PT1940366E - Cápsulas moles compreendendo cloridrato de palonossetrom possuindo estabilidade e disponibilidade biológica melhoradas - Google Patents

Cápsulas moles compreendendo cloridrato de palonossetrom possuindo estabilidade e disponibilidade biológica melhoradas Download PDF

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Publication number
PT1940366E
PT1940366E PT07819163T PT07819163T PT1940366E PT 1940366 E PT1940366 E PT 1940366E PT 07819163 T PT07819163 T PT 07819163T PT 07819163 T PT07819163 T PT 07819163T PT 1940366 E PT1940366 E PT 1940366E
Authority
PT
Portugal
Prior art keywords
bioavailability
improved stability
soft capsules
palonosetron hydrochloride
palonosetron
Prior art date
Application number
PT07819163T
Other languages
English (en)
Inventor
Giorgio Calderari
Daniele Bonadeo
Enrico Braglia
Riccardo Braglia
Original Assignee
Helsinn Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38921772&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1940366(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Helsinn Healthcare Sa filed Critical Helsinn Healthcare Sa
Publication of PT1940366E publication Critical patent/PT1940366E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A61K9/5057—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT07819163T 2006-10-24 2007-10-19 Cápsulas moles compreendendo cloridrato de palonossetrom possuindo estabilidade e disponibilidade biológica melhoradas PT1940366E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85434206P 2006-10-24 2006-10-24

Publications (1)

Publication Number Publication Date
PT1940366E true PT1940366E (pt) 2009-06-17

Family

ID=38921772

Family Applications (1)

Application Number Title Priority Date Filing Date
PT07819163T PT1940366E (pt) 2006-10-24 2007-10-19 Cápsulas moles compreendendo cloridrato de palonossetrom possuindo estabilidade e disponibilidade biológica melhoradas

Country Status (36)

Country Link
US (2) US20080152704A1 (pt)
EP (1) EP1940366B9 (pt)
JP (1) JP5144527B2 (pt)
KR (1) KR101441459B1 (pt)
CN (1) CN101573106B (pt)
AR (1) AR063362A1 (pt)
AT (1) ATE427742T1 (pt)
AU (1) AU2007308378B2 (pt)
BR (1) BRPI0718497B1 (pt)
CA (1) CA2666512C (pt)
CL (1) CL2007003055A1 (pt)
CO (1) CO6160289A2 (pt)
CR (1) CR10728A (pt)
CY (1) CY1109914T1 (pt)
DE (1) DE602007000856D1 (pt)
DK (1) DK1940366T3 (pt)
EA (1) EA016455B1 (pt)
ES (1) ES2325339T3 (pt)
GT (1) GT200900096A (pt)
HK (1) HK1117769A1 (pt)
HN (1) HN2009000785A (pt)
HR (1) HRP20090341T1 (pt)
IL (1) IL198225A (pt)
ME (1) ME01949B (pt)
MX (1) MX2009004461A (pt)
NO (1) NO342353B1 (pt)
NZ (1) NZ576237A (pt)
PL (1) PL1940366T3 (pt)
PT (1) PT1940366E (pt)
RS (1) RS50842B (pt)
SI (1) SI1940366T1 (pt)
SV (1) SV2009003238A (pt)
TW (1) TWI367212B (pt)
UA (1) UA97653C2 (pt)
WO (1) WO2008049552A1 (pt)
ZA (1) ZA200902773B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2550035T3 (es) * 2006-01-27 2015-11-04 Adare Pharmaceuticals, Inc. Sistemas de administración de fármacos que comprenden un agente de bloqueo selectivo de la serotonina 5-HT3 débilmente básico y ácidos orgánicos
KR20140088230A (ko) * 2006-01-27 2014-07-09 앱탈리스 파마테크, 인코포레이티드 약 염기성 약물과 유기산을 포함하는 약물 전달 시스템
US20100143461A1 (en) * 2008-12-08 2010-06-10 Ben-Zion Solomon Palonosetron formulation
US20110003005A1 (en) * 2009-07-06 2011-01-06 Gopi Venkatesh Methods of Treating PDNV and PONV with Extended Release Ondansetron Compositions
CN102048705B (zh) * 2009-11-10 2012-07-18 齐鲁制药有限公司 盐酸帕洛诺司琼口腔崩解片制剂及其制备方法
JP2013510843A (ja) * 2009-11-13 2013-03-28 ヘルシン ヘルスケア ソシエテ アノニム パロノセトロン代謝産物先行出願との関連本出願は２００９年１１月１３日に出願された米国仮出願第６１／２６０，９１６号の優先権を主張する。
EP2722045B1 (en) 2009-11-18 2016-07-06 Helsinn Healthcare SA Compositions for treating centrally mediated nausea and vomiting
PE20121483A1 (es) * 2009-11-18 2012-12-02 Helsinn Healthcare Sa Composiciones para tratar nausea y vomito centralmente mediados
CN106974912A (zh) 2011-10-18 2017-07-25 赫尔辛医疗股份公司 奈妥匹坦和帕洛诺司琼的治疗性组合
CN103446072A (zh) * 2012-06-02 2013-12-18 正大天晴药业集团股份有限公司 帕洛诺司琼的固体药物组合物
BR112015021769A2 (pt) * 2013-03-19 2017-07-18 Galenicum Health Sl composições farmacêuticas compreendendo um agente ativo
CA2919892C (en) 2013-08-12 2019-06-18 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
JP2017504615A (ja) 2013-12-23 2017-02-09 サムヤン バイオファーマシューティカルズ コーポレイション パロノセトロンを含有する薬学組成物
AU2015290098B2 (en) 2014-07-17 2018-11-01 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
CA2964628A1 (en) * 2014-10-20 2016-04-28 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
KR20160128573A (ko) * 2015-04-29 2016-11-08 주식회사 삼양바이오팜 약제학적 패키지
JP2019019067A (ja) * 2017-07-13 2019-02-07 ニプロ株式会社 液体製剤
CN111205283A (zh) * 2020-01-20 2020-05-29 广州九植医药科技有限公司 一种盐酸帕洛诺司琼有关物质b的合成方法
EP4385500A1 (en) 2022-12-12 2024-06-19 Alfred E. Tiefenbacher (GmbH & Co. KG) Fixed dose combination comprising netupitant and palonosetron
EP4385497A1 (en) 2022-12-12 2024-06-19 Alfred E. Tiefenbacher (GmbH & Co. KG) Antioxidant-free fixed dose combination of netupitant and palonosetron

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1015251A (en) * 1963-03-12 1965-12-31 Glaxo Lab Ltd Aqueous pharmaceutical compositions in capsule form
US4182914A (en) * 1974-01-22 1980-01-08 Nippon Oil Company Limited Process for continuously producing diisopropyl ether
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
EP0200444B1 (en) * 1985-04-27 1992-11-11 Beecham Group Plc Azabicyclononyl-indazole-carboxamide having 5-ht antagonist activity
US4937247A (en) * 1985-04-27 1990-06-26 Beecham Group P.L.C. 1-acyl indazoles
US5578628A (en) * 1985-06-25 1996-11-26 Glaxo Group Limited Medicaments for the treatment of nausea and vomiting
GB8516083D0 (en) * 1985-06-25 1985-07-31 Glaxo Group Ltd Heterocyclic compounds
US5240954A (en) * 1985-06-25 1993-08-31 Glaxo Group Limited Medicaments
US4906755A (en) * 1986-11-03 1990-03-06 Merrell Dow Pharmaceuticals Inc. Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one and related compounds
US5011846A (en) * 1988-02-23 1991-04-30 Merrell Dow Pharmaceuticals Inc. Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof
US5344658A (en) * 1989-06-28 1994-09-06 Glaxo Group Limited Process and composition using ondansetron
GB8914804D0 (en) * 1989-06-28 1989-08-16 Glaxo Group Ltd Process
PL166277B1 (pl) * 1989-11-28 1995-04-28 Syntex Inc Sposób wytwarzania nowych zwiazków trójpierscieniowych PL PL PL PL
GB9405304D0 (en) * 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
GB9423511D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
US20030095926A1 (en) * 1997-10-01 2003-05-22 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the gastrointestinal tract or urinary tract
US20040136914A1 (en) * 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing ondansetron
US6294548B1 (en) * 1998-05-04 2001-09-25 Hoffmann-La Roche Inc. Multidose vial formulations for administering endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride
FR2818905A1 (fr) * 2000-12-28 2002-07-05 Cll Pharma Compositions pharmaceutiques colloidales micellaires renfermant un principe actif lipophile
FR2823118B1 (fr) * 2001-04-04 2004-03-19 Lavipharm Lab Inc Nouvelle composition filmogene a usage topique et son utilisation pour la delivrance d'agents actifs
FR2827770B1 (fr) * 2001-07-27 2005-08-19 Gattefosse Ets Sa Composition pharmaceutique a usage oral comprenant un principe actif susceptible de subir un important effet de premier passage intestinal
CA2505990C (en) * 2002-11-15 2009-05-19 Helsinn Healthcare S.A. Palonosetron for the treatment of chemotherapy-induced emesis
TWI355936B (en) * 2003-02-18 2012-01-11 Helsinn Healthcare Sa Uses of palonosetron hydrochloride
IL159729A0 (en) 2004-01-06 2004-06-20 Doron I Friedman Non-aqueous composition for oral delivery of insoluble bioactive agents

Also Published As

Publication number Publication date
ES2325339T3 (es) 2009-09-01
JP2009507933A (ja) 2009-02-26
CN101573106B (zh) 2013-07-24
CA2666512C (en) 2014-05-27
CN101573106A (zh) 2009-11-04
UA97653C2 (ru) 2012-03-12
KR20090073234A (ko) 2009-07-02
IL198225A0 (en) 2009-12-24
EA200970396A1 (ru) 2009-10-30
BRPI0718497B1 (pt) 2024-02-06
WO2008049552A1 (en) 2008-05-02
NZ576237A (en) 2011-12-22
NO20091945L (no) 2009-05-25
CY1109914T1 (el) 2014-09-10
CL2007003055A1 (es) 2008-03-24
EP1940366B1 (en) 2009-04-08
EP1940366A1 (en) 2008-07-09
KR101441459B1 (ko) 2014-09-18
ME01949B (me) 2010-08-31
HN2009000785A (es) 2011-10-14
EP1940366B9 (en) 2009-12-02
TW200827355A (en) 2008-07-01
GT200900096A (es) 2011-08-29
CR10728A (es) 2009-07-23
CO6160289A2 (es) 2010-05-20
ATE427742T1 (de) 2009-04-15
EA016455B1 (ru) 2012-05-30
MX2009004461A (es) 2009-09-16
PL1940366T3 (pl) 2009-09-30
JP5144527B2 (ja) 2013-02-13
ZA200902773B (en) 2010-03-31
HK1117769A1 (en) 2009-01-23
US20170035748A1 (en) 2017-02-09
HRP20090341T1 (en) 2009-07-31
SV2009003238A (es) 2009-11-09
AU2007308378A1 (en) 2008-05-02
RS50842B (sr) 2010-08-31
CA2666512A1 (en) 2008-05-02
AR063362A1 (es) 2009-01-21
DE602007000856D1 (de) 2009-05-20
US20080152704A1 (en) 2008-06-26
DK1940366T3 (da) 2009-06-29
BRPI0718497A2 (pt) 2014-07-08
SI1940366T1 (sl) 2009-08-31
AU2007308378B2 (en) 2013-02-21
TWI367212B (en) 2012-07-01
NO342353B1 (no) 2018-05-07
IL198225A (en) 2013-03-24

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