PL442129A1 - Sposób otrzymywania halfordyny z liści Halfordia kendack (Montrouz.) Guillaumin (Rutaceae) - Google Patents
Sposób otrzymywania halfordyny z liści Halfordia kendack (Montrouz.) Guillaumin (Rutaceae)Info
- Publication number
- PL442129A1 PL442129A1 PL442129A PL44212922A PL442129A1 PL 442129 A1 PL442129 A1 PL 442129A1 PL 442129 A PL442129 A PL 442129A PL 44212922 A PL44212922 A PL 44212922A PL 442129 A1 PL442129 A1 PL 442129A1
- Authority
- PL
- Poland
- Prior art keywords
- leaves
- phase
- mixture
- solvent
- kendack
- Prior art date
Links
- SHOQQSABOUVQLJ-UHFFFAOYSA-N 4,5,6-trimethoxyfuro[3,2-g]chromen-7-one Chemical compound C1=C2OC=CC2=C(OC)C2=C1OC(=O)C(OC)=C2OC SHOQQSABOUVQLJ-UHFFFAOYSA-N 0.000 title abstract 4
- NVCSGIZATKCZKJ-UHFFFAOYSA-N Halfordine Natural products CC(C)(O)C(O)COc1ccc(cc1)c2oc(nc2)c3cccnc3 NVCSGIZATKCZKJ-UHFFFAOYSA-N 0.000 title abstract 3
- 241001079254 Halfordia kendack Species 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 241001093501 Rutaceae Species 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- 239000002904 solvent Substances 0.000 abstract 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 238000000926 separation method Methods 0.000 abstract 3
- 239000011877 solvent mixture Substances 0.000 abstract 3
- USNQTVHRQCVEFD-UHFFFAOYSA-N 3-methyl-1-[4-(2-pyridin-3-yl-1,3-oxazol-4-yl)phenoxy]butane-2,3-diol Chemical compound C1=CC(OCC(O)C(C)(O)C)=CC=C1C1=COC(C=2C=NC=CC=2)=N1 USNQTVHRQCVEFD-UHFFFAOYSA-N 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000000401 methanolic extract Substances 0.000 abstract 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Extraction Or Liquid Replacement (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób otrzymywania halfordyny z liści H. kendack przez ekstrakcję rozpuszczalnikiem lub mieszaniną rozpuszczalników, charakteryzujący się tym, że rozdrobnione liście poddaje się najpierw ekstrakcji metanolem, a następnie ekstrakt metanolowy poddaje się rozdzielaniu przy użyciu chromatografii odśrodkowej z dwufazową mieszaniną rozpuszczalników użytych w proporcji n-heksan, octan etylu, metanol, woda od 1:1:1:1 do 1.6:0.4:1.6:0.4 (v/v/v/v), przy czym ekstrakt w ilości 5% do 30%, korzystnie 27% w stosunku do objętości dozowanej do kolumny mieszaniny rozpuszczalników, przed rozdzielaniem rozpuszcza się w próbce mieszaniny rozpuszczalników o takim samym składzie jak dwufazowa mieszanina rozpuszczalników, albo w jednej z faz stosowanego układu rozpuszczalników, korzystnie w fazie ruchomej, a rozdzielanie prowadzi się w układzie faz odwróconych, stosując rotację kolumny, aż do uzyskania stanu równowagi faz, w temperaturze od 25°C do 35°C korzystnie 26°C, następnie po rozdzieleniu zbiera się frakcje stanowiące halfordynę.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL442129A PL249584B1 (pl) | 2022-08-29 | Sposób otrzymywania halfordyny z liści Halfordia kendack (Montrouz.) Guillaumin (Rutaceae) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL442129A PL249584B1 (pl) | 2022-08-29 | Sposób otrzymywania halfordyny z liści Halfordia kendack (Montrouz.) Guillaumin (Rutaceae) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL442129A1 true PL442129A1 (pl) | 2024-03-04 |
| PL249584B1 PL249584B1 (pl) | 2026-05-18 |
Family
ID=
Non-Patent Citations (4)
| Title |
|---|
| CSIRO; MP Hegarty and FN Lahey "The coumarins of Halfordia scleroxyla F. Muell", Australian Journal of Chemistry 1956, 9(1) 120 – 131, abstract * |
| MDPI; Jarosław Widelski et al."Coumarins from Seseli devenyense Simonk.: Isolation by Liquid–Liquid Chromatography and Potential Anxiolytic Activity Using an In Vivo Zebrafish Larvae Model", Int. J. Mol. Sci. 2021, 22(4), 1829 * |
| NIH; N Sultana et al."3,5-Dimethoxy-3-(1,1-dimethylprop-2-enyl)-3,4-dihydropsoralen-4-one: an unusual furanocoumarin derivative from Halfordia kendack", Phytochemistry 2000 Nov;55(6):675-8 * |
| ScienceDirect; Ewelina Kozioł et al. "High-performance counter-current chromatography isolation and initial neuroactivity characterization of furanocoumarin derivatives from Peucedanum alsaticum L (Apiaceae)", Phytomedicine Volume 54, 15 February 2019, Pages 259-264 * |
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