PT100948A - Uso de um composto da classe de analogos da camptotecina, soluveis em agua, no tratamento do cancro colorectal - Google Patents

Uso de um composto da classe de analogos da camptotecina, soluveis em agua, no tratamento do cancro colorectal

Info

Publication number
PT100948A
PT100948A PT100948A PT10094892A PT100948A PT 100948 A PT100948 A PT 100948A PT 100948 A PT100948 A PT 100948A PT 10094892 A PT10094892 A PT 10094892A PT 100948 A PT100948 A PT 100948A
Authority
PT
Portugal
Prior art keywords
camptotecin
soluable
analogues
class
compound
Prior art date
Application number
PT100948A
Other languages
English (en)
Inventor
Randall Keith Johnson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PT100948A publication Critical patent/PT100948A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
PT100948A 1991-12-10 1992-10-09 Uso de um composto da classe de analogos da camptotecina, soluveis em agua, no tratamento do cancro colorectal PT100948A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80457091A 1991-12-10 1991-12-10

Publications (1)

Publication Number Publication Date
PT100948A true PT100948A (pt) 1994-01-31

Family

ID=25189304

Family Applications (1)

Application Number Title Priority Date Filing Date
PT100948A PT100948A (pt) 1991-12-10 1992-10-09 Uso de um composto da classe de analogos da camptotecina, soluveis em agua, no tratamento do cancro colorectal

Country Status (7)

Country Link
EP (1) EP0661977A1 (pt)
JP (1) JPH07501818A (pt)
AU (1) AU2394392A (pt)
CA (1) CA2125293A1 (pt)
MX (1) MX9205766A (pt)
PT (1) PT100948A (pt)
WO (1) WO1993011770A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
EP1250926B1 (en) * 1993-01-15 2008-03-12 The Stehlin Foundation For Cancer Research Use of a water-insoluble S-camptothecin with a closed lactone ring in the manufacture of a medicament for treatment of colon cancer
US6291425B1 (en) * 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
ES2371171B1 (es) * 2010-06-08 2012-11-16 Consejo Superior De Investigaciones Científicas (Csic) Derivados de camptotecina como agentes antitumorales.
CN102477042A (zh) * 2010-11-26 2012-05-30 复旦大学 10-羟基喜树碱衍生物及其制备方法和用途
CN102659800B (zh) * 2012-05-11 2014-09-03 中国药科大学 一类低氧激活抗肿瘤化合物及其用途
CN103113381B (zh) * 2013-02-26 2014-12-10 大连理工大学 系列水溶性羟基喜树碱环烷胺醇衍生物及其制法与用途
WO2021173773A1 (en) 2020-02-25 2021-09-02 Mediboston, Inc. Camptothecin derivatives and conjugates thereof
CN117462548A (zh) * 2023-03-09 2024-01-30 兰州大学 喜树碱类衍生物在制备治疗膀胱癌药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0641161B2 (ja) * 1988-02-17 1994-06-01 積水化成品工業株式会社 スチレン系樹脂発泡シートの製造方法及び加熱成形用スチレン系樹脂発泡シート
JPH0768403B2 (ja) * 1988-12-15 1995-07-26 東洋エンジニアリング株式会社 発泡体の製造方法
JP2756366B2 (ja) * 1990-11-27 1998-05-25 松下電工株式会社 疎水性エアロゲルの製造方法

Also Published As

Publication number Publication date
MX9205766A (es) 1993-06-01
EP0661977A1 (en) 1995-07-12
JPH07501818A (ja) 1995-02-23
CA2125293A1 (en) 1993-06-24
WO1993011770A1 (en) 1993-06-24
EP0661977A4 (en) 1994-10-20
AU2394392A (en) 1993-07-19

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19930630

FC3A Refusal

Effective date: 19990503