PT1720909E - Anticorpo anti-a¿ò - Google Patents

Anticorpo anti-a¿ò Download PDF

Info

Publication number
PT1720909E
PT1720909E PT05723280T PT05723280T PT1720909E PT 1720909 E PT1720909 E PT 1720909E PT 05723280 T PT05723280 T PT 05723280T PT 05723280 T PT05723280 T PT 05723280T PT 1720909 E PT1720909 E PT 1720909E
Authority
PT
Portugal
Prior art keywords
antibody
peptide
cells
antibodies
gel
Prior art date
Application number
PT05723280T
Other languages
English (en)
Portuguese (pt)
Inventor
Don B Mcclure
Ronald Bradley Demattos
Uma Kuchibhotla
Hsiu-Chiung Yang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT1720909E publication Critical patent/PT1720909E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
PT05723280T 2004-02-23 2005-02-17 Anticorpo anti-a¿ò PT1720909E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54676404P 2004-02-23 2004-02-23

Publications (1)

Publication Number Publication Date
PT1720909E true PT1720909E (pt) 2011-12-23

Family

ID=34910810

Family Applications (1)

Application Number Title Priority Date Filing Date
PT05723280T PT1720909E (pt) 2004-02-23 2005-02-17 Anticorpo anti-a¿ò

Country Status (20)

Country Link
US (1) US20070190046A1 (cg-RX-API-DMAC7.html)
EP (1) EP1720909B1 (cg-RX-API-DMAC7.html)
JP (1) JP4851348B2 (cg-RX-API-DMAC7.html)
KR (2) KR100889430B1 (cg-RX-API-DMAC7.html)
CN (1) CN1922209B (cg-RX-API-DMAC7.html)
AT (1) ATE534667T1 (cg-RX-API-DMAC7.html)
AU (1) AU2005217596B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0507856A (cg-RX-API-DMAC7.html)
CA (1) CA2556436C (cg-RX-API-DMAC7.html)
CY (1) CY1112162T1 (cg-RX-API-DMAC7.html)
DK (1) DK1720909T3 (cg-RX-API-DMAC7.html)
EA (1) EA009872B1 (cg-RX-API-DMAC7.html)
ES (1) ES2375627T3 (cg-RX-API-DMAC7.html)
IL (1) IL177611A (cg-RX-API-DMAC7.html)
NO (1) NO20064239L (cg-RX-API-DMAC7.html)
PL (1) PL1720909T3 (cg-RX-API-DMAC7.html)
PT (1) PT1720909E (cg-RX-API-DMAC7.html)
SI (1) SI1720909T1 (cg-RX-API-DMAC7.html)
UA (1) UA93181C2 (cg-RX-API-DMAC7.html)
WO (1) WO2005082939A2 (cg-RX-API-DMAC7.html)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
PL1976877T5 (pl) 2005-11-30 2017-09-29 Abbvie Inc Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania
PT1954718E (pt) 2005-11-30 2014-12-16 Abbvie Inc Anticorpos anti-globulómeros aβ, suas porções de ligação ao antigénio, correspondentes hibridomas, ácidos nucleicos, vectores, células hospedeiras, métodos de produção dos ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos para uso dos ditos anticorpos
MX358175B (es) 2005-12-12 2018-08-08 Ac Immune Sa Anticuerpos monoclonales especificos 1-42 beta con propiedades terapeuticas.
US7892544B2 (en) 2006-07-14 2011-02-22 Ac Immune Sa Humanized anti-beta-amyloid antibody
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
HRP20140049T1 (hr) 2007-01-05 2014-02-28 University Of Zürich Anti beta-amiloid antitijela i njihova upotreba
HUE034512T2 (en) 2007-01-05 2018-02-28 Univ Zuerich A method for providing disease-specific binding molecules and targets
WO2008084402A2 (en) 2007-01-11 2008-07-17 Philipps-Universitaet Marburg Diagnosis and treatment of alzheimer's and other neurodementing diseases
US20100311767A1 (en) 2007-02-27 2010-12-09 Abbott Gmbh & Co. Kg Method for the treatment of amyloidoses
US8048420B2 (en) * 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
PT2238166E (pt) 2007-10-05 2014-02-11 Genentech Inc Utilização do anticorpo anti-amilóide beta em doenças oculares
RU2542967C2 (ru) * 2007-10-05 2015-02-27 Дженентек, Инк. Применение антитела против амилоида бета при глазных заболеваниях
EA201190025A1 (ru) 2008-11-25 2012-12-28 Байоджен Айдек Ма Инк. ПРИМЕНЕНИЕ АНТАГОНИСТОВ DR6 И p75 ДЛЯ ПРОМОТИРОВАНИЯ ВЫЖИВАНИЯ КЛЕТОК НЕРВНОЙ СИСТЕМЫ
BRPI0923157B1 (pt) 2008-12-19 2021-12-28 University Of Zürich Anticorpos anti-alfa-sinucleína e seus fragmentos, seus usos e método de preparação, composição compreendendo-os, bem como kit e métodos para o diagnóstico e monitoramento de uma doença sinucleinopática
WO2011060246A2 (en) 2009-11-12 2011-05-19 Genentech, Inc. A method of promoting dendritic spine density
CN102933601B (zh) 2010-04-15 2016-06-08 Abbvie公司 β淀粉样蛋白结合蛋白
MY164579A (en) 2010-07-30 2018-01-15 Ac Immune Sa Safe and functional humanized antibodies
PL3042917T3 (pl) * 2010-08-12 2018-07-31 Eli Lilly And Company Przeciwciała przeciwko peptydowi beta amyloidu N3pGlu i ich zastosowanie
MX358739B (es) 2010-08-14 2018-09-03 Abbvie Inc Star Proteinas de union a amiloide beta.
PL2723379T3 (pl) 2011-06-23 2019-05-31 Biogen Int Neuroscience Gmbh Cząsteczki wiążące przeciwko alfa-synukleinie
US20150209406A1 (en) 2012-09-07 2015-07-30 Massachusetts Eye And Ear Infirmary Methods and compositions for regenerating hair cells and/or supporting cells
WO2014039781A1 (en) 2012-09-07 2014-03-13 Massachusetts Eye & Ear Infirmary Treating hearing loss
JP6751344B2 (ja) 2013-09-13 2020-09-02 ジェネンテック， インコーポレイテッド 精製された組み換えポリペプチドを含む方法及び組成物
MA41115A (fr) 2014-12-02 2017-10-10 Biogen Int Neuroscience Gmbh Procédé de traitement de la maladie d'alzheimer
KR102362222B1 (ko) 2016-05-16 2022-02-11 더 제너럴 하스피탈 코포레이션 폐 상피 공학에서 인간 기도 줄기 세포
WO2018031334A1 (en) * 2016-08-11 2018-02-15 Eli Lilly And Company Aminothiazines and their use as bace1 inhibitors
AU2018321335B2 (en) 2017-08-22 2025-08-14 Biogen Ma Inc. Pharmaceutical compositions containing anti-beta amyloid antibodies
TWI843040B (zh) 2021-01-11 2024-05-21 美商美國禮來大藥廠 抗N3pGlu類澱粉β抗體及其用途
WO2022251048A1 (en) 2021-05-24 2022-12-01 Eli Lilly And Company Anti-amyloid beta antibodies and uses thereof
JP2025506411A (ja) 2022-02-03 2025-03-11 イーライ リリー アンド カンパニー アルツハイマー病の診断及び治療のための局所タウイメージング

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT951466E (pt) 1996-12-23 2009-04-09 Lilly Co Eli Compostos cicloalquilo, lactama, lactona e relacionados, composições farmacêuticas compreendendo os mesmos, e métodos para a inibição da libertação do péptido β-amilóide e/ou da sua síntese pela utilização de tais compostos
US6518011B1 (en) * 1999-01-13 2003-02-11 Bristol-Myers Squibb Company Method for screening compounds to identify beta-amyloid production modulators
MXPA02008145A (es) * 2000-02-24 2004-04-05 Univ Washington Anticuerpos humanizados que secuestran al peptido beta amiloide.
AU2001257022B2 (en) * 2000-04-13 2005-02-03 Mayo Foundation For Medical Education And Research Abeta 42 lowering agents
TWI255272B (en) * 2000-12-06 2006-05-21 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
ES2437875T3 (es) * 2001-04-30 2014-01-14 Eli Lilly And Company Anticuerpos humanizados que reconocen el péptido beta-amiloide

Also Published As

Publication number Publication date
AU2005217596B2 (en) 2012-01-19
US20070190046A1 (en) 2007-08-16
CN1922209B (zh) 2012-09-05
KR20090005410A (ko) 2009-01-13
JP2008500279A (ja) 2008-01-10
SI1720909T1 (sl) 2012-01-31
ATE534667T1 (de) 2011-12-15
IL177611A (en) 2013-05-30
DK1720909T3 (da) 2012-01-30
CY1112162T1 (el) 2015-12-09
PL1720909T3 (pl) 2012-04-30
CA2556436C (en) 2014-04-01
EA009872B1 (ru) 2008-04-28
NO20064239L (no) 2006-11-20
EA200601545A1 (ru) 2007-02-27
BRPI0507856A (pt) 2007-07-10
JP4851348B2 (ja) 2012-01-11
KR100889430B1 (ko) 2009-03-23
ES2375627T3 (es) 2012-03-02
UA93181C2 (ru) 2011-01-25
IL177611A0 (en) 2006-12-10
AU2005217596A1 (en) 2005-09-09
KR20060126785A (ko) 2006-12-08
CN1922209A (zh) 2007-02-28
EP1720909A2 (en) 2006-11-15
EP1720909B1 (en) 2011-11-23
CA2556436A1 (en) 2005-09-09
WO2005082939A3 (en) 2005-10-27
WO2005082939A2 (en) 2005-09-09

Similar Documents

Publication Publication Date Title
PT1720909E (pt) Anticorpo anti-a¿ò
TWI705975B (zh) 抗－N3pGlu類澱粉β肽抗體及其用途
TWI747922B (zh) 特異性針對過度磷酸化τ蛋白之抗體及其使用方法
CN109937210B (zh) 用于治疗共核蛋白病的药剂、用途和方法
CN107847595B (zh) 特异性针对过度磷酸化τ蛋白的抗体及其使用方法
ES2934656T3 (es) Anticuerpos antitranstiretina
ES2905311T3 (es) Anticuerpos anti-transtiretina
KR20080090408A (ko) 항-Ａβ 글로불로머 항체, 이의 항원-결합 잔기, 상응하는하이브리도마, 핵산, 벡터, 숙주 세포, 당해 항체의 제조방법, 당해 항체를 포함하는 조성물, 당해 항체의 용도 및당해 항체의 사용 방법
US20250243263A1 (en) Tau binding compounds
CA3180222A1 (en) Tau binding compounds
JP2025094005A (ja) ＡｐｏＥ抗体、融合タンパク質、およびその使用
CN110072888B (zh) 药剂、用途和方法
Krishnaswamy et al. Neuronally expressed anti-tau scFv prevents tauopathy-induced phenotypes in Drosophila models
WO2016053610A1 (en) Antibodies against pathological forms of tdp-43 and uses thereof
US9796778B1 (en) Antibodies against pathological forms of TDP-43 and uses thereof
EP4537842A1 (en) Preventative agent or therapeutic agent for amyotrophic lateral sclerosis, parkinson's disease, huntington's disease, spinocerebellar ataxia, aging-related degenerative or neurological disease, brain aging, or diseases associated with brain aging
HK40125870A (zh) 肌萎缩侧索硬化症、帕金森病、亨廷顿病、脊髓小脑性共济失调、与老化有关的变性疾病或神经疾病、脑老化、或者伴有脑老化的疾病的预防剂或治疗剂
US20240025985A1 (en) Agent for Preventing or Treating Frontotemporal Lobar Degeneration
MXPA06009560A (en) Anti-abeta antibody
WO2025076635A1 (en) Anti-alpha-synuclein antibodies and uses thereof
BR112017016345B1 (pt) Anticorpo humanizado, composição farmacêutica, ácido nucleico, vetor de expressão recombinante, célula hospedeira microbiana e uso de uma quantidade efetiva do anticorpo humanizado
BR112017016324B1 (pt) Anticorpo humanizado, composição farmacêutica, ácido nucleico e uso de um regime efetivo e de uma quantidade efetiva do anticorpo humanizado
BR112017016330B1 (pt) Anticorpo humanizado, composição farmacêutica, ácido nucleico e uso de um regime e de uma quantidade eficaz do anticorpo humanizado
BR112017017076B1 (pt) Uso de il-18bp
BR112016004772B1 (pt) Método para determinação da quantidade de il-18 livre em uma amostra ou in situ, uso de um inibidor de il-18, e, kit de diagnóstico para detectar il-18 livre