RU2421227C2 - Композиция носителя для транспорта нуклеиновой кислоты - Google Patents

Композиция носителя для транспорта нуклеиновой кислоты Download PDF

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Publication number
RU2421227C2
RU2421227C2 RU2008119498/15A RU2008119498A RU2421227C2 RU 2421227 C2 RU2421227 C2 RU 2421227C2 RU 2008119498/15 A RU2008119498/15 A RU 2008119498/15A RU 2008119498 A RU2008119498 A RU 2008119498A RU 2421227 C2 RU2421227 C2 RU 2421227C2
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RU
Russia
Prior art keywords
nucleic acid
carrier composition
composition
cells
oil
Prior art date
Application number
RU2008119498/15A
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English (en)
Russian (ru)
Other versions
RU2008119498A (ru
Inventor
Хидеказу ТОЙОБУКУ (JP)
Хидеказу ТОЙОБУКУ
Хидео МИЯО (JP)
Хидео МИЯО
Масако САТО (JP)
Масако САТО
Казуо СЕКИГУТИ (JP)
Казуо Секигути
Original Assignee
Оцука Фармасьютикал Ко., Лтд.
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Publication of RU2008119498A publication Critical patent/RU2008119498A/ru
Application granted granted Critical
Publication of RU2421227C2 publication Critical patent/RU2421227C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
RU2008119498/15A 2005-10-18 2006-10-17 Композиция носителя для транспорта нуклеиновой кислоты RU2421227C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005-303497 2005-10-18
JP2005303497 2005-10-18

Publications (2)

Publication Number Publication Date
RU2008119498A RU2008119498A (ru) 2009-11-27
RU2421227C2 true RU2421227C2 (ru) 2011-06-20

Family

ID=37962449

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2008119498/15A RU2421227C2 (ru) 2005-10-18 2006-10-17 Композиция носителя для транспорта нуклеиновой кислоты

Country Status (19)

Country Link
US (1) US8030075B2 (https=)
EP (1) EP1946761B8 (https=)
JP (1) JP5046952B2 (https=)
KR (1) KR101324065B1 (https=)
CN (2) CN101291678B (https=)
AR (1) AR057553A1 (https=)
AU (1) AU2006305318B2 (https=)
BR (1) BRPI0617449A2 (https=)
CA (1) CA2624840A1 (https=)
CY (1) CY1114586T1 (https=)
DK (1) DK1946761T3 (https=)
ES (1) ES2412029T3 (https=)
MY (1) MY149502A (https=)
PL (1) PL1946761T3 (https=)
PT (1) PT1946761E (https=)
RU (1) RU2421227C2 (https=)
SI (1) SI1946761T1 (https=)
TW (1) TW200800235A (https=)
WO (1) WO2007046356A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200800235A (en) * 2005-10-18 2008-01-01 Otsuka Pharma Co Ltd Carrier composition for nucleic acid transport
WO2011076807A2 (en) 2009-12-23 2011-06-30 Novartis Ag Lipids, lipid compositions, and methods of using them
WO2011114678A1 (ja) * 2010-03-15 2011-09-22 国立大学法人山口大学 哺乳動物細胞への遺伝子導入効率の向上剤
US9750819B2 (en) * 2012-05-23 2017-09-05 Ohio State Innovation Foundation Lipid nanoparticle compositions and methods of making and methods of using the same
US9833416B2 (en) * 2014-04-04 2017-12-05 Ohio State Innovation Foundation Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same
EP3329011B1 (en) * 2015-07-30 2019-12-18 Arcis Biotechnology Holdings Limited Method and composition
CN117481114A (zh) * 2023-10-27 2024-02-02 硅羿科技（上海）有限公司 纳米核酸农药、其制备方法和应用、以及核酸递送系统

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005162A1 (en) * 1991-08-28 1993-03-18 The University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
RU2123492C1 (ru) * 1993-02-19 1998-12-20 Ниппон Синяку Ко., Лтд Производные глицерина, средство для доставки физиологически активного вещества и фармацевтическая композиция
WO1999031132A1 (en) * 1997-12-12 1999-06-24 The University Of Queensland NOVEL SURFACE PROTEIN OF $i(NEISSERIA MENINGITIDIS)
WO2000027795A1 (en) * 1998-11-12 2000-05-18 Invitrogen Corporation Transfection reagents
WO2004004758A1 (en) * 2002-07-05 2004-01-15 Lipoxen Technologies Limited Method to enhance an immune response of nucleic acid vaccination
WO2004033620A2 (en) * 2001-11-02 2004-04-22 Insert Therapeutics, Inc. Methods and compositions for therapeutic use of rna interference
RU2250782C2 (ru) * 1999-06-29 2005-04-27 Петер СЕГЕ Способ получения биоконъюгатов на основе поликатионов, пригодных для транспортировки в организм различных видов активных веществ

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030092180A1 (en) 2001-08-27 2003-05-15 David Lewis Inhibition of gene expression by delivery of small interfering RNA to post-embryonic animal cells in vivo
US5965542A (en) * 1997-03-18 1999-10-12 Inex Pharmaceuticals Corp. Use of temperature to control the size of cationic liposome/plasmid DNA complexes
AU2002214854A1 (en) * 2000-10-25 2002-05-06 Inex Pharmaceuticals Corporation Lipid formulations for target delivery
WO2002060412A2 (en) * 2001-02-01 2002-08-08 Board Of Regents Stabilised polymeric aerosols for pulmonary gene delivery
US20030096414A1 (en) * 2001-03-27 2003-05-22 Invitrogen Corporation Culture medium for cell growth and transfection
US7713942B2 (en) * 2001-04-04 2010-05-11 Nordic Vaccine Technology A/S Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides
ES2559828T3 (es) * 2003-07-16 2016-02-16 Protiva Biotherapeutics Inc. ARN de interferencia encapsulado en lípidos
AU2005310131A1 (en) * 2004-11-17 2006-06-08 University Of Maryland, Baltimore Highly branched HK peptides as effective carriers of siRNA
US20070087045A1 (en) * 2005-10-14 2007-04-19 Industrial Technology Research Institute Lipid carrier and method of preparing the same
TW200800235A (en) * 2005-10-18 2008-01-01 Otsuka Pharma Co Ltd Carrier composition for nucleic acid transport

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005162A1 (en) * 1991-08-28 1993-03-18 The University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
RU2123492C1 (ru) * 1993-02-19 1998-12-20 Ниппон Синяку Ко., Лтд Производные глицерина, средство для доставки физиологически активного вещества и фармацевтическая композиция
WO1999031132A1 (en) * 1997-12-12 1999-06-24 The University Of Queensland NOVEL SURFACE PROTEIN OF $i(NEISSERIA MENINGITIDIS)
WO2000027795A1 (en) * 1998-11-12 2000-05-18 Invitrogen Corporation Transfection reagents
RU2250782C2 (ru) * 1999-06-29 2005-04-27 Петер СЕГЕ Способ получения биоконъюгатов на основе поликатионов, пригодных для транспортировки в организм различных видов активных веществ
WO2004033620A2 (en) * 2001-11-02 2004-04-22 Insert Therapeutics, Inc. Methods and compositions for therapeutic use of rna interference
WO2004004758A1 (en) * 2002-07-05 2004-01-15 Lipoxen Technologies Limited Method to enhance an immune response of nucleic acid vaccination

Also Published As

Publication number Publication date
WO2007046356A1 (ja) 2007-04-26
EP1946761A1 (en) 2008-07-23
EP1946761A4 (en) 2012-01-25
CN101291678A (zh) 2008-10-22
CY1114586T1 (el) 2016-10-05
DK1946761T3 (da) 2013-04-15
US8030075B2 (en) 2011-10-04
EP1946761B1 (en) 2013-04-03
US20090258923A1 (en) 2009-10-15
MY149502A (en) 2013-09-13
KR20080059648A (ko) 2008-06-30
CA2624840A1 (en) 2007-04-26
JP5046952B2 (ja) 2012-10-10
AU2006305318A1 (en) 2007-04-26
CN102512689A (zh) 2012-06-27
PL1946761T3 (pl) 2013-08-30
SI1946761T1 (sl) 2013-06-28
EP1946761B8 (en) 2013-05-22
KR101324065B1 (ko) 2013-10-31
ES2412029T3 (es) 2013-07-09
PT1946761E (pt) 2013-05-27
AR057553A1 (es) 2007-12-05
TWI376225B (https=) 2012-11-11
RU2008119498A (ru) 2009-11-27
JPWO2007046356A1 (ja) 2009-04-23
AU2006305318B2 (en) 2011-08-25
HK1119956A1 (en) 2009-03-20
CN101291678B (zh) 2012-03-28
CN102512689B (zh) 2014-08-20
TW200800235A (en) 2008-01-01
BRPI0617449A2 (pt) 2011-07-26
HK1171689A1 (en) 2013-04-05

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Effective date: 20161018