PT1515717E - Sais de cálcio de estatinas derivadas de indole - Google Patents

Sais de cálcio de estatinas derivadas de indole Download PDF

Info

Publication number
PT1515717E
PT1515717E PT03740234T PT03740234T PT1515717E PT 1515717 E PT1515717 E PT 1515717E PT 03740234 T PT03740234 T PT 03740234T PT 03740234 T PT03740234 T PT 03740234T PT 1515717 E PT1515717 E PT 1515717E
Authority
PT
Portugal
Prior art keywords
alkyl
calcium
calcium salts
present
aralkyl
Prior art date
Application number
PT03740234T
Other languages
English (en)
Inventor
Guang-Pei Chen
Prasad Koteswara Kapa
Paul Allen Sutton
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT1515717E publication Critical patent/PT1515717E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
PT03740234T 2002-06-13 2003-06-12 Sais de cálcio de estatinas derivadas de indole PT1515717E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38831802P 2002-06-13 2002-06-13

Publications (1)

Publication Number Publication Date
PT1515717E true PT1515717E (pt) 2009-02-20

Family

ID=29736457

Family Applications (1)

Application Number Title Priority Date Filing Date
PT03740234T PT1515717E (pt) 2002-06-13 2003-06-12 Sais de cálcio de estatinas derivadas de indole

Country Status (13)

Country Link
US (2) US20060035941A1 (pt)
EP (1) EP1515717B8 (pt)
JP (1) JP2005532362A (pt)
AT (1) ATE409476T1 (pt)
AU (1) AU2003276960A1 (pt)
CA (1) CA2486557A1 (pt)
CY (1) CY1108675T1 (pt)
DE (1) DE60323835D1 (pt)
DK (1) DK1515717T3 (pt)
ES (1) ES2315510T3 (pt)
PT (1) PT1515717E (pt)
SI (1) SI1515717T1 (pt)
WO (1) WO2003105837A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060024428A (ko) * 2003-06-18 2006-03-16 테바 파마슈티컬 인더스트리즈 리미티드 플루바스타틴 나트륨 결정 형태, 이것의 제조 방법, 상기결정 형태를 포함하는 조성물 및 상기 결정 형태를이용하는 방법
US20090042979A1 (en) * 2004-08-06 2009-02-12 Transform Pharmaceuticals Inc. Novel Statin Pharmaceutical Compositions and Related Methods of Treatment
WO2006017698A2 (en) 2004-08-06 2006-02-16 Transform Pharmaceuticals, Inc. Novel statin pharmaceutical compositions and related methods of treatment
JP2008516890A (ja) * 2004-08-06 2008-05-22 トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド 新規なフェノフィブラート製剤および関連治療方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA814854B (en) * 1980-07-17 1982-07-28 J Klosa Nonhygroscopic salts of 4-hydroxybutryric acid, methods of their production and pharmaceutical preparations containing these salts
EP0044801B1 (de) * 1980-07-17 1984-02-15 Josef Dr. Klosa Nichthygroskopische Salze der 4-Hydroxybuttersäure, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Mittel
JPS643178B2 (pt) * 1980-07-28 1989-01-19 Abbott Lab
US5354772A (en) * 1982-11-22 1994-10-11 Sandoz Pharm. Corp. Indole analogs of mevalonolactone and derivatives thereof
JPS63101320A (ja) * 1986-10-17 1988-05-06 Dainippon Pharmaceut Co Ltd バルプロ酸カルシウム製剤
DE3709230A1 (de) * 1987-03-20 1988-10-06 Desitin Arzneimittel Gmbh Neues calciumsalz der valproinsaeure
US5189164A (en) * 1989-05-22 1993-02-23 Sandoz Ltd. Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
HU9203780D0 (en) * 1991-12-12 1993-03-29 Sandoz Ag Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them
US5777552A (en) * 1995-08-02 1998-07-07 Sentrol, Inc. Curtain door alarm
US7927636B1 (en) * 1997-07-14 2011-04-19 Interhealth Nutraceuticals, Inc. Hydroxycitric acid compositions, pharmaceutical and dietary supplements and food products made therefrom, and methods for their use in reducing body weight
CA2326874C (en) * 1998-04-01 2010-05-25 Ganeden Biotech, Inc. Methods for reducing cholesterol using bacillus coagulans spores, systems and compositions
SI20070A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nove soli inhibitorjev HMG-CoA reduktaze
WO2000053566A1 (en) * 1999-03-08 2000-09-14 Merck & Co., Inc. Crystalline hydrated dihydroxy open-acid simvastatin calcium salt
YU35802A (sh) * 1999-11-17 2005-07-19 Teva Pharmaceutical Industries Ltd. Polimorfni oblik atorvastatin kalcijuma
GB0003305D0 (en) * 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
US6242003B1 (en) * 2000-04-13 2001-06-05 Novartis Ag Organic compounds
US6743926B2 (en) * 2000-05-26 2004-06-01 Ciba Specialty Chemicals Corporation Process for the preparation of indole derivatives and intermediates of the process
WO2001093860A1 (en) * 2000-06-09 2001-12-13 Lek Pharmaceuticals D.D. Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
HU229280B1 (en) * 2000-07-19 2013-10-28 Novartis Ag Valsartan salts
ATE302756T1 (de) * 2000-10-31 2005-09-15 Ciba Sc Holding Ag Kristalline formen von fluvastatin sodium
US6777443B2 (en) * 2001-05-15 2004-08-17 Novartis Ag Dipeptide derivatives
US6686642B2 (en) * 2001-06-11 2004-02-03 Hewlett-Packard Development Company, L.P. Multi-level integrated circuit for wide-gap substrate bonding
KR20040026705A (ko) * 2001-08-16 2004-03-31 테바 파마슈티컬 인더스트리즈 리미티드 스타틴의 칼슘 염 형태의 제조 방법
US6869970B2 (en) * 2002-02-04 2005-03-22 Novartis Ag Crystalline salt forms of valsartan
GB0210234D0 (en) * 2002-05-03 2002-06-12 Novartis Ag Process for the manufacture of organic compounds
US6859970B2 (en) * 2002-07-18 2005-03-01 Matsushita Electric Corporation Of America Agitator for vacuum cleaner/extractor
BRPI0409292A (pt) * 2003-04-11 2006-04-11 Lek Pharmaceuticals processo para a preparação de sal de cálcio amorfo de atorvastatina

Also Published As

Publication number Publication date
US20060035941A1 (en) 2006-02-16
US20100249204A1 (en) 2010-09-30
EP1515717B8 (en) 2009-12-16
JP2005532362A (ja) 2005-10-27
SI1515717T1 (sl) 2009-02-28
AU2003276960A1 (en) 2003-12-31
WO2003105837A1 (en) 2003-12-24
EP1515717B1 (en) 2008-10-01
DK1515717T3 (da) 2009-02-09
CA2486557A1 (en) 2003-12-24
ATE409476T1 (de) 2008-10-15
EP1515717A1 (en) 2005-03-23
ES2315510T3 (es) 2009-04-01
CY1108675T1 (el) 2014-04-09
DE60323835D1 (de) 2008-11-13

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