PT1095015E - N-arilamidas de acido sulfonilamino-carboxilico como activadoras da ciclase do guanilato - Google Patents

N-arilamidas de acido sulfonilamino-carboxilico como activadoras da ciclase do guanilato

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Publication number
PT1095015E
PT1095015E PT99936460T PT99936460T PT1095015E PT 1095015 E PT1095015 E PT 1095015E PT 99936460 T PT99936460 T PT 99936460T PT 99936460 T PT99936460 T PT 99936460T PT 1095015 E PT1095015 E PT 1095015E
Authority
PT
Portugal
Prior art keywords
guanilato
arylamides
sulfonylamino
cyclase
activators
Prior art date
Application number
PT99936460T
Other languages
English (en)
Inventor
Karl Schonafinger
Hartmut Strobel
Ursula Schindler
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of PT1095015E publication Critical patent/PT1095015E/pt

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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/36—Oxygen or sulfur atoms
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3882—Arylalkanephosphonic acids

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  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
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  • Biomedical Technology (AREA)
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  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
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PT99936460T 1998-07-08 1999-06-25 N-arilamidas de acido sulfonilamino-carboxilico como activadoras da ciclase do guanilato PT1095015E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19830431A DE19830431A1 (de) 1998-07-08 1998-07-08 Sulfonylamino-carbonsäure-N-arylamide als Guanylatcyclase-Aktivatoren

Publications (1)

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PT1095015E true PT1095015E (pt) 2005-09-30

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PT99936460T PT1095015E (pt) 1998-07-08 1999-06-25 N-arilamidas de acido sulfonilamino-carboxilico como activadoras da ciclase do guanilato

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Country Link
US (3) US6548547B1 (pt)
EP (1) EP1095015B1 (pt)
JP (1) JP4422335B2 (pt)
KR (1) KR101021042B1 (pt)
AR (1) AR019231A1 (pt)
AT (1) ATE296800T1 (pt)
AU (1) AU5155399A (pt)
BR (1) BR9911942B1 (pt)
CA (1) CA2336702C (pt)
DE (2) DE19830431A1 (pt)
DK (1) DK1095015T3 (pt)
ES (1) ES2242407T3 (pt)
PT (1) PT1095015E (pt)
WO (1) WO2000002850A2 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU228111B1 (en) 1998-07-08 2012-11-28 Sanofi Aventis Deutschland Sulfur substituted sulfonylaminocarboxylic acid n-arylamides, their preparation, their use and pharmaceutical preparations comprising them
DE19830431A1 (de) * 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Sulfonylamino-carbonsäure-N-arylamide als Guanylatcyclase-Aktivatoren
HUP0202142A3 (en) * 1999-06-24 2005-05-30 Smithkline Beecham Corp Philap Macrophage scavenger receptor antagonists
ES2311479T3 (es) * 1999-11-26 2009-02-16 SHIONOGI & CO., LTD. Antagonistas de npy-y5.
AU2001270029A1 (en) * 2000-06-21 2002-01-02 Smith Kline Beecham Corporation Macrophage scavenger receptor antagonists
US6716879B2 (en) 2000-08-30 2004-04-06 Compass Pharmaceuticals, Llc Methods for anti-tumor therapy
DE10046029A1 (de) 2000-09-18 2002-03-28 Bayer Ag Indazole
SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
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US20050080073A1 (en) 2005-04-14
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AR019231A1 (es) 2001-12-26
EP1095015A2 (de) 2001-05-02
CA2336702C (en) 2010-03-09
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US7351703B2 (en) 2008-04-01
BR9911942A (pt) 2001-03-27
US6809089B2 (en) 2004-10-26
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ATE296800T1 (de) 2005-06-15

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