500102B (forum.php) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2988780T (pt) | 2013-04-25 | 2019-03-25 | Janssen Vaccines & Prevention Bv | Polipeptídeos f de pré-fusão do rsv solúveis estabilizados |
| US11571472B2 (en) * | 2014-06-13 | 2023-02-07 | Glaxosmithkline Biologicals Sa | Immunogenic combinations |
| US10561722B2 (en) | 2014-09-03 | 2020-02-18 | Bavarian Nordic A/S | Methods and compositions for enhancing immune responses |
| JP6462861B2 (ja) | 2014-09-03 | 2019-01-30 | バヴァリアン ノルディック エー／エス | フィロウイルス感染に対する防御免疫の誘導を目的とする方法及び組成物 |
| US9630994B2 (en) | 2014-11-03 | 2017-04-25 | University Of Washington | Polypeptides for use in self-assembling protein nanostructures |
| US11559570B2 (en) | 2015-05-15 | 2023-01-24 | CureVac SE | Prime-boost regimens involving administration of at least one mRNA construct |
| CN107847581B (zh) | 2015-07-07 | 2022-03-22 | 扬森疫苗与预防公司 | 稳定化的可溶性融合前rsv f多肽 |
| EP3319633B1 (en) | 2015-07-07 | 2020-11-11 | Janssen Vaccines & Prevention B.V. | Vaccine against rsv |
| HRP20210113T1 (hr) | 2016-04-05 | 2021-03-05 | Janssen Vaccines & Prevention B.V. | Stabilizirani topljivi prefuzijski rsv f protein za upotrebu u profilaksi rsv infekcije |
| KR102401247B1 (ko) | 2016-04-05 | 2022-05-25 | 얀센 백신스 앤드 프리벤션 비.브이. | Rsv에 대한 백신 |
| EP3452087A1 (en) * | 2016-05-02 | 2019-03-13 | Janssen Vaccines & Prevention B.V. | Therapeutic hpv vaccine combinations |
| MX2018014699A (es) | 2016-05-30 | 2019-02-28 | Janssen Vaccines & Prevention Bv | Proteinas f de prefusion del vrs estabilizadas. |
| WO2018011768A1 (en) | 2016-07-15 | 2018-01-18 | Janssen Vaccines And Prevention B.V. | Methods and compositions for inducing protective immunity against a marburg virus infection |
| FI3606942T3 (fi) | 2017-04-04 | 2025-08-29 | Univ Washington | Itsejärjestyviä proteiininanorakenteita, jotka esittävät paramyksovirus- ja/tai pneumovirus f -proteiineja ja niiden käyttö |
| WO2018185732A1 (en) | 2017-04-06 | 2018-10-11 | Janssen Vaccines & Prevention B.V. | Mva-bn and ad26.zebov or ad26.filo prime-boost regimen |
| AU2018267971A1 (en) | 2017-05-17 | 2019-11-07 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against RSV infection |
| WO2018210871A1 (en) * | 2017-05-17 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against rsv infection |
| US11229695B2 (en) | 2017-09-15 | 2022-01-25 | Janssen Vaccines & Prevention B.V. | Method for the safe induction of immunity against RSV |
| CA3076026A1 (en) * | 2017-10-25 | 2019-05-02 | Nouscom Ag | Eukaryotic cell line |
| US20210154277A1 (en) * | 2017-11-07 | 2021-05-27 | Nektar Therapeutics | Immunotherapeutic combination for treating cancer |
| US11771755B2 (en) | 2018-02-28 | 2023-10-03 | University Of Washington | Self-asssembling nanostructure vaccines |
| CN113164583A (zh) | 2018-11-13 | 2021-07-23 | 扬森疫苗与预防公司 | 稳定的融合前rsv f蛋白 |
| GB201910794D0 (en) * | 2019-07-29 | 2019-09-11 | Pirbright Inst | Vaccine |
| CN112220921B (zh) * | 2020-08-25 | 2022-08-16 | 北京交通大学 | 一种针对呼吸道合胞病毒感染的组合疫苗 |
| CN117304280B (zh) * | 2023-11-28 | 2024-04-16 | 江苏瑞科生物技术股份有限公司 | 一种重组rsv f蛋白及其应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6511845B1 (en) * | 1992-08-07 | 2003-01-28 | Alan R. Davis | Methods for producing an immune response against HIV-1 |
| US6180398B1 (en) * | 1996-07-12 | 2001-01-30 | Virogeneitics Corporation | Two-step immunization procedure against the pyramyxoviridae family of viruses using recombinant virus and subunit protein preparation |
| GB9711957D0 (en) * | 1997-06-09 | 1997-08-06 | Isis Innovation | Methods and reagents for vaccination |
| EP1636360A4 (en) * | 2003-06-03 | 2006-11-08 | Cell Genesys Inc | COMPOSITIONS AND METHODS FOR ENHANCED EXPRESSION OF RECOMBINANT POLYPEPTIDES FROM A SINGLE VECTOR USING A PEPTIDE CLEAVAGE SITE |
| ATE449105T1 (de) | 2004-01-23 | 2009-12-15 | Angeletti P Ist Richerche Bio | Impfstoffträger für schimpansen-adenovirus |
| US8501194B2 (en) * | 2006-03-10 | 2013-08-06 | The Regents Of The University Of California | Vaccine for viruses that cause persistent or latent infections |
| US20070292922A1 (en) * | 2006-03-31 | 2007-12-20 | Cell Genesys, Inc. | Regulated expression of recombinant proteins from adeno-associated viral vectors |
| EP2104681A4 (en) * | 2007-01-05 | 2011-01-19 | Inseron Inc | OPTIMIZED GREEN FLUORESCENT PROTEIN FOR EXPRESSION OF SELF-COLDING POLYPEPTIDES |
| GB0706914D0 (en) * | 2007-04-10 | 2007-05-16 | Isis Innovation | Novel adenovirus vectors |
| US20090092635A1 (en) * | 2007-08-17 | 2009-04-09 | Wyeth | Heterologous prime-boost immunization regimen |
| CL2007002710A1 (es) * | 2007-09-20 | 2008-01-04 | Univ Pontificia Catolica Chile | Formulacion inmunogenica que confiere proteccion contra la infeccion o patologia causada por el virus respiratorio sincicial (vrs) que comprende una cepa recombinante atenuada de mycobacterium; y uso de la formulacion inmunogenica para preparar una vacuna para prevenir, tratar o atenuar infecciones del vrs. |
| US7863425B2 (en) * | 2007-09-26 | 2011-01-04 | Cornell University | Compositions and methods for inhibiting Yersinia pestis infection |
| GB0823497D0 (en) * | 2008-12-24 | 2009-01-28 | Isis Innovation | Immunogenic composition and use thereof |
| CA2749325C (en) * | 2009-02-02 | 2021-03-30 | Okairos Ag | Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof |
| JP2012527232A (ja) * | 2009-05-18 | 2012-11-08 | パナセア バイオテック リミテッド | 遺伝子組換え改変ワクシニアアンカラウイルス（ｍｖａ）ベースのインフルエンザ万能ワクチン |
| US9095546B2 (en) * | 2009-07-20 | 2015-08-04 | National Health Research Institutes | Human respiratory syncytial virus (RSV) vaccine |
| WO2012021730A2 (en) | 2010-08-11 | 2012-02-16 | Genvec, Inc. | Respiratory syncytial virus (rsv) vaccine |
| WO2012085936A2 (en) * | 2010-12-20 | 2012-06-28 | Panacea Biotech Ltd | Recombinant respiratory syncytial virus plasmids and vaccines |
| US9125870B2 (en) * | 2012-03-22 | 2015-09-08 | Crucell Holland B.V. | Vaccine against RSV |
-
2012
- 2012-07-05 WO PCT/EP2012/063196 patent/WO2014005643A1/en active Application Filing
-
2013
- 2013-07-05 SG SG11201408746XA patent/SG11201408746XA/en unknown
- 2013-07-05 BR BR112014033077A patent/BR112014033077A2/pt not_active Application Discontinuation
- 2013-07-05 ES ES13734111T patent/ES2895070T3/es active Active
- 2013-07-05 KR KR20157003211A patent/KR20150038010A/ko not_active Withdrawn
- 2013-07-05 WO PCT/EP2013/064286 patent/WO2014006191A1/en active Application Filing
- 2013-07-05 CN CN201380044981.3A patent/CN104780937A/zh active Pending
- 2013-07-05 JP JP2015519233A patent/JP6244358B2/ja not_active Expired - Fee Related
- 2013-07-05 DK DK13734111.1T patent/DK2869841T3/da active
- 2013-07-05 US US14/408,340 patent/US20150209420A1/en not_active Abandoned
- 2013-07-05 PT PT137341111T patent/PT2869841T/pt unknown
- 2013-07-05 AU AU2013285398A patent/AU2013285398A1/en not_active Abandoned
- 2013-07-05 MX MX2014016119A patent/MX365391B/es active IP Right Grant
- 2013-07-05 HU HUE13734111A patent/HUE056675T2/hu unknown
- 2013-07-05 IN IN3063KON2014 patent/IN2014KN03063A/en unknown
- 2013-07-05 LT LTEPPCT/EP2013/064286T patent/LT2869841T/lt unknown
- 2013-07-05 CA CA2878367A patent/CA2878367A1/en active Pending
- 2013-07-05 EA EA201492230A patent/EA201492230A1/ru unknown
-
2014
- 2014-12-23 IL IL236414A patent/IL236414A0/en unknown
-
2015
- 2015-01-07 ZA ZA2015/00102A patent/ZA201500102B/en unknown
-
2017
- 2017-11-01 US US15/800,245 patent/US20180256704A1/en not_active Abandoned
-
2023
- 2023-02-28 US US18/115,556 patent/US20240091338A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013285398A1 (en) | 2015-02-05 |
| JP6244358B2 (ja) | 2017-12-06 |
| LT2869841T (lt) | 2021-11-25 |
| BR112014033077A2 (pt) | 2017-08-01 |
| IL236414A0 (en) | 2015-02-26 |
| US20150209420A1 (en) | 2015-07-30 |
| WO2014006191A1 (en) | 2014-01-09 |
| MX365391B (es) | 2019-05-31 |
| DK2869841T3 (da) | 2021-10-25 |
| IN2014KN03063A (forum.php) | 2015-05-08 |
| CN104780937A (zh) | 2015-07-15 |
| US20180256704A1 (en) | 2018-09-13 |
| SG11201408746XA (en) | 2015-01-29 |
| CA2878367A1 (en) | 2014-01-09 |
| ES2895070T3 (es) | 2022-02-17 |
| JP2015526403A (ja) | 2015-09-10 |
| MX2014016119A (es) | 2015-09-23 |
| KR20150038010A (ko) | 2015-04-08 |
| EA201492230A1 (ru) | 2015-06-30 |
| US20240091338A1 (en) | 2024-03-21 |
| HUE056675T2 (hu) | 2022-02-28 |
| WO2014005643A1 (en) | 2014-01-09 |
| ZA201500102B (en) | 2017-09-27 |
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