PT1946761E - Composição veicular para o transporte de ácido nucleico - Google Patents
Composição veicular para o transporte de ácido nucleico Download PDFInfo
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- PT1946761E PT1946761E PT68118728T PT06811872T PT1946761E PT 1946761 E PT1946761 E PT 1946761E PT 68118728 T PT68118728 T PT 68118728T PT 06811872 T PT06811872 T PT 06811872T PT 1946761 E PT1946761 E PT 1946761E
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- nucleic acid
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- oil
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Classifications
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
Landscapes
- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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- Zoology (AREA)
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- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| JP2005303497 | 2005-10-18 |
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| PT1946761E true PT1946761E (pt) | 2013-05-27 |
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| PT68118728T PT1946761E (pt) | 2005-10-18 | 2006-10-17 | Composição veicular para o transporte de ácido nucleico |
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| SI (1) | SI1946761T1 (https=) |
| TW (1) | TW200800235A (https=) |
| WO (1) | WO2007046356A1 (https=) |
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| TW200800235A (en) * | 2005-10-18 | 2008-01-01 | Otsuka Pharma Co Ltd | Carrier composition for nucleic acid transport |
| WO2011076807A2 (en) | 2009-12-23 | 2011-06-30 | Novartis Ag | Lipids, lipid compositions, and methods of using them |
| WO2011114678A1 (ja) * | 2010-03-15 | 2011-09-22 | 国立大学法人山口大学 | 哺乳動物細胞への遺伝子導入効率の向上剤 |
| US9750819B2 (en) * | 2012-05-23 | 2017-09-05 | Ohio State Innovation Foundation | Lipid nanoparticle compositions and methods of making and methods of using the same |
| US9833416B2 (en) * | 2014-04-04 | 2017-12-05 | Ohio State Innovation Foundation | Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same |
| EP3329011B1 (en) * | 2015-07-30 | 2019-12-18 | Arcis Biotechnology Holdings Limited | Method and composition |
| CN117481114A (zh) * | 2023-10-27 | 2024-02-02 | 硅羿科技（上海）有限公司 | 纳米核酸农药、其制备方法和应用、以及核酸递送系统 |
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| US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
| US6020317A (en) * | 1993-02-19 | 2000-02-01 | Nippon Shinyaku Co. Ltd. | Glycerol derivative, device and pharmaceutical composition |
| US20030092180A1 (en) | 2001-08-27 | 2003-05-15 | David Lewis | Inhibition of gene expression by delivery of small interfering RNA to post-embryonic animal cells in vivo |
| US5965542A (en) * | 1997-03-18 | 1999-10-12 | Inex Pharmaceuticals Corp. | Use of temperature to control the size of cationic liposome/plasmid DNA complexes |
| GB9726398D0 (en) * | 1997-12-12 | 1998-02-11 | Isis Innovation | Polypeptide and coding sequences |
| DK1129064T3 (da) * | 1998-11-12 | 2008-04-28 | Invitrogen Corp | Transfektionsreagenser |
| HUP9902217A3 (en) * | 1999-06-29 | 2002-07-29 | Szegoe Peter | Polycation based bioconjugates and process for producing thereof |
| AU2002214854A1 (en) * | 2000-10-25 | 2002-05-06 | Inex Pharmaceuticals Corporation | Lipid formulations for target delivery |
| WO2002060412A2 (en) * | 2001-02-01 | 2002-08-08 | Board Of Regents | Stabilised polymeric aerosols for pulmonary gene delivery |
| US20030096414A1 (en) * | 2001-03-27 | 2003-05-22 | Invitrogen Corporation | Culture medium for cell growth and transfection |
| US7713942B2 (en) * | 2001-04-04 | 2010-05-11 | Nordic Vaccine Technology A/S | Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides |
| EP1575976A4 (en) * | 2001-11-02 | 2006-08-23 | Insert Therapeutics Inc | METHODS AND COMPOSITIONS FOR THE THERAPEUTIC USE OF RNA INTERFERENCE |
| ES2279127T3 (es) * | 2002-07-05 | 2007-08-16 | Lipoxen Technologies Limited | Procedimiento para aumentar una respuesta inmunitaria de vacunacion de acido nucleico. |
| ES2559828T3 (es) * | 2003-07-16 | 2016-02-16 | Protiva Biotherapeutics Inc. | ARN de interferencia encapsulado en lípidos |
| AU2005310131A1 (en) * | 2004-11-17 | 2006-06-08 | University Of Maryland, Baltimore | Highly branched HK peptides as effective carriers of siRNA |
| US20070087045A1 (en) * | 2005-10-14 | 2007-04-19 | Industrial Technology Research Institute | Lipid carrier and method of preparing the same |
| TW200800235A (en) * | 2005-10-18 | 2008-01-01 | Otsuka Pharma Co Ltd | Carrier composition for nucleic acid transport |
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Also Published As
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| WO2007046356A1 (ja) | 2007-04-26 |
| EP1946761A1 (en) | 2008-07-23 |
| EP1946761A4 (en) | 2012-01-25 |
| CN101291678A (zh) | 2008-10-22 |
| CY1114586T1 (el) | 2016-10-05 |
| DK1946761T3 (da) | 2013-04-15 |
| US8030075B2 (en) | 2011-10-04 |
| RU2421227C2 (ru) | 2011-06-20 |
| EP1946761B1 (en) | 2013-04-03 |
| US20090258923A1 (en) | 2009-10-15 |
| MY149502A (en) | 2013-09-13 |
| KR20080059648A (ko) | 2008-06-30 |
| CA2624840A1 (en) | 2007-04-26 |
| JP5046952B2 (ja) | 2012-10-10 |
| AU2006305318A1 (en) | 2007-04-26 |
| CN102512689A (zh) | 2012-06-27 |
| PL1946761T3 (pl) | 2013-08-30 |
| SI1946761T1 (sl) | 2013-06-28 |
| EP1946761B8 (en) | 2013-05-22 |
| KR101324065B1 (ko) | 2013-10-31 |
| ES2412029T3 (es) | 2013-07-09 |
| AR057553A1 (es) | 2007-12-05 |
| TWI376225B (https=) | 2012-11-11 |
| RU2008119498A (ru) | 2009-11-27 |
| JPWO2007046356A1 (ja) | 2009-04-23 |
| AU2006305318B2 (en) | 2011-08-25 |
| HK1119956A1 (en) | 2009-03-20 |
| CN101291678B (zh) | 2012-03-28 |
| CN102512689B (zh) | 2014-08-20 |
| TW200800235A (en) | 2008-01-01 |
| BRPI0617449A2 (pt) | 2011-07-26 |
| HK1171689A1 (en) | 2013-04-05 |
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