PL442450A1 - Nanocomposite bone scaffold based on curdlan-chitosan matrix and hydroxyapatite and its production method - Google Patents
Nanocomposite bone scaffold based on curdlan-chitosan matrix and hydroxyapatite and its production methodInfo
- Publication number
- PL442450A1 PL442450A1 PL442450A PL44245022A PL442450A1 PL 442450 A1 PL442450 A1 PL 442450A1 PL 442450 A PL442450 A PL 442450A PL 44245022 A PL44245022 A PL 44245022A PL 442450 A1 PL442450 A1 PL 442450A1
- Authority
- PL
- Poland
- Prior art keywords
- curdlan
- hydroxyapatite
- chitosan
- acetic acid
- production method
- Prior art date
Links
- 229920001661 Chitosan Polymers 0.000 title abstract 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title abstract 4
- 210000000988 bone and bone Anatomy 0.000 title abstract 2
- 239000002114 nanocomposite Substances 0.000 title abstract 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000011159 matrix material Substances 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 9
- 229920002558 Curdlan Polymers 0.000 abstract 3
- 239000001879 Curdlan Substances 0.000 abstract 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 3
- 229940078035 curdlan Drugs 0.000 abstract 3
- 235000019316 curdlan Nutrition 0.000 abstract 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- 239000004615 ingredient Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000004068 calcium phosphate ceramic Substances 0.000 abstract 1
- 229940045110 chitosan Drugs 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3847—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Inorganic Chemistry (AREA)
- Vascular Medicine (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
Abstract
Przedmiotem zgłoszenia jest nanokompozytowe rusztowanie kostne, które cechuje się tym, że jego komponentami są kurdlan, chitozan oraz ceramika fosforanowo-wapniowa w formie nanoproszku hydroksyapatytu zawieszone w wodnym roztworze kwasu octowego o stężeniu 1% - 2%, gdzie proporcje wagowe podstawowych składników wynoszą: 4% - 10% (w/v) kurdlanu, 1% - 4% (w/v) chitozanu oraz 10% - 60% (w/v) nanoproszku hydroksyapatytu w stosunku do kwasu octowego. Przedmiotem zgłoszenia jest także sposób otrzymywania rusztowania według wynalazku, który polega na tym, że w roztworze kwasu octowego miesza się składniki: chitozan, kurdlan oraz nanoproszek hydroksyapatytu. Następnie dodaje się wodorowęglan sodu, dokładnie mieszając, po czym mieszaninę inkubuje się w temperaturze 90°C – 95°C, korzystnie 95°C, przez 15 - 25 minut, korzystnie 20 minut, a następnie schładza w temperaturze 4°C - 6°C, po czym otrzymany materiał zamraża się w temperaturze od -65°C do -80°C, po czym poddaje się procesowi liofilizacji (1 – 15 Pa).The subject of the application is a nanocomposite bone scaffold characterized by the fact that its components are curdlan, chitosan and calcium-phosphate ceramics in the form of hydroxyapatite nanopowder suspended in an aqueous solution of acetic acid at a concentration of 1% - 2%, where the weight proportions of the basic ingredients are: 4 % - 10% (w/v) curdlan, 1% - 4% (w/v) chitosan and 10% - 60% (w/v) hydroxyapatite nanopowder in relation to acetic acid. The subject of the application is also the method of obtaining the scaffold according to the invention, which consists in mixing the following ingredients in an acetic acid solution: chitosan, curdlan and hydroxyapatite nanopowder. Sodium bicarbonate is then added, mixing thoroughly, and the mixture is incubated at 90°C - 95°C, preferably 95°C, for 15 - 25 minutes, preferably 20 minutes, and then cooled at 4°C - 6° C, then the obtained material is frozen at a temperature from -65°C to -80°C, and then subjected to the freeze-drying process (1 - 15 Pa).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL442450A PL442450A1 (en) | 2022-10-05 | 2022-10-05 | Nanocomposite bone scaffold based on curdlan-chitosan matrix and hydroxyapatite and its production method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL442450A PL442450A1 (en) | 2022-10-05 | 2022-10-05 | Nanocomposite bone scaffold based on curdlan-chitosan matrix and hydroxyapatite and its production method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL442450A1 true PL442450A1 (en) | 2024-04-08 |
Family
ID=90623477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL442450A PL442450A1 (en) | 2022-10-05 | 2022-10-05 | Nanocomposite bone scaffold based on curdlan-chitosan matrix and hydroxyapatite and its production method |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL442450A1 (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002306090A (en) * | 2001-04-06 | 2002-10-22 | Takeda-Kirin Foods Corp | Curdlan/chitosan-containing composition and method for producing the same |
| PL235822B1 (en) * | 2018-08-24 | 2020-11-02 | Univ Medyczny W Lublinie | Cryogel bone scaffold based on chitosan and calcium phosphate bioceramics as well as method of producing it |
| PL236369B1 (en) * | 2019-09-19 | 2021-01-11 | Univ Medyczny W Lublinie | Method of obtaining bone scaffold based on fluoroapatite ceramics and polymer and bone scaffold |
| PL240639B1 (en) * | 2021-03-08 | 2022-05-09 | Univ Medyczny W Lublinie | Two-phase biomaterial based on curdlane and hydroxyapatite (HAp) for the regeneration of cartilage and bone defects and method of its preparation |
| PL240725B1 (en) * | 2021-03-08 | 2022-05-23 | Univ Medyczny W Lublinie | Biomaterial based on natural polysaccharide - β-1,3-glucan (curdlan) and ceramics for applications in bone tissue engineering and method of its preparation |
-
2022
- 2022-10-05 PL PL442450A patent/PL442450A1/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002306090A (en) * | 2001-04-06 | 2002-10-22 | Takeda-Kirin Foods Corp | Curdlan/chitosan-containing composition and method for producing the same |
| PL235822B1 (en) * | 2018-08-24 | 2020-11-02 | Univ Medyczny W Lublinie | Cryogel bone scaffold based on chitosan and calcium phosphate bioceramics as well as method of producing it |
| PL236369B1 (en) * | 2019-09-19 | 2021-01-11 | Univ Medyczny W Lublinie | Method of obtaining bone scaffold based on fluoroapatite ceramics and polymer and bone scaffold |
| PL240639B1 (en) * | 2021-03-08 | 2022-05-09 | Univ Medyczny W Lublinie | Two-phase biomaterial based on curdlane and hydroxyapatite (HAp) for the regeneration of cartilage and bone defects and method of its preparation |
| PL240725B1 (en) * | 2021-03-08 | 2022-05-23 | Univ Medyczny W Lublinie | Biomaterial based on natural polysaccharide - β-1,3-glucan (curdlan) and ceramics for applications in bone tissue engineering and method of its preparation |
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