PT1421389E - Marcadores neurofibrilares - Google Patents

Marcadores neurofibrilares Download PDF

Info

Publication number
PT1421389E
PT1421389E PT02720102T PT02720102T PT1421389E PT 1421389 E PT1421389 E PT 1421389E PT 02720102 T PT02720102 T PT 02720102T PT 02720102 T PT02720102 T PT 02720102T PT 1421389 E PT1421389 E PT 1421389E
Authority
PT
Portugal
Prior art keywords
tau
tau protein
derivative
agent
binding
Prior art date
Application number
PT02720102T
Other languages
English (en)
Inventor
Claude Michel Wischik
Charles Robert Harrington
Janet Elizabeth Rickard
David Horsley
Original Assignee
Wista Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wista Lab Ltd filed Critical Wista Lab Ltd
Publication of PT1421389E publication Critical patent/PT1421389E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/583—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with non-fluorescent dye label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Lubricants (AREA)
PT02720102T 2001-03-20 2002-03-20 Marcadores neurofibrilares PT1421389E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0106953.3A GB0106953D0 (en) 2001-03-20 2001-03-20 Neufofibrillary labels

Publications (1)

Publication Number Publication Date
PT1421389E true PT1421389E (pt) 2012-07-10

Family

ID=9911161

Family Applications (1)

Application Number Title Priority Date Filing Date
PT02720102T PT1421389E (pt) 2001-03-20 2002-03-20 Marcadores neurofibrilares

Country Status (13)

Country Link
US (3) US7335652B2 (pt)
EP (1) EP1421389B1 (pt)
JP (2) JP4288073B2 (pt)
CN (2) CN1578910A (pt)
AT (1) ATE556323T1 (pt)
AU (1) AU2002251172B2 (pt)
CA (1) CA2440794C (pt)
DK (1) DK1421389T3 (pt)
ES (1) ES2386773T3 (pt)
GB (1) GB0106953D0 (pt)
HK (1) HK1062044A1 (pt)
PT (1) PT1421389E (pt)
WO (1) WO2002075318A2 (pt)

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CN102942537B (zh) * 2012-11-09 2014-07-02 浙江大学 一种用作pH荧光探针的苯并噻唑-苯胺类化合物及其制备方法
US9186361B2 (en) 2013-03-15 2015-11-17 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
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US10765755B1 (en) 2013-11-20 2020-09-08 University Of South Florida Preparation and characterization of methylene blue nanoparticles for Alzheimer's disease and other tauopathies
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CN107163022B (zh) * 2016-03-07 2021-07-16 上海如絮生物科技有限公司 一种异喹啉类化合物、其中间体、制备方法和应用
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Also Published As

Publication number Publication date
CN101696977B (zh) 2014-02-19
AU2002251172B2 (en) 2007-12-06
HK1062044A1 (en) 2004-10-15
US20040213736A1 (en) 2004-10-28
CN101696977A (zh) 2010-04-21
WO2002075318A3 (en) 2004-03-11
US8097615B2 (en) 2012-01-17
EP1421389A2 (en) 2004-05-26
WO2002075318A2 (en) 2002-09-26
DK1421389T3 (da) 2012-08-13
US7713962B2 (en) 2010-05-11
US20100285605A1 (en) 2010-11-11
JP4288073B2 (ja) 2009-07-01
ES2386773T3 (es) 2012-08-30
GB0106953D0 (en) 2001-05-09
JP2009035566A (ja) 2009-02-19
CA2440794C (en) 2012-05-01
US7335652B2 (en) 2008-02-26
ATE556323T1 (de) 2012-05-15
EP1421389B1 (en) 2012-05-02
CN1578910A (zh) 2005-02-09
JP2004537034A (ja) 2004-12-09
CA2440794A1 (en) 2002-09-26
US20080219929A1 (en) 2008-09-11

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