PT2268823E - Produção de esqualeno a partir de leveduras hiperprodutoras - Google Patents
Produção de esqualeno a partir de leveduras hiperprodutoras Download PDFInfo
- Publication number
- PT2268823E PT2268823E PT09786243T PT09786243T PT2268823E PT 2268823 E PT2268823 E PT 2268823E PT 09786243 T PT09786243 T PT 09786243T PT 09786243 T PT09786243 T PT 09786243T PT 2268823 E PT2268823 E PT 2268823E
- Authority
- PT
- Portugal
- Prior art keywords
- squalene
- hyper
- production
- producing yeasts
- yeast
- Prior art date
Links
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 title abstract 4
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 title abstract 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 title abstract 4
- 229940031439 squalene Drugs 0.000 title abstract 4
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 title abstract 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 title abstract 3
- 239000000839 emulsion Substances 0.000 abstract 1
- 239000000568 immunological adjuvant Substances 0.000 abstract 1
- 239000007764 o/w emulsion Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19048608P | 2008-08-28 | 2008-08-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2268823E true PT2268823E (pt) | 2011-09-01 |
Family
ID=41625158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT09786243T PT2268823E (pt) | 2008-08-28 | 2009-08-28 | Produção de esqualeno a partir de leveduras hiperprodutoras |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US11236366B2 (enExample) |
| EP (2) | EP2369003B1 (enExample) |
| JP (3) | JP4938911B2 (enExample) |
| KR (1) | KR101443064B1 (enExample) |
| CN (1) | CN102257149B (enExample) |
| AT (1) | ATE513920T1 (enExample) |
| AU (1) | AU2009286426B2 (enExample) |
| BR (1) | BRPI0917716A2 (enExample) |
| CA (1) | CA2735404C (enExample) |
| CY (1) | CY1114687T1 (enExample) |
| DK (1) | DK2268823T3 (enExample) |
| EA (1) | EA028898B1 (enExample) |
| ES (2) | ES2761697T3 (enExample) |
| HR (1) | HRP20110671T1 (enExample) |
| IL (1) | IL211435A (enExample) |
| MX (1) | MX2011002279A (enExample) |
| NZ (1) | NZ591876A (enExample) |
| PL (1) | PL2268823T3 (enExample) |
| PT (1) | PT2268823E (enExample) |
| RS (1) | RS51999B (enExample) |
| SI (1) | SI2268823T1 (enExample) |
| SM (1) | SMT201100058B (enExample) |
| WO (1) | WO2010023551A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10100334B2 (en) | 2008-05-23 | 2018-10-16 | Nucelis Inc. | Production of squalene using yeast |
| EP2292741A1 (en) * | 2009-08-26 | 2011-03-09 | OrganoBalance GmbH | Genetically modified organisms for the production of lipids |
| JP5978132B2 (ja) | 2009-11-23 | 2016-08-24 | ニューセリス インコーポレイテッド | 酵母を用いるスクアレン生成のための方法および組成物 |
| JP5946188B2 (ja) | 2010-05-12 | 2016-07-05 | ノバルティス アーゲー | スクアレンを調製するための改良された方法 |
| CN102100260B (zh) * | 2010-12-03 | 2013-07-31 | 滨州学院 | 酵母油脂及其制备方法和应用 |
| CN102787140A (zh) | 2011-05-20 | 2012-11-21 | 罗盖特兄弟公司 | 从微藻制备与提取角鲨烯的工艺方法 |
| CN102787074B (zh) | 2011-05-20 | 2016-06-08 | 罗盖特兄弟公司 | 生产角鲨烯的微藻新菌株 |
| FR2975705B1 (fr) | 2011-05-27 | 2014-12-26 | Roquette Freres | Procede d'extraction du squalene a partir de microalgues |
| US9375471B2 (en) | 2012-03-08 | 2016-06-28 | Glaxosmithkline Biologicals Sa | Adjuvanted formulations of booster vaccines |
| IN2014DN08554A (enExample) * | 2012-04-16 | 2015-05-15 | Roquette Freres | |
| FR2989373B1 (fr) * | 2012-04-16 | 2016-05-06 | Roquette Freres | Procede de raffinage du squalene produit par microalgues |
| RU2015106930A (ru) | 2012-09-06 | 2016-10-20 | Новартис Аг | Комбинированные вакцины с менингококком серогруппы в и к/д/с |
| EP2906239A1 (en) | 2012-10-12 | 2015-08-19 | GlaxoSmithKline Biologicals SA | Non-cross-linked acellular pertussis antigens for use in combination vaccines |
| US20150320852A1 (en) | 2012-12-18 | 2015-11-12 | Glaxosmithkline Biologicals Sa | Conjugates for protecting against diphtheria and/or tetanus |
| EP2971049B1 (en) | 2013-03-13 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Production of squalene and/or sterol from cell suspensions of fermented yeast |
| GB2518927A (en) * | 2013-05-21 | 2015-04-08 | Univ Swansea | The production of biomolecules using yeast |
| CN103849643A (zh) * | 2014-03-11 | 2014-06-11 | 北京理工大学 | 一种利用蛋白支架提高酿酒酵母中鲨烯的合成方法 |
| CA2948122C (en) | 2014-04-09 | 2024-05-14 | Adeka Corporation | Mutant enzyme and production method for terpenoid using said mutant enzyme |
| EP3225691B1 (en) * | 2014-11-28 | 2020-10-28 | Ajinomoto Co., Inc. | Method for producing isoprenoid compound |
| ES2861806T3 (es) | 2014-12-02 | 2021-10-06 | Novartis Ag | Fabricación de composiciones que contienen tensioactivo |
| CN104560731B (zh) * | 2014-12-26 | 2018-10-09 | 中国科学院青岛生物能源与过程研究所 | 一种高产角鲨烯的类酵母菌及其应用 |
| CN110373338B (zh) * | 2019-08-15 | 2021-09-28 | 宜昌东阳光生化制药有限公司 | 酿酒酵母及其用途 |
| CN111893049A (zh) * | 2020-06-30 | 2020-11-06 | 厦门大学 | 一种过表达角鲨烯合成酶基因的裂殖壶菌基因工程菌株及其构建方法和应用 |
| WO2025053947A1 (en) * | 2023-09-07 | 2025-03-13 | Avantor Performance Materials, Llc | Synthetic triterpenes composition, method of production and applications thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US5460949A (en) | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| JP2785084B2 (ja) | 1991-11-18 | 1998-08-13 | 三菱石油株式会社 | スクアレンを生産する酵母の作製法及び作製された新規酵母 |
| JPH06116171A (ja) | 1992-10-06 | 1994-04-26 | Nippon Fine Chem Co Ltd | 天然スクワレンの精製方法 |
| DE4316620A1 (de) | 1993-05-18 | 1994-11-24 | Mueller Extract Co Gmbh | Verfahren und Vorrichtung zur Herstellung von Squalen aus Olivenölrückständen |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| JPH10120548A (ja) | 1996-10-23 | 1998-05-12 | Shiseido Co Ltd | 肌荒れ防止剤 |
| DE19744212B4 (de) * | 1997-09-30 | 2006-01-19 | Schering Ag | Verfahren zur Herstellung von Ergosterol und dessen Zwischenprodukten mittels rekombinanter Hefen |
| US20040235088A1 (en) | 1997-09-30 | 2004-11-25 | Schering Aktiengesellschaft | Process for the production of ergosterol and its intermediate products using recombinant yeasts |
| DE10012370A1 (de) * | 2000-03-14 | 2001-09-27 | Chiron Behring Gmbh & Co | Adjuvans für Vakzinen |
| US20020168389A1 (en) * | 2000-12-28 | 2002-11-14 | Prem Chandar | Stable skin conditioning compositions containing retinoid boosters |
| AU2004297299A1 (en) * | 2003-12-12 | 2005-06-23 | Sanofi Pasteur Limited | Production of diphtheria toxin |
| US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
| US20060286046A1 (en) | 2005-01-05 | 2006-12-21 | Haber C Andrew | Skin care compositions |
| CN1930186A (zh) * | 2005-03-03 | 2007-03-14 | 阿勒根公司 | 为获得梭菌毒素的梭菌细菌培养基及方法 |
| US8703095B2 (en) | 2005-07-07 | 2014-04-22 | Sanofi Pasteur S.A. | Immuno-adjuvant emulsion |
| US7375188B2 (en) * | 2005-07-29 | 2008-05-20 | Mallinckrodt Baker, Inc. | Vegetarian protein a preparation and methods thereof |
| DK1909830T3 (da) | 2005-08-02 | 2011-12-19 | Novartis Vaccines & Diagnostic | Formindskelse af interferens mellem olieholdige adjuvanser og antigener indeholdende overfladeaktivt middel |
| JP4210674B2 (ja) | 2005-08-31 | 2009-01-21 | 全国農業協同組合連合会 | マイコプラズマ・ガリセプティカム培養用培地 |
| FR2896162B1 (fr) | 2006-01-13 | 2008-02-15 | Sanofi Pasteur Sa | Emulsion huile dans eau thermoreversible |
| JP5053557B2 (ja) * | 2006-03-24 | 2012-10-17 | 株式会社 資生堂 | 白濁状水中油型乳化化粧料の製造方法 |
| US8273361B2 (en) * | 2006-09-26 | 2012-09-25 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| EP2074214A2 (en) | 2006-09-28 | 2009-07-01 | Microbia, Inc. | Production of sterols in oleaginous yeast and fungi |
| CN101522218B (zh) | 2006-10-12 | 2012-09-26 | 葛兰素史密丝克莱恩生物有限公司 | 包含水包油乳液佐剂的疫苗 |
| GB0622282D0 (en) * | 2006-11-08 | 2006-12-20 | Novartis Ag | Quality control methods |
| US8092813B1 (en) * | 2007-12-28 | 2012-01-10 | Novartis Ag | Polychlorinated biphenyls and squalene-containing adjuvants |
| US10100334B2 (en) * | 2008-05-23 | 2018-10-16 | Nucelis Inc. | Production of squalene using yeast |
| EP2292741A1 (en) | 2009-08-26 | 2011-03-09 | OrganoBalance GmbH | Genetically modified organisms for the production of lipids |
-
2009
- 2009-08-28 AU AU2009286426A patent/AU2009286426B2/en active Active
- 2009-08-28 CN CN2009801391118A patent/CN102257149B/zh active Active
- 2009-08-28 MX MX2011002279A patent/MX2011002279A/es active IP Right Grant
- 2009-08-28 ES ES11170769T patent/ES2761697T3/es active Active
- 2009-08-28 EP EP11170769.1A patent/EP2369003B1/en active Active
- 2009-08-28 RS RS20110410A patent/RS51999B/sr unknown
- 2009-08-28 JP JP2011524473A patent/JP4938911B2/ja active Active
- 2009-08-28 SI SI200930070T patent/SI2268823T1/sl unknown
- 2009-08-28 ES ES09786243T patent/ES2366941T3/es active Active
- 2009-08-28 BR BRPI0917716A patent/BRPI0917716A2/pt not_active Application Discontinuation
- 2009-08-28 US US13/061,505 patent/US11236366B2/en active Active
- 2009-08-28 WO PCT/IB2009/006825 patent/WO2010023551A2/en not_active Ceased
- 2009-08-28 DK DK09786243.7T patent/DK2268823T3/da active
- 2009-08-28 EA EA201170381A patent/EA028898B1/ru not_active IP Right Cessation
- 2009-08-28 CA CA2735404A patent/CA2735404C/en active Active
- 2009-08-28 PL PL09786243T patent/PL2268823T3/pl unknown
- 2009-08-28 IL IL211435A patent/IL211435A/en active IP Right Grant
- 2009-08-28 NZ NZ591876A patent/NZ591876A/xx not_active IP Right Cessation
- 2009-08-28 AT AT09786243T patent/ATE513920T1/de active
- 2009-08-28 PT PT09786243T patent/PT2268823E/pt unknown
- 2009-08-28 HR HR20110671T patent/HRP20110671T1/hr unknown
- 2009-08-28 KR KR1020117007019A patent/KR101443064B1/ko active Active
- 2009-08-28 EP EP09786243A patent/EP2268823B1/en active Active
-
2011
- 2011-09-15 CY CY20111100893T patent/CY1114687T1/el unknown
- 2011-11-17 SM SM201100058T patent/SMT201100058B/it unknown
-
2012
- 2012-02-23 JP JP2012036971A patent/JP5930766B2/ja not_active Expired - Fee Related
-
2015
- 2015-01-05 JP JP2015000249A patent/JP2015061546A/ja active Pending
-
2021
- 2021-12-20 US US17/555,867 patent/US20220177928A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL211435A0 (en) | Production of squalene from hyper-producing yeasts | |
| WO2015043613A8 (en) | Particles comprising a shell with rna | |
| MY155236A (en) | Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant | |
| MX2012005598A (es) | Filtracion hidrofilica durante la fabricacion de adyuvantes de vacuna. | |
| WO2013002479A3 (ko) | 나노에멀젼 조성물 및 그 제조방법 | |
| WO2010009879A3 (en) | Methods for producing paricalcitol | |
| WO2012053794A3 (en) | Microorganism producing o-phosphoserine and method of producing l-cysteine or derivatives thereof from o-phosphoserine using the same | |
| CL2016001883A1 (es) | Método para obtener cepas de levadura con producción de etanol baja, cepas de levadura obtenidas a partir de estas y su uso | |
| BR112016029891A2 (pt) | método para recuperação de lipídeos a partir de biomassa microbiana | |
| WO2012142302A3 (en) | Biocatalytic process for preparing eslicarbazepine and analogs thereof | |
| MY145056A (en) | Method for aging alcoholic liquids | |
| WO2011080271A3 (en) | Exosomes derived from reticulocytes infected with plasmodium sp., method for obtaining them and uses thereof | |
| MY158910A (en) | Surface modified silicic acid semi-gels | |
| WO2011031849A3 (en) | Anionic lipids and lipid nanostructures and methods of producing and using same | |
| UA108343C2 (uk) | Спосіб одержання сквалену за допомогою дріжджів | |
| MX2009011238A (es) | Metodo para la elaboracion de un gas a partir de un fluido acuoso, producto del metodo y aparato para ello. | |
| WO2006063053A3 (en) | Methods of producing influenza vaccine compositions | |
| AR072475A1 (es) | Metodo para producir oxido de titanio microcristalino | |
| PH12016501289A1 (en) | Process for making ethanol by fermentation | |
| PH12013501276A1 (en) | Method for producing concentrated glycerol | |
| WO2011150004A3 (en) | Oral care compositions and methods of making oral care compositions comprising silica from plant materials | |
| WO2010129457A3 (en) | Vaccines against tularemia | |
| IN2014DE03067A (enExample) | ||
| PH12014000201A1 (en) | Method of manufacturing fermentation product from starchy biomass | |
| MY169263A (en) | Recombinant yeast and method for producing ethanol using the same |