PT1909792E - Derivados substituídos da piperidina como antagonistas do receptor sst1 da somatostatina - Google Patents

Derivados substituídos da piperidina como antagonistas do receptor sst1 da somatostatina Download PDF

Info

Publication number
PT1909792E
PT1909792E PT06762563T PT06762563T PT1909792E PT 1909792 E PT1909792 E PT 1909792E PT 06762563 T PT06762563 T PT 06762563T PT 06762563 T PT06762563 T PT 06762563T PT 1909792 E PT1909792 E PT 1909792E
Authority
PT
Portugal
Prior art keywords
receptor antagonists
substituted piperidine
piperidine derivatives
sst1 receptor
somatostatin
Prior art date
Application number
PT06762563T
Other languages
English (en)
Inventor
Thomas J Troxler
Daniel Hoyer
Konstanze Hurth
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT1909792E publication Critical patent/PT1909792E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
PT06762563T 2005-07-15 2006-07-13 Derivados substituídos da piperidina como antagonistas do receptor sst1 da somatostatina PT1909792E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0514615.4A GB0514615D0 (en) 2005-07-15 2005-07-15 Organic compounds

Publications (1)

Publication Number Publication Date
PT1909792E true PT1909792E (pt) 2009-12-09

Family

ID=34897328

Family Applications (1)

Application Number Title Priority Date Filing Date
PT06762563T PT1909792E (pt) 2005-07-15 2006-07-13 Derivados substituídos da piperidina como antagonistas do receptor sst1 da somatostatina

Country Status (17)

Country Link
US (1) US7754719B2 (pt)
EP (1) EP1909792B1 (pt)
JP (1) JP2009501180A (pt)
KR (1) KR20080025731A (pt)
CN (1) CN101222924A (pt)
AT (1) ATE441415T1 (pt)
AU (1) AU2006272049A1 (pt)
BR (1) BRPI0612994A2 (pt)
CA (1) CA2615236A1 (pt)
DE (1) DE602006008957D1 (pt)
ES (1) ES2333165T3 (pt)
GB (1) GB0514615D0 (pt)
MX (1) MX2008000709A (pt)
PL (1) PL1909792T3 (pt)
PT (1) PT1909792E (pt)
RU (1) RU2008105362A (pt)
WO (1) WO2007009662A1 (pt)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149817A (en) 1990-03-05 1992-09-22 Shionogi & Co., Ltd. Teirahydropyridine derivatives
JP2001502712A (ja) * 1996-10-31 2001-02-27 ノボ ノルディスク アクティーゼルスカブ 束縛されたソマトスタチン・アゴニスト及びアンタゴニスト
EP1086947A1 (en) * 1999-09-01 2001-03-28 Pfizer Products Inc. Somatostatin antagonists and agonists that act at the SST subtype 2 receptor
US7115741B2 (en) 2001-09-06 2006-10-03 Levy Daniel E 4-thieno[2,3-D]pyrimidin-4-YL piperazine compounds
GB0127008D0 (en) 2001-11-09 2002-01-02 Novartis Ag Organic compounds
WO2004011430A1 (ja) 2002-07-25 2004-02-05 Yamanouchi Pharmaceutical Co., Ltd. ナトリウムチャネル阻害剤

Also Published As

Publication number Publication date
US20080255142A1 (en) 2008-10-16
EP1909792A1 (en) 2008-04-16
CA2615236A1 (en) 2007-01-25
EP1909792B1 (en) 2009-09-02
ES2333165T3 (es) 2010-02-17
WO2007009662A1 (en) 2007-01-25
RU2008105362A (ru) 2009-08-20
ATE441415T1 (de) 2009-09-15
AU2006272049A1 (en) 2007-01-25
CN101222924A (zh) 2008-07-16
DE602006008957D1 (de) 2009-10-15
BRPI0612994A2 (pt) 2010-12-14
GB0514615D0 (en) 2005-08-24
JP2009501180A (ja) 2009-01-15
KR20080025731A (ko) 2008-03-21
PL1909792T3 (pl) 2010-02-26
MX2008000709A (es) 2008-03-18
US7754719B2 (en) 2010-07-13

Similar Documents

Publication Publication Date Title
TW200637550A (en) Thiazole-4-carboxamide derivatives as mGluR5 antagonists
TW200800956A (en) 2-Aminopyrimidine derivatives
TNSN08269A1 (en) Derives de pyrimidine
TN2010000101A1 (en) Fungicidal 2-alkylthio-2-quinolinyloxy -acetamide derivatives
WO2008020405A3 (en) Azetidine compounds as orexin receptor antagonists
ATE524466T1 (de) 3-azabicycloä3.3.0üoktanverbindungen
MX2009009774A (es) Derivados de quinolina como fungicidas.
MXPA06012595A (es) Analogos de amino-tetrazoles y metodos de uso.
TW200600494A (en) Bisphenyl compounds useful as vitamin d3 receptor agonists
TW200728277A (en) Bicyclic derivatives as P38 inhibitors
WO2007056091A3 (en) 2-phenyl-2h-pyraz0le derivatives as p2x7 receptor antagonists and uses thereof
TW200637837A (en) Fungicides
DK1833791T3 (da) 2,3,4,9-tetrahydor-1H-carbazolderivater som CRTH2 receptorantagonister
EA200700365A1 (ru) Производные индол-2-карбоксамидина как антагонисты nmda рецептора
MXPA06000921A (es) Derivados de benzamidazoles como inhibidores de mek.
TW200700396A (en) Pyrazine-2-carboxamide derivatives as mglur5 antagonists
MX2009010552A (es) Antagonistas de receptor de opioide periferico y usos de los mismos.
TW200619206A (en) Chemokine-binding heterocyclic compound salts, and methods of use thereof
UA101963C2 (en) 4-amino-pyrimidine derivatives
DK1954668T3 (da) Homo- og heterocykliske forbindelser, der er egnede som CETP-inhibitorer
TW200700358A (en) Organic compounds
TN2009000040A1 (en) 5,6-bisaryl-2-pyridine-carboxamide derivatives, preparation and application thereof in therapeutics as urotensin ii receptor antagonists
EA200801365A1 (ru) Замещенные 5-фенил-3,6-дигидро-2-оксо-6h-1,3,4-тиадиазины
EA200801366A1 (ru) Производные 3,6-дигидро-2-оксо-6н-1,3,4-тиадиазина
MXPA05013149A (es) Derivados de imidazol como antagonistas del receptor de glutamato.