PL409283A1 - Enzym o wysokiej aktywności litycznej w stosunku do komórek Enterococcus oraz sposób modyfikacji jego genu pozwalający na nadprodukcję aktywnego enzymu w komórkach bakteryjnych - Google Patents

Enzym o wysokiej aktywności litycznej w stosunku do komórek Enterococcus oraz sposób modyfikacji jego genu pozwalający na nadprodukcję aktywnego enzymu w komórkach bakteryjnych

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Publication number
PL409283A1
PL409283A1 PL409283A PL40928314A PL409283A1 PL 409283 A1 PL409283 A1 PL 409283A1 PL 409283 A PL409283 A PL 409283A PL 40928314 A PL40928314 A PL 40928314A PL 409283 A1 PL409283 A1 PL 409283A1
Authority
PL
Poland
Prior art keywords
gene
cells
enzyme
relation
enterococcus
Prior art date
Application number
PL409283A
Other languages
English (en)
Other versions
PL229262B1 (pl
Inventor
Małgorzata Łobocka
Agnieszka Gozdek
Jarosław Kosakowski
Aleksandra Różycka
Beata Weber-Dąbrowska
Andrzej Górski
Original Assignee
Instytut Biochemii I Biofizyki Polskiej Akademii Nauk
Instytut Immunologii I Terapii Doświadczalnej Polskiej Akademii Nauk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instytut Biochemii I Biofizyki Polskiej Akademii Nauk, Instytut Immunologii I Terapii Doświadczalnej Polskiej Akademii Nauk filed Critical Instytut Biochemii I Biofizyki Polskiej Akademii Nauk
Priority to PL409283A priority Critical patent/PL229262B1/pl
Priority to PCT/IB2015/056510 priority patent/WO2016030855A1/en
Priority to EP15780935.1A priority patent/EP3186370B1/en
Publication of PL409283A1 publication Critical patent/PL409283A1/pl
Publication of PL229262B1 publication Critical patent/PL229262B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Ujawniono enzym o wysokiej aktywności litycznej w stosunku do komórek Enterococcus oraz sposób modyfikacji jego genu pozwalający na nadprodukcję aktywnego enzymu w komórkach bakteryjnych.
PL409283A 2014-08-27 2014-08-27 Polipeptyd zdolny do trawienia peptydoglikanu, jego zastosowania oraz kodujący go polinukleotyd PL229262B1 (pl)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PL409283A PL229262B1 (pl) 2014-08-27 2014-08-27 Polipeptyd zdolny do trawienia peptydoglikanu, jego zastosowania oraz kodujący go polinukleotyd
PCT/IB2015/056510 WO2016030855A1 (en) 2014-08-27 2015-08-27 Enzyme with high lytic activity against enterococcus cell and a method of modification of the gene thereof, enabling overproduction of active enzyme in bacterial cells
EP15780935.1A EP3186370B1 (en) 2014-08-27 2015-08-27 Enzyme with high lytic activity against enterococcus cell and a method of modification of the gene thereof, enabling overproduction of active enzyme in bacterial cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL409283A PL229262B1 (pl) 2014-08-27 2014-08-27 Polipeptyd zdolny do trawienia peptydoglikanu, jego zastosowania oraz kodujący go polinukleotyd

Publications (2)

Publication Number Publication Date
PL409283A1 true PL409283A1 (pl) 2016-02-29
PL229262B1 PL229262B1 (pl) 2018-06-29

Family

ID=54325010

Family Applications (1)

Application Number Title Priority Date Filing Date
PL409283A PL229262B1 (pl) 2014-08-27 2014-08-27 Polipeptyd zdolny do trawienia peptydoglikanu, jego zastosowania oraz kodujący go polinukleotyd

Country Status (3)

Country Link
EP (1) EP3186370B1 (pl)
PL (1) PL229262B1 (pl)
WO (1) WO2016030855A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101957266B1 (ko) * 2017-02-22 2019-03-13 주식회사 인트론바이오테크놀로지 엔테로코쿠스 패슘에 대하여 용균력을 가지는 신규한 항균단백질 efal-2
CN111909917B (zh) * 2019-05-10 2022-10-14 中国科学院微生物研究所 一种内溶素Lysmeta1及其编码基因与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2157100A1 (en) * 2008-08-19 2010-02-24 Profos AG Artificial peptidoglycan lysing enzymes and peptidoglycan binding proteins

Also Published As

Publication number Publication date
PL229262B1 (pl) 2018-06-29
EP3186370A1 (en) 2017-07-05
WO2016030855A1 (en) 2016-03-03
EP3186370B1 (en) 2020-01-01

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