NO920283L - Polyamintioler som radiobeskyttende midler - Google Patents
Polyamintioler som radiobeskyttende midlerInfo
- Publication number
- NO920283L NO920283L NO92920283A NO920283A NO920283L NO 920283 L NO920283 L NO 920283L NO 92920283 A NO92920283 A NO 92920283A NO 920283 A NO920283 A NO 920283A NO 920283 L NO920283 L NO 920283L
- Authority
- NO
- Norway
- Prior art keywords
- spo3h2
- polyamintiols
- integer
- protective agents
- radio protective
- Prior art date
Links
- 239000000718 radiation-protective agent Substances 0.000 title abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
- C07C323/34—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a mercapto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
- C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Materials For Medical Uses (AREA)
- Polyurethanes Or Polyureas (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Display Devices Of Pinball Game Machines (AREA)
- Polyethers (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/644,810 US5217964A (en) | 1991-01-23 | 1991-01-23 | Polyamine thiols as radioprotective agents |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO920283D0 NO920283D0 (no) | 1992-01-22 |
| NO920283L true NO920283L (no) | 1992-07-24 |
| NO179003B NO179003B (no) | 1996-04-09 |
| NO179003C NO179003C (no) | 1996-07-17 |
Family
ID=24586432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO920283A NO179003C (no) | 1991-01-23 | 1992-01-22 | Polyaminthioler som radiobeskyttende midler, og farmasöytisk preparat inneholdende disse |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5217964A (no) |
| EP (1) | EP0497202B1 (no) |
| JP (1) | JP3203582B2 (no) |
| KR (1) | KR100195420B1 (no) |
| AT (1) | ATE127785T1 (no) |
| AU (1) | AU647570B2 (no) |
| CA (1) | CA2059817C (no) |
| DE (1) | DE69204698T2 (no) |
| ES (1) | ES2079695T3 (no) |
| FI (1) | FI111251B (no) |
| IE (1) | IE67961B1 (no) |
| IL (1) | IL100698A (no) |
| NO (1) | NO179003C (no) |
| NZ (1) | NZ241347A (no) |
| PT (1) | PT100045B (no) |
| ZA (1) | ZA92360B (no) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5677351A (en) * | 1986-12-02 | 1997-10-14 | University Of Florida Research Foundation, Inc. | Sterically hindered tetraamines and method for their production |
| US5393757A (en) * | 1986-12-02 | 1995-02-28 | University Of Florida | Polyamines and anti-diarrheal and gastrointestinal anti-spasmodic pharmaceutical compositions and methods of treatment |
| US5342945A (en) * | 1986-12-02 | 1994-08-30 | University Of Florida Research Foundation, Inc. | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives |
| US5354782A (en) * | 1991-01-17 | 1994-10-11 | Merrell Dow Pharmaceuticals Inc. | Polyamine phenols as radioprotective agents |
| US5488042A (en) * | 1992-03-13 | 1996-01-30 | Arch Development Corporation | Method for protection against genotoxic mutagenesis |
| KR100311851B1 (ko) * | 1993-02-23 | 2002-04-24 | 슈테펜엘.네스비트 | 방사선보호제로서의폴리아민유도체 |
| ES2119203T3 (es) * | 1993-05-26 | 1998-10-01 | Merrell Pharma Inc | Derivados de poliamina n-alquiltio utilizados como agentes radioprotectores. |
| US5994409A (en) | 1997-12-09 | 1999-11-30 | U.S. Bioscience, Inc. | Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds |
| JP2002543163A (ja) * | 1999-04-30 | 2002-12-17 | スリル バイオメディカル コーポレイション | 癌および前立腺疾患のための治療としての結合体 |
| US6649587B1 (en) | 1999-04-30 | 2003-11-18 | Slil Biomedical Corporation | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases |
| AU4679900A (en) * | 1999-04-30 | 2000-11-17 | Slil Biomedical Corporation | Conformationally restricted polyamine analogs as disease therapies |
| US6482943B1 (en) | 1999-04-30 | 2002-11-19 | Slil Biomedical Corporation | Quinones as disease therapies |
| US6489312B1 (en) * | 1999-06-15 | 2002-12-03 | Medimmune Oncology, Inc. | Pharmaceutical formulations comprising aminoalkyl phosphorothioates |
| WO2001085142A1 (en) * | 2000-05-05 | 2001-11-15 | Wisconsin Alumni Research Foundation | Compositions and methods for protecting cells during cancer chemotherapy and radiotherapy |
| JP2004513136A (ja) * | 2000-11-08 | 2004-04-30 | スリル バイオメディカル コーポレーション | 抗癌剤として有用な新規ポリアミンアナログ−アミノ酸結合体 |
| US7053072B2 (en) * | 2001-05-11 | 2006-05-30 | Medimmune Oncology, Inc. | Methods for the administration of amifostine and related compounds |
| WO2003013245A1 (en) * | 2001-08-07 | 2003-02-20 | Wisconsin Alumni Research Foundation | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy |
| EP1453787A1 (en) * | 2001-12-07 | 2004-09-08 | SLIL Biomedical Corporation | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor |
| AU2003210883A1 (en) * | 2002-02-07 | 2003-09-02 | Wisconsin Alumni Research Foundation | Polyamine compounds and compositions for use in conjunction with cancer therapy |
| WO2005014524A2 (en) * | 2003-08-07 | 2005-02-17 | Wisconsin Alumni Research Foundation | Amino thiol compounds and compositions for use in conjunction with cancer therapy |
| WO2007149484A2 (en) * | 2006-06-20 | 2007-12-27 | Dana-Farber Cancer Institute | Inhibitors of usp1 deubiquitinating enzyme complex |
| WO2011137320A2 (en) | 2010-04-30 | 2011-11-03 | Dana-Farber Cancer Institute, Inc. | Small molecule inhibitors of usp1 deubiquitinating enzyme activity |
| US9725425B1 (en) | 2014-02-25 | 2017-08-08 | Dana-Farber Cancer Institute, Inc. | Compounds and methods for treating cancer |
| TWM528362U (zh) * | 2016-04-15 | 2016-09-11 | Calendar Entpr Co Ltd | 無繩式電動節能捲簾結構改良 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2901503A (en) * | 1956-08-28 | 1959-08-25 | Campbell Pharmaceuticals Inc | Dialkylaminophenyl esters of thiophosphoric acids |
| US3368972A (en) * | 1965-01-06 | 1968-02-13 | Mobil Oil Corp | High molecular weight mannich bases as engine oil additives |
| NZ223340A (en) * | 1987-02-03 | 1991-03-26 | Merrell Dow Pharma | Polyamine derivatives and pharmaceutical compositions |
| ZA887410B (en) * | 1987-10-08 | 1989-06-28 | Merrell Dow Pharma | Polyamine derivatives as antineoplastic agents |
-
1991
- 1991-01-23 US US07/644,810 patent/US5217964A/en not_active Expired - Fee Related
-
1992
- 1992-01-17 ZA ZA92360A patent/ZA92360B/xx unknown
- 1992-01-17 AU AU10304/92A patent/AU647570B2/en not_active Ceased
- 1992-01-19 IL IL10069892A patent/IL100698A/en not_active IP Right Cessation
- 1992-01-21 NZ NZ241347A patent/NZ241347A/en unknown
- 1992-01-22 KR KR1019920000836A patent/KR100195420B1/ko not_active IP Right Cessation
- 1992-01-22 PT PT100045A patent/PT100045B/pt not_active IP Right Cessation
- 1992-01-22 FI FI920271A patent/FI111251B/fi active
- 1992-01-22 CA CA002059817A patent/CA2059817C/en not_active Expired - Fee Related
- 1992-01-22 IE IE920189A patent/IE67961B1/en not_active IP Right Cessation
- 1992-01-22 NO NO920283A patent/NO179003C/no unknown
- 1992-01-22 EP EP92101017A patent/EP0497202B1/en not_active Expired - Lifetime
- 1992-01-22 AT AT92101017T patent/ATE127785T1/de not_active IP Right Cessation
- 1992-01-22 DE DE69204698T patent/DE69204698T2/de not_active Expired - Fee Related
- 1992-01-22 ES ES92101017T patent/ES2079695T3/es not_active Expired - Lifetime
- 1992-01-23 JP JP03128092A patent/JP3203582B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI920271A0 (fi) | 1992-01-22 |
| NZ241347A (en) | 1994-04-27 |
| ATE127785T1 (de) | 1995-09-15 |
| IE67961B1 (en) | 1996-05-15 |
| DE69204698D1 (de) | 1995-10-19 |
| US5217964A (en) | 1993-06-08 |
| AU647570B2 (en) | 1994-03-24 |
| CA2059817C (en) | 2003-07-15 |
| PT100045B (pt) | 1999-10-29 |
| KR100195420B1 (ko) | 1999-06-15 |
| NO179003C (no) | 1996-07-17 |
| ES2079695T3 (es) | 1996-01-16 |
| PT100045A (pt) | 1993-03-31 |
| JPH04334362A (ja) | 1992-11-20 |
| JP3203582B2 (ja) | 2001-08-27 |
| FI920271A (fi) | 1992-07-24 |
| KR920014772A (ko) | 1992-08-25 |
| IL100698A (en) | 1998-08-16 |
| EP0497202A1 (en) | 1992-08-05 |
| NO179003B (no) | 1996-04-09 |
| IE920189A1 (en) | 1992-07-29 |
| AU1030492A (en) | 1992-07-30 |
| FI111251B (fi) | 2003-06-30 |
| IL100698A0 (en) | 1992-09-06 |
| DE69204698T2 (de) | 1996-02-15 |
| EP0497202B1 (en) | 1995-09-13 |
| NO920283D0 (no) | 1992-01-22 |
| ZA92360B (en) | 1992-11-25 |
| CA2059817A1 (en) | 1992-07-24 |
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