PT2279159E - Intermediários 2'-halogenobifenil-4-ilo na síntese de antagonistas de angiotensina ii - Google Patents

Intermediários 2'-halogenobifenil-4-ilo na síntese de antagonistas de angiotensina ii Download PDF

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Publication number
PT2279159E
PT2279159E PT97231658T PT09723165T PT2279159E PT 2279159 E PT2279159 E PT 2279159E PT 97231658 T PT97231658 T PT 97231658T PT 09723165 T PT09723165 T PT 09723165T PT 2279159 E PT2279159 E PT 2279159E
Authority
PT
Portugal
Prior art keywords
halobiphenyl
angiotensin
antagonists
intermediates
synthesis
Prior art date
Application number
PT97231658T
Other languages
English (en)
Inventor
Anton Copar
Zdenko Casar
Andrej Premrl
Original Assignee
Lek Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP08153084A external-priority patent/EP2103588A1/en
Priority claimed from EP08153085A external-priority patent/EP2103609A1/en
Application filed by Lek Pharmaceuticals filed Critical Lek Pharmaceuticals
Publication of PT2279159E publication Critical patent/PT2279159E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C07C17/2632—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving an organo-magnesium compound, e.g. Grignard synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)
PT97231658T 2008-03-20 2009-03-19 Intermediários 2'-halogenobifenil-4-ilo na síntese de antagonistas de angiotensina ii PT2279159E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08153084A EP2103588A1 (en) 2008-03-20 2008-03-20 2'-Halobiphenyl-4-yl intermediates in the synthesis of angiotensin II antagonists
EP08153085A EP2103609A1 (en) 2008-03-20 2008-03-20 Catalyzed carbonylation in the synthesis of angiotensin ii antagonists

Publications (1)

Publication Number Publication Date
PT2279159E true PT2279159E (pt) 2014-03-10

Family

ID=40647168

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97231658T PT2279159E (pt) 2008-03-20 2009-03-19 Intermediários 2'-halogenobifenil-4-ilo na síntese de antagonistas de angiotensina ii

Country Status (10)

Country Link
US (2) US8410285B2 (pt)
EP (2) EP2279159B1 (pt)
JP (2) JP5462857B2 (pt)
CN (2) CN102036937B (pt)
CA (2) CA2718891C (pt)
ES (1) ES2450370T3 (pt)
PL (1) PL2279159T3 (pt)
PT (1) PT2279159E (pt)
SI (1) SI2279159T1 (pt)
WO (2) WO2009115584A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2279159T1 (sl) * 2008-03-20 2014-04-30 Lek Pharmaceuticals D.D. 2-halobifenil-4-il intermediati v sintezi angiotensin II antagonistov
JP5711888B2 (ja) * 2010-01-26 2015-05-07 株式会社Ｄｎｐファインケミカル宇都宮 テルミサルタンアルキルエステルの製造法
EA025946B1 (ru) 2010-10-27 2017-02-28 Крка, Товарна Здравил, Д. Д., Ново Место Многослойная фармацевтическая композиция, содержащая телмисартан и амлодипин
CN103333204B (zh) * 2013-07-12 2016-01-20 河南省科学院化学研究所有限公司 一类9,9’-螺二芴衍生物的合成方法
EP3196183B1 (en) * 2014-09-19 2019-05-01 Toray Fine Chemicals Co., Ltd. Method for producing 2'-trifluoromethyl group-substituted aromatic ketone
CN114436833A (zh) * 2021-12-27 2022-05-06 南京红太阳医药研究院有限公司 一种替米沙坦关键中间体4′-甲基联苯-2-羧酸酯的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8520662D0 (en) * 1985-08-17 1985-09-25 Wellcome Found Tricyclic aromatic compounds
SI9210098B (sl) 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
WO1994001436A1 (en) * 1992-07-10 1994-01-20 The Boots Company Plc Dioxcyclobutene derivatives as angiotensin ii antagonists
JP3261474B2 (ja) * 1992-09-22 2002-03-04 株式会社ジェムコ ２−クロロ−４，５−ジフルオロ安息香酸の製造法
US5606107A (en) * 1995-06-07 1997-02-25 Monsanto Company Formic acid and formaldehyde destruction in waste streams
JP4001665B2 (ja) * 1997-09-24 2007-10-31 株式会社ヤクルト本社 発酵製品の培養管理方法
JP4573409B2 (ja) * 2000-08-10 2010-11-04 Ａｇｃセイミケミカル株式会社 光学活性化合物、それを含有する液晶組成物および液晶素子
DE10314702A1 (de) * 2003-03-31 2004-10-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Telmisartan
US7501448B2 (en) * 2004-10-15 2009-03-10 Teva Pharmaceutical Industries, Ltd. Process for preparing telmisartan
EP1871764A1 (en) 2005-04-01 2008-01-02 LEK Pharmaceuticals D.D. A synthesis of 4-bromomethyl-2'-formylbiphenyl and 4-bromomethyl-2'- hydroxymethylbiphenyl and its use in preparation of angiotensin ii antagonists
ITMI20050801A1 (it) * 2005-05-03 2006-11-04 Dipharma Spa Procedimento per la preparazione di telmisartan
SI2279159T1 (sl) * 2008-03-20 2014-04-30 Lek Pharmaceuticals D.D. 2-halobifenil-4-il intermediati v sintezi angiotensin II antagonistov

Also Published As

Publication number Publication date
CA2718891A1 (en) 2009-09-24
WO2009115585A1 (en) 2009-09-24
ES2450370T3 (es) 2014-03-24
PL2279159T3 (pl) 2014-05-30
US20110105539A1 (en) 2011-05-05
US20110098329A1 (en) 2011-04-28
US8410285B2 (en) 2013-04-02
CN102015690B (zh) 2014-04-30
CN102036937A (zh) 2011-04-27
EP2279159B1 (en) 2013-12-04
JP2011515374A (ja) 2011-05-19
JP5462857B2 (ja) 2014-04-02
US8445693B2 (en) 2013-05-21
JP5764055B2 (ja) 2015-08-12
CA2719068A1 (en) 2009-09-24
EP2279159A2 (en) 2011-02-02
SI2279159T1 (sl) 2014-04-30
WO2009115584A3 (en) 2009-11-12
CN102015690A (zh) 2011-04-13
EP2279185B1 (en) 2014-01-15
CA2719068C (en) 2016-10-11
CN102036937B (zh) 2014-06-04
CA2718891C (en) 2016-10-18
JP2011515373A (ja) 2011-05-19
EP2279185A1 (en) 2011-02-02
WO2009115584A2 (en) 2009-09-24

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