ATE127785T1 - Polyaminthiole als strahlenschutzmittel. - Google Patents
Polyaminthiole als strahlenschutzmittel.Info
- Publication number
- ATE127785T1 ATE127785T1 AT92101017T AT92101017T ATE127785T1 AT E127785 T1 ATE127785 T1 AT E127785T1 AT 92101017 T AT92101017 T AT 92101017T AT 92101017 T AT92101017 T AT 92101017T AT E127785 T1 ATE127785 T1 AT E127785T1
- Authority
- AT
- Austria
- Prior art keywords
- spo3h2
- polyaminthiols
- integer
- radiation protection
- protection agents
- Prior art date
Links
- 239000011814 protection agent Substances 0.000 title 1
- 230000005855 radiation Effects 0.000 title 1
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000718 radiation-protective agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
- C07C323/34—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a mercapto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
- C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Polyurethanes Or Polyureas (AREA)
- Polyethers (AREA)
- Display Devices Of Pinball Game Machines (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/644,810 US5217964A (en) | 1991-01-23 | 1991-01-23 | Polyamine thiols as radioprotective agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE127785T1 true ATE127785T1 (de) | 1995-09-15 |
Family
ID=24586432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92101017T ATE127785T1 (de) | 1991-01-23 | 1992-01-22 | Polyaminthiole als strahlenschutzmittel. |
Country Status (16)
Country | Link |
---|---|
US (1) | US5217964A (de) |
EP (1) | EP0497202B1 (de) |
JP (1) | JP3203582B2 (de) |
KR (1) | KR100195420B1 (de) |
AT (1) | ATE127785T1 (de) |
AU (1) | AU647570B2 (de) |
CA (1) | CA2059817C (de) |
DE (1) | DE69204698T2 (de) |
ES (1) | ES2079695T3 (de) |
FI (1) | FI111251B (de) |
IE (1) | IE67961B1 (de) |
IL (1) | IL100698A (de) |
NO (1) | NO179003C (de) |
NZ (1) | NZ241347A (de) |
PT (1) | PT100045B (de) |
ZA (1) | ZA92360B (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5342945A (en) * | 1986-12-02 | 1994-08-30 | University Of Florida Research Foundation, Inc. | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives |
US5677351A (en) * | 1986-12-02 | 1997-10-14 | University Of Florida Research Foundation, Inc. | Sterically hindered tetraamines and method for their production |
US5393757A (en) * | 1986-12-02 | 1995-02-28 | University Of Florida | Polyamines and anti-diarrheal and gastrointestinal anti-spasmodic pharmaceutical compositions and methods of treatment |
US5354782A (en) * | 1991-01-17 | 1994-10-11 | Merrell Dow Pharmaceuticals Inc. | Polyamine phenols as radioprotective agents |
US5488042A (en) * | 1992-03-13 | 1996-01-30 | Arch Development Corporation | Method for protection against genotoxic mutagenesis |
NZ262986A (en) * | 1993-02-23 | 1997-06-24 | Merrell Dow Pharma | Polyamine derivatives; use in protecting mammalian cells from the deleterious effects of ionising radiation and/or mutagenic chemicals |
DE69411271T2 (de) * | 1993-05-26 | 1998-11-05 | Merrell Pharma Inc | N-alkylthiopolyaminderivate als radioprotektive mittel |
US5994409A (en) | 1997-12-09 | 1999-11-30 | U.S. Bioscience, Inc. | Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds |
CA2368801A1 (en) * | 1999-04-30 | 2000-11-09 | Slil Biomedical Corporation | Conjugates as therapies for cancer and prostate diseases |
US6649587B1 (en) | 1999-04-30 | 2003-11-18 | Slil Biomedical Corporation | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases |
NZ515140A (en) * | 1999-04-30 | 2003-07-25 | Slil Biomedical Corp | Conformationally restricted polyamine analogs as disease therapies for cancer, epilepsy, alzheimers, infections, grafts and others |
US6482943B1 (en) * | 1999-04-30 | 2002-11-19 | Slil Biomedical Corporation | Quinones as disease therapies |
US6489312B1 (en) | 1999-06-15 | 2002-12-03 | Medimmune Oncology, Inc. | Pharmaceutical formulations comprising aminoalkyl phosphorothioates |
AU2001259484A1 (en) * | 2000-05-05 | 2001-11-20 | Wisconsin Alumni Research Foundation | Compositions and methods for protecting cells during cancer chemotherapy and radiotherapy |
WO2002091989A2 (en) * | 2000-11-08 | 2002-11-21 | Slil Biomedical Corporation | Antiviral therapies using polyamine or polyamine analog-amino acid conjugates |
US7053072B2 (en) | 2001-05-11 | 2006-05-30 | Medimmune Oncology, Inc. | Methods for the administration of amifostine and related compounds |
WO2003013245A1 (en) * | 2001-08-07 | 2003-02-20 | Wisconsin Alumni Research Foundation | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy |
AU2002364539A1 (en) | 2001-12-07 | 2003-06-23 | Cellgate, Inc. | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor |
KR20040091014A (ko) * | 2002-02-07 | 2004-10-27 | 위스콘신 얼럼나이 리서어치 화운데이션 | 항암 요법과 병행해서 사용하기 위한 폴리아민 화합물 및조성물 |
WO2005014524A2 (en) * | 2003-08-07 | 2005-02-17 | Wisconsin Alumni Research Foundation | Amino thiol compounds and compositions for use in conjunction with cancer therapy |
US7754463B2 (en) * | 2006-06-20 | 2010-07-13 | Dana-Farber Cancer Institute | Inhibitors of USP1 Deubiquitinating Enzyme Complex |
US9518032B2 (en) | 2010-04-30 | 2016-12-13 | Dana-Farber Cancer Institute, Inc. | Small molecule inhibitors of USP1 deubiquitinating enzyme activity |
US9725425B1 (en) | 2014-02-25 | 2017-08-08 | Dana-Farber Cancer Institute, Inc. | Compounds and methods for treating cancer |
TWM528362U (zh) * | 2016-04-15 | 2016-09-11 | Calendar Entpr Co Ltd | 無繩式電動節能捲簾結構改良 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2901503A (en) * | 1956-08-28 | 1959-08-25 | Campbell Pharmaceuticals Inc | Dialkylaminophenyl esters of thiophosphoric acids |
US3368972A (en) * | 1965-01-06 | 1968-02-13 | Mobil Oil Corp | High molecular weight mannich bases as engine oil additives |
ZA88600B (en) * | 1987-02-03 | 1988-07-28 | Merrell Dow Pharmaceuticals Inc. | Novel polyamine derivatives |
ZA887410B (en) * | 1987-10-08 | 1989-06-28 | Merrell Dow Pharma | Polyamine derivatives as antineoplastic agents |
-
1991
- 1991-01-23 US US07/644,810 patent/US5217964A/en not_active Expired - Fee Related
-
1992
- 1992-01-17 AU AU10304/92A patent/AU647570B2/en not_active Ceased
- 1992-01-17 ZA ZA92360A patent/ZA92360B/xx unknown
- 1992-01-19 IL IL10069892A patent/IL100698A/en not_active IP Right Cessation
- 1992-01-21 NZ NZ241347A patent/NZ241347A/en unknown
- 1992-01-22 NO NO920283A patent/NO179003C/no unknown
- 1992-01-22 PT PT100045A patent/PT100045B/pt not_active IP Right Cessation
- 1992-01-22 IE IE920189A patent/IE67961B1/en not_active IP Right Cessation
- 1992-01-22 DE DE69204698T patent/DE69204698T2/de not_active Expired - Fee Related
- 1992-01-22 ES ES92101017T patent/ES2079695T3/es not_active Expired - Lifetime
- 1992-01-22 AT AT92101017T patent/ATE127785T1/de not_active IP Right Cessation
- 1992-01-22 KR KR1019920000836A patent/KR100195420B1/ko not_active IP Right Cessation
- 1992-01-22 CA CA002059817A patent/CA2059817C/en not_active Expired - Fee Related
- 1992-01-22 FI FI920271A patent/FI111251B/fi active
- 1992-01-22 EP EP92101017A patent/EP0497202B1/de not_active Expired - Lifetime
- 1992-01-23 JP JP03128092A patent/JP3203582B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IL100698A0 (en) | 1992-09-06 |
PT100045B (pt) | 1999-10-29 |
KR100195420B1 (ko) | 1999-06-15 |
US5217964A (en) | 1993-06-08 |
DE69204698T2 (de) | 1996-02-15 |
FI920271A0 (fi) | 1992-01-22 |
EP0497202B1 (de) | 1995-09-13 |
IE920189A1 (en) | 1992-07-29 |
DE69204698D1 (de) | 1995-10-19 |
PT100045A (pt) | 1993-03-31 |
KR920014772A (ko) | 1992-08-25 |
NO179003B (no) | 1996-04-09 |
JP3203582B2 (ja) | 2001-08-27 |
FI111251B (fi) | 2003-06-30 |
FI920271A (fi) | 1992-07-24 |
JPH04334362A (ja) | 1992-11-20 |
IL100698A (en) | 1998-08-16 |
NZ241347A (en) | 1994-04-27 |
NO920283D0 (no) | 1992-01-22 |
AU1030492A (en) | 1992-07-30 |
NO920283L (no) | 1992-07-24 |
EP0497202A1 (de) | 1992-08-05 |
CA2059817C (en) | 2003-07-15 |
AU647570B2 (en) | 1994-03-24 |
ZA92360B (en) | 1992-11-25 |
NO179003C (no) | 1996-07-17 |
IE67961B1 (en) | 1996-05-15 |
ES2079695T3 (es) | 1996-01-16 |
CA2059817A1 (en) | 1992-07-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REN | Ceased due to non-payment of the annual fee |