PT1553938E - Utilização de derivados de epotilona para o tratamento do hiperparatiroidismo - Google Patents
Utilização de derivados de epotilona para o tratamento do hiperparatiroidismo Download PDFInfo
- Publication number
- PT1553938E PT1553938E PT03748446T PT03748446T PT1553938E PT 1553938 E PT1553938 E PT 1553938E PT 03748446 T PT03748446 T PT 03748446T PT 03748446 T PT03748446 T PT 03748446T PT 1553938 E PT1553938 E PT 1553938E
- Authority
- PT
- Portugal
- Prior art keywords
- parathyroid
- treatment
- hyperparathyroidism
- lower alkyl
- recurrent
- Prior art date
Links
- 201000002980 Hyperparathyroidism Diseases 0.000 title claims abstract description 16
- 150000003883 epothilone derivatives Chemical class 0.000 title claims abstract description 16
- 150000003839 salts Chemical class 0.000 claims abstract description 12
- 241001465754 Metazoa Species 0.000 claims abstract description 10
- 150000001875 compounds Chemical class 0.000 claims description 22
- 208000000821 Parathyroid Neoplasms Diseases 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 14
- 239000001257 hydrogen Substances 0.000 claims description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 201000003913 parathyroid carcinoma Diseases 0.000 claims description 9
- 208000017954 parathyroid gland carcinoma Diseases 0.000 claims description 9
- 206010033964 Parathyroid tumour benign Diseases 0.000 claims description 8
- 201000003686 parathyroid adenoma Diseases 0.000 claims description 8
- 208000014643 parathyroid gland adenoma Diseases 0.000 claims description 8
- 208000025061 parathyroid hyperplasia Diseases 0.000 claims description 8
- 230000002085 persistent effect Effects 0.000 claims description 8
- 230000000306 recurrent effect Effects 0.000 claims description 8
- 208000037147 Hypercalcaemia Diseases 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 6
- 230000000148 hypercalcaemia Effects 0.000 claims description 6
- 208000030915 hypercalcemia disease Diseases 0.000 claims description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
- -1 methoxy, ethoxy, amino, methylamino, dimethylamino Chemical group 0.000 claims description 5
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 230000003442 weekly effect Effects 0.000 claims description 3
- 208000003200 Adenoma Diseases 0.000 claims description 2
- 206010001233 Adenoma benign Diseases 0.000 claims description 2
- 201000009030 Carcinoma Diseases 0.000 claims description 2
- 206010020707 Hyperparathyroidism primary Diseases 0.000 claims description 2
- 201000000981 Primary Hyperparathyroidism Diseases 0.000 claims description 2
- 208000005770 Secondary Hyperparathyroidism Diseases 0.000 claims description 2
- 206010020718 hyperplasia Diseases 0.000 claims description 2
- 241000321096 Adenoides Species 0.000 claims 1
- 210000002534 adenoid Anatomy 0.000 claims 1
- 208000026045 malignant tumor of parathyroid gland Diseases 0.000 claims 1
- 230000000849 parathyroid Effects 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 9
- QXRSDHAAWVKZLJ-PVYNADRNSA-N epothilone B Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 QXRSDHAAWVKZLJ-PVYNADRNSA-N 0.000 description 15
- HESCAJZNRMSMJG-HGYUPSKWSA-N epothilone A Natural products O=C1[C@H](C)[C@H](O)[C@H](C)CCC[C@H]2O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C HESCAJZNRMSMJG-HGYUPSKWSA-N 0.000 description 14
- QXRSDHAAWVKZLJ-OXZHEXMSSA-N Epothilone B Natural products O=C1[C@H](C)[C@H](O)[C@@H](C)CCC[C@@]2(C)O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C QXRSDHAAWVKZLJ-OXZHEXMSSA-N 0.000 description 13
- 206010028980 Neoplasm Diseases 0.000 description 13
- 239000004480 active ingredient Substances 0.000 description 8
- 230000002491 angiogenic effect Effects 0.000 description 6
- 230000000977 initiatory effect Effects 0.000 description 5
- 230000006427 angiogenic response Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical class C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 230000033115 angiogenesis Effects 0.000 description 3
- 230000001142 anti-diarrhea Effects 0.000 description 3
- 208000002458 carcinoid tumor Diseases 0.000 description 3
- 229930013356 epothilone Natural products 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 238000006722 reduction reaction Methods 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 102000003982 Parathyroid hormone Human genes 0.000 description 2
- 108090000445 Parathyroid hormone Proteins 0.000 description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 description 2
- 239000004037 angiogenesis inhibitor Substances 0.000 description 2
- 229940125714 antidiarrheal agent Drugs 0.000 description 2
- 239000003793 antidiarrheal agent Substances 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940034982 antineoplastic agent Drugs 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 150000003951 lactams Chemical class 0.000 description 2
- 229940005483 opioid analgesics Drugs 0.000 description 2
- 239000000199 parathyroid hormone Substances 0.000 description 2
- 229960001319 parathyroid hormone Drugs 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 208000028198 tertiary hyperparathyroidism Diseases 0.000 description 2
- 229960004072 thrombin Drugs 0.000 description 2
- 230000002992 thymic effect Effects 0.000 description 2
- 201000002510 thyroid cancer Diseases 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 description 1
- LVRVABPNVHYXRT-BQWXUCBYSA-N 52906-92-0 Chemical compound C([C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)C(C)C)C1=CC=CC=C1 LVRVABPNVHYXRT-BQWXUCBYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- BEFZAMRWPCMWFJ-JRBBLYSQSA-N Epothilone C Natural products O=C1[C@H](C)[C@@H](O)[C@@H](C)CCC/C=C\C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C BEFZAMRWPCMWFJ-JRBBLYSQSA-N 0.000 description 1
- XOZIUKBZLSUILX-SDMHVBBESA-N Epothilone D Natural products O=C1[C@H](C)[C@@H](O)[C@@H](C)CCC/C(/C)=C/C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C XOZIUKBZLSUILX-SDMHVBBESA-N 0.000 description 1
- 102000029749 Microtubule Human genes 0.000 description 1
- 108091022875 Microtubule Proteins 0.000 description 1
- 102000002419 Motilin Human genes 0.000 description 1
- 101800002372 Motilin Proteins 0.000 description 1
- 108010016076 Octreotide Proteins 0.000 description 1
- 208000006265 Renal cell carcinoma Diseases 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 1
- 229940093265 berberine Drugs 0.000 description 1
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 1
- ZREIPSZUJIFJNP-UHFFFAOYSA-K bismuth subsalicylate Chemical compound C1=CC=C2O[Bi](O)OC(=O)C2=C1 ZREIPSZUJIFJNP-UHFFFAOYSA-K 0.000 description 1
- 229960000782 bismuth subsalicylate Drugs 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 230000037182 bone density Effects 0.000 description 1
- 201000008275 breast carcinoma Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000003021 clonogenic effect Effects 0.000 description 1
- 229960004126 codeine Drugs 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- BEFZAMRWPCMWFJ-UHFFFAOYSA-N desoxyepothilone A Natural products O1C(=O)CC(O)C(C)(C)C(=O)C(C)C(O)C(C)CCCC=CCC1C(C)=CC1=CSC(C)=N1 BEFZAMRWPCMWFJ-UHFFFAOYSA-N 0.000 description 1
- XOZIUKBZLSUILX-UHFFFAOYSA-N desoxyepothilone B Natural products O1C(=O)CC(O)C(C)(C)C(=O)C(C)C(O)C(C)CCCC(C)=CCC1C(C)=CC1=CSC(C)=N1 XOZIUKBZLSUILX-UHFFFAOYSA-N 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229960004192 diphenoxylate Drugs 0.000 description 1
- HYPPXZBJBPSRLK-UHFFFAOYSA-N diphenoxylate Chemical compound C1CC(C(=O)OCC)(C=2C=CC=CC=2)CCN1CCC(C#N)(C=1C=CC=CC=1)C1=CC=CC=C1 HYPPXZBJBPSRLK-UHFFFAOYSA-N 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- BEFZAMRWPCMWFJ-QJKGZULSSA-N epothilone C Chemical compound O1C(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC\C=C/C[C@H]1C(\C)=C\C1=CSC(C)=N1 BEFZAMRWPCMWFJ-QJKGZULSSA-N 0.000 description 1
- XOZIUKBZLSUILX-GIQCAXHBSA-N epothilone D Chemical compound O1C(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC\C(C)=C/C[C@H]1C(\C)=C\C1=CSC(C)=N1 XOZIUKBZLSUILX-GIQCAXHBSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
- 238000010874 in vitro model Methods 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- RDOIQAHITMMDAJ-UHFFFAOYSA-N loperamide Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)N(C)C)CCN(CC1)CCC1(O)C1=CC=C(Cl)C=C1 RDOIQAHITMMDAJ-UHFFFAOYSA-N 0.000 description 1
- 229960001571 loperamide Drugs 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 239000000472 muscarinic agonist Substances 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000014399 negative regulation of angiogenesis Effects 0.000 description 1
- 229960002700 octreotide Drugs 0.000 description 1
- 229940050957 opium tincture Drugs 0.000 description 1
- 239000008414 paregoric Substances 0.000 description 1
- 229940069533 paregoric Drugs 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000005932 reductive alkylation reaction Methods 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41859202P | 2002-10-15 | 2002-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1553938E true PT1553938E (pt) | 2007-03-30 |
Family
ID=32107949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT03748446T PT1553938E (pt) | 2002-10-15 | 2003-10-13 | Utilização de derivados de epotilona para o tratamento do hiperparatiroidismo |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20060142354A1 (https=) |
| EP (1) | EP1553938B1 (https=) |
| JP (1) | JP4672368B2 (https=) |
| CN (1) | CN1297269C (https=) |
| AT (1) | ATE350034T1 (https=) |
| AU (1) | AU2003267751A1 (https=) |
| BR (1) | BR0315293A (https=) |
| CA (1) | CA2501717C (https=) |
| CY (1) | CY1106385T1 (https=) |
| DE (1) | DE60310975T2 (https=) |
| DK (1) | DK1553938T3 (https=) |
| ES (1) | ES2279139T3 (https=) |
| PT (1) | PT1553938E (https=) |
| SI (1) | SI1553938T1 (https=) |
| WO (1) | WO2004035050A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60330407D1 (de) | 2002-08-23 | 2010-01-14 | Sloan Kettering Inst Cancer | Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1155689B1 (en) * | 1993-07-19 | 2006-09-20 | Angiotech Pharmaceuticals, Inc. | Anti-angiogenic stents and methods of their preparation |
| DK1367057T3 (da) * | 1996-11-18 | 2009-01-19 | Biotechnolog Forschung Gmbh | Epothiloner E og F |
| US6380394B1 (en) * | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
| SK287775B6 (sk) * | 1998-02-05 | 2011-09-05 | Novartis Ag | Farmaceutická formulácia obsahujúca epothilon, infúzny roztok a použitie farmaceutickej formulácie |
| US6302838B1 (en) * | 1998-02-25 | 2001-10-16 | Novartis Ag | Cancer treatment with epothilones |
-
2003
- 2003-10-13 CA CA2501717A patent/CA2501717C/en not_active Expired - Fee Related
- 2003-10-13 BR BR0315293-6A patent/BR0315293A/pt not_active IP Right Cessation
- 2003-10-13 SI SI200330741T patent/SI1553938T1/sl unknown
- 2003-10-13 PT PT03748446T patent/PT1553938E/pt unknown
- 2003-10-13 US US10/530,855 patent/US20060142354A1/en not_active Abandoned
- 2003-10-13 ES ES03748446T patent/ES2279139T3/es not_active Expired - Lifetime
- 2003-10-13 EP EP03748446A patent/EP1553938B1/en not_active Expired - Lifetime
- 2003-10-13 CN CNB200380101281XA patent/CN1297269C/zh not_active Expired - Fee Related
- 2003-10-13 AU AU2003267751A patent/AU2003267751A1/en not_active Abandoned
- 2003-10-13 JP JP2004544592A patent/JP4672368B2/ja not_active Expired - Fee Related
- 2003-10-13 WO PCT/IB2003/004514 patent/WO2004035050A1/en not_active Ceased
- 2003-10-13 AT AT03748446T patent/ATE350034T1/de active
- 2003-10-13 DK DK03748446T patent/DK1553938T3/da active
- 2003-10-13 DE DE60310975T patent/DE60310975T2/de not_active Expired - Lifetime
-
2007
- 2007-03-15 CY CY20071100363T patent/CY1106385T1/el unknown
-
2011
- 2011-03-01 US US13/037,989 patent/US20110152329A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110152329A1 (en) | 2011-06-23 |
| DE60310975T2 (de) | 2007-07-12 |
| BR0315293A (pt) | 2005-08-30 |
| EP1553938A1 (en) | 2005-07-20 |
| DE60310975D1 (de) | 2007-02-15 |
| JP4672368B2 (ja) | 2011-04-20 |
| EP1553938B1 (en) | 2007-01-03 |
| AU2003267751A1 (en) | 2004-05-04 |
| WO2004035050A1 (en) | 2004-04-29 |
| CN1703217A (zh) | 2005-11-30 |
| DK1553938T3 (da) | 2007-03-26 |
| SI1553938T1 (sl) | 2007-06-30 |
| CY1106385T1 (el) | 2011-10-12 |
| ES2279139T3 (es) | 2007-08-16 |
| CA2501717C (en) | 2012-09-18 |
| CN1297269C (zh) | 2007-01-31 |
| JP2006504751A (ja) | 2006-02-09 |
| ATE350034T1 (de) | 2007-01-15 |
| CA2501717A1 (en) | 2004-04-29 |
| US20060142354A1 (en) | 2006-06-29 |
| HK1080768A1 (en) | 2006-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU735884B2 (en) | Treatment of carcinomas using squalamine in combination with other anti-cancer agents | |
| EP4322941A1 (en) | Combination comprising ribociclib and amcenestrant | |
| US20040266809A1 (en) | Method of treating multiple myeloma | |
| JP4672257B2 (ja) | エポチロンを含む組成物およびカルチノイド症候群の治療のためのそれらの使用 | |
| ES2330324T3 (es) | Derivados del epotilon para el tratamiento del hepatoma y de otros canceres. | |
| TWI341728B (en) | Combinations comprising epothilones and anti-metabolites | |
| CZ284966B6 (cs) | Použití kreatinfosfátu a fosfoenolpyrohroznové kyseliny pro přípravu léčiv pro léčení nádorů a farmaceutický prostředek | |
| PT1553938E (pt) | Utilização de derivados de epotilona para o tratamento do hiperparatiroidismo | |
| JP2023509191A (ja) | 癌を治療するための組み合わせ療法 | |
| WO2021133862A1 (en) | Targeting the intrinsic apoptotic machinery in glioblastoma | |
| South-East European Oncology Group (SEEOG) et al. | Phase II study of 4′-epi-doxorubicin in patients with untreated, extensive small cell lung cancer | |
| JP2008514721A (ja) | 治療方法 | |
| US4517309A (en) | Method for the treatment of calcifying pancreatitis | |
| CA2519037A1 (en) | Treatment of proliferative diseases with epothilone derivatives and radiation | |
| AU2002366531B2 (en) | Compositions comprising epothilones and their use for the treatment of carcinoid syndrome | |
| HK1080768B (en) | Use of epothilone derivatives for the treatment of hyperparathyroidism | |
| WO2003037322A1 (en) | Combination of an atp-competitive inhibitor of bcr/abl kinase activity and a tyrphostin analog | |
| JP2004514683A (ja) | レバミゾール及び５−フルオロウラシルの同時投与法 | |
| JP2002524481A (ja) | 他の抗癌剤または理学療法と組み合わせたスクアラミンを使用する癌腫の処置 | |
| HK1069983B (en) | Compositions comprising epothilones and their use for the treatment of the carcinoid syndrome |