PT1086082E - Aminas olefinicas substituidas com arilo e seu uso como agonistas de receptores colinergicos - Google Patents
Aminas olefinicas substituidas com arilo e seu uso como agonistas de receptores colinergicosInfo
- Publication number
- PT1086082E PT1086082E PT99926152T PT99926152T PT1086082E PT 1086082 E PT1086082 E PT 1086082E PT 99926152 T PT99926152 T PT 99926152T PT 99926152 T PT99926152 T PT 99926152T PT 1086082 E PT1086082 E PT 1086082E
- Authority
- PT
- Portugal
- Prior art keywords
- methyl
- amine
- penten
- pyridyl
- arylium
- Prior art date
Links
- 150000001412 amines Chemical class 0.000 title abstract 2
- 239000000556 agonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- KETAPARGUJRPEI-HWKANZROSA-N (e)-5-(5-bromopyridin-3-yl)-n-methylpent-4-en-2-amine Chemical compound CNC(C)C\C=C\C1=CN=CC(Br)=C1 KETAPARGUJRPEI-HWKANZROSA-N 0.000 abstract 1
- KJZMFQZAEDAMAE-FNORWQNLSA-N (e)-5-(5-ethoxypyridin-3-yl)-n-methylpent-4-en-2-amine Chemical compound CCOC1=CN=CC(\C=C\CC(C)NC)=C1 KJZMFQZAEDAMAE-FNORWQNLSA-N 0.000 abstract 1
- HXZJTUDXVFHWOB-GQCTYLIASA-N (e)-5-(5-methoxypyridin-3-yl)-n-methylpent-4-en-2-amine Chemical compound CNC(C)C\C=C\C1=CN=CC(OC)=C1 HXZJTUDXVFHWOB-GQCTYLIASA-N 0.000 abstract 1
- RPCVIAXDAUMJJP-FNORWQNLSA-N (e)-n-methyl-5-(5-propan-2-yloxypyridin-3-yl)pent-4-en-2-amine Chemical compound CNC(C)C\C=C\C1=CN=CC(OC(C)C)=C1 RPCVIAXDAUMJJP-FNORWQNLSA-N 0.000 abstract 1
- IEVJOUFGBRDCNE-ZZXKWVIFSA-N (e)-n-methyl-5-pyridin-3-ylpent-4-en-2-amine Chemical compound CNC(C)C\C=C\C1=CC=CN=C1 IEVJOUFGBRDCNE-ZZXKWVIFSA-N 0.000 abstract 1
- VZNTWLIIJWUCEP-HWKANZROSA-N (e)-n-methyl-5-pyrimidin-5-ylpent-4-en-2-amine Chemical compound CNC(C)C\C=C\C1=CN=CN=C1 VZNTWLIIJWUCEP-HWKANZROSA-N 0.000 abstract 1
- RPCVIAXDAUMJJP-HOSRBBHYSA-N (e,2r)-n-methyl-5-(5-propan-2-yloxypyridin-3-yl)pent-4-en-2-amine Chemical compound CN[C@H](C)C\C=C\C1=CN=CC(OC(C)C)=C1 RPCVIAXDAUMJJP-HOSRBBHYSA-N 0.000 abstract 1
- IEVJOUFGBRDCNE-QLCVYAKKSA-N (e,2r)-n-methyl-5-pyridin-3-ylpent-4-en-2-amine Chemical compound CN[C@H](C)C\C=C\C1=CC=CN=C1 IEVJOUFGBRDCNE-QLCVYAKKSA-N 0.000 abstract 1
- IEVJOUFGBRDCNE-YVGDHZEHSA-N (e,2s)-n-methyl-5-pyridin-3-ylpent-4-en-2-amine Chemical compound CN[C@@H](C)C\C=C\C1=CC=CN=C1 IEVJOUFGBRDCNE-YVGDHZEHSA-N 0.000 abstract 1
- XDXHBRXUPFIIRK-GQCTYLIASA-N 3-methyl-5-[(e)-4-(methylamino)pent-1-enyl]pyridin-2-amine Chemical compound CNC(C)C\C=C\C1=CN=C(N)C(C)=C1 XDXHBRXUPFIIRK-GQCTYLIASA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- RPCVIAXDAUMJJP-PZBABLGHSA-N ispronicline Chemical compound CN[C@@H](C)C\C=C\C1=CN=CC(OC(C)C)=C1 RPCVIAXDAUMJJP-PZBABLGHSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9828598A | 1998-06-16 | 1998-06-16 | |
| US09/098,133 US6232316B1 (en) | 1998-06-16 | 1998-06-16 | Methods for treatment of CNS disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1086082E true PT1086082E (pt) | 2005-01-31 |
Family
ID=26794206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99926152T PT1086082E (pt) | 1998-06-16 | 1999-06-03 | Aminas olefinicas substituidas com arilo e seu uso como agonistas de receptores colinergicos |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1086082B9 (cg-RX-API-DMAC7.html) |
| JP (4) | JP4240815B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR100593433B1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE273956T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU4230799A (cg-RX-API-DMAC7.html) |
| BR (1) | BR9911325A (cg-RX-API-DMAC7.html) |
| CA (3) | CA2334923C (cg-RX-API-DMAC7.html) |
| DE (1) | DE69919537T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1086082T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2228054T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1086082E (cg-RX-API-DMAC7.html) |
| WO (1) | WO1999065876A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6979695B2 (en) * | 1996-04-23 | 2005-12-27 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
| DE69919537T2 (de) * | 1998-06-16 | 2005-09-08 | Targacept, Inc. | Arylsubstituierte olefinische amine und ihre verwendung als cholinergische rezeptoragonisten |
| WO2000075110A1 (en) * | 1999-06-07 | 2000-12-14 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| WO2001016107A1 (en) * | 1999-08-31 | 2001-03-08 | Targacept, Inc. | Arylalkyloxyalkylamines and arylalkylthioalkylamines, pharmaceutical compositions containing them and their use as inhibitors of nicotinic cholinergic receptors |
| WO2001082978A2 (en) * | 2000-05-01 | 2001-11-08 | Targacept, Inc. | Imaging of nicotinic acetylcholine receptor subtypes |
| US6432954B1 (en) * | 2000-07-14 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| BR0214929A (pt) | 2001-12-14 | 2006-05-30 | Targacept Inc | métodos e composições para o tratamento de distúrbios do sistema nervoso central |
| US8580842B2 (en) | 2003-09-30 | 2013-11-12 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
| US7402592B2 (en) | 2003-10-15 | 2008-07-22 | Targacept, Inc. | Pharmaceutical compositions and methods for relieving pain and treating central nervous system disorders |
| US7459469B2 (en) | 2004-11-10 | 2008-12-02 | Targacept, Inc. | Hydroxybenzoate salts of metanicotine compounds |
| UA88792C2 (ru) * | 2004-11-10 | 2009-11-25 | Таргасепт, Інк. | Гидроксибензоатные соли метаникотиновых соединений |
| TWI389889B (zh) | 2006-05-09 | 2013-03-21 | Targacept Inc | （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型 |
| WO2007134038A2 (en) | 2006-05-09 | 2007-11-22 | Astrazeneca Ab | Salt forms of (2s)-(4e)-n-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine |
| EP2083921A2 (en) | 2006-09-04 | 2009-08-05 | Neurosearch A/S | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer |
| US8486979B2 (en) | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
| US20080167286A1 (en) | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
| UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
| KR20100052490A (ko) * | 2007-07-31 | 2010-05-19 | 타가셉트 인코포레이티드 | (2ｓ)-(4ｅ)-ｎ-메틸-5-(3-(5-이소프로폭시피리딘)일)-4-펜텐-2-아민의 경피투여 |
| JP5595926B2 (ja) | 2007-12-07 | 2014-09-24 | アボット ゲーエムベーハー ウント カンパニー カーゲー | ５−ハロゲン−置換オキシインドール誘導体およびバソプレッシン依存性疾患の治療へのこれらの使用 |
| WO2010009775A1 (de) | 2007-12-07 | 2010-01-28 | Abbott Gmbh & Co. Kg | Carbamat-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen |
| JP5701607B2 (ja) | 2007-12-07 | 2015-04-15 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | アミドメチル置換オキシインドール誘導体およびバソプレッシン依存性疾患の治療へのこれらの使用 |
| CA2707671C (en) | 2007-12-07 | 2016-02-02 | Abbott Gmbh & Co. Kg | 5,6-disubstituted oxindole-derivatives and use thereof for treating vasopressine-dependent diseases |
| US8383657B2 (en) | 2007-12-21 | 2013-02-26 | Abbott Laboratories | Thiazolylidine urea and amide derivatives and methods of use thereof |
| JP2011516489A (ja) | 2008-03-31 | 2011-05-26 | ユニバーシティ・オブ・サウス・フロリダ | 疾患誘発性運動失調症および非運動失調性平衡異常の治療法 |
| EP2435080A2 (en) | 2009-05-29 | 2012-04-04 | Abbott Laboratories | Pharmaceutical compositions for the treatment of pain |
| JP2013528601A (ja) * | 2010-05-20 | 2013-07-11 | アストラゼネカ・アクチエボラーグ | アリール置換オレフィン系アミンの新規な製造方法 |
| WO2013184732A1 (en) * | 2012-06-06 | 2013-12-12 | Targacept, Inc. | Crystalline (2s)-(4e)-n-methyl-5-[3-(5-isopropoxypyridin)yl]4-penten-2-amine 1,5-naphthalenedisulfonate |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5242935A (en) * | 1992-03-06 | 1993-09-07 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
| US5597716A (en) * | 1993-11-18 | 1997-01-28 | Mitsubishi Rayon Co., Ltd. | Process for producing D-lactic acid and L-lactamide |
| DE69535131T2 (de) * | 1995-01-06 | 2007-03-01 | Targacept, Inc. | Pharmazeutische zusammensetzungen zur vorbeugung und behandlung von störungen des zentralnervensystems |
| US5616707A (en) * | 1995-01-06 | 1997-04-01 | Crooks; Peter A. | Compounds which are useful for prevention and treatment of central nervous system disorders |
| US5597919A (en) * | 1995-01-06 | 1997-01-28 | Dull; Gary M. | Pyrimidinyl or Pyridinyl alkenyl amine compounds |
| US5585388A (en) * | 1995-04-07 | 1996-12-17 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acetylcholine receptors |
| AU5383196A (en) * | 1995-05-17 | 1996-11-29 | R.J. Reynolds Tobacco Company | Pharmaceutical compositions for prevention and treatment of central nervous system disorders |
| US5616716A (en) * | 1996-01-06 | 1997-04-01 | Dull; Gary M. | (3-(5-ethoxypyridin)yl)-alkenyl 1 amine compounds |
| DE69739142D1 (de) * | 1996-04-23 | 2009-01-15 | Targacept Inc | Pharmazeutische zusammenstellungen zur prävention und behandlung von zns-erkrankungen |
| US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
| DE69825879T2 (de) * | 1997-02-21 | 2005-09-01 | Targacept, Inc. | Pharmazeutische zusammensetzungen welche aryl-substituierte olefinische amin-verbindungen enthalten |
| DE69919537T2 (de) * | 1998-06-16 | 2005-09-08 | Targacept, Inc. | Arylsubstituierte olefinische amine und ihre verwendung als cholinergische rezeptoragonisten |
-
1999
- 1999-06-03 DE DE69919537T patent/DE69919537T2/de not_active Expired - Lifetime
- 1999-06-03 ES ES99926152T patent/ES2228054T3/es not_active Expired - Lifetime
- 1999-06-03 CA CA002334923A patent/CA2334923C/en not_active Expired - Fee Related
- 1999-06-03 CA CA002677519A patent/CA2677519A1/en not_active Abandoned
- 1999-06-03 CA CA2709735A patent/CA2709735A1/en not_active Abandoned
- 1999-06-03 WO PCT/US1999/012340 patent/WO1999065876A1/en not_active Ceased
- 1999-06-03 KR KR1020007014279A patent/KR100593433B1/ko not_active Expired - Fee Related
- 1999-06-03 DK DK99926152T patent/DK1086082T3/da active
- 1999-06-03 PT PT99926152T patent/PT1086082E/pt unknown
- 1999-06-03 AT AT99926152T patent/ATE273956T1/de active
- 1999-06-03 JP JP2000554703A patent/JP4240815B2/ja not_active Expired - Fee Related
- 1999-06-03 EP EP99926152A patent/EP1086082B9/en not_active Expired - Lifetime
- 1999-06-03 BR BR9911325-2A patent/BR9911325A/pt not_active Application Discontinuation
- 1999-06-03 AU AU42307/99A patent/AU4230799A/en not_active Abandoned
-
2008
- 2008-05-19 JP JP2008130502A patent/JP4972608B2/ja not_active Expired - Fee Related
- 2008-05-19 JP JP2008130504A patent/JP4896923B2/ja not_active Expired - Fee Related
-
2010
- 2010-06-15 JP JP2010135746A patent/JP2010229149A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1086082A1 (en) | 2001-03-28 |
| EP1086082B9 (en) | 2005-03-02 |
| CA2677519A1 (en) | 1999-12-23 |
| DE69919537T2 (de) | 2005-09-08 |
| BR9911325A (pt) | 2001-04-03 |
| WO1999065876A1 (en) | 1999-12-23 |
| CA2334923A1 (en) | 1999-12-23 |
| JP2008255122A (ja) | 2008-10-23 |
| JP2002518373A (ja) | 2002-06-25 |
| JP4972608B2 (ja) | 2012-07-11 |
| DE69919537D1 (de) | 2004-09-23 |
| KR20010083052A (ko) | 2001-08-31 |
| CA2709735A1 (en) | 1999-12-23 |
| JP2010229149A (ja) | 2010-10-14 |
| JP4896923B2 (ja) | 2012-03-14 |
| EP1086082B1 (en) | 2004-08-18 |
| JP2008260774A (ja) | 2008-10-30 |
| JP4240815B2 (ja) | 2009-03-18 |
| AU4230799A (en) | 2000-01-05 |
| ES2228054T3 (es) | 2005-04-01 |
| KR100593433B1 (ko) | 2006-06-28 |
| ATE273956T1 (de) | 2004-09-15 |
| CA2334923C (en) | 2009-09-29 |
| DK1086082T3 (da) | 2004-11-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1086082E (pt) | Aminas olefinicas substituidas com arilo e seu uso como agonistas de receptores colinergicos | |
| BR9810342A (pt) | Novos compostos imidazola substituìdos | |
| PT1228147E (pt) | Compostos de imidazoquinolina marcados com corante | |
| SV2005002148A (es) | "compuestos moduladores de la actividad c-kit y usos de los mismos" | |
| EA200101177A1 (ru) | Производные индола в качестве антагонистов прогестерона | |
| TR200300322T2 (tr) | Kemokin alıcısını bağlayan heterosiklik bileşikler | |
| TR200100922T2 (tr) | Aktif maddelerin akciğerler yolu ile tatbik edilmesi. | |
| BR0115400A (pt) | Compostos de piperazinilpirazina atuando como agonistas ou antagonistas do receptor 5ht-2 de serotonina | |
| EA200301213A1 (ru) | Лиганды рецепторов 5-ht и их применение | |
| TR200102029T2 (tr) | 1-Heterosiklil ikameli diarilaminler. | |
| EA200000251A1 (ru) | Производные резорцинола | |
| PT1214936E (pt) | Utilizacao de derivados de tiazolidina ou pirrolidina de aminoacidos como agentes anti-hiperglicemicos | |
| ES2187200T3 (es) | Proteina hibrida para inhibir la desgranulacion de mastocitos y su uso. | |
| ATE247667T1 (de) | Gdnf-rezeptor und dessen verwendung | |
| PT1093819E (pt) | Compostos e composicoes para fornecimento de agentes activos | |
| ES2146774T3 (es) | Polimeros de ioneno que contienen aniones biologicamente activos. | |
| YU83600A (sh) | Adenozin a3 receptorski modulatori | |
| TR200101764T2 (tr) | Yeni bileşikler. | |
| PT888384E (pt) | Polipeptido de fusao para influenciar as interaccoes entre proteinas | |
| SE9702773D0 (sv) | Novel compounds | |
| EA200300593A1 (ru) | Соединения пиперазинилпиразинов в качестве агонистов или антагонистов серотонин 5-ht2 рецептора | |
| BR9909486A (pt) | Compostos calcilìticos | |
| BR0007864A (pt) | Composto, e, uso de um composto | |
| EA199800867A1 (ru) | Соединения тетрагидробетакарболина | |
| EA200500830A1 (ru) | Производные имидазохинолина в качестве лигандов аденозиновых a3 рецепторов |