PL401345A1 - Pochodne kamptotecyny, sposób ich otrzymywania i zastosowanie - Google Patents
Pochodne kamptotecyny, sposób ich otrzymywania i zastosowanieInfo
- Publication number
- PL401345A1 PL401345A1 PL401345A PL40134512A PL401345A1 PL 401345 A1 PL401345 A1 PL 401345A1 PL 401345 A PL401345 A PL 401345A PL 40134512 A PL40134512 A PL 40134512A PL 401345 A1 PL401345 A1 PL 401345A1
- Authority
- PL
- Poland
- Prior art keywords
- camptothecin derivatives
- preparation
- general formula
- synthesis
- iii
- Prior art date
Links
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Przedmiotem wynalazku są rozpuszczalne w wodzie pochodne kamptotecyny o wzorze ogólnym (I), ich synteza, związki pośrednie o wzorze ogólnym (II) i (III) oraz ich zastosowanie do wytwarzania leków przeciwnowotworowych.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL401345A PL235836B1 (pl) | 2012-10-25 | 2012-10-25 | Pochodne kamptotecyny, sposób ich otrzymywania i zastosowanie |
EP13824167.4A EP2912039B1 (en) | 2012-10-25 | 2013-10-25 | Derivatives of camptothecin, a method of producing them and their use |
PCT/IB2013/059668 WO2014064654A1 (en) | 2012-10-25 | 2013-10-25 | Derivatives of camptothecin, a method of producing them and their use |
PL13824167T PL2912039T3 (pl) | 2012-10-25 | 2013-10-25 | Pochodne kamptotecyny, sposób ich otrzymywania i zastosowanie |
US14/432,553 US9682992B2 (en) | 2012-10-25 | 2013-10-25 | Derivatives of camptothecin, a method of producing them and their use |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL401345A PL235836B1 (pl) | 2012-10-25 | 2012-10-25 | Pochodne kamptotecyny, sposób ich otrzymywania i zastosowanie |
Publications (2)
Publication Number | Publication Date |
---|---|
PL401345A1 true PL401345A1 (pl) | 2014-04-28 |
PL235836B1 PL235836B1 (pl) | 2020-11-02 |
Family
ID=50001041
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL401345A PL235836B1 (pl) | 2012-10-25 | 2012-10-25 | Pochodne kamptotecyny, sposób ich otrzymywania i zastosowanie |
PL13824167T PL2912039T3 (pl) | 2012-10-25 | 2013-10-25 | Pochodne kamptotecyny, sposób ich otrzymywania i zastosowanie |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL13824167T PL2912039T3 (pl) | 2012-10-25 | 2013-10-25 | Pochodne kamptotecyny, sposób ich otrzymywania i zastosowanie |
Country Status (4)
Country | Link |
---|---|
US (1) | US9682992B2 (pl) |
EP (1) | EP2912039B1 (pl) |
PL (2) | PL235836B1 (pl) |
WO (1) | WO2014064654A1 (pl) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109206432A (zh) * | 2017-06-30 | 2019-01-15 | 江苏汉邦科技有限公司 | 一种喜树碱单体的制备方法 |
LU102067B1 (en) * | 2020-09-17 | 2022-03-18 | Narodowy Inst Lekow | 7-Ethyl-10-hydroxycamptothecin derivatives for use in the treatment of cancer |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
JP2684104B2 (ja) * | 1990-02-09 | 1997-12-03 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
ITMI20061474A1 (it) * | 2006-07-26 | 2008-01-27 | Indena Spa | Derivati della camptotecina ad attivita antitumorale |
CN101133813B (zh) | 2007-09-17 | 2010-06-09 | 国投中鲁果汁股份有限公司 | 一种浓缩黄瓜清汁及生产方法 |
ES2371171B1 (es) * | 2010-06-08 | 2012-11-16 | Consejo Superior De Investigaciones Científicas (Csic) | Derivados de camptotecina como agentes antitumorales. |
CN103113381B (zh) * | 2013-02-26 | 2014-12-10 | 大连理工大学 | 系列水溶性羟基喜树碱环烷胺醇衍生物及其制法与用途 |
-
2012
- 2012-10-25 PL PL401345A patent/PL235836B1/pl unknown
-
2013
- 2013-10-25 PL PL13824167T patent/PL2912039T3/pl unknown
- 2013-10-25 EP EP13824167.4A patent/EP2912039B1/en active Active
- 2013-10-25 US US14/432,553 patent/US9682992B2/en active Active
- 2013-10-25 WO PCT/IB2013/059668 patent/WO2014064654A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
PL2912039T3 (pl) | 2018-01-31 |
PL235836B1 (pl) | 2020-11-02 |
US9682992B2 (en) | 2017-06-20 |
EP2912039B1 (en) | 2017-07-12 |
WO2014064654A1 (en) | 2014-05-01 |
US20150266888A1 (en) | 2015-09-24 |
EP2912039A1 (en) | 2015-09-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1123649T1 (el) | Παραγωγα ιμιδαζολινης, μεθοδοι παρασκευης αυτων και εφαρμογες αυτων στην ιατρικη | |
CY1118379T1 (el) | Αναστολεις ιου ηπατιτιδας c | |
PH12015501289A1 (en) | Novel benzimidazole derivatives as ep4 antagonists | |
NZ710729A (en) | Amatoxin derivatives | |
EA201491447A1 (ru) | Ендиины, их конъюгаты и способы их получения и применения | |
UA116648C2 (uk) | Фумарати як проліки та їх застосування при лікуванні різних захворювань | |
NZ743274A (en) | Substituted tricyclic compounds as fgfr inhibitors | |
EA201390203A1 (ru) | Способы получения тубулизинов | |
GB201106743D0 (en) | Novel compounds | |
IN2015DN03998A (pl) | ||
CY1124529T1 (el) | Ενωσεις λευκοχρυσου λειτουργικοποιημενες με μονομηλεινιμιδιο για θεραπεια καρκινου | |
CO7170173A2 (es) | Derivados de carbamato/urea | |
PH12018501709A1 (en) | Naphthridinedione derivatives | |
TR201819263T4 (tr) | Nörolojik hastalıkların tedavisi için pantotenat türevleri. | |
EA201590372A1 (ru) | Бициклические гетероарилциклоалкилдиаминовые производные в качестве ингибиторов тирозинкиназ селезенки (syk) | |
EP3126356A4 (en) | Sigma-2 receptor ligand drug conjugates as antitumor compounds, methods of synthesis and uses thereof | |
CY1119871T1 (el) | Στερεη μορφη αλατος της aλφa-6-mpeg6-o- υδροξυκωδονης ως αγωνιστες οπιοειδων και χρησεις αυτων | |
UA109804C2 (xx) | 2-метоксипіридин-4-ільні похідні | |
WO2014172363A3 (en) | Combretastatin analogs | |
MX365192B (es) | Derivados de bendamustina y compuestos relacionados, y uso medico de los mismos para la terapia de cancer. | |
MX2018004696A (es) | Analogos de epotilona, metodos de sintesis, metodos de tratamiento y conjugados con farmacos de los mismos. | |
PL401345A1 (pl) | Pochodne kamptotecyny, sposób ich otrzymywania i zastosowanie | |
MX2013003859A (es) | Polimorfos de picropodofilina b o c para su uso en la terapia del cancer. | |
PH12018500014A1 (en) | Total synthesis of shishijimicin a and analogs thereof | |
IN2014DN07481A (pl) |