PT1658854E - Formulações úteis no tratamento da impotência masculina e feminina - Google Patents
Formulações úteis no tratamento da impotência masculina e feminina Download PDFInfo
- Publication number
- PT1658854E PT1658854E PT05025315T PT05025315T PT1658854E PT 1658854 E PT1658854 E PT 1658854E PT 05025315 T PT05025315 T PT 05025315T PT 05025315 T PT05025315 T PT 05025315T PT 1658854 E PT1658854 E PT 1658854E
- Authority
- PT
- Portugal
- Prior art keywords
- treatment
- male
- impotence
- formulations useful
- female
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 9
- 239000000203 mixture Substances 0.000 title abstract description 7
- 201000001881 impotence Diseases 0.000 title description 10
- 238000009472 formulation Methods 0.000 title description 3
- 240000000143 Turnera diffusa Species 0.000 claims abstract description 4
- 235000009206 Turnera diffusa Nutrition 0.000 claims abstract description 4
- 239000000284 extract Substances 0.000 claims abstract description 4
- 235000004952 turnera diffusa Nutrition 0.000 claims abstract description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims description 6
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 claims description 3
- 206010057671 Female sexual dysfunction Diseases 0.000 claims description 3
- 235000008100 Ginkgo biloba Nutrition 0.000 claims description 3
- 244000194101 Ginkgo biloba Species 0.000 claims description 3
- 206010057672 Male sexual dysfunction Diseases 0.000 claims description 3
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims description 3
- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 claims description 3
- 229940117916 cinnamic aldehyde Drugs 0.000 claims description 3
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 claims description 3
- VNONINPVFQTJOC-ZGXDEBHDSA-N dioscin Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O[C@H]1[C@@H]([C@H](O)[C@@H](O)[C@H](C)O1)O)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@H]5[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@@H]([C@]1(OC[C@H](C)CC1)O5)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O VNONINPVFQTJOC-ZGXDEBHDSA-N 0.000 claims description 3
- 229930003944 flavone Natural products 0.000 claims description 3
- 150000002212 flavone derivatives Chemical class 0.000 claims description 3
- 235000011949 flavones Nutrition 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims description 3
- 239000000539 dimer Substances 0.000 claims description 2
- 230000001568 sexual effect Effects 0.000 abstract description 2
- 239000004475 Arginine Substances 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 abstract 1
- 239000009429 Ginkgo biloba extract Substances 0.000 abstract 1
- 241001521901 Tribulus lanuginosus Species 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 235000017803 cinnamon Nutrition 0.000 abstract 1
- -1 esters salts Chemical class 0.000 abstract 1
- 229940068052 ginkgo biloba extract Drugs 0.000 abstract 1
- 235000020686 ginkgo biloba extract Nutrition 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 description 4
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 description 3
- 208000010228 Erectile Dysfunction Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229930008281 A03AD01 - Papaverine Natural products 0.000 description 2
- 201000001880 Sexual dysfunction Diseases 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- ZOOGRGPOEVQQDX-UHFFFAOYSA-N cyclic GMP Natural products O1C2COP(O)(=O)OC2C(O)C1N1C=NC2=C1NC(N)=NC2=O ZOOGRGPOEVQQDX-UHFFFAOYSA-N 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229960001789 papaverine Drugs 0.000 description 2
- 230000035790 physiological processes and functions Effects 0.000 description 2
- 231100000872 sexual dysfunction Toxicity 0.000 description 2
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 108060003345 Adrenergic Receptor Proteins 0.000 description 1
- 102000017910 Adrenergic receptor Human genes 0.000 description 1
- 206010002652 Anorgasmia Diseases 0.000 description 1
- 208000021663 Female sexual arousal disease Diseases 0.000 description 1
- 208000030663 Libido disease Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- QZVCTJOXCFMACW-UHFFFAOYSA-N Phenoxybenzamine Chemical compound C=1C=CC=CC=1CN(CCCl)C(C)COC1=CC=CC=C1 QZVCTJOXCFMACW-UHFFFAOYSA-N 0.000 description 1
- 208000006262 Psychological Sexual Dysfunctions Diseases 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229960002986 dinoprostone Drugs 0.000 description 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 1
- 230000003291 dopaminomimetic effect Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007915 intraurethral administration Methods 0.000 description 1
- VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 238000011458 pharmacological treatment Methods 0.000 description 1
- 229960003418 phenoxybenzamine Drugs 0.000 description 1
- MRBDMNSDAVCSSF-UHFFFAOYSA-N phentolamine Chemical compound C1=CC(C)=CC=C1N(C=1C=C(O)C=CC=1)CC1=NCCN1 MRBDMNSDAVCSSF-UHFFFAOYSA-N 0.000 description 1
- 229960001999 phentolamine Drugs 0.000 description 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 208000012201 sexual and gender identity disease Diseases 0.000 description 1
- 208000015891 sexual disease Diseases 0.000 description 1
- 229960003310 sildenafil Drugs 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940068797 tribulus terrestris extract Drugs 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Reproductive Health (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Description
1
DESCRIÇÃO
"FORMULAÇÕES ÚTEIS NO TRATAMENTO DA IMPOTÊNCIA MASCULINA E FEMININA" A presente invenção diz respeito a formulações que são úteis no tratamento de disfunções sexuais masculinas e femininas.
As disfunções sexuais possuem uma importância considerável, e constituem a matéria de intensivos esforços de investigação biomédica. De acordo com estatisticas recentes, o problema da impotência nas suas diferentes formas (ausência de libido e disfunções erécteis) afecta cerca de 70% da população com a idade de cerca de 50 anos e mais. 0 grau de impotência nas suas diferentes formas varia obviamente quanto à gravidade, especialmente entre indivíduos com idade avançada próximo da velhice, em que muitas vezes se associa sob o ponto de vista fisiológico com outros distúrbios tais como doença cardíaca ou renal.
Os fármacos actualmente disponíveis para tratar tais disfunções, especialmente a disfunção eréctil, incluem hormonas tais como testosterona, VIP, derivados de prostaglandinas (PGES) , e princípios activos cardiovasculares tais como papaverina, fenoxibenzamina e fentolamina.
No entanto, nenhum desses fármacos proporciona uma solução satisfatória permanente para o problema, devido aos efeitos secundários pelos quais são responsáveis e à necessidade de uma injecção intercavernosa ou intrauretral no caso da papaverina e da PGE2, por exemplo. 2
Recentemente, surgiram inibidores de fosfodiesterases específicas para o GMP cíclico (Monofosfato de Guanosina Cíclico) que são especialmente úteis no tratamento da impotência, e são activos pela via oral. Um desses agentes, denominado Sildenafil (WO 94/28902), encontra-se já comercializado. A seguir mais uma vez, contudo, os efeitos secundários não são de modo nenhum desprezáveis, e a necessidade de tratamentos mais seguros e mais eficazes é ainda fortemente sentida.
Presentemente estudam-se, através da farmacologia moderna, muitos produtos de origem natural (principalmente à base de plantas mas também à base de animais), com base nas indicações obtidas a partir da medicina tradicional, para avaliar a possível base científica para a sua utilização empírica.
Os estudos bioquímicos demonstram a grande complexidade dos mecanismos envolvidos nos processos fisiológicos associados à actividade sexual, tal como erecção peniana e clitoridiana, lubrificação vaginal, ejaculação e orgasmo.
Os mediadores tais como o óxido nítrico (NO), os factores enzimáticos envolvidos no metabolismo dos mensageiros cAMP e cGMP, os receptores adrenérgicos das membranas celulares do músculo liso, os neurotransmissores dopaminérgicos e os receptores de PGES ou outras hormonas constituem os alvos possíveis de um tratamento farmacológico da impotência e de outras disfunções sexuais. 3 É obviamente difícil fornecer uma solução satisfatória para este problema específico, em parte porque além dos aspectos puramente bioquímicos e fisiológicos existem igualmente factores ambientais e psicológicos que podem ainda complicar o quadro clínico dos doentes que padecem de perturbações sexuais.
Actualmente tem-se verificado que uma associação de extractos de plantas medicinais com propriedades específicas, em determinadas proporções quantitativas, proporciona resultados terapêuticos especialmente satisfatórios no tratamento de disfunções sexuais masculinas e femininas. A presente invenção diz respeito em particular à utilização de dioscina, uma flavona dimérica da ginkgo biloba, e de aldeído cinâmico em associação com um extracto lipofílico de Turnera diffusa na preparação de um fármaco para o tratamento de impotência, disfunção eréctil, perturbações da libido, frigidez e anorgasmia bem como aos fármacos que contêm a referida associação. A administração crónica das composições de acordo com a presente invenção não provoca quaisquer efeitos secundários significativos, é bem tolerada e não altera os delicados equilíbrios hormonais, especialmente o equilíbrio androgénio/estrogénio, que governam os acontecimentos fisiológicos principais nos homens e nas mulheres tais como a andropausa e a menopausa.
Exemplos de formas de administração apropriadas das composições de acordo com a presente invenção incluem 4 comprimidos, cápsulas de gelatina mole e dura, supositórios e preparações bebíveis que contêm doses unitárias compreendidas entre 100 e 300 mg de extracto de Tribulus terrestris e doses unitárias dos outros componentes. Preferem-se especialmente as formulações de fases sólidas tais como comprimidos de libertação não modificada ou gastrorresistentes ou formas líquidas bebíveis.
Lisboa, 13 de Março de 2009
Claims (2)
1 REIVINDICAÇÕES 1. Composição farmacêutica que compreende dioscina, um extracto lipofilico de Turnera diffusa, uma flavona dimérica de ginkgo biloba, e aldeído cinâmico.
2. Utilização de dioscina, um extracto lipofilico de Turnera diffusa, uma flavona dimérica de ginkgo biloba e aldeído cinâmico na preparação de um medicamento para o tratamento de disfunções sexuais masculinas e femininas. Lisboa, 13 de Março de 2009
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI000990A ITMI20020990A1 (it) | 2002-05-10 | 2002-05-10 | Formulazioni utili nel trattamento dell'impotenza maschile e femminile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1658854E true PT1658854E (pt) | 2009-03-23 |
Family
ID=11449866
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT05025315T PT1658854E (pt) | 2002-05-10 | 2003-04-30 | Formulações úteis no tratamento da impotência masculina e feminina |
| PT03729955T PT1503775E (pt) | 2002-05-10 | 2003-04-30 | Formulacoes uteis no tratamento da impotencia masculina e feminina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT03729955T PT1503775E (pt) | 2002-05-10 | 2003-04-30 | Formulacoes uteis no tratamento da impotencia masculina e feminina |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7128932B2 (pt) |
| EP (2) | EP1658854B1 (pt) |
| JP (1) | JP4603351B2 (pt) |
| KR (1) | KR20040102212A (pt) |
| CN (2) | CN101164559A (pt) |
| AT (2) | ATE319466T1 (pt) |
| AU (1) | AU2003240478B8 (pt) |
| CA (1) | CA2485264A1 (pt) |
| DE (2) | DE60303925T2 (pt) |
| DK (2) | DK1503775T3 (pt) |
| ES (2) | ES2259139T3 (pt) |
| HK (1) | HK1085374A1 (pt) |
| IL (2) | IL165081A (pt) |
| IT (1) | ITMI20020990A1 (pt) |
| NO (2) | NO332805B1 (pt) |
| PT (2) | PT1658854E (pt) |
| RU (2) | RU2313357C2 (pt) |
| SI (2) | SI1658854T1 (pt) |
| WO (1) | WO2003094943A1 (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6952691B2 (en) * | 2002-02-01 | 2005-10-04 | International Business Machines Corporation | Method and system for searching a multi-lingual database |
| EP1689373B1 (en) * | 2003-10-10 | 2019-04-03 | Ethypharm | Sustained-release microgranules containing ginkgo biloba extract and the process for manufacturing these |
| WO2006021930A2 (en) * | 2004-08-25 | 2006-03-02 | Femi-X A/S | Aphrodisiac herbal composition for a female comprising epimedium grandiflorum, turnera diffusa var. aphrodisiaca, ilex paraguariensis and smilax spp |
| KR100660116B1 (ko) * | 2005-01-26 | 2006-12-20 | (주)포메디 | 홍삼 및 대두를 주성분으로 포함하는 복합 한방 제제를유효성분으로 함유하는 성기능 개선용 조성물 |
| US20070042054A1 (en) * | 2005-04-20 | 2007-02-22 | Council Of Scientific And Industrial Research | Functional aphrodisiac rolled herbal bidis and cigarettes |
| EP1932531A1 (de) | 2006-12-11 | 2008-06-18 | Finzelberg GmbH & Co. KG | Spezialextrakt und seine Verwendung zur Hemmung des Abbaus von cyclischem Guanosinmonophosphat (cGMP) |
| US8362088B2 (en) * | 2006-12-14 | 2013-01-29 | Warnock W Matthew | Method and article of manufacture for encapsulating a homeopathic ingredient with a second ingredient |
| US20100178413A1 (en) * | 2008-12-17 | 2010-07-15 | Mark Gorris | Food-based Supplement Delivery System |
| US9918489B2 (en) * | 2008-12-17 | 2018-03-20 | Mark Gorris | Food-based supplement delivery system |
| CN102612370B (zh) * | 2009-09-17 | 2014-10-29 | 特拉达药物有限公司 | 刺激男性性功能的膳食补充剂 |
| ES2386859B1 (es) * | 2011-02-07 | 2013-03-22 | Eduardo Antonio Gómez De Diego | Composición natural para aumentar el vigor. |
| RU2458537C1 (ru) * | 2011-03-14 | 2012-08-20 | Общество С Ограниченной Ответственностью "Парафарм" | Биологически активная добавка к пище для профилактики эректильной дисфункции у мужчин |
| ITLI20110007A1 (it) * | 2011-09-10 | 2013-03-11 | Lloyds Internat Credit Llc | Una innovativa composizione naturale efficace per la cura dell'impotenza |
| TW201420745A (zh) * | 2012-11-26 | 2014-06-01 | Tian-De Li | 擴充男性海綿體的複方精油 |
| US10226418B2 (en) | 2014-05-12 | 2019-03-12 | Susie Q, Ltd. | Arginine-containing topical composition |
| US10016477B1 (en) | 2015-01-13 | 2018-07-10 | Roger Yomba Ngue | Natural composition |
| IT201700115753A1 (it) * | 2017-10-13 | 2019-04-13 | Cristalfarma S R L | Integratore per attenuare i disturbi nella donna causati dall’invecchiamento |
| EP3560488A1 (en) * | 2018-04-24 | 2019-10-30 | Procare Health Iberia, S.L. | Compositions for treating female sexual dysfunction |
| WO2022027122A1 (en) * | 2020-08-06 | 2022-02-10 | Ramade & Cia Holding Corp. | Compositions with cannabinoids of cannabis sativa for treating erectile and sexual dysfunction |
| IT202100031175A1 (it) * | 2021-12-13 | 2023-06-13 | Anvest Group S R L | Composizione per il trattamento della disfunzione erettile |
| GR1010519B (el) * | 2022-07-04 | 2023-08-10 | Νικολαος Τυμπανιδης | Καταπινομενο σκευασμα για τονωση της ζωτικοτητας, της αντοχης και της γενικοτερης ευεξιας των ανδρων |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1084746A (zh) * | 1992-11-25 | 1994-04-06 | 王立本 | 防治性病的特效壮阳药液及其制作方法 |
| KR0148511B1 (ko) * | 1993-09-14 | 1998-11-02 | 최형기 | 성신경과민증 예방 및 치료용 의약조성물 |
| IT1269634B (it) * | 1994-05-06 | 1997-04-08 | Indena Spa | Medicamento topico ad attivita' cicatrizzante |
| CN1141185A (zh) * | 1996-02-16 | 1997-01-29 | 范凯 | 保健药酒 |
| FR2765483B1 (fr) * | 1997-07-04 | 2000-02-04 | Philippe Gorny | Medicament destine a traiter les dysfonctions erectiles |
| US6007824A (en) * | 1998-07-09 | 1999-12-28 | Duckett; Melvin J. | Natural composition and method for the treatment of sexual dysfunction |
| CA2339356C (en) * | 1998-08-03 | 2007-06-26 | Ronald E. Wheeler | Prostate formula |
| WO2000072861A1 (en) * | 1999-05-27 | 2000-12-07 | Armadillo Pharmaceuticals, Inc. | Pharmaceutical preparations of bioactive substances extracted from natural sources |
| RU2153347C1 (ru) | 1999-06-04 | 2000-07-27 | Общество с ограниченной ответственностью "Доктор Н" | Гомеопатическое лекарственное средство для лечения импотенции |
| US6803060B2 (en) * | 2000-09-07 | 2004-10-12 | Joe Reyes | Composition to boost libido |
| US6444237B1 (en) * | 2001-09-13 | 2002-09-03 | Pamela A. Heleen | Herbal composition for enhancing sexual response |
| US20030068391A1 (en) * | 2001-10-04 | 2003-04-10 | Harris Dennis H. | Ingestible nerve and circulatory nutritional formulation |
-
2002
- 2002-05-10 IT IT2002MI000990A patent/ITMI20020990A1/it unknown
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2003
- 2003-04-30 PT PT05025315T patent/PT1658854E/pt unknown
- 2003-04-30 CN CNA2007101849612A patent/CN101164559A/zh active Pending
- 2003-04-30 AT AT03729955T patent/ATE319466T1/de active
- 2003-04-30 DK DK03729955T patent/DK1503775T3/da active
- 2003-04-30 RU RU2004132833/15A patent/RU2313357C2/ru not_active IP Right Cessation
- 2003-04-30 EP EP05025315A patent/EP1658854B1/en not_active Expired - Lifetime
- 2003-04-30 AU AU2003240478A patent/AU2003240478B8/en not_active Ceased
- 2003-04-30 EP EP03729955A patent/EP1503775B1/en not_active Expired - Lifetime
- 2003-04-30 SI SI200331496T patent/SI1658854T1/sl unknown
- 2003-04-30 CN CNB038103842A patent/CN100356935C/zh not_active Expired - Fee Related
- 2003-04-30 DE DE60303925T patent/DE60303925T2/de not_active Expired - Lifetime
- 2003-04-30 KR KR10-2004-7017861A patent/KR20040102212A/ko active Search and Examination
- 2003-04-30 ES ES03729955T patent/ES2259139T3/es not_active Expired - Lifetime
- 2003-04-30 SI SI200330200T patent/SI1503775T1/sl unknown
- 2003-04-30 AT AT05025315T patent/ATE418995T1/de active
- 2003-04-30 DE DE60325657T patent/DE60325657D1/de not_active Expired - Lifetime
- 2003-04-30 CA CA002485264A patent/CA2485264A1/en not_active Abandoned
- 2003-04-30 WO PCT/EP2003/004528 patent/WO2003094943A1/en active IP Right Grant
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- 2003-04-30 JP JP2004503026A patent/JP4603351B2/ja not_active Expired - Fee Related
- 2003-04-30 DK DK05025315T patent/DK1658854T3/da active
- 2003-04-30 PT PT03729955T patent/PT1503775E/pt unknown
- 2003-04-30 US US10/513,730 patent/US7128932B2/en not_active Expired - Fee Related
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2004
- 2004-11-08 IL IL165081A patent/IL165081A/en not_active IP Right Cessation
- 2004-11-22 NO NO20044855A patent/NO332805B1/no not_active IP Right Cessation
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2005
- 2005-09-16 HK HK05108114A patent/HK1085374A1/xx not_active IP Right Cessation
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2007
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2008
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