PL426788A1 - Cryogel bone scaffold based on chitosan and calcium phosphate bioceramics as well as method of producing it - Google Patents
Cryogel bone scaffold based on chitosan and calcium phosphate bioceramics as well as method of producing itInfo
- Publication number
- PL426788A1 PL426788A1 PL426788A PL42678818A PL426788A1 PL 426788 A1 PL426788 A1 PL 426788A1 PL 426788 A PL426788 A PL 426788A PL 42678818 A PL42678818 A PL 42678818A PL 426788 A1 PL426788 A1 PL 426788A1
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- PL
- Poland
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- chitosan
- acetic acid
- calcium phosphate
- solution
- biomaterial
- Prior art date
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- Materials For Medical Uses (AREA)
Abstract
Przedmiotem zgłoszenia jest makroporowate rusztowanie kostne na bazie chitozanu w roztworze kwasu octowego oraz bioceramiki fosforanowo-wapniowej, które charakteryzuje się tym, że stanowi go chitozan, agaroza oraz bioceramika fosforanowo-wapniowa w postaci proszku lub nanoproszku, rozprowadzone w 0,5 - 3% wodnym roztworze kwasu octowego, przy czym proporcje wagowe stałych komponentów wynoszą odpowiednio 0,5 - 4% (w/v) chitozanu, 0,5 - 5% (w/v) agarozy oraz 1 - 70% (w/v) bioceramiki fosforanowo-wapniowej w odniesieniu do kwasu octowego. Zgłoszenie niniejsze obejmuje też sposób wytwarzania rusztowania kostnego który polega na zastosowaniu następczo dwóch metod wprowadzania porów do biomateriału jednej z wykorzystaniem NaHCO3 jako źródło gazu CO2 (porogen) oraz drugiej - procesu liofilizacji. Bioceramikę fosforanowo-wapniową w postaci proszku lub nanoproszku oraz agarozę rozprowadza się w roztworze chitozanu przygotowanym w kwasie octowym. Następnie do jednolitej masy dodaje się wodorowęglan sodu (NaHCO3) jako pośrednie źródło CO2. Otrzymany rodzaj pasty poddano działaniu wysokiej temperatury, a następnie zamrożeniu oraz procesowi liofilizacji. Po liofilizacji, biomateriał zanurza się na 10 minut (próbka o objętości 2 cm3) w 0,5 - 2% (w/v) wodnym roztworze zasady sodowej, w celu zneutralizowania pozostałości kwasu octowego w próbce. Po wyjęciu biomateriału z roztworu NaOH, płucze się go trzykrotnie przez okres 30 minut w wodzie dejonizowanej.The subject of the application is a macroporous bone scaffold based on chitosan in a solution of acetic acid and calcium phosphate bioceramics, which is characterized by chitosan, agarose and calcium phosphate bioceramics in the form of a powder or nanopowder, dispersed in 0.5 - 3% water acetic acid solution, with the weight proportions of solid components being, respectively, 0.5 - 4% (w / v) chitosan, 0.5 - 5% (w / v) agarose and 1-70% (w / v) phosphate- of calcium with respect to acetic acid. The present application also includes a method of producing a bone scaffold which consists in the subsequent application of two methods of introducing pores into the biomaterial, one using NaHCO3 as a CO2 gas source (porogen) and the other - a freeze drying process. Calcium phosphate bioceramics in the form of a powder or nanopowder and agarose are spread in a chitosan solution prepared in acetic acid. Then sodium bicarbonate (NaHCO3) is added to the homogeneous mass as an indirect CO2 source. The obtained type of paste was subjected to high temperature and then freezing and the process of lyophilization. After lyophilization, the biomaterial is immersed for 10 minutes (2 cm3 sample) in 0.5 - 2% (w / v) aqueous sodium base solution to neutralize residual acetic acid in the sample. After removing the biomaterial from the NaOH solution, it is rinsed three times for a period of 30 minutes in deionized water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL426788A PL235822B1 (en) | 2018-08-24 | 2018-08-24 | Cryogel bone scaffold based on chitosan and calcium phosphate bioceramics as well as method of producing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL426788A PL235822B1 (en) | 2018-08-24 | 2018-08-24 | Cryogel bone scaffold based on chitosan and calcium phosphate bioceramics as well as method of producing it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL426788A1 true PL426788A1 (en) | 2020-03-09 |
| PL235822B1 PL235822B1 (en) | 2020-11-02 |
Family
ID=69709483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL426788A PL235822B1 (en) | 2018-08-24 | 2018-08-24 | Cryogel bone scaffold based on chitosan and calcium phosphate bioceramics as well as method of producing it |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL235822B1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL442450A1 (en) * | 2022-10-05 | 2024-04-08 | Uniwersytet Medyczny W Lublinie | Nanocomposite bone scaffold based on curdlan-chitosan matrix and hydroxyapatite and its production method |
| PL442451A1 (en) * | 2022-10-05 | 2024-04-08 | Uniwersytet Medyczny W Lublinie | Hydroxyapatite-polymer nanocomposite granulate based on curdlan-chitosan matrix and its production method |
-
2018
- 2018-08-24 PL PL426788A patent/PL235822B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL235822B1 (en) | 2020-11-02 |
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