PT100045A - Poliamina-tiois com accao radioprotectora e processo para a sua preparacao - Google Patents
Poliamina-tiois com accao radioprotectora e processo para a sua preparacaoInfo
- Publication number
- PT100045A PT100045A PT100045A PT10004592A PT100045A PT 100045 A PT100045 A PT 100045A PT 100045 A PT100045 A PT 100045A PT 10004592 A PT10004592 A PT 10004592A PT 100045 A PT100045 A PT 100045A
- Authority
- PT
- Portugal
- Prior art keywords
- spo3h2
- thiois
- radioprotection
- polyamine
- preparation
- Prior art date
Links
- 230000001950 radioprotection Effects 0.000 title 1
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000718 radiation-protective agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
- C07C323/34—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a mercapto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
- C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Polyurethanes Or Polyureas (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Display Devices Of Pinball Game Machines (AREA)
- Polyethers (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/644,810 US5217964A (en) | 1991-01-23 | 1991-01-23 | Polyamine thiols as radioprotective agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT100045A true PT100045A (pt) | 1993-03-31 |
| PT100045B PT100045B (pt) | 1999-10-29 |
Family
ID=24586432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT100045A PT100045B (pt) | 1991-01-23 | 1992-01-22 | Poliamina-tiois com accao radioprotectora e processo para a sua preparacao e sua utilizacao na preparacao de composicoes farmaceuticas |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5217964A (pt) |
| EP (1) | EP0497202B1 (pt) |
| JP (1) | JP3203582B2 (pt) |
| KR (1) | KR100195420B1 (pt) |
| AT (1) | ATE127785T1 (pt) |
| AU (1) | AU647570B2 (pt) |
| CA (1) | CA2059817C (pt) |
| DE (1) | DE69204698T2 (pt) |
| ES (1) | ES2079695T3 (pt) |
| FI (1) | FI111251B (pt) |
| IE (1) | IE67961B1 (pt) |
| IL (1) | IL100698A (pt) |
| NO (1) | NO179003C (pt) |
| NZ (1) | NZ241347A (pt) |
| PT (1) | PT100045B (pt) |
| ZA (1) | ZA92360B (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5342945A (en) * | 1986-12-02 | 1994-08-30 | University Of Florida Research Foundation, Inc. | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives |
| US5393757A (en) * | 1986-12-02 | 1995-02-28 | University Of Florida | Polyamines and anti-diarrheal and gastrointestinal anti-spasmodic pharmaceutical compositions and methods of treatment |
| US5677351A (en) * | 1986-12-02 | 1997-10-14 | University Of Florida Research Foundation, Inc. | Sterically hindered tetraamines and method for their production |
| US5354782A (en) * | 1991-01-17 | 1994-10-11 | Merrell Dow Pharmaceuticals Inc. | Polyamine phenols as radioprotective agents |
| US5488042A (en) * | 1992-03-13 | 1996-01-30 | Arch Development Corporation | Method for protection against genotoxic mutagenesis |
| WO1994019311A1 (en) * | 1993-02-23 | 1994-09-01 | Merrell Dow Pharmaceuticals Inc. | Polyamine derivatives as radioprotective agents |
| CA2161869C (en) * | 1993-05-26 | 2001-11-13 | Michael L. Edwards | N-alkylthio polyamine derivatives as radioprotective agents |
| US5994409A (en) | 1997-12-09 | 1999-11-30 | U.S. Bioscience, Inc. | Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds |
| EP1177197B1 (en) | 1999-04-30 | 2006-08-09 | Cellgate, Inc. | Polyamines and their use in therapy |
| US6482943B1 (en) | 1999-04-30 | 2002-11-19 | Slil Biomedical Corporation | Quinones as disease therapies |
| US6649587B1 (en) | 1999-04-30 | 2003-11-18 | Slil Biomedical Corporation | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases |
| BR0010700A (pt) * | 1999-04-30 | 2002-02-13 | Slil Biomedical Corp | Conjugados análogos de poliamina e conjugados de quinona como terapias para cânceres e doenças na próstata |
| US6489312B1 (en) | 1999-06-15 | 2002-12-03 | Medimmune Oncology, Inc. | Pharmaceutical formulations comprising aminoalkyl phosphorothioates |
| AU2001259484A1 (en) * | 2000-05-05 | 2001-11-20 | Wisconsin Alumni Research Foundation | Compositions and methods for protecting cells during cancer chemotherapy and radiotherapy |
| AU2002235126A1 (en) * | 2000-11-08 | 2002-05-21 | Slil Biomedical Corporation | Novel polyamine analog-amino acid conjugates useful as anticancer agents |
| US7053072B2 (en) * | 2001-05-11 | 2006-05-30 | Medimmune Oncology, Inc. | Methods for the administration of amifostine and related compounds |
| WO2003013245A1 (en) * | 2001-08-07 | 2003-02-20 | Wisconsin Alumni Research Foundation | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy |
| CA2469354A1 (en) | 2001-12-07 | 2003-06-19 | Slil Biomedical Corporation | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor |
| JP2005517004A (ja) * | 2002-02-07 | 2005-06-09 | ウィスコンシン アルムニ リサーチ ファンデーション | 癌治療に関連した使用に対するポリアミン化合物及び組成 |
| US7314959B2 (en) * | 2003-08-07 | 2008-01-01 | Wisconsin Alumni Research Foundation | Amino thiol compounds and compositions for use in conjunction with cancer therapy |
| US7754463B2 (en) * | 2006-06-20 | 2010-07-13 | Dana-Farber Cancer Institute | Inhibitors of USP1 Deubiquitinating Enzyme Complex |
| WO2011137320A2 (en) | 2010-04-30 | 2011-11-03 | Dana-Farber Cancer Institute, Inc. | Small molecule inhibitors of usp1 deubiquitinating enzyme activity |
| US9725425B1 (en) | 2014-02-25 | 2017-08-08 | Dana-Farber Cancer Institute, Inc. | Compounds and methods for treating cancer |
| TWM528362U (zh) * | 2016-04-15 | 2016-09-11 | Calendar Entpr Co Ltd | 無繩式電動節能捲簾結構改良 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2901503A (en) * | 1956-08-28 | 1959-08-25 | Campbell Pharmaceuticals Inc | Dialkylaminophenyl esters of thiophosphoric acids |
| US3368972A (en) * | 1965-01-06 | 1968-02-13 | Mobil Oil Corp | High molecular weight mannich bases as engine oil additives |
| NZ223340A (en) * | 1987-02-03 | 1991-03-26 | Merrell Dow Pharma | Polyamine derivatives and pharmaceutical compositions |
| ZA887410B (en) * | 1987-10-08 | 1989-06-28 | Merrell Dow Pharma | Polyamine derivatives as antineoplastic agents |
-
1991
- 1991-01-23 US US07/644,810 patent/US5217964A/en not_active Expired - Fee Related
-
1992
- 1992-01-17 ZA ZA92360A patent/ZA92360B/xx unknown
- 1992-01-17 AU AU10304/92A patent/AU647570B2/en not_active Ceased
- 1992-01-19 IL IL10069892A patent/IL100698A/en not_active IP Right Cessation
- 1992-01-21 NZ NZ241347A patent/NZ241347A/en unknown
- 1992-01-22 ES ES92101017T patent/ES2079695T3/es not_active Expired - Lifetime
- 1992-01-22 NO NO920283A patent/NO179003C/no unknown
- 1992-01-22 FI FI920271A patent/FI111251B/fi active
- 1992-01-22 IE IE920189A patent/IE67961B1/en not_active IP Right Cessation
- 1992-01-22 EP EP92101017A patent/EP0497202B1/en not_active Expired - Lifetime
- 1992-01-22 AT AT92101017T patent/ATE127785T1/de not_active IP Right Cessation
- 1992-01-22 DE DE69204698T patent/DE69204698T2/de not_active Expired - Fee Related
- 1992-01-22 PT PT100045A patent/PT100045B/pt not_active IP Right Cessation
- 1992-01-22 KR KR1019920000836A patent/KR100195420B1/ko not_active IP Right Cessation
- 1992-01-22 CA CA002059817A patent/CA2059817C/en not_active Expired - Fee Related
- 1992-01-23 JP JP03128092A patent/JP3203582B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE127785T1 (de) | 1995-09-15 |
| EP0497202B1 (en) | 1995-09-13 |
| IE67961B1 (en) | 1996-05-15 |
| IL100698A0 (en) | 1992-09-06 |
| AU647570B2 (en) | 1994-03-24 |
| ES2079695T3 (es) | 1996-01-16 |
| FI920271A0 (fi) | 1992-01-22 |
| NO920283L (no) | 1992-07-24 |
| CA2059817A1 (en) | 1992-07-24 |
| FI920271A (fi) | 1992-07-24 |
| KR100195420B1 (ko) | 1999-06-15 |
| NO179003C (no) | 1996-07-17 |
| NO920283D0 (no) | 1992-01-22 |
| NO179003B (no) | 1996-04-09 |
| AU1030492A (en) | 1992-07-30 |
| ZA92360B (en) | 1992-11-25 |
| CA2059817C (en) | 2003-07-15 |
| PT100045B (pt) | 1999-10-29 |
| IE920189A1 (en) | 1992-07-29 |
| IL100698A (en) | 1998-08-16 |
| EP0497202A1 (en) | 1992-08-05 |
| US5217964A (en) | 1993-06-08 |
| KR920014772A (ko) | 1992-08-25 |
| DE69204698T2 (de) | 1996-02-15 |
| JP3203582B2 (ja) | 2001-08-27 |
| NZ241347A (en) | 1994-04-27 |
| DE69204698D1 (de) | 1995-10-19 |
| JPH04334362A (ja) | 1992-11-20 |
| FI111251B (fi) | 2003-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19921106 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19990722 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20050124 |