PT1845084E - Processo para a produ??o de (z)-1-fenil-1-(n,ndietilaminocarbonil)- 2-ftalimidometilciclopropano - Google Patents

Processo para a produ??o de (z)-1-fenil-1-(n,ndietilaminocarbonil)- 2-ftalimidometilciclopropano Download PDF

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Publication number
PT1845084E
PT1845084E PT06712854T PT06712854T PT1845084E PT 1845084 E PT1845084 E PT 1845084E PT 06712854 T PT06712854 T PT 06712854T PT 06712854 T PT06712854 T PT 06712854T PT 1845084 E PT1845084 E PT 1845084E
Authority
PT
Portugal
Prior art keywords
diethylaminocarbonyl
phenyl
producing
idomethylcyclopropane
reacting
Prior art date
Application number
PT06712854T
Other languages
English (en)
Inventor
Yoshihide Niimoto
Hiroharu Kumazawa
Koh Kawami
Original Assignee
Sumitomo Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co
Publication of PT1845084E publication Critical patent/PT1845084E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
PT06712854T 2005-01-28 2006-01-26 Processo para a produ??o de (z)-1-fenil-1-(n,ndietilaminocarbonil)- 2-ftalimidometilciclopropano PT1845084E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005022188 2005-01-28
JP2005145875A JP4828863B2 (ja) 2005-01-28 2005-05-18 （ｚ）−１−フェニル−１−（ｎ，ｎ−ジエチルアミノカルボニル）−２−フタルイミドメチルシクロプロパンの製造方法

Publications (1)

Publication Number Publication Date
PT1845084E true PT1845084E (pt) 2011-05-31

Family

ID=36740567

Family Applications (1)

Application Number Title Priority Date Filing Date
PT06712854T PT1845084E (pt) 2005-01-28 2006-01-26 Processo para a produ??o de (z)-1-fenil-1-(n,ndietilaminocarbonil)- 2-ftalimidometilciclopropano

Country Status (13)

Country Link
US (2) US7943785B2 (pt)
EP (1) EP1845084B1 (pt)
JP (1) JP4828863B2 (pt)
KR (1) KR20070115896A (pt)
CN (1) CN101107228B (pt)
AT (1) ATE506346T1 (pt)
AU (1) AU2006209453B2 (pt)
CA (1) CA2594721A1 (pt)
DE (1) DE602006021397D1 (pt)
IL (1) IL184338A (pt)
PT (1) PT1845084E (pt)
WO (1) WO2006080555A1 (pt)
ZA (1) ZA200706196B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101070721B1 (ko) 2004-06-25 2011-10-07 스미또모 가가꾸 가부시키가이샤 (ｚ)-1-페닐-1-디에틸아미노카르보닐-2-히드록시메틸시클로프로판의 제조 방법
CN101195583B (zh) * 2006-12-04 2012-07-04 四川抗菌素工业研究所有限公司 一种光学纯米那普仑及其盐的制备方法
FR2941454B1 (fr) 2009-01-29 2011-04-01 Pf Medicament Proced de synthese du (1s,2r)-milnacipran
WO2011158249A1 (en) * 2010-06-16 2011-12-22 Glenmark Generics Limited Process for preparation of milnacipran intermediate and its use in preparation of pure milnacipran
WO2014009767A1 (en) 2012-07-07 2014-01-16 Micro Labs Limited An improved process for the preparation of 1-aryl 2-aminomethyl cyclopropane carboxyamide (z) derivatives, their isomers and salts
EP2805936A1 (en) 2013-05-20 2014-11-26 Cosma S.p.A. Process for preparing levomilnacipran HCL
CN103613513B (zh) * 2013-12-09 2016-01-20 上海现代制药股份有限公司 盐酸米那普仑中间体及其制备方法和应用
CN103694162B (zh) * 2014-01-03 2015-09-02 上海现代制药股份有限公司 (1s,2r)-1-苯基2-(酞酰亚胺)甲基-n,n-二乙基-环丙甲酰胺的制备方法
WO2016071303A1 (en) * 2014-11-04 2016-05-12 Quimica Sintetica, S.A. Process for the preparation of (1s,2r)-milnacipran

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2581059B1 (fr) 1985-04-25 1988-04-22 Pf Medicament Procede de preparation du chlorhydrate de phenyl-1 diethyl amino carbonyl-1 aminomethyl-2 cyclopropane (z)
FR2640972B1 (pt) * 1988-12-28 1991-04-19 Pf Medicament
JP4418717B2 (ja) * 2004-06-24 2010-02-24 住友化学株式会社 （ｚ）−１−フェニル−１−ジエチルアミノカルボニル−２−アミノメチルシクロプロパン塩酸塩の製造方法

Also Published As

Publication number Publication date
US20090292127A1 (en) 2009-11-26
KR20070115896A (ko) 2007-12-06
EP1845084B1 (en) 2011-04-20
US7943785B2 (en) 2011-05-17
JP2006232802A (ja) 2006-09-07
CN101107228A (zh) 2008-01-16
EP1845084A4 (en) 2009-04-29
CN101107228B (zh) 2011-04-13
AU2006209453A1 (en) 2006-08-03
WO2006080555A1 (ja) 2006-08-03
ZA200706196B (en) 2008-10-29
IL184338A0 (en) 2007-10-31
CA2594721A1 (en) 2006-08-03
IL184338A (en) 2011-09-27
EP1845084A1 (en) 2007-10-17
DE602006021397D1 (de) 2011-06-01
US20110130576A1 (en) 2011-06-02
JP4828863B2 (ja) 2011-11-30
ATE506346T1 (de) 2011-05-15
AU2006209453B2 (en) 2011-03-24

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