PT2338508T - Vírus da dengue quimérico recombinante rden3/4delta30(me), rden2/4delta30(me) ou rden1/4delta30(me) contendo uma deleção de 30 nucleótidos (delta30) numa secção da região não traduzida a 3¿ do genoma da dengue de tipo 4, em que a referida deleção de 30 nucleótidos corresponde à estrutura em gancho de cabelo tl2 - Google Patents

Vírus da dengue quimérico recombinante rden3/4delta30(me), rden2/4delta30(me) ou rden1/4delta30(me) contendo uma deleção de 30 nucleótidos (delta30) numa secção da região não traduzida a 3¿ do genoma da dengue de tipo 4, em que a referida deleção de 30 nucleótidos corresponde à estrutura em gancho de cabelo tl2

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Publication number
PT2338508T
PT2338508T PT101777357T PT10177735T PT2338508T PT 2338508 T PT2338508 T PT 2338508T PT 101777357 T PT101777357 T PT 101777357T PT 10177735 T PT10177735 T PT 10177735T PT 2338508 T PT2338508 T PT 2338508T
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PT
Portugal
Prior art keywords
4delta30
nucleotide deletion
genome
4delta
delta30
Prior art date
Application number
PT101777357T
Other languages
English (en)
Inventor
S Whitehead Stephen
Markoff Lewis
Falgout Barry
Hanley Kathryn
R Murphy Brian
Blaney Joseph
Lai Ching-Juh
Original Assignee
The Government Of The Us Secretary Department Of Health And Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Government Of The Us Secretary Department Of Health And Human Services filed Critical The Government Of The Us Secretary Department Of Health And Human Services
Publication of PT2338508T publication Critical patent/PT2338508T/pt

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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24161—Methods of inactivation or attenuation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Immunology (AREA)
  • Virology (AREA)
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  • Wood Science & Technology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
PT101777357T 2002-05-03 2003-04-25 Vírus da dengue quimérico recombinante rden3/4delta30(me), rden2/4delta30(me) ou rden1/4delta30(me) contendo uma deleção de 30 nucleótidos (delta30) numa secção da região não traduzida a 3¿ do genoma da dengue de tipo 4, em que a referida deleção de 30 nucleótidos corresponde à estrutura em gancho de cabelo tl2 PT2338508T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37786002P 2002-05-03 2002-05-03
US43650002P 2002-12-23 2002-12-23

Publications (1)

Publication Number Publication Date
PT2338508T true PT2338508T (pt) 2018-05-16

Family

ID=29406814

Family Applications (2)

Application Number Title Priority Date Filing Date
PT03724319T PT1554301E (pt) 2002-05-03 2003-04-25 Vacina tetravalente contra a dengue contendo uma deleção comum de 30 nucleótidos na 3¿-utr da dengue de tipos 1, 2, 3 e 4 ou vírus quiméricos antigénicos da dengue 1, 2, 3 e 4
PT101777357T PT2338508T (pt) 2002-05-03 2003-04-25 Vírus da dengue quimérico recombinante rden3/4delta30(me), rden2/4delta30(me) ou rden1/4delta30(me) contendo uma deleção de 30 nucleótidos (delta30) numa secção da região não traduzida a 3¿ do genoma da dengue de tipo 4, em que a referida deleção de 30 nucleótidos corresponde à estrutura em gancho de cabelo tl2

Family Applications Before (1)

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PT03724319T PT1554301E (pt) 2002-05-03 2003-04-25 Vacina tetravalente contra a dengue contendo uma deleção comum de 30 nucleótidos na 3¿-utr da dengue de tipos 1, 2, 3 e 4 ou vírus quiméricos antigénicos da dengue 1, 2, 3 e 4

Country Status (15)

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US (7) US7517531B2 (pt)
EP (5) EP2319532A1 (pt)
JP (1) JP4977811B2 (pt)
AT (1) ATE481982T1 (pt)
BR (1) BRPI0309631B1 (pt)
CA (1) CA2483653C (pt)
CY (1) CY1120558T1 (pt)
DE (1) DE60334310D1 (pt)
DK (2) DK2338508T3 (pt)
ES (2) ES2355719T3 (pt)
HU (1) HUE037330T2 (pt)
PT (2) PT1554301E (pt)
SI (2) SI2338508T1 (pt)
TR (1) TR201806655T4 (pt)
WO (1) WO2003092592A2 (pt)

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US20070009552A1 (en) 2007-01-11
BRPI0309631B1 (pt) 2021-07-20
CA2483653C (en) 2014-10-28
EP1554301A4 (en) 2006-11-08
EP2338508B1 (en) 2018-02-14
ES2355719T3 (es) 2011-03-30
EP1554301A2 (en) 2005-07-20
EP2319532A1 (en) 2011-05-11
US9783787B2 (en) 2017-10-10
JP4977811B2 (ja) 2012-07-18
US20130011433A1 (en) 2013-01-10
HUE037330T2 (hu) 2018-08-28
ATE481982T1 (de) 2010-10-15
US7517531B2 (en) 2009-04-14
US20200392469A1 (en) 2020-12-17
US8075903B2 (en) 2011-12-13
DK2338508T3 (en) 2018-05-28
USRE46631E1 (en) 2017-12-12
US11753627B2 (en) 2023-09-12
CA2483653A1 (en) 2003-11-13
SI1554301T1 (sl) 2011-01-31
DE60334310D1 (de) 2010-11-04
AU2003231185A1 (en) 2003-11-17
TR201806655T4 (tr) 2018-06-21
ES2677348T3 (es) 2018-08-01
US20090258036A1 (en) 2009-10-15
WO2003092592A3 (en) 2005-05-19
DK1554301T3 (da) 2011-01-24
EP2338508A1 (en) 2011-06-29
US10837003B2 (en) 2020-11-17
USRE46641E1 (en) 2017-12-19
US20180010099A1 (en) 2018-01-11
PT1554301E (pt) 2010-12-28
CY1120558T1 (el) 2019-07-10
EP3205352A1 (en) 2017-08-16
EP1554301B1 (en) 2010-09-22
JP2005532044A (ja) 2005-10-27
SI2338508T1 (en) 2018-07-31
WO2003092592A2 (en) 2003-11-13
BRPI0309631A2 (pt) 2016-11-01
EP3763382A1 (en) 2021-01-13
BRPI0309631A8 (pt) 2018-09-25

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