PT2274005E - Tratamento de doenças tumorais pela enzima conversora de angiotensina 2 (ace2) - Google Patents

Tratamento de doenças tumorais pela enzima conversora de angiotensina 2 (ace2) Download PDF

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Publication number
PT2274005E
PT2274005E PT97307714T PT09730771T PT2274005E PT 2274005 E PT2274005 E PT 2274005E PT 97307714 T PT97307714 T PT 97307714T PT 09730771 T PT09730771 T PT 09730771T PT 2274005 E PT2274005 E PT 2274005E
Authority
PT
Portugal
Prior art keywords
ace2
tumor
cancer
activity
use according
Prior art date
Application number
PT97307714T
Other languages
English (en)
Portuguese (pt)
Inventor
Evelyne Janzek-Hawlat
Manfred Schuster
Bernhard Peball
Original Assignee
Apeiron Biologics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apeiron Biologics Ag filed Critical Apeiron Biologics Ag
Publication of PT2274005E publication Critical patent/PT2274005E/pt

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4813Exopeptidases (3.4.11. to 3.4.19)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/17Metallocarboxypeptidases (3.4.17)
    • C12Y304/17023Angiotensin-converting enzyme 2 (3.4.17.23)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT97307714T 2008-04-09 2009-04-07 Tratamento de doenças tumorais pela enzima conversora de angiotensina 2 (ace2) PT2274005E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0056608A AT506632A1 (de) 2008-04-09 2008-04-09 Behandlung von tumorerkrankungen

Publications (1)

Publication Number Publication Date
PT2274005E true PT2274005E (pt) 2013-08-27

Family

ID=41130316

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97307714T PT2274005E (pt) 2008-04-09 2009-04-07 Tratamento de doenças tumorais pela enzima conversora de angiotensina 2 (ace2)

Country Status (12)

Country Link
US (1) US8946162B2 (enExample)
EP (2) EP2274005B1 (enExample)
JP (1) JP5650639B2 (enExample)
AT (1) AT506632A1 (enExample)
AU (1) AU2009235931B2 (enExample)
CA (1) CA2720616C (enExample)
DK (1) DK2274005T3 (enExample)
ES (1) ES2425308T3 (enExample)
NZ (1) NZ588435A (enExample)
PL (1) PL2274005T3 (enExample)
PT (1) PT2274005E (enExample)
WO (1) WO2009124330A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT505262A1 (de) * 2007-06-12 2008-12-15 Apeiron Biolog Forschungs Und Rekombinantes ace2 polypeptid
PL2859343T3 (pl) * 2012-06-06 2020-05-18 Attoquant Diagnostics Gmbh Sposób pomiaru peptydowych produktów degradacji kaskady proteolitycznej w próbkach krwi
US8557958B1 (en) 2012-06-18 2013-10-15 Tarix Pharmaceuticals Ltd. Compositions and methods for treatment of diabetes
US8633158B1 (en) 2012-10-02 2014-01-21 Tarix Pharmaceuticals Ltd. Angiotensin in treating brain conditions
EP2943216B1 (en) * 2013-01-14 2019-05-01 Apeiron Biologics AG Modified ace2 polypeptides
US9839668B2 (en) * 2013-12-11 2017-12-12 Attoquant Diagnostics Gmbh Compositions and methods for the treatment of diseases related to the renin-angiotensin-system
US9333233B2 (en) 2014-02-25 2016-05-10 Tarix Pharmaceuticals Ltd. Methods and compositions for the delayed treatment of stroke
US20200188473A1 (en) * 2017-05-02 2020-06-18 Beth Israel Deaconess Medical Center, Inc. Combination therapy for cancer
US11337909B2 (en) 2017-11-29 2022-05-24 Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft Methods for modulating pigmentation by angiotensin-converting enzyme 2 modulation
WO2021190980A1 (en) 2020-03-22 2021-09-30 Quadrucept Bio Limited Multimers for viral strain evolution
WO2021202912A1 (en) * 2020-04-01 2021-10-07 Washington University Compositions for treatment of viral respiratory infections and methods of use thereof
CN112626099A (zh) * 2020-09-29 2021-04-09 清华大学 使用原核细胞发酵表达血管紧张素转化酶2的方法
WO2022184659A1 (en) 2021-03-01 2022-09-09 Quadrucept Bio Limited Antibody domains & multimers
US20250009853A1 (en) 2021-12-03 2025-01-09 Wisconsin Alumni Research Foundation Mutant ace2 proteins and methods of using same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6989363B1 (en) 1997-12-11 2006-01-24 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
US6610497B1 (en) 1997-12-11 2003-08-26 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
US6194556B1 (en) 1997-12-11 2001-02-27 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therfor
US7375073B2 (en) * 2002-02-27 2008-05-20 Wake Forest University Health Sciences Angiotensin-(1-7) and angiotensin-(1-7) agonists for inhibition of cancer cell growth
ES2318137T3 (es) 2002-06-19 2009-05-01 University Health Network Activacion de ace2 para el tratamiento de enfermedades cardiacas, pulmonares y renales e hipertension.
EP1374907A3 (en) 2002-06-24 2004-01-07 Ghanem Elias c/o Institut Jules Bordet Ghanem Drug transport and delivery system
EP1723962A1 (en) * 2005-05-19 2006-11-22 IMBA-Institut für Molekulare Biotechnologie GmbH Use of inhibitors of the renin-angiotensin system for the treatment of lung injuries
AT505262A1 (de) * 2007-06-12 2008-12-15 Apeiron Biolog Forschungs Und Rekombinantes ace2 polypeptid

Also Published As

Publication number Publication date
AT506632A1 (de) 2009-10-15
WO2009124330A2 (de) 2009-10-15
EP2644203A1 (de) 2013-10-02
CA2720616C (en) 2016-08-09
EP2274005A2 (de) 2011-01-19
US20110033524A1 (en) 2011-02-10
WO2009124330A3 (de) 2009-12-10
JP2011516501A (ja) 2011-05-26
US8946162B2 (en) 2015-02-03
EP2274005B1 (de) 2013-05-29
AU2009235931B2 (en) 2015-07-23
PL2274005T3 (pl) 2013-12-31
JP5650639B2 (ja) 2015-01-07
DK2274005T3 (da) 2013-08-19
AU2009235931A1 (en) 2009-10-15
CA2720616A1 (en) 2009-10-15
ES2425308T3 (es) 2013-10-14
NZ588435A (en) 2012-10-26

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