PT1186601E - Novos derivados de isoquinolina ou seus sais - Google Patents
Novos derivados de isoquinolina ou seus saisInfo
- Publication number
- PT1186601E PT1186601E PT00931652T PT00931652T PT1186601E PT 1186601 E PT1186601 E PT 1186601E PT 00931652 T PT00931652 T PT 00931652T PT 00931652 T PT00931652 T PT 00931652T PT 1186601 E PT1186601 E PT 1186601E
- Authority
- PT
- Portugal
- Prior art keywords
- compound
- cardiac
- dialkoxy
- drug
- derivatives
- Prior art date
Links
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical class C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title 1
- 230000000747 cardiac effect Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010061216 Infarction Diseases 0.000 abstract 1
- 206010042600 Supraventricular arrhythmias Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 230000036461 convulsion Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000007574 infarction Effects 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- ZTHRQJQJODGZHV-UHFFFAOYSA-N n-phenylpropanamide Chemical class CCC(=O)NC1=CC=CC=C1 ZTHRQJQJODGZHV-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15621799 | 1999-06-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1186601E true PT1186601E (pt) | 2004-06-30 |
Family
ID=15622928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00931652T PT1186601E (pt) | 1999-06-03 | 2000-06-01 | Novos derivados de isoquinolina ou seus sais |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6573279B1 (pt) |
| EP (1) | EP1186601B1 (pt) |
| JP (1) | JP3741042B2 (pt) |
| KR (1) | KR100664893B1 (pt) |
| CN (1) | CN1136215C (pt) |
| AT (1) | ATE262518T1 (pt) |
| AU (1) | AU4952800A (pt) |
| CA (1) | CA2373880C (pt) |
| DE (1) | DE60009287T2 (pt) |
| DK (1) | DK1186601T3 (pt) |
| ES (1) | ES2214276T3 (pt) |
| MX (1) | MXPA01012392A (pt) |
| PT (1) | PT1186601E (pt) |
| WO (1) | WO2000075133A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1362590E (pt) * | 2002-07-25 | 2004-05-31 | Boehringer Ingelheim Pharma | Utilizacao de cilobradina ou dos seus sais farmaceuticamente aceitaveis para o tratamento ou prevencao de falha cardiaca |
| US20040138306A1 (en) | 2002-07-25 | 2004-07-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of a specific cyclic amine derivative or the pharmaceutically acceptable salts thereof for the treatment or prevention of heart failure |
| WO2004058710A1 (ja) * | 2002-12-25 | 2004-07-15 | Astellas Pharma Inc. | 新規ベンズアミド誘導体及びその製造法 |
| JPWO2004089933A1 (ja) * | 2003-04-02 | 2006-07-06 | アステラス製薬株式会社 | フルオロベンズアミド誘導体の新規結晶 |
| JPWO2007023775A1 (ja) * | 2005-08-23 | 2009-02-26 | アステラス製薬株式会社 | 心房細動治療剤 |
| US20100210633A1 (en) * | 2006-10-12 | 2010-08-19 | Epix Delaware, Inc. | Carboxamide compounds and their use |
| KR101352709B1 (ko) * | 2007-05-22 | 2014-01-16 | 아스테라스 세이야쿠 가부시키가이샤 | 1위 치환 테트라히드로이소퀴놀린 화합물 |
| WO2009076404A1 (en) * | 2007-12-10 | 2009-06-18 | Epix Delaware, Inc. | Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor |
| US8569282B2 (en) | 2007-12-11 | 2013-10-29 | Cytopathfinder, Inc. | Carboxamide compounds and their use |
| KR20140057604A (ko) | 2011-08-12 | 2014-05-13 | 베링거잉겔하임베트메디카게엠베하 | 고양잇과 동물의 심부전을 치료 및 예방하는 방법에 사용하기 위한 퍼니 전류 억제제 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4059583A (en) * | 1975-11-13 | 1977-11-22 | Mcneil Laboratories, Incorporated | Substituted indoles |
| JPH02138172A (ja) * | 1988-11-19 | 1990-05-28 | Mitsubishi Kasei Corp | β−アミノ酸アミド誘導体 |
| AU4319797A (en) * | 1996-09-25 | 1998-04-17 | Yamanouchi Pharmaceutical Co., Ltd. | 2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinoline derivatives or medicinal compositions thereof |
-
2000
- 2000-06-01 CA CA002373880A patent/CA2373880C/en not_active Expired - Fee Related
- 2000-06-01 ES ES00931652T patent/ES2214276T3/es not_active Expired - Lifetime
- 2000-06-01 EP EP00931652A patent/EP1186601B1/en not_active Expired - Lifetime
- 2000-06-01 AU AU49528/00A patent/AU4952800A/en not_active Abandoned
- 2000-06-01 CN CNB008082707A patent/CN1136215C/zh not_active Expired - Fee Related
- 2000-06-01 MX MXPA01012392A patent/MXPA01012392A/es active IP Right Grant
- 2000-06-01 DE DE60009287T patent/DE60009287T2/de not_active Expired - Lifetime
- 2000-06-01 WO PCT/JP2000/003564 patent/WO2000075133A1/ja active IP Right Grant
- 2000-06-01 KR KR1020017015403A patent/KR100664893B1/ko not_active IP Right Cessation
- 2000-06-01 AT AT00931652T patent/ATE262518T1/de active
- 2000-06-01 DK DK00931652T patent/DK1186601T3/da active
- 2000-06-01 US US09/980,402 patent/US6573279B1/en not_active Expired - Fee Related
- 2000-06-01 PT PT00931652T patent/PT1186601E/pt unknown
- 2000-06-01 JP JP2001502416A patent/JP3741042B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6573279B1 (en) | 2003-06-03 |
| CA2373880A1 (en) | 2000-12-14 |
| DE60009287T2 (de) | 2005-02-17 |
| KR100664893B1 (ko) | 2007-01-09 |
| ATE262518T1 (de) | 2004-04-15 |
| JP3741042B2 (ja) | 2006-02-01 |
| EP1186601A4 (en) | 2002-10-30 |
| KR20020005765A (ko) | 2002-01-17 |
| AU4952800A (en) | 2000-12-28 |
| MXPA01012392A (es) | 2002-07-30 |
| ES2214276T3 (es) | 2004-09-16 |
| CA2373880C (en) | 2009-04-07 |
| WO2000075133A1 (fr) | 2000-12-14 |
| EP1186601A1 (en) | 2002-03-13 |
| DE60009287D1 (de) | 2004-04-29 |
| EP1186601B1 (en) | 2004-03-24 |
| CN1379773A (zh) | 2002-11-13 |
| DK1186601T3 (da) | 2004-06-01 |
| CN1136215C (zh) | 2004-01-28 |
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