PL43804B1 - - Google Patents

Info

Publication number

PL43804B1

PL43804B1 PL43804A PL4380459A PL43804B1 PL 43804 B1 PL43804 B1 PL 43804B1 PL 43804 A PL43804 A PL 43804A PL 4380459 A PL4380459 A PL 4380459A PL 43804 B1 PL43804 B1 PL 43804B1

Authority

PL

Poland

Prior art keywords

impurities

antibiotic

acid

environment

iron

Prior art date

1959-10-16

Links

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• Global Dossier
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• 230000003115 biocidal Effects 0.000 claims description 13
• 239000012535 impurity Substances 0.000 claims description 6
• 239000003242 anti bacterial agent Substances 0.000 claims description 5
• 150000003839 salts Chemical class 0.000 claims description 4
• 239000011780 sodium chloride Substances 0.000 claims description 4
• 229940064005 Antibiotic throat preparations Drugs 0.000 claims description 3
• 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 claims description 3
• 229940042052 Antibiotics for systemic use Drugs 0.000 claims description 3
• 229940042786 Antitubercular Antibiotics Drugs 0.000 claims description 3
• 229940093922 Gynecological Antibiotics Drugs 0.000 claims description 3
• 229940024982 Topical Antifungal Antibiotics Drugs 0.000 claims description 3
• 229940079866 intestinal antibiotics Drugs 0.000 claims description 3
• 238000000034 method Methods 0.000 claims description 3
• 229940005935 ophthalmologic Antibiotics Drugs 0.000 claims description 3
• 125000001165 hydrophobic group Chemical group 0.000 claims description 2
• 244000005700 microbiome Species 0.000 claims description 2
• 241000204060 Streptomycetaceae Species 0.000 claims 1
• 230000002378 acidificating Effects 0.000 claims 1
• YAGKRVSRTSUGEY-UHFFFAOYSA-Q hydron;iron(3+);hexacyanide Chemical class [H+].[H+].[H+].[Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-Q 0.000 claims 1
• VRWKTAYJTKRVCU-UHFFFAOYSA-N iron(6+);hexacyanide Chemical class [Fe+6].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] VRWKTAYJTKRVCU-UHFFFAOYSA-N 0.000 claims 1
• 150000003856 quaternary ammonium compounds Chemical class 0.000 claims 1
• MUBZPKHOEPUJKR-UHFFFAOYSA-N oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 15
• XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 13
• 229910052742 iron Inorganic materials 0.000 description 7
• 238000000855 fermentation Methods 0.000 description 5
• 230000004151 fermentation Effects 0.000 description 5
• 239000000706 filtrate Substances 0.000 description 5
• 235000006408 oxalic acid Nutrition 0.000 description 5
• SVDOODSCHVSYEK-IFLJXUKPSA-N (4S,4aR,5S,5aR,6S,12aR)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydron;chloride Chemical compound Cl.C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O SVDOODSCHVSYEK-IFLJXUKPSA-N 0.000 description 4
• VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
• 239000005909 Kieselgur Substances 0.000 description 4
• 229960004368 Oxytetracycline Hydrochloride Drugs 0.000 description 4
• 239000000276 potassium ferrocyanide Substances 0.000 description 4
• OCPOWIWGGAATRP-UHFFFAOYSA-N potassium hexacyanoferrate(4-) Chemical compound [K+].[K+].[K+].[K+].N#C[Fe-4](C#N)(C#N)(C#N)(C#N)C#N OCPOWIWGGAATRP-UHFFFAOYSA-N 0.000 description 4
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
• 229960000625 Oxytetracycline Drugs 0.000 description 3
• 239000004100 Oxytetracycline Substances 0.000 description 3
• IWVCMVBTMGNXQD-PXOLEDIWSA-N Oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 3
• 239000002253 acid Substances 0.000 description 3
• 150000007513 acids Chemical class 0.000 description 3
• VHUUQVKOLVNVRT-UHFFFAOYSA-N ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 3
• 235000011114 ammonium hydroxide Nutrition 0.000 description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
• 150000001875 compounds Chemical class 0.000 description 3
• 239000012530 fluid Substances 0.000 description 3
• -1 iron ions Chemical class 0.000 description 3
• 235000019366 oxytetracycline Nutrition 0.000 description 3
• 239000002244 precipitate Substances 0.000 description 3
• 239000000047 product Substances 0.000 description 3
• DNMNDNSFJMUUFM-UHFFFAOYSA-N Prussian blue Chemical compound [Fe+3].[Fe+3].[Fe+3].[Fe+3].N#C[Fe-4](C#N)(C#N)(C#N)(C#N)C#N.N#C[Fe-4](C#N)(C#N)(C#N)(C#N)C#N.N#C[Fe-4](C#N)(C#N)(C#N)(C#N)C#N DNMNDNSFJMUUFM-UHFFFAOYSA-N 0.000 description 2
• 239000007857 degradation product Substances 0.000 description 2
• 238000001914 filtration Methods 0.000 description 2
• 239000007788 liquid Substances 0.000 description 2
• 229910052751 metal Inorganic materials 0.000 description 2
• 239000002184 metal Substances 0.000 description 2
• OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 2
• 239000002002 slurry Substances 0.000 description 2
• 230000036740 Metabolism Effects 0.000 description 1
• JUJWROOIHBZHMG-UHFFFAOYSA-O Pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 description 1
• 150000003863 ammonium salts Chemical class 0.000 description 1
• 239000007795 chemical reaction product Substances 0.000 description 1
• 238000004140 cleaning Methods 0.000 description 1
• 238000001035 drying Methods 0.000 description 1
• KCXVZYZYPLLWCC-UHFFFAOYSA-N edta Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
• ORXDSIPBTFAEKJ-UHFFFAOYSA-N ferrocyanide Chemical class N#C[Fe-4](C#N)(C#N)(C#N)(C#N)C#N ORXDSIPBTFAEKJ-UHFFFAOYSA-N 0.000 description 1
• 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
• IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
• AEIXRCIKZIZYPM-UHFFFAOYSA-M hydroxy(oxo)iron Chemical compound [O][Fe]O AEIXRCIKZIZYPM-UHFFFAOYSA-M 0.000 description 1
• 229910000462 iron(III) oxide hydroxide Inorganic materials 0.000 description 1
• 239000010807 litter Substances 0.000 description 1
• 230000004060 metabolic process Effects 0.000 description 1
• 230000035786 metabolism Effects 0.000 description 1
• 150000002739 metals Chemical class 0.000 description 1
• 230000000813 microbial Effects 0.000 description 1
• 150000007522 mineralic acids Chemical class 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 239000000049 pigment Substances 0.000 description 1
• AOJFQRQNPXYVLM-UHFFFAOYSA-N pyridin-1-ium;chloride Chemical compound [Cl-].C1=CC=[NH+]C=C1 AOJFQRQNPXYVLM-UHFFFAOYSA-N 0.000 description 1
• 239000007787 solid Substances 0.000 description 1
• 239000000725 suspension Substances 0.000 description 1
• 239000002699 waste material Substances 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1