PL3784666T3 - Związki przeciwproliferacyjne i ich zastosowania - Google Patents

Związki przeciwproliferacyjne i ich zastosowania

Info

Publication number
PL3784666T3
PL3784666T3 PL19726792.5T PL19726792T PL3784666T3 PL 3784666 T3 PL3784666 T3 PL 3784666T3 PL 19726792 T PL19726792 T PL 19726792T PL 3784666 T3 PL3784666 T3 PL 3784666T3
Authority
PL
Poland
Prior art keywords
antiproliferation
compounds
antiproliferation compounds
Prior art date
Application number
PL19726792.5T
Other languages
English (en)
Inventor
Henry Yu
Michael Clark
Guy Bemis
Michael Boyd
Kishan Chandupatla
Philip Collier
Hongbo Deng
Huijun DONG
Warren Dorsch
Russell R. Hoover
Mac Arthur Johnson Jr.
Shashank KULKARNI
Marina PENNEY
Steven Ronkin
Darin TAKEMOTO
Qing Tang
Nathan D. Waal
Tiansheng Wang
David J. Lauffer
Pan Li
Original Assignee
Merck Patent Gmbh
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Vertex Pharmaceuticals Incorporated filed Critical Merck Patent Gmbh
Publication of PL3784666T3 publication Critical patent/PL3784666T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
PL19726792.5T 2018-04-24 2019-04-23 Związki przeciwproliferacyjne i ich zastosowania PL3784666T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862661719P 2018-04-24 2018-04-24
PCT/US2019/028607 WO2019209759A1 (en) 2018-04-24 2019-04-23 Antiproliferation compounds and uses thereof

Publications (1)

Publication Number Publication Date
PL3784666T3 true PL3784666T3 (pl) 2022-07-18

Family

ID=66655429

Family Applications (2)

Application Number Title Priority Date Filing Date
PL19726792.5T PL3784666T3 (pl) 2018-04-24 2019-04-23 Związki przeciwproliferacyjne i ich zastosowania
PL22161962.0T PL4043460T3 (pl) 2018-04-24 2019-04-23 Związki przeciwproliferacyjne i ich zastosowania

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL22161962.0T PL4043460T3 (pl) 2018-04-24 2019-04-23 Związki przeciwproliferacyjne i ich zastosowania

Country Status (27)

Country Link
US (4) US10815225B2 (pl)
EP (2) EP3784666B1 (pl)
JP (2) JP7304892B2 (pl)
KR (1) KR102813581B1 (pl)
CN (1) CN112236428B (pl)
AR (1) AR114496A1 (pl)
AU (1) AU2019261308B2 (pl)
BR (1) BR112020020940A2 (pl)
CA (1) CA3098335A1 (pl)
CY (1) CY1125433T1 (pl)
DK (2) DK4043460T3 (pl)
ES (2) ES2919572T3 (pl)
FI (1) FI4043460T3 (pl)
HR (2) HRP20220710T1 (pl)
HU (2) HUE067936T2 (pl)
IL (2) IL278142B2 (pl)
LT (1) LT3784666T (pl)
MX (1) MX2020011089A (pl)
PL (2) PL3784666T3 (pl)
PT (2) PT4043460T (pl)
RS (1) RS63281B1 (pl)
SG (1) SG11202009500QA (pl)
SI (1) SI3784666T1 (pl)
SM (1) SMT202200308T1 (pl)
TW (1) TWI813673B (pl)
WO (1) WO2019209759A1 (pl)
ZA (1) ZA202006071B (pl)

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HUE067936T2 (hu) 2018-04-24 2024-11-28 Merck Patent Gmbh Proliferáció-gátló vegyületek és alkalmazásuk
WO2020010451A1 (en) * 2018-07-10 2020-01-16 Trillium Therapeutics Inc. Heteroaromatic-fused imidazolyl amides, compositions and uses thereof as sting agonists
WO2020236834A1 (en) * 2019-05-20 2020-11-26 Seshadri Raju Modified z stents for iliac vein stenting
CN118496197A (zh) 2019-12-20 2024-08-16 拜耳公司 取代的噻吩甲酰胺、噻吩甲酸及其衍生物
WO2024073502A1 (en) * 2022-09-28 2024-04-04 Accutar Biotechnology Inc. Heterocyclic compounds as e3 ligase inhibitors
WO2025223536A1 (zh) * 2024-04-26 2025-10-30 正大天晴药业集团股份有限公司 稠合双环化合物及其用途

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Also Published As

Publication number Publication date
CN112236428A (zh) 2021-01-15
JP2023101824A (ja) 2023-07-21
TW202012400A (zh) 2020-04-01
US20190322658A1 (en) 2019-10-24
US10815225B2 (en) 2020-10-27
PT4043460T (pt) 2024-09-10
HUE067936T2 (hu) 2024-11-28
EP3784666B1 (en) 2022-03-16
LT3784666T (lt) 2022-06-10
HUE058746T2 (hu) 2022-09-28
CY1125433T1 (el) 2025-05-09
MX2020011089A (es) 2020-11-06
US11440907B1 (en) 2022-09-13
BR112020020940A2 (pt) 2021-03-02
IL278142B1 (en) 2023-07-01
SI3784666T1 (sl) 2022-07-29
JP2021522242A (ja) 2021-08-30
PL4043460T3 (pl) 2024-10-28
US20230150993A1 (en) 2023-05-18
IL301501A (en) 2023-05-01
US12195453B2 (en) 2025-01-14
DK3784666T3 (da) 2022-06-20
EP3784666A1 (en) 2021-03-03
TWI813673B (zh) 2023-09-01
PT3784666T (pt) 2022-06-06
RS63281B1 (sr) 2022-06-30
JP7304892B2 (ja) 2023-07-07
KR102813581B1 (ko) 2025-05-29
FI4043460T3 (fi) 2025-05-09
IL301501B1 (en) 2024-06-01
DK4043460T3 (da) 2024-08-26
AR114496A1 (es) 2020-09-09
WO2019209759A1 (en) 2019-10-31
IL278142B2 (en) 2023-11-01
IL278142A (en) 2020-11-30
SG11202009500QA (en) 2020-11-27
HRP20220710T1 (hr) 2022-07-22
AU2019261308A1 (en) 2020-10-22
ZA202006071B (en) 2024-01-31
CA3098335A1 (en) 2019-10-31
IL301501B2 (en) 2024-10-01
KR20210005151A (ko) 2021-01-13
ES2919572T3 (es) 2022-07-27
CN112236428B (zh) 2025-04-01
US20250188070A1 (en) 2025-06-12
AU2019261308B2 (en) 2022-09-08
EP4043460A1 (en) 2022-08-17
HRP20241163T1 (hr) 2024-11-22
EP4043460B1 (en) 2024-06-05
ES2987356T3 (es) 2024-11-14
SMT202200308T1 (it) 2022-09-14

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