PT2078073E - Células derivadas do rim e métodos de utilização na reparação e regeneração de tecidos - Google Patents

Células derivadas do rim e métodos de utilização na reparação e regeneração de tecidos Download PDF

Info

Publication number
PT2078073E
PT2078073E PT78526514T PT07852651T PT2078073E PT 2078073 E PT2078073 E PT 2078073E PT 78526514 T PT78526514 T PT 78526514T PT 07852651 T PT07852651 T PT 07852651T PT 2078073 E PT2078073 E PT 2078073E
Authority
PT
Portugal
Prior art keywords
cells
kidney
cell
population
renal
Prior art date
Application number
PT78526514T
Other languages
English (en)
Portuguese (pt)
Inventor
Anna Gosiewska
David C Colter
Agnieszka Seyda
Charito S Buensuceso
Original Assignee
Ethicon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethicon Inc filed Critical Ethicon Inc
Publication of PT2078073E publication Critical patent/PT2078073E/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0684Cells of the urinary tract or kidneys
    • C12N5/0686Kidney cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0684Cells of the urinary tract or kidneys
    • C12N5/0687Renal stem cells; Renal progenitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/30Synthetic polymers
    • C12N2533/40Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
PT78526514T 2006-10-12 2007-10-11 Células derivadas do rim e métodos de utilização na reparação e regeneração de tecidos PT2078073E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82923806P 2006-10-12 2006-10-12

Publications (1)

Publication Number Publication Date
PT2078073E true PT2078073E (pt) 2013-11-11

Family

ID=39116540

Family Applications (1)

Application Number Title Priority Date Filing Date
PT78526514T PT2078073E (pt) 2006-10-12 2007-10-11 Células derivadas do rim e métodos de utilização na reparação e regeneração de tecidos

Country Status (12)

Country Link
US (2) US10500230B2 (https=)
EP (1) EP2078073B1 (https=)
JP (1) JP5450072B2 (https=)
CN (1) CN101595212B (https=)
AU (1) AU2007308168B2 (https=)
CA (1) CA2673521C (https=)
DK (1) DK2078073T3 (https=)
ES (1) ES2432395T3 (https=)
PL (1) PL2078073T3 (https=)
PT (1) PT2078073E (https=)
SI (1) SI2078073T1 (https=)
WO (1) WO2008045498A1 (https=)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7862810B2 (en) * 2000-07-31 2011-01-04 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
US20110091428A1 (en) * 2000-07-31 2011-04-21 New York Medical College Compositions of adult organ stem cells and uses thereof
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US8518390B2 (en) 2003-06-27 2013-08-27 Advanced Technologies And Regenerative Medicine, Llc Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US8491883B2 (en) * 2003-06-27 2013-07-23 Advanced Technologies And Regenerative Medicine, Llc Treatment of amyotrophic lateral sclerosis using umbilical derived cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
EP2399990B1 (en) 2003-06-27 2015-07-22 DePuy Synthes Products, Inc. Cells derived from post-partum umbilical cord for use in treatment of disease of the heart and circulatory system
US20060166361A1 (en) * 2004-12-21 2006-07-27 Agnieszka Seyda Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same
US20060153815A1 (en) * 2004-12-21 2006-07-13 Agnieszka Seyda Tissue engineering devices for the repair and regeneration of tissue
US20060171930A1 (en) * 2004-12-21 2006-08-03 Agnieszka Seyda Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same
EP1835924B1 (en) 2004-12-23 2013-08-21 Ethicon, Incorporated Treatment of parkinson's disease and related disorders using postpartum derived cells
CA2589041C (en) 2004-12-23 2019-08-20 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
WO2007070870A1 (en) * 2005-12-16 2007-06-21 Ethicon, Inc. Compositions and methods for inhibiting adverse immune response in histocompatibility-mismatched transplantation
US8741638B2 (en) * 2005-12-19 2014-06-03 DePuy Synthes Products, LLC In vitro expansion of postpartum-derived cells in roller bottles
EP1979050B1 (en) * 2005-12-28 2017-04-19 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using postpartum-derived cells
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
EP1989144A4 (en) 2006-02-02 2014-01-29 Innovative Bio Therapies EXTRACORPOREAL THERAPEUTIC DEVICE AND DELIVERY SYSTEM BASED ON CELLS
CN101595212B (zh) 2006-10-12 2014-04-30 伊西康公司 肾源细胞及在组织修复和再生中的使用方法
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
CN101827933B (zh) 2007-06-08 2014-01-29 韦克福里斯特大学健康科学院 治疗肾功能衰竭的选择性细胞疗法
US9580688B2 (en) 2007-06-08 2017-02-28 Wake Forest University Health Sciences Kidney structures and methods of forming the same
US10590391B2 (en) 2007-06-08 2020-03-17 Wake Forest University Health Sciences Selective cell therapy for the treatment of renal failure
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
CN101801405A (zh) 2007-08-07 2010-08-11 先进科技及再生医学有限责任公司 包含于酸性水溶液中的gdf-5的蛋白质配方
ES2525718T3 (es) * 2007-10-05 2014-12-29 DePuy Synthes Products, LLC Reparación y regeneración de tejido renal mediante células derivadas de tejido de cordón umbilical humano
US8236538B2 (en) * 2007-12-20 2012-08-07 Advanced Technologies And Regenerative Medicine, Llc Methods for sterilizing materials containing biologically active agents
BRPI0911048A2 (pt) 2008-04-14 2015-12-29 Atrm Llc formulações líquidas tamponadas de gdf-5
CN102171332A (zh) * 2008-06-18 2011-08-31 创新生物制剂疗法公司 促进肾前体细胞增殖的方法
AU2009308094A1 (en) * 2008-10-24 2010-04-29 Childrens Hospital Los Angeles Amniotic fluid cells and uses thereof
EP2186883A1 (en) * 2008-11-04 2010-05-19 Fresenius Medical Care An isolated multipotent mesenchymal stem cell from human adult glomeruli (hGL-MSC), a method of preparing thereof and uses thereof in the regenerative medicine of the kidney
KR102428795B1 (ko) 2008-11-12 2022-08-04 인리젠 분리된 신장 세포 및 이의 용도
US20100151575A1 (en) * 2008-12-15 2010-06-17 Colter David C Method of Making Conditioned Media from Kidney Derived Cells
JP5518893B2 (ja) 2008-12-19 2014-06-11 アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー 肺ならびに肺の疾患および障害の治療
EP2379087B1 (en) * 2008-12-19 2014-08-20 DePuy Synthes Products, LLC Umbilical cord tissue derived cells for treating neuropathic pain and spasticity
CN102458425A (zh) * 2008-12-19 2012-05-16 伊西康公司 损伤后神经组织的再生和修复
US10179900B2 (en) * 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
EP2411504B1 (en) 2009-03-26 2017-05-10 DePuy Synthes Products, Inc. Human umbilical cord tissue cells as therapy for alzheimer's disease
US20110142805A1 (en) 2009-12-15 2011-06-16 Advanced Technologies And Regenerative Medicine, Llc Method of renal repair and regeneration and the treatment of diabetic nephropathy
TWI762890B (zh) * 2010-05-12 2022-05-01 開曼群島商英瑞金公司 生物活性腎細胞
CA3065694A1 (en) 2010-11-10 2012-05-18 Inregen Methods of forming injectable formulations for providing regenerative effects to an organ such as a kidney
US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
US20120156780A1 (en) 2010-12-21 2012-06-21 Cooper Kevin L Polymer Substrates Having Improved Biological Response From HKDCS
US20120156433A1 (en) 2010-12-21 2012-06-21 Natarajan Sriram N Silicone polymer substrates having improved biological response from hkdcs
EP2714894B1 (en) 2011-05-27 2019-10-30 DePuy Synthes Products, Inc. Bioartificial proximal tubule systems and methods of use
US20130157368A1 (en) 2011-12-20 2013-06-20 Advanced Technologies And Regenerative Medicine, Llc Induced pluripotent stem cells prepared from human kidney-derived cells
RU2702721C2 (ru) * 2012-10-24 2019-10-09 инРиджен Популяции клеток почек и их применение
CN107208055B (zh) * 2015-01-17 2021-06-15 浙江大学 引起免疫原性反应降低的被修饰细胞
DE102016109067B4 (de) * 2016-05-17 2018-07-19 Leibniz-Institut Für Polymerforschung Dresden E.V. Verfahren zur Bildung von Nierentubuli
US11123372B2 (en) 2016-07-29 2021-09-21 Prokidney Bioactive renal cells for the treatment of chronic kidney disease
CN106166161A (zh) * 2016-08-03 2016-11-30 中国人民解放军总医院 用于治疗系膜增生性肾小球肾炎的药物
CN106267192A (zh) * 2016-09-14 2017-01-04 中国人民解放军总医院 一种用于治疗系膜增生性肾炎的药物
AU2017377309B9 (en) * 2016-12-14 2021-06-03 Otsuka Pharmaceutical Factory, Inc. Mammalian cell cryopreservation liquid
AU2018244776B2 (en) 2017-03-30 2023-12-14 Wake Forest University Health Sciences Methods of treatment for kidney disease
JPWO2019045049A1 (ja) * 2017-09-01 2020-12-03 学校法人帝京大学 腎尿細管細胞特異的発現ベクター
CN111836884B (zh) * 2018-03-28 2023-07-25 国立大学法人大阪大学 源自干细胞的泪腺组织的制作方法
US11331333B2 (en) 2019-11-08 2022-05-17 Georg-August-Universität Göttingen Stiftung Öffentichen Rechts, Universitätsmadizin Treatment of aberrant fibroblast proliferation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2646438B1 (fr) 1989-03-20 2007-11-02 Pasteur Institut Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration
US5574205A (en) 1989-07-25 1996-11-12 Cell Genesys Homologous recombination for universal donor cells and chimeric mammalian hosts
ATE352612T1 (de) 1990-08-29 2007-02-15 Pharming Intellectual Pty Bv Homologe rekombination in säugetier-zellen
US5342761A (en) * 1990-10-01 1994-08-30 Research Development Foundation Oncofetal gene, gene product and uses therefor
US5286632A (en) * 1991-01-09 1994-02-15 Jones Douglas H Method for in vivo recombination and mutagenesis
WO1993004169A1 (en) 1991-08-20 1993-03-04 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
US5355699A (en) * 1992-04-16 1994-10-18 Tsudakoma Kogyo Kabushiki Kaisha Flat knitting machine and a method of operating the rocking sinkers of the flat knitting machine
US5320962A (en) * 1992-07-22 1994-06-14 Duke University DNA encoding the human A1 adenosine receptor
JPH11313675A (ja) * 1998-04-30 1999-11-16 Hoechst Marion Roussel Kk ヒトbmp−7プロモーターおよびこれを用いた骨関連物質の探索法
US6355699B1 (en) 1999-06-30 2002-03-12 Ethicon, Inc. Process for manufacturing biomedical foams
US6759039B2 (en) * 2000-06-30 2004-07-06 Amcyte, Inc. Culturing pancreatic stem cells having a specified, intermediate stage of development
WO2002061053A1 (en) 2001-01-31 2002-08-08 The General Hospital Corporation Renal stem cells and uses thereof
US6458588B1 (en) * 2001-01-31 2002-10-01 The General Hospital Corporation Renal stem cells and uses thereof
EP2399990B1 (en) 2003-06-27 2015-07-22 DePuy Synthes Products, Inc. Cells derived from post-partum umbilical cord for use in treatment of disease of the heart and circulatory system
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
AU2004269409A1 (en) * 2003-08-29 2005-03-10 Regents Of The University Of Minnesota Kidney derived stem cells and methods for their isolation, differentiation and use
US8039258B2 (en) 2004-09-28 2011-10-18 Ethicon, Inc. Tissue-engineering scaffolds containing self-assembled-peptide hydrogels
US20060171930A1 (en) 2004-12-21 2006-08-03 Agnieszka Seyda Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same
US20060153815A1 (en) 2004-12-21 2006-07-13 Agnieszka Seyda Tissue engineering devices for the repair and regeneration of tissue
US20060166361A1 (en) 2004-12-21 2006-07-27 Agnieszka Seyda Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same
CA2589041C (en) 2004-12-23 2019-08-20 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
EP1835924B1 (en) 2004-12-23 2013-08-21 Ethicon, Incorporated Treatment of parkinson's disease and related disorders using postpartum derived cells
WO2007070870A1 (en) 2005-12-16 2007-06-21 Ethicon, Inc. Compositions and methods for inhibiting adverse immune response in histocompatibility-mismatched transplantation
US8741638B2 (en) 2005-12-19 2014-06-03 DePuy Synthes Products, LLC In vitro expansion of postpartum-derived cells in roller bottles
EP1979050B1 (en) 2005-12-28 2017-04-19 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using postpartum-derived cells
CN101595212B (zh) 2006-10-12 2014-04-30 伊西康公司 肾源细胞及在组织修复和再生中的使用方法
CN101611139B (zh) 2006-11-13 2012-07-04 伊西康公司 利用微载体的产后来源的细胞的体外扩增

Also Published As

Publication number Publication date
ES2432395T3 (es) 2013-12-03
CN101595212B (zh) 2014-04-30
CA2673521A1 (en) 2008-04-17
PL2078073T3 (pl) 2013-12-31
CA2673521C (en) 2017-01-17
DK2078073T3 (da) 2013-10-28
AU2007308168A1 (en) 2008-04-17
JP2010506563A (ja) 2010-03-04
WO2008045498A1 (en) 2008-04-17
CN101595212A (zh) 2009-12-02
SI2078073T1 (sl) 2013-11-29
US10500230B2 (en) 2019-12-10
AU2007308168B2 (en) 2013-09-26
US20160375062A1 (en) 2016-12-29
EP2078073A1 (en) 2009-07-15
EP2078073B1 (en) 2013-07-24
US10413571B2 (en) 2019-09-17
US20080112939A1 (en) 2008-05-15
JP5450072B2 (ja) 2014-03-26

Similar Documents

Publication Publication Date Title
US10413571B2 (en) Kidney-derived cells and methods of use in tissue repair and regeneration
US20240360408A1 (en) Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs
JP7706785B2 (ja) 腎臓病治療のための免疫特権を有する生物活性腎細胞
RU2722361C2 (ru) Органоиды, содержащие изолированные почечные клетки, и их применение
BRPI0613811A2 (pt) composição contendo células tronco estromais derivadas de tecido adiposo, suporte, método de preparação de uma composição contendo células tronco estromais derivadas de tecido adiposo, método de preparação de um adesivo para o reparo de fìstulas, método de tratamento de uma fìstula em um indivìduo, método de tratamento de uma ferida em um indivìduo, célula tronco estromal derivada de tecido adiposo e uso de células tronco estromais derivadas de tecido adiposo
US12291725B2 (en) Systems and methods for producing injectable enhanced stem cell exosomes, improved exosomes and methods of use
Navaei-Nigjeh et al. Reduction of marginal mass required for successful islet transplantation in a diabetic rat model using adipose tissue–derived mesenchymal stromal cells
US20250073272A1 (en) Production of enhanced stem cell-based exosomes and uses in scar tissue prevention and treatment
RU2816753C2 (ru) Иммунологически привилегированные биоактивные почечные клетки для лечения заболевания почек
Minagawa et al. Bladder Reconstruction Using Amniotic Mesenchymal Stem Cells
Benedetti et al. Developmental Approaches to Kidney Regeneration
BR122024023993A2 (pt) Método de produção de uma célula renal bioativa genomicamente modificada (brc), brc engenheirada e seu uso
HK40025177A (en) Immunoprivileged bioactive renal cells for the treatment of kidney disease