PL437235A1 - Biomaterial based on natural polysaccharide - β-1,3-glucan (curdlan) and ceramics for applications in bone tissue engineering and method of its preparation - Google Patents

Biomaterial based on natural polysaccharide - β-1,3-glucan (curdlan) and ceramics for applications in bone tissue engineering and method of its preparation

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Publication number
PL437235A1
PL437235A1 PL437235A PL43723521A PL437235A1 PL 437235 A1 PL437235 A1 PL 437235A1 PL 437235 A PL437235 A PL 437235A PL 43723521 A PL43723521 A PL 43723521A PL 437235 A1 PL437235 A1 PL 437235A1
Authority
PL
Poland
Prior art keywords
curdlan
glucan
hap
natural polysaccharide
ceramics
Prior art date
Application number
PL437235A
Other languages
Polish (pl)
Other versions
PL240725B1 (en
Inventor
Katarzyna Klimek
Grażyna GINALSKA
Original Assignee
Uniwersytet Medyczny W Lublinie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Medyczny W Lublinie filed Critical Uniwersytet Medyczny W Lublinie
Priority to PL437235A priority Critical patent/PL240725B1/en
Publication of PL437235A1 publication Critical patent/PL437235A1/en
Publication of PL240725B1 publication Critical patent/PL240725B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Przedmiotem zgłoszenia jest biomateriał na bazie naturalnego polisacharydu —β-1,3-glukanu (kurdlanu) oraz ceramiki hydroksyapatytowej (HAp), który charakteryzuje się tym, że zawiera komponent białkowy - izolat białka serwatkowego (WPI) w ilości 20 - 50% (w/v), korzystnie 35% (w/v), zaś pozostałe składniki jak β-1,3-glukan (kurdlan) oraz ceramika hydroksyapatytowa (HAp) występują w ilościach: naturalny polisacharyd —β-1,3-glukan (kurdlan) w ilości 6 - 20% (w/v), korzystnie 8% (w/v), a ceramika hydroksyapatytowa (HAp) w ilości od 10 g do 180 g w odniesieniu do 100 ml wodnego roztworu. Zgłoszenie obejmuje także sposób wytwarzania biomateriału na bazie naturalnego polisacharydu —β-1,3-glukanu (kurdlanu) oraz ceramiki hydroksyapatytowej (HAp) charakteryzujący się tym że 20 - 50% (w/v) roztwór izolatu białka serwatkowego (WPI), korzystnie 35% (w/v), przygotowuje się w wodzie destylowanej i dodaje się do proszku β-1,3-glukanu (kurdlanu), tak aby stężenie kurdlanu względem 100 ml roztworu WPI wynosiło 6 - 20% (w/v), korzystnie 8% (w/v), następnie do takiej mieszaniny dodaje się ceramikę hydroksyapatytową (HAp) w postaci nanoproszku, proszku lub granul o rozmiarze 0,1 – 1,0 mm, wypalanych w temperaturze 500 - 1300°C, w ilości 10 - 180 g, tak otrzymany biomateriał inkubuje od 1 do 60 minut, korzystnie 15 minut w temperaturze 90 - 120°C, korzystnie 90°C, a następnie sterylizuje.The subject of the application is a biomaterial based on the natural polysaccharide -β-1,3-glucan (curdlan) and hydroxyapatite ceramics (HAp), which is characterized by the fact that it contains a protein component - whey protein isolate (WPI) in the amount of 20 - 50% (in / v), preferably 35% (w / v), and the remaining ingredients such as β-1,3-glucan (curdlan) and hydroxyapatite ceramics (HAp) are present in the following amounts: natural polysaccharide -β-1,3-glucan (curdlan) in an amount of 6-20% (w / v), preferably 8% (w / v), and a hydroxyapatite ceramic (HAp) in an amount of 10 to 180 g based on 100 ml of aqueous solution. The application also covers a method for the production of a biomaterial based on natural polysaccharide -β-1,3-glucan (curdlan) and hydroxyapatite ceramics (HAp), characterized in that a 20 - 50% (w / v) solution of whey protein isolate (WPI), preferably 35 % (w / v), is prepared in distilled water and added to the β-1,3-glucan (curdlan) powder so that the concentration of curdlan relative to 100 ml of WPI solution is 6 - 20% (w / v), preferably 8 % (w / v), then hydroxyapatite ceramics (HAp) in the form of nanopowder, powder or granules with a size of 0.1 - 1.0 mm, fired at a temperature of 500 - 1300 ° C, in the amount of 10 - 180 are added to this mixture. g, the biomaterial thus obtained is incubated for 1 to 60 minutes, preferably 15 minutes at a temperature of 90-120 ° C, preferably 90 ° C, and then sterilized.

PL437235A 2021-03-08 2021-03-08 Biomaterial based on natural polysaccharide - β-1,3-glucan (curdlan) and ceramics for applications in bone tissue engineering and method of its preparation PL240725B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL437235A PL240725B1 (en) 2021-03-08 2021-03-08 Biomaterial based on natural polysaccharide - β-1,3-glucan (curdlan) and ceramics for applications in bone tissue engineering and method of its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL437235A PL240725B1 (en) 2021-03-08 2021-03-08 Biomaterial based on natural polysaccharide - β-1,3-glucan (curdlan) and ceramics for applications in bone tissue engineering and method of its preparation

Publications (2)

Publication Number Publication Date
PL437235A1 true PL437235A1 (en) 2021-12-13
PL240725B1 PL240725B1 (en) 2022-05-23

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL437235A PL240725B1 (en) 2021-03-08 2021-03-08 Biomaterial based on natural polysaccharide - β-1,3-glucan (curdlan) and ceramics for applications in bone tissue engineering and method of its preparation

Country Status (1)

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PL (1) PL240725B1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL442451A1 (en) * 2022-10-05 2024-04-08 Uniwersytet Medyczny W Lublinie Hydroxyapatite-polymer nanocomposite granulate based on curdlan-chitosan matrix and its production method
PL442450A1 (en) * 2022-10-05 2024-04-08 Uniwersytet Medyczny W Lublinie Nanocomposite bone scaffold based on curdlan-chitosan matrix and hydroxyapatite and its production method

Also Published As

Publication number Publication date
PL240725B1 (en) 2022-05-23

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