JPH09504960A - ナタマイシン回収方法 - Google Patents
ナタマイシン回収方法Info
- Publication number
- JPH09504960A JPH09504960A JP7525534A JP52553495A JPH09504960A JP H09504960 A JPH09504960 A JP H09504960A JP 7525534 A JP7525534 A JP 7525534A JP 52553495 A JP52553495 A JP 52553495A JP H09504960 A JPH09504960 A JP H09504960A
- Authority
- JP
- Japan
- Prior art keywords
- broth
- natamycin
- water
- isopropanol
- adjusted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.ナタマイシンを含む発酵ブロスからナタマイシンを回収する方法であって、 下記段階からなる方法: a)上記ブロスのpHを約10より上に調節し、上記ブロスにナタマイシンを溶 解させるに十分な量の実質的に水混和性の溶媒を加え; b)上記pH調節されたブロスから不溶性固体を除去し; c)該ブロスのpHをナタマイシンを沈殿させるに十分なレベルに低下させ; d)ナタマイシンを上記ブロスから取り出す。 2.水混和性溶媒が、エタノール、プロパノール、イソプロパノール、アセトン 、テトラヒドロフランおよびそれらの組み合わせから選択される請求項1記載の 方法。 3.水混和性溶媒がイソプロパノールである請求項2記載の方法。 4.段階a)において上記ブロスのpHが10と11との間に調節される請求項 1記載の方法。 5.段階a)において上記ブロスのpHが10と11との間に調節される請求項 3記載の方法。 6.段階c)において上記ブロスのpHを5.5と7.5との間に低下させる請 求項1記載の方法。 7.段階c)において上記ブロスのpHがを.5と7.5との間に低下させる請 求項5記載の方法。 8.段階b)が交差流濾過を利用する請求項1記載の方法。 9.段階b)が交差流濾過を利用する請求項7記載の方法。 10.上記ブロスを濃縮する予備段階を含む請求項1記載の方法。 11.上記ブロスが10−50重量/容量%の固体濃度に濃縮される請求項10 記載の方法。 12.上記予備段階が交差流濾過を利用する請求項10記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22196094A | 1994-03-31 | 1994-03-31 | |
US221,960 | 1994-03-31 | ||
US08/221,960 | 1994-03-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09504960A true JPH09504960A (ja) | 1997-05-20 |
JP2750222B2 JP2750222B2 (ja) | 1998-05-13 |
Family
ID=22830169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7525534A Expired - Lifetime JP2750222B2 (ja) | 1994-03-31 | 1995-01-19 | ナタマイシン回収方法 |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0754239B1 (ja) |
JP (1) | JP2750222B2 (ja) |
AT (1) | ATE159051T1 (ja) |
AU (1) | AU677890B2 (ja) |
CA (1) | CA2186259C (ja) |
DE (1) | DE69500846T2 (ja) |
DK (1) | DK0754239T3 (ja) |
ES (1) | ES2112042T3 (ja) |
GR (1) | GR3025755T3 (ja) |
MX (1) | MX9604372A (ja) |
WO (1) | WO1995027073A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0251582A (ja) * | 1988-08-12 | 1990-02-21 | Kyokado Eng Co Ltd | 地盤注入用薬液 |
JP2009268479A (ja) * | 2000-10-05 | 2009-11-19 | Teva Gyogyszergyar Zartkoruen Mukodo Rt | プラバスタチンラクトン及びエピプラバスタチンを実質的に含まないプラバスタチンナトリウムの製造方法 |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0896627B1 (en) * | 1996-02-09 | 2003-05-02 | Dsm N.V. | Natamycin recovery |
US6150143A (en) * | 1996-02-09 | 2000-11-21 | Gist-Brocades B.V. | Natamycin recovery |
CA2527120C (en) | 2003-06-02 | 2011-11-08 | Dsm Ip Assets B.V. | Stable aqueous solution of natamycin fungicide |
CN102964409B (zh) | 2004-10-28 | 2015-05-13 | 帝斯曼知识产权资产管理有限公司 | 游霉素的稳定针形晶体 |
CN100393738C (zh) * | 2005-07-05 | 2008-06-11 | 广州市微生物研究所 | 纳他霉素的提取纯化方法 |
EP2260706B1 (en) * | 2005-10-04 | 2016-05-04 | DSM IP Assets B.V. | Improved anti-fungal composition |
US20210267239A1 (en) * | 2018-07-11 | 2021-09-02 | Lanxess Deutschland Gmbh | Process for Sanitizing and Preserving Foodstuffs and Beverages |
CN117587087A (zh) * | 2023-11-22 | 2024-02-23 | 浙江新银象生物工程有限公司 | 一种液体纳他霉素的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3892850A (en) * | 1956-03-13 | 1975-07-01 | Gist Brocades Nv | Pimaricin and process of producing same |
JPS63117952A (ja) * | 1986-11-07 | 1988-05-21 | 呉羽化学工業株式会社 | 高靭性コランダム−ルチル複合焼結体およびその製造方法 |
DE69104624T2 (de) * | 1990-12-07 | 1995-05-04 | E.I. Du Pont De Nemours & Co., Wilmington, Del. | Natamycingewinnung. |
-
1995
- 1995-01-19 JP JP7525534A patent/JP2750222B2/ja not_active Expired - Lifetime
- 1995-01-19 AU AU13911/95A patent/AU677890B2/en not_active Expired
- 1995-01-19 DK DK95905216.8T patent/DK0754239T3/da active
- 1995-01-19 ES ES95905216T patent/ES2112042T3/es not_active Expired - Lifetime
- 1995-01-19 MX MX9604372A patent/MX9604372A/es unknown
- 1995-01-19 EP EP95905216A patent/EP0754239B1/en not_active Expired - Lifetime
- 1995-01-19 AT AT95905216T patent/ATE159051T1/de active
- 1995-01-19 CA CA002186259A patent/CA2186259C/en not_active Expired - Lifetime
- 1995-01-19 DE DE69500846T patent/DE69500846T2/de not_active Expired - Lifetime
- 1995-01-19 WO PCT/IB1995/000040 patent/WO1995027073A1/en active IP Right Grant
-
1997
- 1997-12-23 GR GR970403405T patent/GR3025755T3/el unknown
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0251582A (ja) * | 1988-08-12 | 1990-02-21 | Kyokado Eng Co Ltd | 地盤注入用薬液 |
JP2009268479A (ja) * | 2000-10-05 | 2009-11-19 | Teva Gyogyszergyar Zartkoruen Mukodo Rt | プラバスタチンラクトン及びエピプラバスタチンを実質的に含まないプラバスタチンナトリウムの製造方法 |
JP2015212300A (ja) * | 2000-10-05 | 2015-11-26 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | プラバスタチンラクトン及びエピプラバスタチンを実質的に含まないプラバスタチンナトリウムの製造方法 |
Also Published As
Publication number | Publication date |
---|---|
AU677890B2 (en) | 1997-05-08 |
DK0754239T3 (da) | 1998-05-18 |
ES2112042T3 (es) | 1998-03-16 |
DE69500846D1 (de) | 1997-11-13 |
EP0754239B1 (en) | 1997-10-08 |
ATE159051T1 (de) | 1997-10-15 |
CA2186259A1 (en) | 1995-10-12 |
CA2186259C (en) | 1999-12-14 |
MX9604372A (es) | 1997-06-28 |
WO1995027073A1 (en) | 1995-10-12 |
AU1391195A (en) | 1995-10-23 |
EP0754239A1 (en) | 1997-01-22 |
DE69500846T2 (de) | 1998-04-23 |
GR3025755T3 (en) | 1998-03-31 |
JP2750222B2 (ja) | 1998-05-13 |
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