PT115056A - Formas amorfas de agentes quelantes e seus métodos de preparação - Google Patents

Formas amorfas de agentes quelantes e seus métodos de preparação

Info

Publication number
PT115056A
PT115056A PT115056A PT11505618A PT115056A PT 115056 A PT115056 A PT 115056A PT 115056 A PT115056 A PT 115056A PT 11505618 A PT11505618 A PT 11505618A PT 115056 A PT115056 A PT 115056A
Authority
PT
Portugal
Prior art keywords
agents
cheling
amorphic
preparation methods
production
Prior art date
Application number
PT115056A
Other languages
English (en)
Other versions
PT115056B (pt
Inventor
Antunes Rafael
Saldanha Susana
Parreira Antonio
Sequeira Sara
Original Assignee
Hovione Farm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Farm Sa filed Critical Hovione Farm Sa
Priority to PT115056A priority Critical patent/PT115056B/pt
Priority to PCT/GB2019/052799 priority patent/WO2020070508A1/en
Priority to AU2019354251A priority patent/AU2019354251A1/en
Priority to EP19790705.8A priority patent/EP3860973A1/en
Priority to US17/281,732 priority patent/US20220002226A1/en
Priority to CN201980065426.6A priority patent/CN113015718A/zh
Priority to JP2021516727A priority patent/JP2022503804A/ja
Priority to CA3114278A priority patent/CA3114278A1/en
Priority to KR1020217013330A priority patent/KR20210078503A/ko
Publication of PT115056A publication Critical patent/PT115056A/pt
Priority to IL281892A priority patent/IL281892A/en
Publication of PT115056B publication Critical patent/PT115056B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/76—Metal complexes of amino carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A PRESENTE INVENÇÃO REFERE-SE A UMA NOVA FORMA AMORFA E ESTÁVEL DE AGENTES QUELANTES, PARA COMPOSIÇÕES E OUTROS USOS, BEM COMO AO PROCESSO DE PRODUÇÃO DA MESMA ESPECIALMENTE NA FORMA DE PARTÍCULAS. MAIS ESPECIFICAMENTE, ESTA INVENÇÃO REFERE-SE A UM PROCESSO DE PRODUÇÃO DE AGENTES QUELANTES ESSENCIALMENTE AMORFOS ATRAVÉS DA DISSOLUÇÃO DOS MESMOS NUM SOLVENTE ADEQUADO OU NUMA MISTURA DE SOLVENTES, OPCIONALMENTE PURIFICANDO A SOLUÇÃO E ISOLANDO AS PARTÍCULAS DE AGENTE QUELANTE AMORFO ATRAVÉS DA REMOÇÃO DE SOLVENTE, PREFERIVELMENTE POR SECAGEM POR ATOMIZAÇÃO. ALÉM DISSO, AS PARTÍCULAS AMORFAS PRODUZIDAS DE ACORDO COM O PROCESSO DA PRESENTE INVENÇÃO APRESENTAM CARACTERÍSTICAS VANTAJOSAS NO QUE REFERE À CONSISTÊNCIA ENTRE LOTES E SOLUBILIDADE. ESTES AGENTES PODEM SER UTILIZADOS NA ÁREA FARMACÊUTICA PARTICULARMENTE EM NOVAS FORMULAÇÕES TENDO ESTES EXCIPIENTES NA COMPOSIÇÃO.
PT115056A 2018-10-04 2018-10-04 Formas amorfas de agentes quelantes e seus métodos de preparação PT115056B (pt)

Priority Applications (10)

Application Number Priority Date Filing Date Title
PT115056A PT115056B (pt) 2018-10-04 2018-10-04 Formas amorfas de agentes quelantes e seus métodos de preparação
CN201980065426.6A CN113015718A (zh) 2018-10-04 2019-10-03 螯合剂的无定形形式及其制备方法
AU2019354251A AU2019354251A1 (en) 2018-10-04 2019-10-03 Amorphous form of chelating agents and process for preparing them
EP19790705.8A EP3860973A1 (en) 2018-10-04 2019-10-03 Amorphous form of chelating agents and process for preparing them
US17/281,732 US20220002226A1 (en) 2018-10-04 2019-10-03 Amorphous Form of Chelating Agents and Process for Preparing them
PCT/GB2019/052799 WO2020070508A1 (en) 2018-10-04 2019-10-03 Amorphous form of chelating agents and process for preparing them
JP2021516727A JP2022503804A (ja) 2018-10-04 2019-10-03 キレート化剤の非晶質形態及びそれを調製する方法
CA3114278A CA3114278A1 (en) 2018-10-04 2019-10-03 Amorphous form of chelating agents and process for preparing them
KR1020217013330A KR20210078503A (ko) 2018-10-04 2019-10-03 킬레이트화제의 무정형 형태 및 이들의 제조방법
IL281892A IL281892A (en) 2018-10-04 2021-03-29 Amorphous form of chelating agents and process for preparing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT115056A PT115056B (pt) 2018-10-04 2018-10-04 Formas amorfas de agentes quelantes e seus métodos de preparação

Publications (2)

Publication Number Publication Date
PT115056A true PT115056A (pt) 2020-07-24
PT115056B PT115056B (pt) 2021-12-10

Family

ID=68296519

Family Applications (1)

Application Number Title Priority Date Filing Date
PT115056A PT115056B (pt) 2018-10-04 2018-10-04 Formas amorfas de agentes quelantes e seus métodos de preparação

Country Status (10)

Country Link
US (1) US20220002226A1 (pt)
EP (1) EP3860973A1 (pt)
JP (1) JP2022503804A (pt)
KR (1) KR20210078503A (pt)
CN (1) CN113015718A (pt)
AU (1) AU2019354251A1 (pt)
CA (1) CA3114278A1 (pt)
IL (1) IL281892A (pt)
PT (1) PT115056B (pt)
WO (1) WO2020070508A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114053859B (zh) * 2021-11-17 2023-08-18 重庆科技学院 一种硫化氢脱除剂及其制备方法
WO2023245463A1 (en) * 2022-06-21 2023-12-28 L'oreal A stabilized composition comprising a thiopyridinone compound and chelating agent

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU797224A1 (ru) * 1979-04-12 1998-02-20 Институт химической кинетики и горения Сибирского отделения АН СССР Способ получения винилидендифосфоновой кислоты или ее натриевых солей
US4636336A (en) * 1984-11-02 1987-01-13 Rockwell International Corporation Process for drying a chelating agent
US4978763A (en) * 1988-09-27 1990-12-18 Salutar, Inc. Novel manganese(II) DTPA chelate
KR100249323B1 (ko) 1997-12-09 2000-03-15 이상현 고순도 에틸렌디아민4아세트산4나트륨염의 제조방법
CN1190413C (zh) * 2001-12-19 2005-02-23 钟林 乙二胺四乙酸络合金属盐的生产方法
EP1891081B1 (en) * 2005-06-13 2014-08-20 Jubilant Organosys Limited Process for producing bisphosphonic acids and forms thereof
WO2010092446A1 (en) * 2009-01-19 2010-08-19 Orchid Chemicals & Pharmaceuticals Ltd Pharmaceutical composition comprising cilastatin, a chelating agent and opt. a penem antibiotic
CN103108643B (zh) * 2010-01-22 2016-10-26 希普罗特克有限公司 包含过氧化物、醇和螯合剂的抗菌剂
CN102229620B (zh) * 2011-04-27 2014-05-28 河南清水源科技股份有限公司 一种高纯度固体羟基亚乙基二膦酸四钠盐及其生产工艺
CN102875400B (zh) * 2012-09-21 2014-08-06 万华化学集团股份有限公司 一种制备二乙烯三胺五乙酸的方法

Also Published As

Publication number Publication date
EP3860973A1 (en) 2021-08-11
AU2019354251A1 (en) 2021-04-15
US20220002226A1 (en) 2022-01-06
WO2020070508A1 (en) 2020-04-09
CA3114278A1 (en) 2020-04-09
CN113015718A (zh) 2021-06-22
PT115056B (pt) 2021-12-10
JP2022503804A (ja) 2022-01-12
KR20210078503A (ko) 2021-06-28
IL281892A (en) 2021-05-31

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Effective date: 20200721

FG3A Patent granted, date of granting

Effective date: 20211206