PT2300474E - Espiro(piperidina-4,2'-pirrolidina)-1-(3,5-trifluorometil-fenil metilcarboxamidas como antagonistas do recetor nk1 de taquicinina - Google Patents
Espiro(piperidina-4,2'-pirrolidina)-1-(3,5-trifluorometil-fenil metilcarboxamidas como antagonistas do recetor nk1 de taquicininaInfo
- Publication number
- PT2300474E PT2300474E PT97381792T PT09738179T PT2300474E PT 2300474 E PT2300474 E PT 2300474E PT 97381792 T PT97381792 T PT 97381792T PT 09738179 T PT09738179 T PT 09738179T PT 2300474 E PT2300474 E PT 2300474E
- Authority
- PT
- Portugal
- Prior art keywords
- tachikynin
- methylcarboxamides
- spiro
- pyrrolidine
- piperidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Addiction (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Nutrition Science (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0808030.1A GB0808030D0 (en) | 2008-05-01 | 2008-05-01 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2300474E true PT2300474E (pt) | 2013-01-07 |
Family
ID=39537192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97381792T PT2300474E (pt) | 2008-05-01 | 2009-04-29 | Espiro(piperidina-4,2'-pirrolidina)-1-(3,5-trifluorometil-fenil metilcarboxamidas como antagonistas do recetor nk1 de taquicinina |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US8367692B2 (pt) |
| EP (1) | EP2300474B1 (pt) |
| JP (1) | JP5524183B2 (pt) |
| KR (1) | KR101645743B1 (pt) |
| CN (1) | CN102083832B (pt) |
| AU (1) | AU2009242120B2 (pt) |
| BR (1) | BRPI0910530B8 (pt) |
| CA (1) | CA2723062C (pt) |
| CY (1) | CY1113458T1 (pt) |
| DK (1) | DK2300474T3 (pt) |
| EA (1) | EA017960B1 (pt) |
| ES (1) | ES2395571T3 (pt) |
| GB (1) | GB0808030D0 (pt) |
| HR (1) | HRP20121018T1 (pt) |
| IL (1) | IL208917A (pt) |
| MX (1) | MX2010011985A (pt) |
| PL (1) | PL2300474T3 (pt) |
| PT (1) | PT2300474E (pt) |
| RS (1) | RS52719B (pt) |
| SI (1) | SI2300474T1 (pt) |
| WO (1) | WO2009133135A1 (pt) |
| ZA (1) | ZA201007519B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2484674A1 (en) * | 2011-02-02 | 2012-08-08 | Rottapharm S.P.A. | Spiro aminic compounds with NK1 antagonist activity |
| CN109651368A (zh) * | 2018-12-17 | 2019-04-19 | 武汉药明康德新药开发有限公司 | 4-甲酸甲酯-2-氧-1,8-二氮杂螺[4.5]癸烷-8-甲酸叔丁酯的制备方法 |
| CN115697332A (zh) * | 2020-06-02 | 2023-02-03 | 尼尔医疗有限公司 | 用于治疗由肺的机械损伤促进的肺纤维化状况的神经激肽(nk)-1受体拮抗剂 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9215706D0 (en) | 1992-07-23 | 1992-09-09 | Tollpass Limited | Parking toll collecting system |
| EP0702681A1 (en) * | 1993-06-07 | 1996-03-27 | Merck & Co. Inc. | Spiro-substituted azacycles as neurokinin antagonists |
| JP2000514455A (ja) | 1996-07-17 | 2000-10-31 | メルク エンド カンパニー インコーポレーテッド | タキキニンアンタゴニストによるサーカディアンリズムの改変 |
| US6013652A (en) | 1997-12-04 | 2000-01-11 | Merck & Co., Inc. | Spiro-substituted azacycles as neurokinin antagonists |
| WO2001030348A1 (en) | 1999-10-25 | 2001-05-03 | Janssen Pharmaceutica N.V. | Use of substance p antagonists for influencing the circadian timing system |
| US7482365B2 (en) * | 2002-02-08 | 2009-01-27 | Glaxo Group Limited | Piperidylcarboxamide derivatives and their use in the treatment of tachykinin-mediated diseases |
| GB0203022D0 (en) * | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
| JP4389478B2 (ja) * | 2002-05-29 | 2009-12-24 | 田辺三菱製薬株式会社 | 新規ピペリジン誘導体 |
| JP4380508B2 (ja) * | 2003-11-28 | 2009-12-09 | 田辺三菱製薬株式会社 | 医薬組成物 |
| KR100877641B1 (ko) * | 2003-11-28 | 2009-01-09 | 미쓰비시 타나베 파마 코퍼레이션 | 피페리딘 화합물 및 그의 제조 방법 |
| JP2005154380A (ja) * | 2003-11-28 | 2005-06-16 | Tanabe Seiyaku Co Ltd | ピペリジン誘導体 |
| GB0514707D0 (en) * | 2005-07-18 | 2005-08-24 | Glaxo Group Ltd | Chemical compounds |
-
2008
- 2008-05-01 GB GBGB0808030.1A patent/GB0808030D0/en not_active Ceased
-
2009
- 2009-04-29 PT PT97381792T patent/PT2300474E/pt unknown
- 2009-04-29 EA EA201071259A patent/EA017960B1/ru not_active IP Right Cessation
- 2009-04-29 US US12/989,699 patent/US8367692B2/en active Active
- 2009-04-29 DK DK09738179.2T patent/DK2300474T3/da active
- 2009-04-29 KR KR1020107026865A patent/KR101645743B1/ko active IP Right Grant
- 2009-04-29 CA CA2723062A patent/CA2723062C/en active Active
- 2009-04-29 AU AU2009242120A patent/AU2009242120B2/en not_active Ceased
- 2009-04-29 SI SI200930430T patent/SI2300474T1/sl unknown
- 2009-04-29 CN CN2009801257867A patent/CN102083832B/zh active Active
- 2009-04-29 JP JP2011506703A patent/JP5524183B2/ja active Active
- 2009-04-29 ES ES09738179T patent/ES2395571T3/es active Active
- 2009-04-29 PL PL09738179T patent/PL2300474T3/pl unknown
- 2009-04-29 MX MX2010011985A patent/MX2010011985A/es active IP Right Grant
- 2009-04-29 WO PCT/EP2009/055190 patent/WO2009133135A1/en active Application Filing
- 2009-04-29 BR BRPI0910530A patent/BRPI0910530B8/pt active IP Right Grant
- 2009-04-29 EP EP09738179A patent/EP2300474B1/en active Active
- 2009-04-29 RS RS20120551A patent/RS52719B/en unknown
-
2010
- 2010-10-21 ZA ZA2010/07519A patent/ZA201007519B/en unknown
- 2010-10-25 IL IL208917A patent/IL208917A/en active IP Right Grant
-
2012
- 2012-11-21 US US13/682,889 patent/US8633214B2/en active Active
- 2012-12-12 HR HRP20121018AT patent/HRP20121018T1/hr unknown
- 2012-12-17 CY CY20121101226T patent/CY1113458T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2091533A4 (en) | CONTAINING SPIROCYCLIC COMPOUNDS AS ANTAGONISTS OF CGRP RECEPTORS | |
| EP2349270A4 (en) | 2,5-DISUBSTITUTED MORPHOLINE OREXIN RECEPTOR ANTAGONISTS | |
| EP2349269A4 (en) | 2,5-DISUBSTITUTED PIPERIDINOREXINE RECEPTOR ANTAGONISTS | |
| EP2350066A4 (en) | 2,5-DISUBSTITUTED PIPERIDINES AS ANTAGONISTS OF THE OREXIN RECEPTOR | |
| IL212551A0 (en) | Cxcr4 receptor compounds | |
| ZA200800320B (en) | Indol-3-carbonyl-spiro-piperidine derivatives as Via receptor antagonists | |
| ZA201001125B (en) | Pyrrolidine Aryl-Ether as NK3 receptor antagonists | |
| ZA201000676B (en) | Pyrrolidine aryl-ether as NK3 receptor antagonists | |
| SI2001876T1 (sl) | 8-azabiciklo(3.2.1)oktanske spojine kot antagonisti mu-opioidnega receptorja | |
| IL212545A0 (en) | Toll-like receptor 3 antagonists | |
| IL190686A0 (en) | Il-21 receptor antagonists | |
| EP2170064A4 (en) | 6,5-pyrrolopiperidine tachykinin receptor antagonists | |
| HK1163063A1 (en) | Novel pyrazole-3-carboxamide derivate having 5-ht2b receptor antagonist activity 5-ht2b -3- | |
| PL2238110T3 (pl) | Pochodne 5,6-bisarylo-2-pirydyno-karboksamidu, ich wytwarzanie i ich zastosowanie terapeutyczne jako antagonistów receptora Urotensyny II | |
| HK1135110A1 (en) | Nk1 receptor antagonist composition nk1 | |
| IL209266A0 (en) | Pyrrolidine derivatives as nk2 receptor antagonists | |
| ZA201100841B (en) | Novel compounds active as muscarinic receptor antagonists | |
| IL207577A0 (en) | Pyrrolidine ether derivatives as nk3 receptor antagonists | |
| EP2120564A4 (en) | BENZAZEPINE COMPOUNDS AS CGRP RECEPTOR ANTAGONISTS | |
| IL208917A0 (en) | Spiro (piperidine-4,2-pyrolidine)-1-(3,5-trifluoromethyl phenyl) methylcarboxamides as nk1 tachikynin receptor antagonists | |
| IL207700A0 (en) | 3-aminoalkyl-1,4-diazepan-2-one melanocortin -5 receptor antagonists | |
| ZA200903496B (en) | Spiro-piperidine derivatives as via receptor antagonists | |
| IL185640A0 (en) | Use of 2-anilino-3 ,4-dihydro-quinazolines as 5ht5a receptor antagonists | |
| ZA201202150B (en) | [1,4]-benzodiazepines as vasopressin v2 receptor antagonists | |
| GB0916792D0 (en) | (1,4)-Benzodiazepines as vasopressin V2 receptor antagonists |